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Perennial / Wisdoms

UV Exposure
Aging Skin and Mature Skin
Theories of Aging
Antioxidants
Sunscreens

Skin Care

Allergan
Alyria
Anthelios
Avene
Biomedic
Blue Lizard
Cellex-C
Citrix
Clarisonic
Colorescience
DCL
Dermatix
Elastiderm
Elta MD
Ethocyn
Glycolix
Glytone
Heliocare
IS Clinical
Jane Iredale
Jan Marini
Kinerase
Kinerase Clear
Kinerase PhotoFacials
Kinerase Pro+
La Roche Posay
L-M-X
MD Rx
Neoceuticals
Neocutis
Neostrata
Neova
Nia24
Obagi
Obagi Clenziderm
Obagi Professional-C
Obagi Rosaclear
OC Eight
Olos
PCA Skin
Prevage MD
Remergent
Replenix
RevaleSkin
Revitalash
Scarguard
Skinceuticals
SkinMedica
Teamine
Ti-Silc / Z-Silc
Topix
Tricomin
VitaMedica
Zeno MD
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Facial Skin Condition Treatments

Adult Acne
Broken Capillaries
Dark Circles
Deep Wrinkles
Dry Skin
Fine Lines
Hyperpigmentation
Open Pores
Puffy Eyes
Rosacea
Sagging Skin

Body Skin Condition Treatments

Aging Hands
Breast Firming
Cellulite
Hands
Keratosis Pilaris
Lips
Scalp Acne
Stretch Marks

Skin Care Ingredients

Alpha Lipoic Acid
Arginine + Serine
Asiatic Acid
Blueberry
Caffeine
Capryloyl Salicylic Acid
Ceramides
Chlorogenic Acid
Chrysin
Coffee Berry
Hydrolyzed Hyaluronic Acid
Mexoryl
Pro-Xylane
Silymarin
Sodium Laureth Sulfate/Sulphate
Browse more ingredients.

Clinical Procedures and Topics

Four Fundamentals
Absurd Skin Care
Aging Skin
Antioxidants
Botox
Enzyme Exfoliation
Free Radical Damage
French Skin Care
Glycolic Acid
Idebenone
Irrational Fears
Klein Becker
Oxidative Stress
Paula Begoun
Perricone
Restylane
Skin Structure
Stem Cells
Healthy Skin Barrier Function
Smoking
Sun Protection
Topical Vitamin C/Firming
Choices and Needs
Strivectin
Additional clinical skincare topics.

accuracy acid activity addition aging alone amounts ascorbic asiatica back better both bounce break care centella chiefly clinical collagen combination combinations combined components compounds concentrations connective containing dating decrease degrading dermal down effectiveness effects either enhances enzymes expected experience extracts firming found glycosides greater healthy iii implementations impossible increase indicate inextricably isolated judge least linked madecassoside major matrix metalloproteinases mmps obvious occurring particularly peptides perform poor popular produce products protects provide pure reduces significant six skin studies synthesis tissue trace turgidity type used vitamin weeks –

Skin aging is inextricably linked with a decrease in type I collagen.

Studies dating back to the 1980s indicate that glycosides found in Centella Asiatica such as madecassoside increase collagen synthesis and that combinations of glycosides of Centella Asiatica combined with Vitamin C as ascorbic acid produce greater collagen type I synthesis than either alone.

In addition madecassoside reduces the activity of dermal matrix degrading enzymes (MMPs – Matrix MetalloProteinases of type I, 3 and 9) which break down the compounds occurring chiefly as components of connective tissue.

Madecassoside, particularly in combination with ascorbic acid, both enhances and protects the turgidity (bounce) of skin.

The clinical experience has been that skin care products containing significant concentrations of pure extracts of Centella Asiatica such as madecassoside provide obvious skin firming effects when used for at least six weeks.

The effectiveness of skin care products containing trace amounts of Centella Asiatica, and products not containing the isolated glycosides of Centella Asiatica, has either been poor or impossible to judge with any accuracy.

Skin care products containing healthy amounts of extracts of Centella Asiatica such as madecassoside can be expected to perform better than the popular implementations of peptides used in skin care.