Clinical Procedures and Topics

according acid active advanced ageing agents aging amount another anti appearance applying atom blood body care class clinical collagen composition containing contours cosmetic derivatives diets effect effective elastin embodiment emulsion ergothioneine example extract face fatty fenugreek firming foods form glutathione glycation group high include includes including inhibiting interrupter invention known least less levels loss method mixtures need oils optionally orange particular particularly peel person phase phenomenon possible preferably present prevent preventing product products proteins reduce reducing related relative selected serotonin serum signs silhouette skin skincare skinceuticals slimming specifically sugar thereof thus tonicity topical topically treating treatment used vasco weight wrinkles

Glycation is a prime cause of intrinsic aging (non-environmental skin aging unable to be prevented by photoprotection).

Glycation is a chemical reaction which permanently reduces your skin's ability to produce and regenerate high quality collagen and elastin — the proteins responsible for resilient skin characterised by structure and elasticity.

Glycation occurs when sugar enters the bloodstream and bonds to vital skin proteins like collagen and elastin, causing them to become more brittle and less elastic, producing the look of older skin, characterised by fine lines, wrinkles, sagging and a reduced ability to "snap" back.

Once sugars bind to your skin's collagen and elastin, the proteins mutate, creating deleterious new molecules, known as advanced glycation end-products ("A.G.E.s").

The fine lines, wrinkles, sagging and reduced ability to "snap" back produced by A.G.E.s are permanent — once established, it is only possible to reduce the symptoms of their outward cosmetic expression.

Preventing and Limiting Glycation

The most substantially effective means by which to prevent the formation of harmful A.G.E.s and to preserve more of your skin's resilience is to cut all optional sugar out of your life.

When doing so, it's probably also a good idea to stop using artificial sweetners as these stimulate sugar cravings.

Adopting a lower-GI diet, which still provides adequate carbohydrates, such as those advocated by Frederic Brandt and Nicholas Perricone, also markedly reduces glycation.

Reducing alcohol consumption and making use of topical and dietary antioxidants can also reduce A.G.E.s to prolong and enhance skin's structure, firmness and elasticity.

Agents to Reduce Glycation

A.G.E.s are the subject of ongoing research, however a combination of agents including antioxidants are likely more effective against A.G.E.s than any single agent.

Worthwhile agents against glycation include carnosine, Japanese green tea, white tea, aminoguanidine, grape seed extract, salicylic acid, resveratrol, alpha lipoic acid, carnitine, ergothioneine, carnosine, pomegranate, idebenone, berries, lycopene and pycnogenol (pine bark extract).

Topical Skin Care to Reduce A.G.E.s

Topical products containing substantial concentrations of agents thought to reduce A.G.E.s in skin include:

Green Tea — Topix "Replenix" and Skinceuticals Face Cream.

Idebenone — Prevage MD.

Blueberry — Skinceuticals A.G.E. Interrupter, IS Clinical Poly-Vitamin Serum, IS Clinical Active Serum.

Aminoguanidine — Danné Montague-King Aminoguanidine Spray.

Further Information

Glutathione: Anti-Aging and Anti-Glycation of Skin.

Related Skin Care Information, Products and Expert Discussions

Skin Care and Dermatological Glossary :

File Glycation for reference.

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Preventing and Limiting Glycation

Agents to Reduce Glycation

Topical Skin Care to Reduce A.G.E.s

Further Information


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	Glycation Glycation is a prime cause of intrinsic aging (non-environmental skin aging unable to be prevented by photoprotection). Glycation is a chemical reaction which permanently reduces your skin's ability to produce and regenerate high quality collagen and elastin — the proteins responsible for resilient skin characterised by structure and elasticity. Glycation occurs when sugar enters the bloodstream and bonds to vital skin proteins like collagen and elastin, causing them to become more brittle and less elastic, producing the look of older skin, characterised by fine lines, wrinkles, sagging and a reduced ability to "snap" back. Once sugars bind to your skin's collagen and elastin, the proteins mutate, creating deleterious new molecules, known as advanced glycation end-products ("A.G.E.s"). The fine lines, wrinkles, sagging and reduced ability to "snap" back produced by A.G.E.s are permanent — once established, it is only possible to reduce the symptoms of their outward cosmetic expression. Preventing and Limiting Glycation The most substantially effective means by which to prevent the formation of harmful A.G.E.s and to preserve more of your skin's resilience is to cut all optional sugar out of your life. When doing so, it's probably also a good idea to stop using artificial sweetners as these stimulate sugar cravings. Adopting a lower-GI diet, which still provides adequate carbohydrates, such as those advocated by Frederic Brandt and Nicholas Perricone, also markedly reduces glycation. Reducing alcohol consumption and making use of topical and dietary antioxidants can also reduce A.G.E.s to prolong and enhance skin's structure, firmness and elasticity. Agents to Reduce Glycation A.G.E.s are the subject of ongoing research, however a combination of agents including antioxidants are likely more effective against A.G.E.s than any single agent. Worthwhile agents against glycation include carnosine, Japanese green tea, white tea, aminoguanidine, grape seed extract, salicylic acid, resveratrol, alpha lipoic acid, carnitine, ergothioneine, carnosine, pomegranate, idebenone, berries, lycopene and pycnogenol (pine bark extract). Topical Skin Care to Reduce A.G.E.s Topical products containing substantial concentrations of agents thought to reduce A.G.E.s in skin include: Green Tea — Topix "Replenix" and Skinceuticals Face Cream. Idebenone — Prevage MD. Blueberry — Skinceuticals A.G.E. Interrupter, IS Clinical Poly-Vitamin Serum, IS Clinical Active Serum. Aminoguanidine — Danné Montague-King Aminoguanidine Spray. Further Information Glutathione: Anti-Aging and Anti-Glycation of Skin. Advanced Glycation End Products (AGEs) Alternative to Skinceuticals AGE Interrupter Gernetic Vasco — Facial Blotchyness/Puffy Eyes/Dark Circles/Broken Capillaries Glutathione: Anti-Aging and Anti-Glycation of Skin Skin Longevity Medicine and Treatment Skinceuticals A.G.E. Interrupter Product Description Skinceuticals Claimed Benefits of A.G.E. Interrupter Related Skin Care Information, Products and Expert Discussions Ergothioneine Open Pores Carnosine Millia/Millium Ferulic Acid Skin Care and Dermatological Glossary : File Glycation for reference.	August 2010 Special Preparation / Special Order Items July 2010 SkinMedica Chemical Peels Nia24 Reference Manual June 2010 New Anthelios 45 Sunscreens for Face and Body Replenix Anti-Photoaging Sunscreen SPF 45 VitaMedica HA + A Program May 2010 New Skinceuticals Sheer Physical UV Defense SPF 50 Alyria Antioxidant Capsules (Vitamin C + E) IS Clinical Youth Complex April 2010 RevaleSkin — CoffeeBerry Extract Retin-A Gel Availability March 2010 RevaleSkin Day Cream SPF 15 Trehalose February 2010 Injuv Polyphenols Kinerase Pro+ C8 Peptide Intensive Treatment with Kinetin and Zeatin January 2010 La Roche-Posay Redermic December 2009 Anti-Aging Sunscreen Reminders November 2009 Complimentary Shipping The Sun Zinc: An Important Antioxidant for Skin La Roche-Posay Derm AOX Biomedic Potent-C 10.5 Concentrate Tocotrienols Skinceuticals Pigment Regulator SkinMedica Retinol Complex October 2009 The Connection Between Oxidative Stress and Aging Definition of Oxidative Stress Sources of Free Radical Damage Ozone Obagi Professional C Ingredients Citrix Antioxidant Body Lotion September 2009 Tricomin Erythema from Retinoids Carnosine Interleukin-6 (IL-6) Asiaticoside vs. Madecassoside for Collagen Synthesis New Elta MD UV Clear SPF 46 New DCL Super Sheer Sunscreen SPF 50+ PCA pHaze 16+ C-Strength 20% Arginine and Serine Chrysin August 2009 Glytone Lipo-Lift Serum Ergothioneine Ubiquinone (Co-Enzyme Q-10) Tetrahexyldecyl Ascorbate Hydrolyzed Hyaluronic Acid Polymorphous Light Eruption Saccharomyces Ferment (Filtrate Lysate) La Roche-Posay Effaclar AI Intensive Acne Spot Treatment New Skinceuticals Retexturing Activator New Vivite Defining Lip Plumper Neova Advanced Essential Lash July 2009 Ceramide 3 Oxido Reductases Cellex-C vs. Skinceuticals D-Tocopheryl Glucoside Human Fibroblast Conditioned Media Kinerase Pro+ Therapy Advanced Radiance Facial Peel June 2009 Pentapeptides Ineffective ReVivé Peau Magnifique Madecassoside Natural/Organic Instinct Products Contain Unlisted + Mislabelled Chemicals Neutrogena Amber Bar Sculpture La Roche-Posay, Vienne, France Obagi Rosaclear May 2009 Myristyl Nicotinate Topical Myristyl Nicotinate Creams Oxofulleram Benefits of Mexoryl SX Anthelios 60 Sunscreens Anthelios SX Daily Moisturizer RevaleSkin CoffeeBerry Kit April 2009 Biomedic Facial Shield SPF 20 IS Clinical Peptides Skin Care for Dry Body Skin Site Upgrades and Updates March 2009 Safety of Micronized Zinc Sunscreens Kinetin RevaleSkin — CoffeeBerry Extract Glycation Biomedic Collagenist Powder p53 Protein Expression Photoprotective (UVB) Salen-Manganese Complex (EUK-134) Clinique Medical Skin Care (Newly Available)