Clinical Procedures and Topics

accordingly acid acne additional aging although appears appreciable barrier biochemical biology bioscience biosynthesis blue blush body booster brand cells ceramide chromosome class clear cleaver collagen companies company consequence containing contains crowley cycles damage days derivatives dermatology dinucleotide discovering effects epidermal evidence experience extremely fekkai firm first form forms formulas found frederic frontiers function gamble generally genome giacomoni hair healing help higdon homogenous href html http hugely human hydrating hyperpigmentation images implicates inactive inci include increase increasing investigative jacobson johnson journal lhnv loss manual myristyl niacin niacinamide nicotinate nicotinic products reduce reference rosacea skin skincare telomeres topical treatment used useful vitamin

Nia24 (Niadyne, Inc.) contains a patented form of niacin known as Pro-Niacin (INCI: myristyl nicotinate) found throughout the company's own brand (manufactured and distributed by Mentorcorp, Johnson & Johnson) and licensed for use in a selection of products from Canyon Ranch and the hair care brand Frederic Fekkai.

A large body of evidence supports the use of niacin to increase collagen synthesis (to firm skin and reduce wrinkles) and ceramide biosynthesis (to relieve dryness, skin barrier function and reduce trans-epidermal water loss, sensitivity and stinging).

Niacin is also useful in inhibiting the transfer of melanosomes (making it useful in the treatment and prevention of hyperpigmentation) and in reducing inflammation in skin disorders such as acne and rosacea.

Topical niacin is thought to have beneficial effects on DNA metabolism which help prevent skin cancer and possibly skin aging.

The loss of chromosome ends termed telomeres has been shown to result in cellular aging of normal skin cells (senescence). Recent research implicates NAD (niacinamide adenine dinucleotide) in the maintenance of telomeres, suggesting niacinamide — and not topical telomerase — retards aging of skin cells.

Unlike Vitamin C and retinol, niacin formulas are generally non-irritating and effective. Perhaps as a consequence, the Nia24 range has become hugely popular online.

An increasing number of companies now include niacin (also referred to as Vitamin B3, niacinamide, nicotinic acid, myristyl nicotinate and nicotinamide) in their products. Olay Total Effects (Procter and Gamble) contains predominantly niacinamide, although it is marketed on the purported efficacy of its inactive peptides. Other products containing appreciable quantities of niacinamide include La Roche-Posay Rosaliac, B. Kamins Booster Blue Rosacea Masque, Elta MD UV Clear SPF 46 (Sunscreen for Acne-Prone Skin) and PCA Hydrating Serum.

The myristyl nicotinate form of niacin appears to be the most potent, producing a warmth and sometimes even homogenous blush when first used. In our experience this response is absent when other forms are used. Accordingly, extremely sensitive skin may require 7-10 days to adjust to myristyl nicotinate.

Nia24 Niacin (Myristyl Nicotinate) Reference Manual

Download the Nia24 Reference Manual.

Additional Nia24 Myristyl Nicotinate References

Cleaver JE and Crowley E. UV damage, DNA repair and skin carcinogenesis. Frontiers in Bioscience. April 2002;7:1024-1043.

Ullrich SE. Photoimmune suppression and photocarcinogenesis. Frontiers in Bioscience. March 2002;7:684-703.

Jacobson MK and Jacobson EL. Discovering new ADP-ribose polymer cycles: protecting the genome and more. Trends in Biochemical Sciences. 1999;24:415-417.

Jacobson EL, Giacomoni PU, Roberts MJ, Wondra GT and Jacobson MK. Optimizing the energy status of skin cells during solar radiation. Journal of Photochemistry and Photobiology B: Biology. 2001;63:141-147.

Kim H, Jacobson M, Kim M, Jacobson E and Qasem J. A topical niacin prodrug enhances wound healing by stimulation of leptin secretion. Journal of Investigative Dermatology. 2002;119:347(A840).

Higdon, J. Niacin. The Linus Pauling Institute’s Micronutrient Center. http://lpi.oregonstate.edu/infocenter/vitamins/niacin/printniacin.html.

Jacobson MK, Jacobson EL, Kim H, Kim M, Rizer RL and Trookman NS. Enhancement of human skin barrier integrity by nicotinic acid derivatives. Journal of Investigative Dermatology. 2004;122:58(A345).

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Nia24 Niacin (Myristyl Nicotinate) Reference Manual

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	Nia24 Reference Manual Tweet Nia24 (Niadyne, Inc.) contains a patented form of niacin known as Pro-Niacin (INCI: myristyl nicotinate) found throughout the company's own brand (manufactured and distributed by Mentorcorp, Johnson & Johnson) and licensed for use in a selection of products from Canyon Ranch and the hair care brand Frederic Fekkai. A large body of evidence supports the use of niacin to increase collagen synthesis (to firm skin and reduce wrinkles) and ceramide biosynthesis (to relieve dryness, skin barrier function and reduce trans-epidermal water loss, sensitivity and stinging). Niacin is also useful in inhibiting the transfer of melanosomes (making it useful in the treatment and prevention of hyperpigmentation) and in reducing inflammation in skin disorders such as acne and rosacea. Topical niacin is thought to have beneficial effects on DNA metabolism which help prevent skin cancer and possibly skin aging. The loss of chromosome ends termed telomeres has been shown to result in cellular aging of normal skin cells (senescence). Recent research implicates NAD (niacinamide adenine dinucleotide) in the maintenance of telomeres, suggesting niacinamide — and not topical telomerase — retards aging of skin cells. Unlike Vitamin C and retinol, niacin formulas are generally non-irritating and effective. Perhaps as a consequence, the Nia24 range has become hugely popular online. An increasing number of companies now include niacin (also referred to as Vitamin B3, niacinamide, nicotinic acid, myristyl nicotinate and nicotinamide) in their products. Olay Total Effects (Procter and Gamble) contains predominantly niacinamide, although it is marketed on the purported efficacy of its inactive peptides. Other products containing appreciable quantities of niacinamide include La Roche-Posay Rosaliac, B. Kamins Booster Blue Rosacea Masque, Elta MD UV Clear SPF 46 (Sunscreen for Acne-Prone Skin) and PCA Hydrating Serum. The myristyl nicotinate form of niacin appears to be the most potent, producing a warmth and sometimes even homogenous blush when first used. In our experience this response is absent when other forms are used. Accordingly, extremely sensitive skin may require 7-10 days to adjust to myristyl nicotinate. Nia24 Niacin (Myristyl Nicotinate) Reference Manual Download the Nia24 Reference Manual. Additional Nia24 Myristyl Nicotinate References Cleaver JE and Crowley E. UV damage, DNA repair and skin carcinogenesis. Frontiers in Bioscience. April 2002;7:1024-1043. Ullrich SE. Photoimmune suppression and photocarcinogenesis. Frontiers in Bioscience. March 2002;7:684-703. Jacobson MK and Jacobson EL. Discovering new ADP-ribose polymer cycles: protecting the genome and more. Trends in Biochemical Sciences. 1999;24:415-417. Jacobson EL, Giacomoni PU, Roberts MJ, Wondra GT and Jacobson MK. Optimizing the energy status of skin cells during solar radiation. Journal of Photochemistry and Photobiology B: Biology. 2001;63:141-147. Kim H, Jacobson M, Kim M, Jacobson E and Qasem J. A topical niacin prodrug enhances wound healing by stimulation of leptin secretion. Journal of Investigative Dermatology. 2002;119:347(A840). Higdon, J. Niacin. The Linus Pauling Institute’s Micronutrient Center. http://lpi.oregonstate.edu/infocenter/vitamins/niacin/printniacin.html. Jacobson MK, Jacobson EL, Kim H, Kim M, Rizer RL and Trookman NS. Enhancement of human skin barrier integrity by nicotinic acid derivatives. Journal of Investigative Dermatology. 2004;122:58(A345). Related Skin Care Information, Products and Expert Discussions Nia24 Reference Manual DEL Top RHC Old RHC Dr. Albert Laporte RHC Nia 24 : SkinMedica Chemical Peels : Nia24 Reference Manual : File Nia24 Reference Manual for reference.	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