Skin Care and Treatments of Melbourne Dermatology - Aging Skin

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Aging Skin

Aging Skin

Monday, 9 November 2009

Pathogenisis of Skin Aging

The pathogenesis of skin aging is well defined.

It is characterized by a decrease in collagen synthesis and an increase in collagen breakdown, mediated by metalloproteinases (Arch. Dermatol. 138[11]:1462-70, 2002).

This net loss in dermal collagen is believed to cause wrinkling.

Biologic factors that stimulate collagen production in wound healing might provide similar benefits for aging skin.

Accordingly, growth factors, peptide fragments, and other biologically active molecules are being incorporated into antiaging cosmeceuticals.

Friday, 12 February 2010

La Roche-Posay — Aging Skin Video: Deep Wrinkles, Loss of Firmness


The pathogenesis of skin aging is well defined.

It is characterized by a decrease in collagen synthesis and an increase in collagen breakdown, mediated by metalloproteinases (Arch. Dermatol. 138[11]:1462-70, 2002).

This net loss in dermal collagen is believed to cause wrinkling.

Biologic factors that stimulate collagen production in wound healing might provide similar benefits for aging skin.

Accordingly, growth factors, peptide fragments, and other biologically active molecules are being incorporated into antiaging cosmeceuticals.

Monday, 17 May 2010

Effects of Madecassoside on Aging Skin

In skin, the major components are collagen type I and collagen type III.

Skin aging is inextricably linked with a decrease in type I collagen.

Studies dating back to the 1980s indicate that glycosides found in Centella Asiatica such as madecassoside increase collagen synthesis and that combinations of glycosides of Centella Asiatica combined with Vitamin C as ascorbic acid produce greater collagen type I synthesis than either alone.

In addition madecassoside reduces the activity of dermal matrix degrading enzymes (MMPs — Matrix MetalloProteinases of type I, 3 and 9) which break down the compounds occurring chiefly as components of connective tissue.

Madecassoside, particularly in combination with ascorbic acid, both enhances and protects the turgidity (bounce) of skin.

The clinical experience has been that skin care products containing significant concentrations of pure extracts of Centella Asiatica such as madecassoside provide obvious skin firming effects when used for at least six weeks.

The effectiveness of skin care products containing trace amounts of Centella Asiatica, and products not containing the isolated glycosides of Centella Asiatica, has either been poor or impossible to judge with any accuracy.

Skin care products containing healthy amounts of extracts of Centella Asiatica such as madecassoside can be expected to perform better than the popular implementations of peptides used in skin care.

Sunday, 7 June 2009

Topical Niacinamide Reduces Yellowing, Wrinkling, Red Blotchiness and Hyperpigmented Spots in Aging Facial Skin

Previous clinical testing of topical niacinamide (vitamin B3) has revealed a broad array of improvements in the appearance of aging facial skin.

The study reported here was done to confirm some of those previous observations and to evaluate additional end points such as skin anti-yellowing.

Caucasian female subjects (n = 50, aged 40—60 years) participated in a 12-week, double-blind, placebo-controlled, split-face, left—right randomized clinical study assessing two topical products: moisturizer control product versus the same moisturizer product containing 5% niacinamide.

Niacinamide was well tolerated by the skin and provided significant improvements versus control in end points evaluated previously: fine lines/wrinkles, hyperpigmentation spots, texture, and red blotchiness.

In addition, skin yellowing (sallowness) versus control was significantly improved. The mechanism by which this array of benefits is achieved with niacinamide is discussed.

International Journal of Cosmetic Science 26 (5) , 231—238 doi:10.1111/j.1467-2494.2004.00228.x.

D. L. Bissett, K. Miyamoto, P. Sun, J. Li, C. A. Berge (2004).

Thursday, 1 April 2010

Glycolic Acid

Glycolic Acid, the smallest molecule of the AHAs, accelerates the skin’s own natural shedding process.

Known as the exfoliant of choice, glycolic acid helps smooth the surface of dry, sun-damaged or aging skin, improving roughness and minimizing fine lines by removing the build-up of dead skin cells on the surface of the skin.

Thursday, 3 April 2008

Visible and Invisible Light and Heat Are Photoaging

IR/visible light and heat of natural sunlight, in addition to UV, play a role in modulating the expressions of MMPs and procollagen, and inflammatory cell infiltration in human skin.


Infrared plus visible light and heat from natural sunlight participate in the expression of MMPs and type I procollagen as well as infiltration of inflammatory cell in human skin in vivo.

Soyun Cho, Min Jung Lee, Mi Sun Kim, Serah Lee, Yoon Kyung Kim, Dong Hun Lee, Chae Wook Lee, Kwang Hyun Cho, Jin Ho Chung.

Journal of dermatological science 1 May 2008 (volume 50 issue 2 Pages 123-133 DOI: 10.1016/j.jdermsci.2007.11.009).

Sunday, 9 August 2009

Signs of Aging

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New/Notable 2016

Open Pores — Treatment and Prevention

MD Rx Melbourne Dermatology Open Pores Overnight Solution

The Sun

Radiation

Mexoryl

Pentapeptides Ineffective

Asiaticoside vs. Madecassoside for Collagen Synthesis

La Roche-Posay Redermic

Valeant Pharmaceuticals

Rainbow

Telomerase

Azelaic Acid

Bisabolol

Avena Sativa

Panthenol

Aster Family of Plants

Green Tea (Camellia Sinensis) Extract

Polyphenols

Caffeine

Oxofulleram

Salicylic Acid

Capryloyl Salicylic Acid

Open Pores

Phytosphingosine

Glycerin

Idebenone

Ascorbyl Palmitate

Kojic Acid

Algorithm for Optimal Sustained Exfoliation: Glycolic Acid

Comparison of 33 Sunscreens