Skin Care and Treatments of Melbourne Dermatology - Glycation

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Glycation

Glycation

Glycation is a prime cause of intrinsic aging (non-environmental skin aging unable to be prevented by photoprotection).

Glycation is a chemical reaction which permanently reduces your skin's ability to produce and regenerate high quality collagen and elastin — the proteins responsible for resilient skin characterised by structure and elasticity.

Glycation occurs when sugar enters the bloodstream and bonds to vital skin proteins like collagen and elastin, causing them to become more brittle and less elastic, producing the look of older skin, characterised by fine lines, wrinkles, sagging and a reduced ability to "snap" back.

Once sugars bind to your skin's collagen and elastin, the proteins mutate, creating deleterious new molecules, known as advanced glycation end-products ("A.G.E.s").

The fine lines, wrinkles, sagging and reduced ability to "snap" back produced by A.G.E.s are permanent — once established, it is only possible to reduce the symptoms of their outward cosmetic expression.

Preventing and Limiting Glycation

The most substantially effective means by which to prevent the formation of harmful A.G.E.s and to preserve more of your skin's resilience is to cut all optional sugar out of your life.

When doing so, it's probably also a good idea to stop using artificial sweetners as these stimulate sugar cravings.

Adopting a lower-GI diet, which still provides adequate carbohydrates, such as those advocated by Frederic Brandt and Nicholas Perricone, also markedly reduces glycation.

Reducing alcohol consumption and making use of topical and dietary antioxidants can also reduce A.G.E.s to prolong and enhance skin's structure, firmness and elasticity.

Agents to Reduce Glycation

A.G.E.s are the subject of ongoing research, however a combination of agents including antioxidants are likely more effective against A.G.E.s than any single agent.

Worthwhile agents against glycation include carnosine, Japanese green tea, white tea, aminoguanidine, grape seed extract, salicylic acid, resveratrol, alpha lipoic acid, carnitine, ergothioneine, carnosine, pomegranate, idebenone, berries, lycopene and pycnogenol (pine bark extract).

Topical Skin Care to Reduce A.G.E.s

Topical products containing substantial concentrations of agents thought to reduce A.G.E.s in skin include:

Green Tea — Topix "Replenix" and Skinceuticals Face Cream.

Idebenone — Prevage MD.

Blueberry — Skinceuticals A.G.E. Interrupter, IS Clinical Poly-Vitamin Serum, IS Clinical Active Serum.

Aminoguanidine — Danné Montague-King Aminoguanidine Spray.

Further Information

Glutathione: Anti-Aging and Anti-Glycation of Skin.

Related Skin Care Information, Products and Expert Discussions

Ergothioneine

Carnosine

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Millia/Millium

Ferulic Acid


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Mexoryl

Pentapeptides Ineffective

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La Roche-Posay Redermic

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Telomerase

Azelaic Acid

Bisabolol

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Panthenol

Aster Family of Plants

Green Tea (Camellia Sinensis) Extract

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Oxofulleram

Salicylic Acid

Capryloyl Salicylic Acid

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Phytosphingosine

Glycerin

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Algorithm for Optimal Sustained Exfoliation: Glycolic Acid

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