Skin Care and Treatments of Melbourne Dermatology - Protective Effects of (-)-Epigallocatechin-3-Gallate on UVA- and UVB-Induced Skin Damage

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Protective Effects of (-)-Epigallocatechin-3-Gallate on UVA- and UVB-Induced Skin Damage

It has been known that green tea and its components possess significant chemopreventive effects against chemical carcinogens and photo-caused skin tumor formation. In this study, the protective effects of (-)-epigallocatechin-3-gallate (EGCG), a major green tea catechin, on the ultraviolet (UV)-induced skin damage (photoaging) were studied in guinea pigs, hairless mice and human dermal fibroblast cultures. The lipid peroxidation was significantly reduced in the EGCG-treated group. The amount of lipid peroxides produced in the control and EGCG treated group were 838 144 and 286 57 nmol/mg at 18 h after UV irradiation, respectively. UVB-induced erythema was also significantly reduced in the EGCG treated group. The erythema relative index of the control and the EGCG treated group were 311 45 and 191 49 at 16 h after UV irradiation, respectively. EGCG treatment reduced UVA-induced skin damage (roughness and sagginess) and protected from the decrease of dermal collagen in hairless mouse skin. EGCG treatment blocked the UV-induced increase of collagen secretion and collagenase mRNA level in fibroblast culture. The nuclear transcription factors NF-B and AP-1 binding activities were also inhibited by EGCG treatment.

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Green Tea and Skin : Beneficial Effects of Green Tea—A Review : Photoprotective effects of green tea polyphenols : Protective Effects of (-)-Epigallocatechin-3-Gallate on UVA- and UVB-Induced Skin Damage : Skin photoprotection by green tea: antioxidant and immunomodulatory effects : Polyphenolic Antioxidant (-)-Epigallocatechin-3-Gallate from Green Tea Reduces UVB-lnduced Inflammatory Responses and Infiltration of Leukocytes in Human Skin : Green Tea Polyphenols Prevent Ultraviolet Light-Induced Oxidative Damage and Matrix Metalloproteinases Expression in Mouse Skin : Double-Blinded, Placebo-Controlled Trial of Green Tea Extracts in the Clinical and Histologic Appearance of Photoaging Skin : Green tea polyphenol (—)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress :


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