Topical Tretinoin (Retinoic Acid) Improves Early Stretch Marks: Melbourne Dermatology Skin Care

Clinical Procedures and Topics

acid active affected analysis ann appearance application applied arbor areas before biopsy blind caused center clinical clinically collagen compared comparison conclusions controlled cream daily decrease definite department dermal dermatology differences double early eight either elastic ellis end evaluated examination excessive factor fibers fisher gordon griffiths hamilton hr improvement improvements improves increase investigated jan kang kim length lesions marini marked marks mean medical michigan monthly months normal obtained patients physical plus processes quality quantity randomized received remain respectively response responsible results retinoic scores severity significant significantly skin specimens stretch stretching striae study suggested talwar targeted therapy topical treated treatment tretinoin vehicle

Topical Tretinoin (Retinoic Acid) Improves Early Stretch Marks

S. Kang, K. J. Kim, C. E. Griffiths, T. Y. Wong, H. S. Talwar, G. J. Fisher, D. Gordon, T. A. Hamilton, C. N. Ellis and J. J. Voorhees

Department of Dermatology, University of Michigan Medical Center, Ann Arbor, USA.

Stretch marks are disfiguring lesions usually caused by excessive stretching of skin.

We investigated the response of early, clinically active stretch marks to topical 0.1% tretinoin (retinoic acid) cream.

In a double-blind, randomized, vehicle-controlled study, 22 patients applied either 0.1% tretinoin (n = 10) or vehicle (n = 12) daily for 6 months to the affected areas.

Patients were evaluated by physical examination monthly and by analysis of biopsy specimens of stretch marks obtained before and at the end of therapy in comparison with untreated normal skin.

RESULTS

After 2 months, patients treated with tretinoin had significant improvements in severity scores of stretch marks compared with patients who received vehicle (P < .05).

After 6 months, eight (80%) of the 10 tretinoin-treated patients had definite or marked improvement compared with one (8%) of the 12 vehicle-treated patients (P = .002).

Targeted stretch marks in patients treated with tretinoin had a decrease in mean length and width of 14% and 8%, respectively, compared with an increase of 10% (P < .001) and 24% (P = .008), respectively, in patients who received vehicle.

There were no significant differences in various measures of quality and quantity of dermal collagen and elastic fibers in stretch marks when tretinoin and vehicle treatments were compared.

CONCLUSIONS

Topical application of tretinoin significantly improves the clinical appearance of early, active stretch marks.

The processes that are responsible for the clinical improvement remain unknown.

Suggested treatment: Jan Marini Factor A Plus Cream.

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Topical Tretinoin (Retinoic Acid) Improves Early Stretch Marks


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	Topical Tretinoin (Retinoic Acid) Improves Early Stretch Marks Tweet S. Kang, K. J. Kim, C. E. Griffiths, T. Y. Wong, H. S. Talwar, G. J. Fisher, D. Gordon, T. A. Hamilton, C. N. Ellis and J. J. Voorhees Department of Dermatology, University of Michigan Medical Center, Ann Arbor, USA. Stretch marks are disfiguring lesions usually caused by excessive stretching of skin. We investigated the response of early, clinically active stretch marks to topical 0.1% tretinoin (retinoic acid) cream. In a double-blind, randomized, vehicle-controlled study, 22 patients applied either 0.1% tretinoin (n = 10) or vehicle (n = 12) daily for 6 months to the affected areas. Patients were evaluated by physical examination monthly and by analysis of biopsy specimens of stretch marks obtained before and at the end of therapy in comparison with untreated normal skin. RESULTS After 2 months, patients treated with tretinoin had significant improvements in severity scores of stretch marks compared with patients who received vehicle (P < .05). After 6 months, eight (80%) of the 10 tretinoin-treated patients had definite or marked improvement compared with one (8%) of the 12 vehicle-treated patients (P = .002). Targeted stretch marks in patients treated with tretinoin had a decrease in mean length and width of 14% and 8%, respectively, compared with an increase of 10% (P < .001) and 24% (P = .008), respectively, in patients who received vehicle. There were no significant differences in various measures of quality and quantity of dermal collagen and elastic fibers in stretch marks when tretinoin and vehicle treatments were compared. CONCLUSIONS Topical application of tretinoin significantly improves the clinical appearance of early, active stretch marks. The processes that are responsible for the clinical improvement remain unknown. Suggested treatment: Jan Marini Factor A Plus Cream. Related Skin Care Information, Products and Expert Discussions Sederma Matrixyl "Anti-Wrinkle Effects" Study Double-Blinded, Placebo-Controlled Trial of Green Tea Extracts in the Clinical and Histologic Appearance of Photoaging Skin A Pilot Study Evaluating The Efficacy of Topically Applied Niacin Derivatives for Treatment of Female Pattern Alopecia Comparison: Clinique Medical IPL Treatment Study for Enhanced Outcomes Comparison: Clinique Medical TCA Peel Treatment Study for Enhanced Outcomes Skin Care – June 2006 Topical Tretinoin (Retinoic Acid) Improves Early Stretch Marks File Topical Tretinoin (Retinoic Acid) Improves Early Stretch Marks for reference.	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