Skinceuticals C E Ferulic Study - Introduction: Melbourne Dermatology Skin Care

Clinical Procedures and Topics

absorption acid addition against allows although antioxidant antioxidants application applied ascorbic best both cell cells cellular chain characteristics chemical chemically coantioxidants combination compound concentration conjugation cosmetic damage demonstrate demonstrated dimer effects elegance environments erythema extended ferulic figure form formation formulated formulation found fourfold free graf hydrophilic important improve improves increases induced initiating introduction isomerization kikuzaki leading light lignin lipophilic lower markedly maximize meaningful measured molecular nucleus number participate percutaneous phenolic phenoxy photo photoprotection plant plants previously properly protection protects provide provided pure radiation radical readily reservoirs resonance scavenging side simulated skin skinceuticals solar solubility solution stability stabilized study tocopherol topical

Skinceuticals C E Ferulic Study - Introduction

We previously demonstrated that topical antioxidants, when properly formulated to maximize percutaneous absorption, can supplement the antioxidant reservoirs of skin and provide meaningful photoprotection (Lin et al., 2003).

Thus, 15% L-ascorbic acid and 1% a-tocopherol formulated at pH lower than 3.5 [as per Skinceuticals C + E] to allow percutaneous absorption provide synergistic photoprotection when topically applied to skin.

We have demonstrated that this combination protects skin fourfold against photo-induced erythema, cellular damage as measured by sunburn cells, and thymine dimer formation.

In an attempt to improve the stability of this antioxidant formulation, we have surveyed a number of low molecular weight, chemically pure coantioxidants.

Ferulic acid at a concentration of 0.5% provided the best combination of stability and cosmetic elegance. Ferulic acid is a ubiquitous plant antioxidant. (Figure 1) (Graf, 1992; Kikuzaki et al., 2002).

It is important in plant cell wall and lignin synthesis.

Although this compound is found only in plants, it has characteristics that may provide useful antioxidant protection for skin. It has solubility in both hydrophilic and lipophilic environments.

Its phenolic nucleus and extended side chain conjugation allows it to readily form a resonance stabilized phenoxy radical which accounts for its strong radical-scavenging effects.

In addition, it absorbs ultraviolet light initiating phenoxy radical formation leading to cis-trans isomerization.

The phenoxy radical can participate in free radical scavenging (Graf, 1992).

In this study, we demonstrate that 0.5% ferulic acid improves the chemical stability of a solution of 15% L-ascorbic acid and 1% a-tocopherol.

In addition, topical application to skin of the ferulic acid stabilized formulation markedly increases photoprotection against solar-simulated radiation.

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Skinceuticals C E Ferulic Study - Introduction


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	Skinceuticals C E Ferulic Study - Introduction We previously demonstrated that topical antioxidants, when properly formulated to maximize percutaneous absorption, can supplement the antioxidant reservoirs of skin and provide meaningful photoprotection (Lin et al., 2003). Thus, 15% L-ascorbic acid and 1% a-tocopherol formulated at pH lower than 3.5 [as per Skinceuticals C + E] to allow percutaneous absorption provide synergistic photoprotection when topically applied to skin. We have demonstrated that this combination protects skin fourfold against photo-induced erythema, cellular damage as measured by sunburn cells, and thymine dimer formation. In an attempt to improve the stability of this antioxidant formulation, we have surveyed a number of low molecular weight, chemically pure coantioxidants. Ferulic acid at a concentration of 0.5% provided the best combination of stability and cosmetic elegance. Ferulic acid is a ubiquitous plant antioxidant. (Figure 1) (Graf, 1992; Kikuzaki et al., 2002). It is important in plant cell wall and lignin synthesis. Although this compound is found only in plants, it has characteristics that may provide useful antioxidant protection for skin. It has solubility in both hydrophilic and lipophilic environments. Its phenolic nucleus and extended side chain conjugation allows it to readily form a resonance stabilized phenoxy radical which accounts for its strong radical-scavenging effects. In addition, it absorbs ultraviolet light initiating phenoxy radical formation leading to cis-trans isomerization. The phenoxy radical can participate in free radical scavenging (Graf, 1992). In this study, we demonstrate that 0.5% ferulic acid improves the chemical stability of a solution of 15% L-ascorbic acid and 1% a-tocopherol. In addition, topical application to skin of the ferulic acid stabilized formulation markedly increases photoprotection against solar-simulated radiation. Related Skin Care Information, Products and Expert Discussions Skinceuticals C E Ferulic Study - Discussion Antioxidant Potential of Ferulic Acid Skinceuticals C E Ferulic Study - Conclusions Skinceuticals C E Ferulic Study - Results Skinceuticals C E Ferulic Published Scientific Data Skin Care Procedures, Protocols and Topics : Skinceuticals C E Ferulic Clinical Notes : Idebenone — Prevage and Priori vs Skinceuticals C E Ferulic : A Topical Antioxidant Solution Containing Vitamin C, Vitamin E, and Ferulic Acid Prevents Ultraviolet Radiation-Induced Caspase-3 Induction in Skin : Antioxidant Potential of Ferulic Acid : Skinceuticals Antioxidant Protection - Serums Comparison Graph : Skinceuticals C E Ferulic Published Scientific Data : Skinceuticals C E Ferulic Study - Conclusions : Skinceuticals C E Ferulic Study - Discussion : Skinceuticals C E Ferulic Study - Introduction : Skinceuticals C E Ferulic Study - Methods : Skinceuticals C E Ferulic Study - Reference List : Skinceuticals C E Ferulic Study - Results : Skinceuticals C E Ferulic Video : Skinceuticals Sunburn Cell Reduction - Serums Comparison Chart : File Skinceuticals C E Ferulic Study - Introduction for reference.	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