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acid addition aging alpha alt anti antioxidant antioxidants appearance ascorbic ascorbyl beta biocell body calcium cancer carotene carotenoids cells cellulose coenzyme collagen com conditions connective contains daily damage dioxide dunaliella effective energy esta estamins evening facial ferulic fine found glucosamine ha high however hr http hyaluronic images img internal iu jan levels lines lipoic loss marini mcg medical mg micrograms niacinamide noshade nutritional palmitate per prevent primrose product products provides pyridoxine research riboflavin salina seed selenite selenium serum size skin skincare skinceuticals sodium src studies sulfate sun supplement take thiamine tissue treatment type vitamin volume wrinkles www xue zeaxanthin  

In essence, Jan Marini C-ESTAMINS provides a new and more refined level of skin rejuvenation from the inside out, for the entire body skin, particularly in the areas of skin volume/plumpness and elasticity.

Based on extensive medical nutritional research, C-ESTAMINS are the most advanced and comprehensive anti-aging nutritional supplement available today. 

C-ESTAMINS supplies many critical components that have been shown to promote energy and provide support for enhanced well-being, energy and longevity while noticeably improving the appearance of aging and sun-damaged skin.

What's new about Jan Marini C-ESTAMINS?

In addition to the previous dynamic formula, C-ESTAMINS now contains a patented technology called BioCell Collagen II. 

BioCell has been the focus of two double blind placebo controlled studies that have confirmed the effects of BioCell on factors that influence skin elasticity and volume, improving skin texture and reducing the appearance of fine lines and wrinkles. 

BioCell is a revolutionary discovery that addresses one of the common denominators in aging: loss of connective tissue.  Connective tissue helps to give form and structure by acting as a “filler agent” and providing volume.

One of the primary components involved in this process is Hyaluronic Acid which is a water filled gel.  The human body produces approximately 3,000 milligrams of Hyaluronic Acid (HA) each day.  Each day we lose Hyaluronic Acid, so our body constantly produces more in order to replenish daily loss.

As we age, sun exposure and factors such as a decline in hormones cause a sharp drop in our internal concentrations of HA.  By the time we are 40 years of age, most people are producing significantly lower levels of HA.

Some of the highest levels of HA are found in the skin. Many researchers today believe that if we could maintain or increase our levels of HA, we would prevent many of the outward signs of aging such as wrinkles and sagging skin.

Replenishing Hyaluronic Acid Orally

What if we could increase our internal levels of HA?  Topical application, with moisturizers for example, involves large molecules that can only help to lock in existing surface moisture.

BioCell is a breakthrough technology where the HA molecule has been reduced and combined with other constituents of connective tissue into a natural matrix. 

Taken orally, BioCell is easily absorbed by the body. 

It is the most potent and well documented substance of this type shown to increase internal stores of Hyaluronic Acid and visibly improve the appearance of skin.

What Benefits will Patients Notice?

More than half of the body’s HA is found in the skin. Numerous clinical studies have demonstrated that by increasing Hyaluronic Acid through oral supplementation, users report:

• A visible lessening of facial wrinkles;
• Improved facial and body skin texture;
• Noticeably increased skin moisture content;
• An increased appearance of firmness and volume.

JMSR is the only company to produce a comprehensive anti-aging supplement that contains the full recommended amount of BioCell.

• Each one month supply is conveniently packed in a sealed canister, containing 30 daily packets of 5 tablets each.
• Simply take one packet daily with food and you will start seeing and feeling the difference within a few months time.

Known for its antioxidant activity, it is used in Jan Marini C-ESTAMINS.

Few organisms can survive in such highly saline conditions as salt evaporation ponds.

To survive, these organisms have high concentrations of carotenoids to protect against the intense light and temperature to which they're subjected.

This remarkable marine plant actually produces antioxidants in response to free radicals.

In a study performed at the Department of Chemistry, El Carmen University in Huelva, Spain, scientists subjected Dunaliella salina to high levels of UV, which is known to cause damage by encouraging the production of free radicals.

This type of damage is the same as that produced by exposure to the sun, which results in wrinkles.

Shortly after exposure to high UV, the plant literally oozes strong antioxidant carotenoids (Salguero A, et al. Biomol Eng 2003, 20(4-6): 249-253).

Natural Mixed Carotenoids found in Dunaliella salina are among nature's best antioxidants, containing a variety of carotenoids including Beta Carotene, Alphacarotene and Xanthophylls like Zeaxanthin, Cryptoxanthin and Lutein.

• Dunaliella salina contains previously unknown forms of beta-carotene that are far more powerful than any of those found in fruit and vegetables. Research performed at the Cancer Research Centre of Hawaii shows that Dunaliella salina contains a certain type of betacarotene called 9-cis-beta-carotene, which is up to ten times stronger at preventing cancer than ordinary beta-carotene (Hieber AD, King TJ et al. Nutr Cancer 2000:37(2):234-244).
• Beta-carotene reduces the amount of harmful free radicals present in your body that can damage DNA and cause cosmetic problems by promoting wrinkles and skin cancer. Researchers from the Institute of Cancer Research in Nanjing, in China have studied another type of beta-carotene isolated from Dunaliella salina called beta-CDS on human cancer cells. They found that when the extract was applied to cancerous cells it was able to prevent them from multiplying, and concluded that beta-CDS is an effective anti-cancer agent (Ma GJ, Xue KX et al. Zhongguo Yao Li Xue Bao 1998;19(3):282-284).
• Dr LX Xue from the Laboratory Centre for Medical Sciences, Henan Medical University in China has found that found that carotenoids from Dunaliella salina were 55 per cent stronger compared to ordinary beta-carotene when it comes to inhibiting the development of cancerous cells. According to Dr Xue: "Dunaliella salina increases the activities of the immune system by boosting the actions of the immune cells [such as macrophages and spleen cells, which identify a cancerous cell and destroy it].
• More recent studies show that Dunaliella salina also contains another carotenoid called zeaxanthin, a valuable antioxidant valued for its ability to both help prevent and treat macular degeneration – a debilitating condition that causes progressive vision loss. Researchers from the Department of Plant and Microbial Biology, University of California in the US, have reported that Dunaliella salina can be encouraged (by allowing it to grow in near darkness) to produce large amounts of good quality zeaxanthin. Under these low-light conditions, they found that for every gram of dry Dunaliella salina, 6mg of zeaxanthin is produced, compared to only 0.2mg of zeaxanthin found in ordinary plants (Jin E., Feth B, Melis A. Biotechnol Bioeng 2003;81(1):115-124).

Ingredients for Jan Marini C-ESTAMINS

BioCell Collagen 2000mg (Hydrolyzed Collagen Type II 1200mg; Chondroitin Sulfate 400mg; Hyaluronic Acid 200mg), Grape Seed (Vitis Vinifera Seed) Proanthocyanidins 15.79mcg, Ascorbyl Palmitate 250mg, Carotenoids Complex (Dunaliella Salina) 5mg, Evening Primrose Seed Oil (Gamma Linoleic Acid (G.L.A.) 6.75) 67.5mg, CoEnzyme Q10 30mg, Idebenone 10mg, Alpha Lipoic Acid 50mg, Glucosamine Sulfate (Glucosamine Sulfate Potassium) 100mg, Retinol 5000 IU, Ascorbic Acid 500mg, D-Alpha Tocopherol Succinate 200 IU, Thiamine Mononitrate 15mg, Riboflavin 10mg, Niacinamide 50mg, Pyridoxine Hydrochlorate 10mg, Folic Acid 400mcg, Cyanocobalamin 10mcg, D-Calcium-Pantothenate 25mg, Calcium Phosphate 445mg, Zinc Picolinate 2mg, Sodium Selenite (Selinium) 500mcg, Cellulose, Stearic Acid, Modified Cellulose Gum, Magnesium Stearate, Hypromellose, Silicon Dioxide, Titanium Dioxide, Annato.

Jan Marini C-ESTAMINS provides 500 micrograms of selenium per day (along with a diversity of other beneficial though often hard to acquire nutrients), a dose recognised as providing therapeutic rather than maintenance benefit, although if you take Jan Marini C-ESTAMINS you should not also eat generous amounts of brazil nuts on a regular basis. Selenosis can occur if daily intake is in excess of 1000 to 1500 micrograms.

The absolute minimum recommended daily allowance of selenium is 55 micrograms per day, while 90 micrograms per day represents a minimum daily requirement for more optimal biological conditions. However habitual intake of 200 or more micrograms (up to a maximum of 1000-1500 micrograms) per day is shown to markedly prevent lung, colorectal and prostate cancers.

Also refer the effect of topical selenium on skin, effectiveness of selenium against skin cancer, incidence of non-melanoma skin cancer in the US as pertaining to selenium, effect of selenium against UV-induced inflammatory cytokines, Essential Fatty Acid Supplementation - Important Skin Treatment Notes and a list of foods high in selenium.

For general information, see Melbourne Dermatology's overview on selenium.

Milk thistle (silymarin), rainbow chard and Faire Le Marché will meaningfully enhance your skin, too.

Proven effective in two double-blind placebo controlled studies with results published in medical journals, C-ESTAMINS can catapult your skincare management program to new heights. 

C-ESTAMINS are particularly effective on the following visually apparent symptoms:

• loss of connective tissue which gives the face and body form and structure;
• decreased levels of internal hyaluronic acid which provides the face and body with volume and firmness;
• decreased levels of internal collagen which are responsible for skin and muscle tension;
• broken capillaries and varicose veins;
• irregular skin texture and lack-lustre tone;
• fine lines and deep wrinkles;
• rosacea;
• skin thinned by environmental damage or excess topical steroid use;
• sun damage.

Among its arsenal of critical anti-aging components are the patented nutrients BioCell Collagen, Ascorbyl Palmitate and Alpha Lipoic Acid; in addition are Idebenone, CoEnzyme Q10, Proanthocyanidins, Glucosamine, Ascorbic Acid, Vitamin E, Evening Primrose, Carotenoids, Retinol, Selinium, Silica, Zinc, Thiamine, Riboflavin, Pyridoxine, Cobalmin, Niacinamide, Pantothenol, Folic Acid, Biotin and Calcium.

Apart from proven skin rejuvenation, C-ESTAMINS give you more energy, promote well-being through their unrivaled antioxidant combination (both in spectrum and strength) and improves:

• dry skin conditions;
• acne;
• cracked/thin nails;
• brittle hair;
• seborrheic dermatitis;
• joint function and repair;
• natural process of blood detoxification and fat metabolism;
• heart health.

Skin treatment aside, C-ESTAMINS can replace other supplements with ease. For example, each daily packet already provides more than the minimum daily requirement of Vitamins A, C, E and B; 70% of your daily selenium needs, and 45% of your daily calcium needs.

C-ESTAMINS: Grab-and-Go Rejuvenation and Youthfulness has arrived.

Do not take while pregnant or lactating.

BioCell Collagen 2000mg (Hydrolyzed Collagen Type II 1200mg; Chondroitin Sulfate 400mg; Hyaluronic Acid 200mg), Grape Seed (Vitis Vinifera Seed) Proanthocyanidins 15.79mcg, Ascorbyl Palmitate 250mg, Carotenoids Complex (Dunaliella Salina) 5mg, Evening Primrose Seed Oil (Gamma Linoleic Acid (G.L.A.) 6.75) 67.5mg, CoEnzyme Q10 30mg, Idebenone 10mg, Alpha Lipoic Acid 50mg, Glucosamine Sulfate (Glucosamine Sulfate Potassium) 100mg, Retinol 5000 IU, Ascorbic Acid 500mg, D-Alpha Tocopherol Succinate 200 IU, Thiamine Mononitrate 15mg, Riboflavin 10mg, Niacinamide 50mg, Pyridoxine Hydrochlorate 10mg, Folic Acid 400mcg, Cyanocobalamin 10mcg, D-Calcium-Pantothenate 25mg, Calcium Phosphate 445mg, Zinc Picolinate 2mg, Sodium Selenite (Selinium) 500mcg, Cellulose, Stearic Acid, Modified Cellulose Gum, Magnesium Stearate, Hypromellose, Silicon Dioxide, Titanium Dioxide, Annato.

Superseded Jan Marini C-ESTAMINS Formula:

Cellulose, marine cartilage polysaccharides, ascorbic acid, calcium carbonate, Vitamin E (d-alpha tocopheryl succinate), evening primrose seed oil, stearic acid, ascorbyl palmitate, silicon dioxide, glucosamine sulfate potassium, niacinamide, croscarmellose sodium, coenzyme Q10, calcium D-panthothenate, maltrin, thiamine mononitrate, grape seed extract 95-98%, biotin, calcium silicate, magnesium stearate, pyridoxine HCI, Vitamin A acetate, riboflavin, syloid, beta carotene, alpha lipoic acid, sodium selenite, zinc picolinate, cyanocobalamin, folic acid, cellulose film-coat.

Plus which one would be better for a younger skin in their early 20's?

Jan Marini C-ESTA Serum contains ascorbyl palmitate and deanol and Skinceuticals C E Ferulic contains ascorbic acid, tocopherol and ferulic acid.

It should be noted that there are some concerns over the safety and suitability of large concentrations of ascorbyl palmitate and deanol.

In recent times, some manufacturers have removed or replaced ascorbyl palmitate from their products.

This includes the "Ester-C" products marketed by Dr. Nicholas Perricone's N.V. Perricone Cosmeceuticals, from which Jan Marini C-ESTA is said to be derived.

Skinceuticals C E Ferulic is a more effective protective product in theory however most people use oxidized versions of Vitamin C products which are useless or possibly harmful.

It was once thought that ascorbyl palmitate was more stable than ascorbic acid, however testing has confirmed that in fact both are inherently prone to considerable oxidation, therefore the claimed shelf-life and superior antioxidant advantage of Jan Marini C-ESTA over Skinceuticals C E Ferulic and similar products may not actually exist.

It is true that Jan Marini C-ESTA Cream is less prone to discolouration (oxidation) when refrigerated so it seems likely it is not stable.

People generally report more immediate skin firming with Jan Marini C-ESTA than Skinceuticals C E Ferulic however long-term firming results are likely to be different.

Skinceuticals C E Ferulic may irritate sensitive skin and stimulate acne in prone individuals while Jan Marini C-ESTA is generally well-tolerated.

If you'd like to try using a Vitamin C product, rather than use either of these, it is better to start with Alyria Antioxidant Capsules, the 10% Vitamin C content of which does not oxidize prior to use by virtue of a combination of formulation and packaging, and which is gentle enough to safely and comfortably test suitability on virtually any skin type or condition.

For additional advice it would be best to ask actual users including specialists at: http://www.derm.net.au/discussions/.