Skin Care and Treatments of Melbourne Dermatology - Asiaticoside vs. Madecassoside for Collagen Synthesis

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Asiaticoside vs. Madecassoside for Collagen Synthesis

Asiaticoside vs. Madecassoside for Collagen Synthesis

Skin aging is marked by a decrease in collagen synthesis and an increase in collagen breakdown effected by metalloproteinases.

The net loss in dermal collagen is thought to cause wrinkles.

Purified isolates of Centella Asiatica, such as asiaticoside and madecassoside, which have been shown to stimulate collagen production, are incorporated into some anti-aging products with the aim of preventing and reducing wrinkles.

Twenty-nine types of collagen have thus far been identified, however Type I and III collagens are the major components of the dermis, where wrinkling changes occur.

While both asiaticoside and madecassoside stimulate collagen Type I and III, thus far only madecassoside has been shown to significantly increase collagen III.

Skin care products containing asiaticoside and madecassoside such as La Roche-Posay Redermic may be used in addition to retinoids, Vitamin C and sunscreen for greater collagen synthesis.

Reference: Bonté F, Dumas M, Chaudagne C, Meybeck A. Ann Pharm Fr. 1995;53(1):38-42.

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