Skin Care

Facial Skin Condition Treatments

Adult Acne
Broken Capillaries
Dark Circles
Deep Wrinkles
Dry Skin
Fine Lines
Hyperpigmentation
Open Pores
Puffy Eyes
Rosacea
Sagging Skin

Body Skin Condition Treatments

Aging Hands
Breast Firming
Cellulite
Hands
Keratosis Pilaris
Lips
Scalp Acne
Stretch Marks

Skin Care Ingredients

Clinical Procedures and Topics

Four Fundamentals
Absurd Skin Care
Aging Skin
Antioxidants
Botox
Enzyme Exfoliation
Free Radical Damage
French Skin Care
Glycolic Acid
Idebenone
Irrational Fears
Klein Becker
Oxidative Stress
Paula Begoun
Perricone
Restylane
Skin Structure
Stem Cells
Healthy Skin Barrier Function
Smoking
Sun Protection
Topical Vitamin C/Firming
Choices and Needs
Strivectin
Additional clinical skincare topics.

Skin aging is inextricably linked with a decrease in type I collagen.

Studies dating back to the 1980s indicate that glycosides found in Centella Asiatica such as madecassoside increase collagen synthesis and that combinations of glycosides of Centella Asiatica combined with Vitamin C as ascorbic acid produce greater collagen type I synthesis than either alone.

In addition madecassoside reduces the activity of dermal matrix degrading enzymes (MMPs — Matrix MetalloProteinases of type I, 3 and 9) which break down the compounds occurring chiefly as components of connective tissue.

Madecassoside, particularly in combination with ascorbic acid, both enhances and protects the turgidity (bounce) of skin.

The clinical experience has been that skin care products containing significant concentrations of pure extracts of Centella Asiatica such as madecassoside provide obvious skin firming effects when used for at least six weeks.

The effectiveness of skin care products containing trace amounts of Centella Asiatica, and products not containing the isolated glycosides of Centella Asiatica, has either been poor or impossible to judge with any accuracy.

Skin care products containing healthy amounts of extracts of Centella Asiatica such as madecassoside can be expected to perform better than the popular implementations of peptides used in skin care.

Madecassoside enhances post procedure healing and improves the outcome of the inflammatory phase of hypertrophic scars and keloids.

Madecassoside may also assist the treatment of phlebitis, cellulitis, slow-healing wounds, scars and stretch marks.

La Roche-Posay Redermic formulas contain madecassoside in combination with Vitamin C as ascorbic acid, a combination which has been shown to be superior to either ingredient alone, however is best not applied at the same time as retinoids.

Use of La Roche-Posay Redermic has not been associated with contact sensitivity.

La Roche-Posay Cicaplast is a barrier repair product which contains madecassoside in addition to gluconates of copper, zinc and manganese.

Dermalogica Super Rich Repair (now discontinued) also contained madecassoside albeit without ascorbic acid and in small concentration.

Cellex-C Cellulite Smoothing Complex contains madecassoside as part of its Centella Asiatica content and may help prevent and reduce new stretch marks.

Madecassoside is also found in La Roche-Posay Kerium Anti-Hair Loss.

AM Madecassoside Skin Care Protocol for Aging Skin

After the application of any antioxidant serums (optional), apply La Roche-Posay Redermic Eyes and either La Roche-Posay Redermic for Combination Skin or La Roche-Posay Redermic for Dry Skin before the application of sunscreen.

Alternatively, use La Roche-Posay Redermic UV in place of any of the Redermic formulas for facial (excluding eye contour) skin and sunscreen.

PM Madecassoside Skin Care Protocol for Aging Skin

As per AM excluding sunscreen and not at the same time as retinoids.

Madecassoside Skin Care Notes

Ideally, wait several minutes when layering any products.

These isolates are mainly found in skin care from IS Clinical and to a lesser extent Skinceuticals.

The net loss in dermal collagen is thought to cause wrinkles.

Purified isolates of Centella Asiatica, such as asiaticoside and madecassoside, which have been shown to stimulate collagen production, are incorporated into some anti-aging products with the aim of preventing and reducing wrinkles.

Twenty-nine types of collagen have thus far been identified, however Type I and III collagens are the major components of the dermis, where wrinkling changes occur.

While both asiaticoside and madecassoside stimulate collagen Type I and III, thus far only madecassoside has been shown to significantly increase collagen III.

Skin care products containing asiaticoside and madecassoside such as La Roche-Posay Redermic may be used in addition to retinoids, Vitamin C and sunscreen for greater collagen synthesis.

Reference: Bonté F, Dumas M, Chaudagne C, Meybeck A. Ann Pharm Fr. 1995;53(1):38-42.