Skin Care and Treatments of Melbourne Dermatology - Heliocare Prevents Sunburn, Phototoxic Reactions and Langerhans Cell Depletion in Human Skin

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Heliocare Prevents Sunburn, Phototoxic Reactions and Langerhans Cell Depletion in Human Skin

Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in human skin.

González S, Pathak MA, Cuevas J, Villarrubia VG, Fitzpatrick TB.

Department of Dermatology, Massachusetts General Hospital, Boston 02114, USA.

Sunburn, immune suppression, photoaging, and skin cancers result from uncontrolled overexposure of human skin to solar ultraviolet radiation (UVR).

Preventive measures, including photoprotection, are helpful and can be achieved by topical sunscreening agents.

Polypodium leucotomos (PL) has been used for the treatment of inflammatory diseases and has shown some in vitro and in vivo inmunomodulating properties.

Its beneficial photoprotective effects in the treatment of vitiligo and its antioxidant properties encouraged us to evaluate in vivo the potentially useful photoprotective property of natural extract of PL after topical application or oral ingestion.

Twenty-one healthy volunteers [either untreated or treated with oral psoralens (8-MOP or 5-MOP)] were enrolled in this study and exposed to solar radiation for evaluation of the following clinical parameters: immediate pigment darkening (IPD), minimal erythema dose (MED), minimal melanogenic dose (MMD), and minimal phototoxic dose (MPD) before and after topical or oral administration of PL.

Immunohistochemical assessment of CD1a-expressing epidermal cells were also performed.

PL was found to be photoprotective after topical application as well as oral administration.

PL increased UV dose required for IPD (P < 0.01), MED (P < 0.001) and MPD (P < 0.001).

After oral administration of PL, MED increased 2.8 +/- 0.59 times and MPD increased 2.75 +/- 0.5 and 6.8 +/- 1.3 times depending upon the type of psoralen used.

Immunohistochemical study revealed photoprotection of Langherhans cells by oral as well as topical PL.

The observed photoprotective activities of oral or topical PL reveal a new avenue in examining the potentially useful field of systemic photoprotection and suggests that PL can be used as adjunct treatment and can make photochemotherapy and phototherapy possibly safe and effective when the control of cutaneous phototoxicity to PUVA or UVB is a limiting factor in such phototherapies.

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Heliocare :

Heliocare Sun Protection Supplement Capsules : Heliocare Instructions for Photoaging Prevention : Heliocare Instructions for Protection Against Direct Sun : Heliocare's Main Effects : Heliocare vs. Sunscreen : Extent of Protection from Heliocare : Heliocare Research : Heliocare Studies : Photoprotective Properties of Heliocare : Heliocare Limits UV-Induced Free Radical Skin Damage : Heliocare Decreases UV Damage of Human Skin : Heliocare Decreases UVA Damage of Human Skin : Heliocare Appears to Minimize Photoaging Changes : Heliocare May Limit and Reverse Extrinsic and Intrinsic Elastin Destruction : Heliocare Prevents Sunburn, Phototoxic Reactions and Langerhans Cell Depletion in Human Skin : Heliocare Exhibits Anti-Angiogenic Activities In Vivo : Antioxidant Properties of Heliocare and Kojic Acid : PDF: Vitiligo Treatment with UVA and Heliocare : PDF: Vitiligo Treatment with UVB and Heliocare : PDF: Photoprotective Properties of Heliocare : PDF: Photoprotective Properties of Neutraceutical Heliocare Extract : PDF: Heliocare Inhibits UV-Induced TNF and INOS Expression : Heliocare News: Suntan Pill Might Help Prevent Skin Cancer : Heliocare News: Sun Protection in a Pill :


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