The pentacyclic triterpenoid glycoside Madecassoside is the latest purified isolate of Centella Asiatica with healthy effects against aging skin, scars, stretch marks and psoriasis.
Centella Asiatica is a pantropical (umbelliferous) plant with a millennium-long medicinal history, used for over 2000 years in India, as shown in Sanscrit manuscripts and, later, in Ayurvedic medicine.
Centella Asiatica appeared relatively late in modern Western medicine, making its entrance in the Codex only in 1884.
The first dry extract was not produced until 1941, three years before the triterpenoids were isolated by Pierre Boiteau, who used it for its soothing and healing properties.
The beneficial properties of the molecules asiatic and madecassic acid, followed by asiaticoside, were discovered first and marketed from 1959 as TECA and are used today in products such as Skinceuticals Epidermal Repair and IS Clinical Body Complex.
Madecassoside was discovered in 1973 but only isolated and purified (at 95%+) in 2003 with advances in separation and purification made possible by new chromatography techniques.
A high level of purity is required to guarantee efficacy and skin tolerance.