Skin Care and Treatments of Melbourne Dermatology - Ubiquinone (Co-Enzyme Q-10)

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Ubiquinone (Co-Enzyme Q-10)

Ubiquinone (Co-Enzyme Q-10)

Discovered in 1957, Ubiquinone is any of a class of lipid vitamin-like compounds (substituted quinones) that occur in all living cells and that act as electron-transfer agents in cell respiration.

The word originates in the 1950s and is a blend of "ubiquitous" and "quinone."

The highest concentration is found on the inner membranes of mitochondria.

The most common CoQ in human mitochondria is Q10 (also known as Ubiquinone-50). The number refers to the number of isoprenoid side-chains.

The safety of Coenzyme Q10 was established in the mid-90s.

The adult human body pool of Coenzyme Q10 has been found to be approximately 2 grams and requiring replacement of about 0.5 grams/day, based on an average reservoir effect of approximately 4 days.

Synthesis decreases progressively after the age of 21.

While there are literally thousand of antioxidants, Ubiquinone is one of the most important antioxidants in the skin (along with Vitamin C, Vitamin E, Glutathione and Alpha Lipoic Acid) and the one depleted most readily by UV exposure.

In addition to the production of energy (ATP), Ubiquinone has been shown to provide antioxidant defense in excess of Vitamin C and Vitamin E.

Topically applied Ubiquinone can counteract free radical damage and provide significant protection against UVA-induced detrimental effects of photoaging, however as with oral Coenzyme Q10 supplements, the bioavailability from and effectiveness of many formulations is not known.

Prevage MD contains 1% Hydroxydecyl Ubiquinone (Idebenone), a molecule smaller than Coenzyme Q10, and has been shown to penetrate deeply and embed itself in skin cell membranes to provide protection against both environmentally and endogenously induced free radicals.

By EPF rating Hydroxydecyl Ubiquinone is the most powerful antioxidant available.

Higher concentrations of conventional ubiquinone are available in DCL YQ Stratum, Citrix Antioxidant Sunscreen, SkinMedica TNS Essential Serum and SPF 20, Neova Antioxidant Therapy Serum, Manganese Skin Brightening Serum and Eye Therapy.

Note: CoQ10 is not recommended in healthy pregnant women or nursing mothers due to a lack of data. Oral Coenzyme Q10 supplements may increase the glucose-lowering effect of diabetes medications and decrease the anticoagulant effect of warfarin. Check with your healthcare provider before using Coenzyme Q10 supplements.

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