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Cellex-C and Skinceuticals were created by some of the same co-operative research dermatologists and chemists (Drs. Sheldon Pinnell, Omar Mostafa, Steven S. Traikovich, Jan Zielinski), with Cellex-C being the original creation.

In the past, the Cellex-C formulations may have provided superior antioxidant protection compared with those of Skinceuticals because they contained more diverse antioxidant combinations, however both manufacturers now feature "broad-spectrum" antioxidants.

Skinceuticals claim their most photoprotective antioxidants are Skinceuticals CE Ferulic and Phloretin CF.

Cellex-C claim their superior antioxidant is Advanced-C Serum.

Further complicating matters, IS Clinical holds that IS Super Serum Advance+ is superior, and Obagi that even one of their 10% Vitamin C serums readily outperforms Skinceuticals' 20% serum.

Cellex-C use tyrosine, zinc and bioflavonoids in all their Vitamin C Serums whereas no Skinceuticals Serums contain tyrosine and only some contain zinc.

The use of tyrosine is protected by a Cellex-C patent.

Medical literature states that when tyrosine is combined with ascorbic acid (Vitamin C) it helps to promote regeneration of new connective tissue through the stimulation of fibroblasts enabling them to make more collagen.

A study co-authored by Skinceuticals' Dr. Sheldon Pinnell holds that zinc is an important and neglected antioxidant for skin.

Interestingly, zinc sulphate was a part of the original Skinceuticals C+E formula but was removed from the "new and improved" Skinceuticals CE Ferulic.

Zinc has been shown to help support increased collagen turnover stimulated by ascorbic acid — it is an essential component of collagenase, which is required to dismantle old, defective and stiffened collagen in order for new collagen to be constructed.

If more types of antioxidants are better than less, it could be that Cellex-C Advanced C Serum is the most optimal antioxidant — it contains five diverse antioxidants (l-ascorbic acid, zinc, resveratrol, pycnogenol and L-ergothioneine) and contains tyrosine, as opposed to Skinceuticals CE Ferulic's three (ascorbic acid, ferulic acid and Vitamin E) without tyrosine or zinc.

My general impression is that Skinceuticals CE Ferulic is less firming and gentler than the original Skinceuticals C+E formula, and also less firming than the current Cellex-C High-Potency Serum or Cellex-C Advanced-C Serum.

However it is not possible to know without comparative studies which is the superior antioxidant.

Skinceuticals CE Ferulic has been shown to provide a remarkable 8x endogenous photoprotection — no studies into the photoprotection offered by Cellex-C Vitamin C Serums have been published.

There are many grounds on which to consider the many skin care brands available.

I do not believe you will ever find a brand which is "best" — I suggest you use more than one brand for greater benefit and reduced cost.

You can also do your own comparative study by using Cellex-C Advanced-C Serum for at least 4 months and then switching to Skinceuticals CE Ferulic for another 4 months.

At minimum, use a good sunscreen during the day and an effective retinoid in the evening, and forego the brand concern.

If you do try either or both, please let us know at Derm Net Discussions — reviews from genuine and informed users would be helpful to all concerned and are lacking despite the heavy use of these products.