Skin Care and Treatments of Melbourne Dermatology - Pentapeptides Ineffective

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Pentapeptides Ineffective

Television advertisement for Olay Regenerist pentapeptides.


The UK's ASA (Advertising Standards Authority) has determined that pentapeptides, popular in an increasing number of newly released "anti-aging" skin care products, and one of the most expensive ingredients in skin care, are not effective at reducing the appearance of fine lines and wrinkles.

Pentapeptides are tiny strings of amino acids which are claimed to be able to communicate with skin cells in highly specific ways by directly improving or correcting instructions the cell needs in order to function properly so that they create younger-looking skin.

These latest peptides are held to outperform earlier versions by being even more specific in their pre-programmed actions, allowing for even greater skin repair or assistance.

After examining all available data, the ASA reached the conclusion that the magnitude of changes recorded by pentapeptides were so small that they were not sufficient to support claims of efficacy.

It is also not clear if pentapeptides penetrate skin, and if they do that they are used to beneficial effect rather than being broken down by the skin's enzymes for elimination.

Pentapeptides have reached the point of mass-market distribution. Assuming the mechanisms by which they are said to operate are true, prudent manufacturers may be formulating to ensure they do not penetrate skin or remain active in formulations to avoid side-effects or safety concerns.

Monday, 29 June 2009

Example Pentapeptide Products

Example Pentapeptide Products

Products featuring pentapeptides as a "skin care technology" include Gernetic Concentré Reparateur Serum, Jan Marini TGF, Age Intervention and Marini Lash, Olay Regenerist, StriVectin-SD and Strixaderm.

Although users often report improvement, the improvement is likely largely attributable to other ingredients and characteristics of these products.

Monday, 29 June 2009

ASA Finding Quotations Regarding Pentapeptides

"The differences between the observed changes in the control product group and the peptide containing product group were small at all stages of the trial. "

"... changes [did not reach] a level of significance sufficient to support the claim that pentapeptides were effective at reducing the appearance of lines and wrinkles. "

"in the self-evaluation part of the study, the test subjects themselves overall reported no effect for the pentapeptide containing product."

"he did not consider those changes, measured by instruments, which were reported in favour of the pentapeptide containing product, were likely to be visually significant to the consumer."

Monday, 29 June 2009

Superior Alternatives to Pentapeptides

Consumers who have had poor experiences with other ingredients or are enthusiastic about new ingredients, are among those using the newest peptide products, sometimes to the relative detriment of their skins.

Where the pentapeptide products replace retinoids, alpha-hydroxy acids, better antioxidants and sunscreens, and even certain botanical extracts, the result can be greater expense for lesser result.

Wednesday, 8 July 2009

Effective Peptide Products

Copper peptides are regarded as genuinely effective.

Among those currently included in our database (as of 29/6/09) are IS Clinical, La Roche-Posay Cicaplast, Hydraphase Light and Avene Cicalfate.

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