Skin Care and Treatments of Melbourne Dermatology - Photoprotective (UVB) Salen-Manganese Complex (EUK-134)

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Photoprotective (UVB) Salen-Manganese Complex (EUK-134)

EUK-134 Salen-Manganese Complex is a UVB photoprotective agent, for supplementary use with sunscreens, available in Alyria Corrective Protection SPF 30 Lotion.


Salen-manganese complexes exhibit powerful superoxide dismutase and catalase activity, with pharmacologic efficacy in several oxidative-stress-associated disease models.

Ultraviolet UVB not only induces direct DNA damage, but also generates oxidative stress.

EUK-134, a salen-manganese complex, might therefore confer a direct protection against UVB-induced oxidative stress and consequently alleviate UVB-damage-induced signal transduction.

We investigated the effect of EUK-134 on the UVB-induced accumulation and stabilization of the p53 protein.

Cells treated with EUK-134 before UVB irradiation showed a significantly lower accumulation of the p53 protein in a concentration-dependent fashion.

Furthermore, EUK-134 severely reduced N-terminal phosphorylation of p53.

The extracellular signal-regulated kinase ERK and the stress-activated kinases JNK and p38 have been implicated in the UVB-induced N-terminal phosphorylation and accumulation of p53.

Pre-treatment with EUK-134 inhibited the UVB-induced activation of these mitogen-activated protein kinase (MAPK) pathways.

We hypothesize that EUK-134, by direct protection of the membrane from UVB-induced oxidative damage, reduces oxidative stress induced MAPK signaling and consequently lowers the level of p53 induction.

The protection conferred by EUK-134 resulted in a significant increase in cell survival following UVB irradiation.


A Synthetic Superoxide Dismutase/Catalase Mimetic (EUK-134) Inhibits Membrane-Damage-Induced Activation of Mitogen-Activated Protein Kinase Pathways and Reduces p53 Accumulation in Ultraviolet B-Exposed Primary Human Keratinocytes

David Decraene*, Katrien Smaers*, David Gan†, Tom Mammone†, Mary Matsui†, Daniel Maes†, Lieve Declercqŗ and Marjan Garmyn*

Department of Dermatology, University of Leuven, Leuven, Belgium

†Estée Lauder Companies, Melville, New York, USA

ŗEstée Lauder Coordination Center, Oevel, Belgium

Correspondence: Marjan Garmyn, Department of Dermatology, UZ St. Rafaël, Kapucijnenvoer 33, B-3000 Leuven, Belgium. Email: Marjan.Garmyn@med.kuleuven.ac.be

Received 14 February 2003; Revised 4 August 2003; Accepted 22 October 2003; Published online 12 February 2004.

Keywords: oxidative stress, skin, p53 phosphorylation, manganese compounds, hydrogen peroxide.

Abbreviations: AAPH, 2,2'-azobis(2-amidinopropane)dihydrochloride; ERK, extracellular signal-regulated kinase; JNK/SAPK, c-Jun N-terminal kinase/stress-activated protein kinase; MAPK, mitogen-activated protein kinase; ROS, reactive oxygen species; SOD, superoxide dismutase; UV, ultraviolet.

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Alyria : Alyria Corrective Protection SPF 30 Oil Free Lotion :

Photoprotective (UVB) Salen-Manganese Complex (EUK-134) : Alyria Corrective Protection SPF 30 Oil Free Lotion Sunscreen Ingredients : Alyria Corrective Protection SPF 30 Oil Free Lotion Ingredients :


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