Effect of Myristyl Nicotinate on Retinoic Acid Therapy for Facial Photodamage: Melbourne Dermatology Skin Care

Clinical Procedures and Topics

acid again ameliorated analysis approximately arizona associated az barrier based baseline biopsies blind cells center changes clinical college combined concurrent contributor controlled corneum coyle demonstrated department derivative double during edu effect effects efficacy either el enhances epidermal examined facial female function greatest hypothesis impairment improve improved improvement inc incidence increase increased initiation intensity interfere jacobson kim laxity lipophilic loricrin loss mild mitigate mjacobson mk mn moderate month months myristyl niacin niadyne nicotinate parameters period pharmacology pharmacy photodamage pilot placebo positive prior protected protection provided rate reduced reduction resulted results retinoic revealed rizer rl side skin study subjects tewl therapy versus

Effect of Myristyl Nicotinate on Retinoic Acid Therapy for Facial Photodamage

Based on the hypothesis that skin barrier impairment is a contributor to side-effects associated with retinoic acid therapy, a double-blind, placebo-controlled pilot study examined the combined use of retinoic acid with myristyl nicotinate (MN), a lipophilic derivative of niacin that enhances skin barrier function, in female subjects with mild to moderate facial photodamage.

The study involved a 1-month run-in period with placebo or MN prior to initiation of retinoic acid therapy for 3 months. Analysis of skin biopsies revealed that retinoic acid therapy resulted in stratum corneum thinning of approximately 25% (P = 0.006 versus baseline) that was ameliorated by myristyl nicotinate use (P < 0.005).

Therapy resulted in an increased rate of transepidermal water loss (TEWL) of approximately 45% (P = 0.001 versus baseline) and use of myristyl nicotinate protected against the increase in TEWL with the strongest protection provided by prior use of myristyl nicotinate (P = 0.056 versus placebo).

Myristyl nicotinate use reduced the incidence of side-effects of the therapy and again prior use provided the greatest reduction of side-effects.

Subjects showed statistically significant clinical improvement (P < 0.05 versus baseline) during the study.

Myristyl nicotinate use did not interfere with any clinical improvement parameters and improved effects on temple laxity (P = 0.01 versus placebo).

Analysis of changes in epidermal thickness, Ki67-positive cells and intensity of loricrin staining demonstrated that MN either improved or did not interfere with retinoic acid efficacy.

These results show that prior and concurrent use of myristyl nicotinate can mitigate barrier impairment and improve the tolerability of retinoic acid therapy for facial photodamage without interfering with efficacy.

Department of Pharmacology & Toxicology, College of Pharmacy, and Arizona Cancer Center, University of Arizona, Niadyne Development Inc.,Tucson, AZ 85724, USA. mjacobson@pharmacy.arizona.edu

Jacobson MK, Kim H, Coyle WR, Kim M, Coyle DL, Rizer RL, Jacobson EL.

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Effect of Myristyl Nicotinate on Retinoic Acid Therapy for Facial Photodamage


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	Effect of Myristyl Nicotinate on Retinoic Acid Therapy for Facial Photodamage Tweet Based on the hypothesis that skin barrier impairment is a contributor to side-effects associated with retinoic acid therapy, a double-blind, placebo-controlled pilot study examined the combined use of retinoic acid with myristyl nicotinate (MN), a lipophilic derivative of niacin that enhances skin barrier function, in female subjects with mild to moderate facial photodamage. The study involved a 1-month run-in period with placebo or MN prior to initiation of retinoic acid therapy for 3 months. Analysis of skin biopsies revealed that retinoic acid therapy resulted in stratum corneum thinning of approximately 25% (P = 0.006 versus baseline) that was ameliorated by myristyl nicotinate use (P < 0.005). Therapy resulted in an increased rate of transepidermal water loss (TEWL) of approximately 45% (P = 0.001 versus baseline) and use of myristyl nicotinate protected against the increase in TEWL with the strongest protection provided by prior use of myristyl nicotinate (P = 0.056 versus placebo). Myristyl nicotinate use reduced the incidence of side-effects of the therapy and again prior use provided the greatest reduction of side-effects. Subjects showed statistically significant clinical improvement (P < 0.05 versus baseline) during the study. Myristyl nicotinate use did not interfere with any clinical improvement parameters and improved effects on temple laxity (P = 0.01 versus placebo). Analysis of changes in epidermal thickness, Ki67-positive cells and intensity of loricrin staining demonstrated that MN either improved or did not interfere with retinoic acid efficacy. These results show that prior and concurrent use of myristyl nicotinate can mitigate barrier impairment and improve the tolerability of retinoic acid therapy for facial photodamage without interfering with efficacy. Department of Pharmacology & Toxicology, College of Pharmacy, and Arizona Cancer Center, University of Arizona, Niadyne Development Inc.,Tucson, AZ 85724, USA. mjacobson@pharmacy.arizona.edu Jacobson MK, Kim H, Coyle WR, Kim M, Coyle DL, Rizer RL, Jacobson EL. Related Skin Care Information, Products and Expert Discussions A Topical Lipophilic Niacin Derivative Increases NAD, Epidermal Differentiation and Barrier Function in Photodamaged Skin A Pilot Study Evaluating The Efficacy of Topically Applied Niacin Derivatives for Treatment of Female Pattern Alopecia Sederma Matrixyl "Anti-Wrinkle Effects" Study Formulation Compatibility of Myristyl Nicotinate with Drugs Used to Treat Dermatological Conditions Involving an Impaired Skin Barrier Kinetin + Niacinamide Superior to Niacinamide Alone Myristyl Nicotinate Topical Myristyl Nicotinate Creams Formulation Compatibility of Myristyl Nicotinate with Drugs Used to Treat Dermatological Conditions Involving an Impaired Skin Barrier Study: Topical Myristyl Nicotinate Cream on the Skin of Healthy Volunteers Effect of Myristyl Nicotinate on Retinoic Acid Therapy for Facial Photodamage A Topical Lipophilic Niacin Derivative Increases NAD, Epidermal Differentiation and Barrier Function in Photodamaged Skin Analysis and Stability Study of Myristyl Nicotinate in Dermatological Preparations by High-Performance Liquid Chromatography Simultaneous Determination of Myristyl Nicotinate, Nicotinic Acid and Nicotinamide in Rabbit Plasma by Liquid Chromatography–Tandem Mass Spectrometry Using Methyl Ethyl Ketone as a Deproteinization Solvent Niacin Niacinamide File Effect of Myristyl Nicotinate on Retinoic Acid Therapy for Facial Photodamage for reference.	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