Skin Care and Treatments of Melbourne Dermatology - Ergothioneine

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Ergothioneine

Ergothioneine

Discovered in 1909 and named after ergot fungus, Ergothioneine (EGT) is a sulfur-containing amino acid obtained exclusively from the diet presumed to function as a natural antioxidant against UV-induced hydrogen peroxide responsible for oxidative and DNA damage.

Foods rich in ergothioneine include black and red beans and some species of mushrooms.

The chemistry of ergothioneine differs from conventional sulfur-containing antioxidants such as glutathione and alpha lipoic acid.

Skin cells and tissue are capable of using ergothioneine as an integral component of their antioxidant defense system.

Ergothioneine suppresses the expression of MMP-1 (proteins involved in the breakdown of extracellular matrix) and reduce inflammation.

Ergothioneine protects mitochondrial membranes against oxidation by transferring fatty acids into the mitochondria to help use oxygen efficiently and to produce more energy.

Ergothioneine also protects DNA from the oxidation of guanine.

Ergothioneine is available in a variety of Kinerase products (Hydrating Antioxidant Mist, Lip Treatment, Pro+ Cream, Pro+ Lotion), Cellex-C Advanced-C Neck Firming Cream, Advanced-C Serum and SkinMedica TNS Essential Serum.

Various IS Clinical products contain mushroom extracts containing ergothioneine.

Alternate scavengers of UV-induced hydrogen peroxide include EUK-134 (found in Alyria Corrective Protection SPF 30) and green tea polyphenols (available in highest (90%) concentration in Replenix).

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Ergothioneine protects the skin from oxidative and DNA damage. …


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