Skin Care and Treatments of Melbourne Dermatology - Genistein

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Genistein


The isoflavone genistein occurs naturally as the major active constituent of soybeans.

Thursday, 18 March 2010

Genistein Protects Against UVB-Induced Senescence-Like Characteristics in Human Dermal Fibroblast by p66Shc Down-Regulation

Background

Genistein, as an active compound of dietary antioxidants, has shown considerable promise as an effective agent against aging process. However, the effect of genistein on skin photoaging and the associated mechanism remain unclear.

Objective

To delineate the effect of genistein on UVB-induced senescence in human dermal fibroblasts (HDFs) with emphasis on the mechanism of oxidative pathway regulated by p66Shc involved in the events.

Methods

HDFs were induced to premature senescence by repetitive subcytotoxic doses of UVB irradiation. Cellular apoptosis and DNA cell cycle were analyzed using flow cytometry. Intracellular levels of superoxide dismutase (SOD) and malondialdehyde (MDA) were detected by ELISA. Mutation levels of two large deletions of mitochondrial DNA, 4977bp and 3895bp deletion, were determined by quantitative PCR. Western blot was applied to detect the expression and activation of p66Shc (the 66-kilodalton isoform of the growth factor adapter Shc) and FKHRL1 (a forkhead protein that is intimately linked with intracellular oxidation).

Results

Strong activity of senescence-associated beta-galactosidase (SA-?-gal), high percent of cell apoptosis as well as cell cycle arrest in G0/G1 phase, and increased intracellular oxidative stress were observed in HDFs irradiated by UVB. Genistein exerted dramatically protective effects on HDFs in a dose-dependent manner. Elevated copy numbers of large deletions in mitochondrial DNA were also inhibited by genistein. Down-regulation of total and phosphorylated p66Shc on Ser36, as well as FKHRL1 and its phosphorylation on Thr32, were observed after genistein treatment.

Conclusion

The results indicate that genistein protects UVB-induced senescence-like characteristics in HDFs via maintenance of antioxidant enzyme activities and modulation of mitochondrial oxidative stress through down-regulation of a p66Shc-dependent signaling pathway, which may provide potential prevention against skin aging and even photoaging.

Keywords: Genistein, Photoaging, UVB, p66Shc, FKHRL1

Yi Na Wanga1, Wei Wub1, Hong Chao Chena, Hong Fanga

Skin Care and Dermatological Glossary :

Phospholipids : Alcohols : Dietary Antioxidants : Glycolic Acid : Rosacea : ATP : About Trehalose : Accutane (Isotretinoin) : Acidic : Actinic : Alkaline : Alopecia : Amino Acids : Amphoteric : Angiogenesis : Angioma : Antioxidants : Aqueous : Arc : Arteriole : Artery : Ascorbic Acid / Vitamin C : Atherogenic : Atopic : Benzene : Bioavailability : Bioflavonoid : Biopsy : Biotechnology : Blackhead : Cadaver : Calcium : Capillary : Carboxyl : Carcinogenicity : Carcinoma : Cartilage : Catechins : Cell Division : Cellulitis : Chromatography : Cicatrix : Citric Acid : Citronellol : Coccidioidomycosis : Colitis : Collagen : Colourimetre : Comedo/Comedone : Compound : Connective Tissue : Contusion : Corpus Luteum : Cosmesis : Cyst : Cytochrome : Cytotoxin : Denature : Dermatitis : Dermis : Diabetes : Dibasic Acid : Diploidy/Diploid : Diuretic : Eczema : Edema/Oedema : Elastase: The Unrestrained Thief of Skin Elasticity : Elastin : Electrolysis : Electrophoresis : Emollient : Enantiomer : Endothelium : Environmental Stressors : Enzymes : Eosin : Epidermal Necrosis : Epidermis : Epithelium : Erythema : Essential Fatty Acids : Essential Oils : Esters : Eugenol : Eukaryote/Eukaryotic : Exanthem/Exanthema : Extirpation : Fatty Acids : Ferulic Acid : Fibroblast : Flavonolignan : Flora : Folic Acid (Pteroylglutamic Acid/Vitamin M) : Follicle : Free Radical : Fullerene : Galapagos Tortoise : Gamete : Gene : Genistein : Genome : Genomic DNA : Genotoxin : Glasswort : Glucagon : Glutamic Acid : Glycation : Glycerin : Glycopeptide : Glycoprotein : Glycosaminoglycans : Haploidy/Haploid : Hematoxylin : High Frequency Glass Electrode Beauty Devices : Histology/Histologic : Hives : Hormone : Humectant : Hyaluronic Acid/Sodium Hyaluronate : Hydrocarbon : Hydrolysis : Hydrophilic : Hydrophobic : Hydroxyl (OH) : Hygroscopic : Hypertrophic Scar : Hypochlorous Acid : Hypopigmentation : Immunosuppression : In Summary: Oxidation/Reduction and Tanning : In Vitro : In Vivo : Insulin : Interleukins : Ischemia : Islet : Islets of Langerhans/Islands of Langerhans : Isoprene : Keloid : Keratin : Keratinocytes : Kinase : Lactic Acid : Lactoferrin : Lignin : Limonene : Lipids : Lipophilic : Lymphatic System : MMPs (Matrix Metalloproteinases) : Macromolecule : Malic Acid : Mandelic Acid : Melanin : Melanoma : Membrane : Membrane : Mermaid : Metabolism : Metalloproteinases : Metastatic : Methionine : Micellization : Microtubule : Mineral : Molecular/Cellular Biology: Skin Functioning at the most Essential Level : Molecule : Moles (Blemishes)/Moles Per Litre : Monomer : Mucin : Mucoproteins : Myelin : Nanotechnology : Neurotoxin : Nitrogen : Nodule : Nymph : ORAC : Occlusive : Optic : Otorhinolaryngology : Oxygen : Oxytalan Fibers/Fibres : Ozone : Palmitic Acid : Papain : Papillary Dermis : Papule : Pentacyclic : Pentapeptides GM and GD : Pentose : Peptidases : Peptides : Perichondrium : Peroxidase : Peroxide : Phenol : Phlebitis : Photosensitivity : Phytostimulines : Pigmentation : Pimple : Pledget : Polymer : Polymer/Polymeric : Polypeptide : Polyquaterium-51 : Post-Inflammatory Hyperpigmentation : Pro-Collagen : Prodrug : Proenzymes : Prophylaxis : Propionibacterium / P. Acnes Bacteria : Proteases : Protein : Proteoglycans : Proteolytic Enzymes : Proteome : Pruritus : Psoriasis : Pure/Purity : Pustule : Radiation : Radical : Redox : Reductase : Reperfusion : Restenosis : Reticular Dermis : Retinol : Rhinoplasty : Rockfish : Saccharides : Sebum : Selenium (Definition) : Selenosis : Senescence : Sentinel : Skin Resurfacing by Laser : Skin Structure Diagram : Sodium PCA : Squamous : Stable/Stability : Stenosis : Stratum Corneum : Subclinical Inflammation : Subcutis : Sulfur : Surfactant : Synovial : Tannins : Tartaric Acid : Telomere : Temporal Bones : Thermoregulation / Thermoregulate : Thymine Dimer : Tocopherol : Transferase : Tribasic Acid : Triterpenoid : Tropoelastin : Tubulin : Ubiquinone — Co-Enzyme Q-10 : Vascular : Vascular Epithelial Growth Factor : Vein : Venule : Vestibule : Viscous : Vitamin K : Vitamin PP/Nicotinate : Vitamins : Whitehead : Xerosis : Zygoma : Zygote : pH :

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Skin Care and Dermatological Glossary :

Phospholipids : Alcohols : Dietary Antioxidants : Glycolic Acid : Rosacea : ATP : About Trehalose : Accutane (Isotretinoin) : Acidic : Actinic : Alkaline : Alopecia : Amino Acids : Amphoteric : Angiogenesis : Angioma : Antioxidants : Aqueous : Arc : Arteriole : Artery : Ascorbic Acid / Vitamin C : Atherogenic : Atopic : Benzene : Bioavailability : Bioflavonoid : Biopsy : Biotechnology : Blackhead : Cadaver : Calcium : Capillary : Carboxyl : Carcinogenicity : Carcinoma : Cartilage : Catechins : Cell Division : Cellulitis : Chromatography : Cicatrix : Citric Acid : Citronellol : Coccidioidomycosis : Colitis : Collagen : Colourimetre : Comedo/Comedone : Compound : Connective Tissue : Contusion : Corpus Luteum : Cosmesis : Cyst : Cytochrome : Cytotoxin : Denature : Dermatitis : Dermis : Diabetes : Dibasic Acid : Diploidy/Diploid : Diuretic : Eczema : Edema/Oedema : Elastase: The Unrestrained Thief of Skin Elasticity : Elastin : Electrolysis : Electrophoresis : Emollient : Enantiomer : Endothelium : Environmental Stressors : Enzymes : Eosin : Epidermal Necrosis : Epidermis : Epithelium : Erythema : Essential Fatty Acids : Essential Oils : Esters : Eugenol : Eukaryote/Eukaryotic : Exanthem/Exanthema : Extirpation : Fatty Acids : Ferulic Acid : Fibroblast : Flavonolignan : Flora : Folic Acid (Pteroylglutamic Acid/Vitamin M) : Follicle : Free Radical : Fullerene : Galapagos Tortoise : Gamete : Gene : Genistein : Genome : Genomic DNA : Genotoxin : Glasswort : Glucagon : Glutamic Acid : Glycation : Glycerin : Glycopeptide : Glycoprotein : Glycosaminoglycans : Haploidy/Haploid : Hematoxylin : High Frequency Glass Electrode Beauty Devices : Histology/Histologic : Hives : Hormone : Humectant : Hyaluronic Acid/Sodium Hyaluronate : Hydrocarbon : Hydrolysis : Hydrophilic : Hydrophobic : Hydroxyl (OH) : Hygroscopic : Hypertrophic Scar : Hypochlorous Acid : Hypopigmentation : Immunosuppression : In Summary: Oxidation/Reduction and Tanning : In Vitro : In Vivo : Insulin : Interleukins : Ischemia : Islet : Islets of Langerhans/Islands of Langerhans : Isoprene : Keloid : Keratin : Keratinocytes : Kinase : Lactic Acid : Lactoferrin : Lignin : Limonene : Lipids : Lipophilic : Lymphatic System : MMPs (Matrix Metalloproteinases) : Macromolecule : Malic Acid : Mandelic Acid : Melanin : Melanoma : Membrane : Membrane : Mermaid : Metabolism : Metalloproteinases : Metastatic : Methionine : Micellization : Microtubule : Mineral : Molecular/Cellular Biology: Skin Functioning at the most Essential Level : Molecule : Moles (Blemishes)/Moles Per Litre : Monomer : Mucin : Mucoproteins : Myelin : Nanotechnology : Neurotoxin : Nitrogen : Nodule : Nymph : ORAC : Occlusive : Optic : Otorhinolaryngology : Oxygen : Oxytalan Fibers/Fibres : Ozone : Palmitic Acid : Papain : Papillary Dermis : Papule : Pentacyclic : Pentapeptides GM and GD : Pentose : Peptidases : Peptides : Perichondrium : Peroxidase : Peroxide : Phenol : Phlebitis : Photosensitivity : Phytostimulines : Pigmentation : Pimple : Pledget : Polymer : Polymer/Polymeric : Polypeptide : Polyquaterium-51 : Post-Inflammatory Hyperpigmentation : Pro-Collagen : Prodrug : Proenzymes : Prophylaxis : Propionibacterium / P. Acnes Bacteria : Proteases : Protein : Proteoglycans : Proteolytic Enzymes : Proteome : Pruritus : Psoriasis : Pure/Purity : Pustule : Radiation : Radical : Redox : Reductase : Reperfusion : Restenosis : Reticular Dermis : Retinol : Rhinoplasty : Rockfish : Saccharides : Sebum : Selenium (Definition) : Selenosis : Senescence : Sentinel : Skin Resurfacing by Laser : Skin Structure Diagram : Sodium PCA : Squamous : Stable/Stability : Stenosis : Stratum Corneum : Subclinical Inflammation : Subcutis : Sulfur : Surfactant : Synovial : Tannins : Tartaric Acid : Telomere : Temporal Bones : Thermoregulation / Thermoregulate : Thymine Dimer : Tocopherol : Transferase : Tribasic Acid : Triterpenoid : Tropoelastin : Tubulin : Ubiquinone — Co-Enzyme Q-10 : Vascular : Vascular Epithelial Growth Factor : Vein : Venule : Vestibule : Viscous : Vitamin K : Vitamin PP/Nicotinate : Vitamins : Whitehead : Xerosis : Zygoma : Zygote : pH :


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