Wednesday, 17 September 2008
Collagenase is a proteolytic enzyme capable of breaking collagen by digesting their peptide bonds.
Once the initial cleavage is made, less specific proteases complete the degradation.
Collagenase production can be induced by an immune response, by cytokines which stimulate cells such as fibroblasts and osteoblasts, and cause indirect damage to skin tissues.
Collagenases from mammalian cells are metallo enzymes and are collagen type specific.
Collagenases be released in latent proenzyme form into tissues and require activation by other proteases before they will degrade fibrillar matrix.
Bacterial collagenases are used in tissue disruption for cell harvesting.
Tuesday, 17 March 2009
Collagen is a protein that makes up most of the dermis, the middle layer of the skin. Collagen forms a network of fibers that provides a framework for the growth of cells and blood vessels, and also acts as the support structure for the skin. In young skin, the collagen framework is intact and the skin remains moisturized and elastic. Over time, collagen fibers loosen and unravel, and skin loses its elasticity.
Sunday, 2 August 2009
Monday, 3 August 2009
Wednesday, 19 August 2009
Tuesday, 25 August 2009
Tuesday, 25 August 2009
Tuesday, 25 August 2009
Tuesday, 17 March 2009
Collagen is a protein that makes up most of the dermis, the middle layer of the skin.
Collagen forms a network of fibers that provides a framework for the growth of cells and blood vessels, and also acts as the support structure for the skin.
In young skin, the collagen framework is intact and the skin remains moisturized and elastic.
Over time, collagen fibers loosen and unravel, and skin loses its elasticity.