Skin Care and Treatments of Melbourne Dermatology - Effects of Oxidative Stress on Skin's Nutrient Reservoir

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Effects of Oxidative Stress on Skin's Nutrient Reservoir

Oxidative stress, particularly in skin, is induced by photo-damage, inflammation and ischemia-reperfusion.

Under these circumstances, many skin antioxidants undergo depletion and must be replaced continuously in order to delay the otherwise inevitable deterioration which would lead to skin aging.

There is considerable interest in the use of natural compounds in skin protection.

Topical application of antioxidants, experimentally, indicates that they may usefully decrease photo-damage and associated inflammation.

The use of various antioxidants such as vitamin C, vitamin E (-tocopherol) and their combinations as topical photo-protectants has been the subject of various investigations.

However, the role of daily food intake in actinic skin damage has not been studied so far.

Tuesday, 11 December 2007

Skin Antioxidants Undergo Depletion

Punnonen K, Jansen C, Puntala A, Ahotupa M: Effects in vitro UVA irradiation and PUFA treatment on membrane fatty acids and activities of antioxidant enzymes in human keratinocytes. J Invest Dermatol 96: 255—259, 1991.

Thursday, 18 December 2008

Photoprotective Effect of Superoxide Scavenging Antioxidants

Bisset D, Chaterjee R, Hannon D: Photoprotective effect of superoxide scavenging antioxidants against ultraviolet radiation-induced chronic skin damage in the hairless mouse. Photoderm Photoimmunol Photomed 7: 56—62, 1990.

Wednesday, 9 December 2009

Topical Vitamin C Protects Swine Skin from Ultraviolet Radiation-Induced Damage

Darr D, Combs S, Dunston S, Manning T, Pinnell S: Topical vitamin C protects swine skin from ultraviolet radiation-induced damage. Br J Dermatol 127: 247—253, 1992.

Tuesday, 25 August 2009

Vitamin E/Tocopherol References

Trevithick JR, Xiong H, Lee S, Shum DT, Sanford SE, Karilick SJ: Topical tocopherol acetate reduces post-UVB, sunburn-associated erythema, edema, and skin sensitivity in hairless mice. Arch Biochim Biophys 296: 575—582, 1992.

Ricciarelli R, Maroni P, Ozer N, Zingg JM, Azzi A: Age-dependent increase of collagenase expression can be reduced by alpha-tocopherol via protein kinase C inhibition. Free Radic Biol Med 27: 729—737, 1999.

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