Skin Care and Treatments of Melbourne Dermatology - Heliocare Decreases UV Damage of Human Skin

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Heliocare Decreases UV Damage of Human Skin

Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin

Middelkamp-Hup MA, Pathak MA, Parrado C, Goukassian D, Rius-Díaz F, Mihm MC, Fitzpatrick TB, González S.

Wellman Laboratories of Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

UV radiation induces damage to human skin. Protection of skin by an oral photoprotective agent would have substantial benefits.

We investigated the photoprotective effect of oral administration of an extract of the natural antioxidant Polypodium leucotomos (PL).

A total of 9 healthy participants of skin types II to III were exposed to varying doses of artificial UV radiation without and after oral administration of PL (7.5 mg/kg). At 24 hours after exposure the erythema reaction was assessed and paired biopsy specimens were obtained from PL-treated and untreated skin.

A significant decrease in erythema was found in PL-treated skin (P < .01). Histologically, PL-treated biopsy specimens showed less sunburn cells (P < .05), cyclobutane pyrimidine dimers (P < .001), proliferating epidermal cells (P < .001), and dermal mast cell infiltration (P < .05). A trend toward Langerhans cell preservation was seen.

Oral administration of PL is an effective systemic chemophotoprotective agent leading to significant protection of skin against UV radiation.

Related Skin Care Information, Products and Expert Discussions

Heliocare Decreases UVA Damage of Human Skin

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Heliocare Prevents Sunburn, Phototoxic Reactions and Langerhans Cell Depletion in Human Skin

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Heliocare :

Heliocare Sun Protection Supplement Capsules : Heliocare Instructions for Photoaging Prevention : Heliocare Instructions for Protection Against Direct Sun : Heliocare's Main Effects : Heliocare vs. Sunscreen : Extent of Protection from Heliocare : Heliocare Research : Heliocare Studies : Photoprotective Properties of Heliocare : Heliocare Limits UV-Induced Free Radical Skin Damage : Heliocare Decreases UV Damage of Human Skin : Heliocare Decreases UVA Damage of Human Skin : Heliocare Appears to Minimize Photoaging Changes : Heliocare May Limit and Reverse Extrinsic and Intrinsic Elastin Destruction : Heliocare Prevents Sunburn, Phototoxic Reactions and Langerhans Cell Depletion in Human Skin : Heliocare Exhibits Anti-Angiogenic Activities In Vivo : Antioxidant Properties of Heliocare and Kojic Acid : PDF: Vitiligo Treatment with UVA and Heliocare : PDF: Vitiligo Treatment with UVB and Heliocare : PDF: Photoprotective Properties of Heliocare : PDF: Photoprotective Properties of Neutraceutical Heliocare Extract : PDF: Heliocare Inhibits UV-Induced TNF and INOS Expression : Heliocare News: Suntan Pill Might Help Prevent Skin Cancer : Heliocare News: Sun Protection in a Pill :


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