Clinical Procedures and Topics

ability acid adequate adopting against agent agents aging alcohol aminoguanidine anti antioxidants artificial back bark become berries bind bloodstream blueberry bonds carnosine cause causing characterised chemical class clinical collagen combination concentrations consumption containing cosmetic cravings cream creating dannŽ deleterious diet dietary doing effective elastic elasticity elastin extract face fine firmness formation frederic further glossary glutathione glycation glycationÊoccurs good grape green harmful high however hspace http idea idebenone images include including information interrupter intrinsic japanese king known less lhnv life likely limiting lines lipoic look once products proteins reduce reduced reduces sagging serum skin skincare skinceuticals snap structure sugar topical wrinkles

Glycation is a prime cause of intrinsic aging (non-environmental skin aging unable to be prevented by photoprotection).

Glycation is a chemical reaction which permanently reduces your skin's ability to produce and regenerate high quality collagen and elastin — the proteins responsible for resilient skin characterised by structure and elasticity.

Glycation occurs when sugar enters the bloodstream and bonds to vital skin proteins like collagen and elastin, causing them to become more brittle and less elastic, producing the look of older skin, characterised by fine lines, wrinkles, sagging and a reduced ability to "snap" back.

Once sugars bind to your skin's collagen and elastin, the proteins mutate, creating deleterious new molecules, known as advanced glycation end-products ("A.G.E.s").

The fine lines, wrinkles, sagging and reduced ability to "snap" back produced by A.G.E.s are permanent — once established, it is only possible to reduce the symptoms of their outward cosmetic expression.

Preventing and Limiting Glycation

The most substantially effective means by which to prevent the formation of harmful A.G.E.s and to preserve more of your skin's resilience is to cut all optional sugar out of your life.

When doing so, it's probably also a good idea to stop using artificial sweetners as these stimulate sugar cravings.

Adopting a lower-GI diet, which still provides adequate carbohydrates, such as those advocated by Frederic Brandt and Nicholas Perricone, also markedly reduces glycation.

Reducing alcohol consumption and making use of topical and dietary antioxidants can also reduce A.G.E.s to prolong and enhance skin's structure, firmness and elasticity.

Agents to Reduce Glycation

A.G.E.s are the subject of ongoing research, however a combination of agents including antioxidants are likely more effective against A.G.E.s than any single agent.

Worthwhile agents against glycation include carnosine, Japanese green tea, white tea, aminoguanidine, grape seed extract, salicylic acid, resveratrol, alpha lipoic acid, carnitine, ergothioneine, carnosine, pomegranate, idebenone, berries, lycopene and pycnogenol (pine bark extract).

Topical Skin Care to Reduce A.G.E.s

Topical products containing substantial concentrations of agents thought to reduce A.G.E.s in skin include:

Green Tea — Topix "Replenix" and Skinceuticals Face Cream.

Idebenone — Prevage MD.

Blueberry — Skinceuticals A.G.E. Interrupter, IS Clinical Poly-Vitamin Serum, IS Clinical Active Serum.

Aminoguanidine — Danné Montague-King Aminoguanidine Spray.

Further Information

Glutathione: Anti-Aging and Anti-Glycation of Skin.

Related Skin Care Information, Products and Expert Discussions

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Further Information


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	Glycation Tweet Glycation is a prime cause of intrinsic aging (non-environmental skin aging unable to be prevented by photoprotection). Glycation is a chemical reaction which permanently reduces your skin's ability to produce and regenerate high quality collagen and elastin — the proteins responsible for resilient skin characterised by structure and elasticity. Glycation occurs when sugar enters the bloodstream and bonds to vital skin proteins like collagen and elastin, causing them to become more brittle and less elastic, producing the look of older skin, characterised by fine lines, wrinkles, sagging and a reduced ability to "snap" back. Once sugars bind to your skin's collagen and elastin, the proteins mutate, creating deleterious new molecules, known as advanced glycation end-products ("A.G.E.s"). The fine lines, wrinkles, sagging and reduced ability to "snap" back produced by A.G.E.s are permanent — once established, it is only possible to reduce the symptoms of their outward cosmetic expression. Preventing and Limiting Glycation The most substantially effective means by which to prevent the formation of harmful A.G.E.s and to preserve more of your skin's resilience is to cut all optional sugar out of your life. When doing so, it's probably also a good idea to stop using artificial sweetners as these stimulate sugar cravings. Adopting a lower-GI diet, which still provides adequate carbohydrates, such as those advocated by Frederic Brandt and Nicholas Perricone, also markedly reduces glycation. Reducing alcohol consumption and making use of topical and dietary antioxidants can also reduce A.G.E.s to prolong and enhance skin's structure, firmness and elasticity. Agents to Reduce Glycation A.G.E.s are the subject of ongoing research, however a combination of agents including antioxidants are likely more effective against A.G.E.s than any single agent. Worthwhile agents against glycation include carnosine, Japanese green tea, white tea, aminoguanidine, grape seed extract, salicylic acid, resveratrol, alpha lipoic acid, carnitine, ergothioneine, carnosine, pomegranate, idebenone, berries, lycopene and pycnogenol (pine bark extract). Topical Skin Care to Reduce A.G.E.s Topical products containing substantial concentrations of agents thought to reduce A.G.E.s in skin include: Green Tea — Topix "Replenix" and Skinceuticals Face Cream. Idebenone — Prevage MD. Blueberry — Skinceuticals A.G.E. Interrupter, IS Clinical Poly-Vitamin Serum, IS Clinical Active Serum. Aminoguanidine — Danné Montague-King Aminoguanidine Spray. Further Information Glutathione: Anti-Aging and Anti-Glycation of Skin. Related Skin Care Information, Products and Expert Discussions Glycation Dr. Albert Laporte Ergothioneine Alternative to Skinceuticals AGE Interrupter Carnosine Skin Care and Dermatological Glossary : File Glycation for reference.	New/Notable New — MD Rx Melbourne Dermatology Open Pores Overnight Solution La Roche-Posay Effaclar RevaléSkin Coffeeberry Kit Available Again Azelaic Acid Special Preparation / Special Order Items SkinMedica Chemical Peels Nia24 Reference Manual New Anthelios 45 Sunscreens for Face and Body Replenix Anti-Photoaging Sunscreen SPF 45 VitaMedica HA + A Program New Skinceuticals Sheer Physical UV Defense SPF 50 Alyria Antioxidant Capsules (Vitamin C + E) IS Clinical Youth Complex RevaleSkin — CoffeeBerry Extract Retin-A Gel Availability RevaleSkin Day Cream SPF 15 Trehalose Injuv Polyphenols Kinerase Pro+ C8 Peptide Intensive Treatment with Kinetin and Zeatin La Roche-Posay Redermic Anti-Aging Sunscreen Reminders Complimentary Shipping The Sun Zinc: An Important Antioxidant for Skin New La Roche-Posay Derm AOX Biomedic Potent-C 10.5 Concentrate Tocotrienols Skinceuticals Pigment Regulator SkinMedica Retinol Complex The Connection Between Oxidative Stress and Aging Definition of Oxidative Stress Sources of Free Radical Damage Ozone Obagi Professional C Ingredients Citrix Antioxidant Body Lotion Tricomin Erythema from Retinoids Carnosine Interleukin-6 (IL-6) Asiaticoside vs. Madecassoside for Collagen Synthesis New Elta MD UV Clear SPF 46 New DCL Super Sheer Sunscreen SPF 50+ PCA pHaze 16+ C-Strength 20% Arginine and Serine Chrysin