Skin Care and Treatments of Melbourne Dermatology - Back Acne

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Back Acne

Back Acne

Sunday, 9 August 2009

NeoStrata Gel Plus AHA 15

NeoStrata Gel Plus AHA 15 is a quickly absorbed, nongreasy, oil free extra-strength 15% Glycolic Acid gel based in Alcohol for the body by those who prefer the light fresh feel of a gel instead of a cream or lotion.


Specially formulated for the relief of rough, dry, thickened skin on the hands, elbows and other areas of the body.

NeoStrata Gel Plus AHA 15 is ideal for oily and back acne-prone skin.

Fragrance-free.

Note: This product replaces NeoStrata 'AHA Enhanced Gel- 15.'

Wednesday, 7 November 2007

ClindaReach Back Acne Treatment

ClindaReach Back Acne Treatment

ClindaReach is a new prescription back acne treatment combining 1% clindamycin (phosphate solution) with a collapsible applicator featuring a pivoting head.

The "starter treatment set" comprises a set of various single-use disposable pads (for cleansing and applying the clindamycin medication).


ClindaReach Prescribing Information

ClindaReach (Clindamycin Phosphate Topical Solution USP, 1%), Pledgets (ClindaReach) contain clindamycin phosphate, USP at a concentration equivalent to 10 mg clindamycin per milliliter.

Each ClindaReach pledget applicator contains approximately 1 mL of topical solution.

Clindamycin phosphate is a water soluble ester of the semi-synthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent antibiotic lincomycin.

The solution contains isopropyl alcohol 50% v/v, propylene glycol, sodium hydroxide (to adjust the pH to between 4.0-7.0) and purified water.

The chemical name for clindamycin phosphate is Methyl 7-chloro-6, 7,8-trideoxy-6- (1-methyltrans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-?-D-galacto-octopyranoside 2- (dihydrogen phosphate).

It has a molecular weight of 504.96, and the molecular formula is C18H34CIN2O8PS.

ClindaReach Clinical Pharmacology

Although clindamycin phosphate is inactive in vitro, rapid in vivo hydrolysis converts this compound to the antibacterially active clindamycin.

Cross resistance has been demonstrated between clindamycin and lincomycin.

Antagonism has been demonstrated between clindamycin and erythromycin.

Following multiple topical applications of clindamycin phosphate at a concentration equivalent to 10 mg clindamycin per mL in an isopropyl alcohol and water solution, very low levels of clindamycin are present in the serum (0-3 ng/mL) and less than 0.2% of the dose is recovered in urine as clindamycin.

Clindamycin activity has been demonstrated in comedones from acne patients.

The mean concentration of antibiotic activity in extracted comedones after application of Clindamycin Phosphate Topical Solution for 4 weeks was 597 mcg/g of comedonal material (range 0-1490).

Clindamycin in vitro inhibits all Propionibacterium acnes cultures tested (MICs 0.4 mcg/mL).

Free fatty acids on the skin surface have been decreased from approximately 14% to 2% following application of clindamycin.

ClindaReach Indications and Usage

ClindaReach is indicated in the treatment of acne vulgaris.

In view of the potential for diarrhea, bloody diarrhea and pseudomembranous colitis, the physician should consider whether other agents are more appropriate.

ClindaReach Contraindications

ClindaReach is contraindicated in individuals with a history of hypersensitivity to preparations containing clindamycin or lincomycin, a history of regional enteritis or ulcerative colitis, or a history of antibiotic-associated colitis.

ClindaReach Warnings

Orally and parenterally administered clindamycin has been associated with severe colitis which may result in patient death.

Use of the topical formulation of clindamycin results in absorption of the antibiotic from the skin surface.

Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of topical and systemic clindamycin.

Studies indicate a toxin(s) produced by clostridia is one primary cause of antibiotic-associated colitis.

The colitis is usually characterized by severe persistent diarrhea and severe abdominal cramps and may be associated with the passage of blood and mucus.

Endoscopic examination may reveal pseudomembranous colitis. Stool culture for Clostridium difficile and stool assay for C. difficile toxin may be helpful diagnostically.

When significant diarrhea occurs, the drug should be discontinued.

Large bowel endoscopy should be considered to establish a definitive diagnosis in cases of severe diarrhea.

Antiperistaltic agents such as opiates and diphenoxylate with atropine may prolong and/or worsen the condition.

Vancomycin has been found to be effective in the treatment of antibiotic-associated pseudomembranous colitis produced by Clostridiumdifficile.

The usual adult dosage is 500 milligrams to 2 grams of vancomycin orally per day in three to four divided doses administered for 7 to 10 days.

Cholestyramine or colestipol resins bind vancomycin in vitro. If both a resin and vancomycin are to be administered concurrently, it may be advisable to separate the time of administration of each drug.

Diarrhea, colitis, and pseudomembranous colitis have been observed to begin up to several weeks following cessation of oral and parenteral therapy with clindamycin.

ClindaReach Precautions

General

ClindaReach contains an alcohol base that will cause burning and irritation of the eye.

In the event of accidental contact with sensitive surfaces (eye, abraded skin, mucous membranes), bathe with copious amounts of cool tap water.

The solution has an unpleasant taste and caution should be exercised when applying medication around the mouth.

ClindaReach should be prescribed with caution in atopic individuals.

Drug Interactions

Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore it should be used with caution in patients receiving such agents.

Pregnancy: Teratogenic Effects-Pregnancy Category B

Reproduction studies have been performed in rats and mice using subcutaneous and oral doses of clindamycin ranging from 100 to 600 mg/kg/day and have revealed no evidence of impaired fertility or harm to the fetus due to clindamycin.

There are, however, no adequate and well-controlled studies in pregnant women.

Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

Nursing Mothers

It is not known whether clindamycin is excreted in human milk following use of ClindaReach.

However, orally and parenterally administered clindamycin has been reported to appear in breast milk.

Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Pediatric Use

Safety and effectiveness in pediatric patients under the age of 12 have not been established.

ClindaReach Adverse Reactions

ClindaReach Adverse Reactions

In 18 clinical studies of various formulations of topical Clindamycin Phosphate using placebo vehicle and/or active comparator drugs as controls, patients experienced a number of treatment emergent adverse dermatologic events [see table below].

Orally and parenterally administered clindamycin has been associated with severe colitis which may end fatally.

Cases of diarrhea, bloody diarrhea and colitis (including pseudomembranous colitis) have been reported as adverse reactions in patients treated with oral and parenteral formulations of clindamycin and rarely with topical clindamycin (see WARNINGS).

Abdominal pain and gastrointestinal disturbances as well as gram-negative folliculitis have also been reported in association with the use of topical formulations of clindamycin.

Overdosage

Topically applied ClindaReach can be absorbed in sufficient amounts to produce systemic effects. (See WARNINGS.)

ClindaReach Dosage and Administration

Apply a thin film of ClindaReach twice daily to affected area. More than one pledget may be used.

Each pledget should be used only once and then be discarded.

Remove pledget from jar just before use. Do not use if the seal under the cap is broken. Discard after single use. Keep all liquid dosage forms in containers tightly closed.

ClindaReach Supply

ClindaReach Pledgets contain Clindamycin Phosphate Topical Solution.

The solution contains Clindamycin Phosphate equivalent to 10 mg clindamycin per milliliter.

ClindaReach is supplied as 120 single use pledgets, packaged as two jars of 60 single use pledgets each.

Store at controlled room temperature 15° to 30°C (59° to 86°F) [See USP]. Protect from freezing. Flash Point 75°F.

Rx only.

Manufactured for: Sirius Laboratories, a wholly owned subsidiary of DUSA Pharmaceuticals, Inc., 25 Upton Dr,Wilmington, MA 01887.

Manufactured by:

PERRIGO, Bronx, NY 10457.

Patent pending.

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