Comparative Medical Evaluation of Botox and Strivectin among Others: Melbourne Dermatology Skin Care

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adverse annually appearance assessment author background baseline beach beer better blinded botox botox¨ botulinum center change claims clinical comparative comparator compare comprised conclusion creams difference documented dollars efficacy emphasis esthetic evaluation events facial female five follow frown glabellar global greater groups hydroderm hydrodermª improvements injection investigator kenneth line lines moderate none nonprescription objective observed occurred others outcomes overall palm parallel patient patients perception placebo post preparations products provided purport randomized ratings received reductions related relax relaxª reported result resulted results rhytids safety satisfaction scale self several severe severity significant statistically strivectin subject subjects three topical toxin treating treatment type wrinkle

Comparative Medical Evaluation of Botox and Strivectin among Others

Comparative Evaluation of the Safety and Efficacy of Botulinum Toxin Type A and Topical Creams for Treating Moderate-to-Severe Glabellar Rhytids

Author: KENNETH R. BEER, MD, Palm beach Esthetic Center, West Palm Beach, FL 33401, USA.

BACKGROUND

Several nonprescription products purport similar or better outcomes than botulinum toxin type A (Botox® Cosmetic) for treating wrinkles, but these have not been documented in comparative clinical trials. Patients spend millions of dollars annually on the topical products, yet there are, to date, no data to support any of the claims made.

OBJECTIVE

To compare the efficacy and safety of botulinum toxin type A to placebo and three topical products in treating moderate-to-severe glabellar lines.

METHODS

This single-center, randomized, investigator-blinded, parallel study of 77 female subjects comprised five treatment groups: botulinum toxin type A, placebo injection, StriVectin-SD®, Wrinkle Relax™, and HydroDerm™. Baseline and follow-up visits (weeks 4, 8, and 12) assessed safety and key efficacy measures: blinded investigator assessment of glabellar line severity on the Facial Wrinkle Scale (FWS); subjects' global assessment of overall change in appearance; subject ratings of glabellar-related self-perception pre- and post-treatment and satisfaction with treatment.

RESULTS

Botulinum toxin type A treatment consistently resulted in statistically significant reductions in wrinkle severity on the FWS than any comparator (p<.001). Statistically significant improvements were similarly observed for subject-reported outcomes and satisfaction with botulinum toxin type A treatment, whereas treatment with any of the three topical creams did not result in a significant difference from placebo. Three adverse events occurred in three subjects who received StriVectin-SD.

CONCLUSION

Botulinum toxin type A provided significantly greater efficacy and patient satisfaction in the treatment of glabellar frown lines than StriVectin-SD, Wrinkle Relax, and HydroDerm, and in the objective measurements utilized, none of the topical preparations were better than Botox.

[emphasis added]

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Comparative Medical Evaluation of Botox and Strivectin among Others


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	Comparative Medical Evaluation of Botox and Strivectin among Others Comparative Evaluation of the Safety and Efficacy of Botulinum Toxin Type A and Topical Creams for Treating Moderate-to-Severe Glabellar Rhytids Author: KENNETH R. BEER, MD, Palm beach Esthetic Center, West Palm Beach, FL 33401, USA. BACKGROUND Several nonprescription products purport similar or better outcomes than botulinum toxin type A (Botox® Cosmetic) for treating wrinkles, but these have not been documented in comparative clinical trials. Patients spend millions of dollars annually on the topical products, yet there are, to date, no data to support any of the claims made. OBJECTIVE To compare the efficacy and safety of botulinum toxin type A to placebo and three topical products in treating moderate-to-severe glabellar lines. METHODS This single-center, randomized, investigator-blinded, parallel study of 77 female subjects comprised five treatment groups: botulinum toxin type A, placebo injection, StriVectin-SD®, Wrinkle Relax™, and HydroDerm™. Baseline and follow-up visits (weeks 4, 8, and 12) assessed safety and key efficacy measures: blinded investigator assessment of glabellar line severity on the Facial Wrinkle Scale (FWS); subjects' global assessment of overall change in appearance; subject ratings of glabellar-related self-perception pre- and post-treatment and satisfaction with treatment. RESULTS Botulinum toxin type A treatment consistently resulted in statistically significant reductions in wrinkle severity on the FWS than any comparator (p<.001). Statistically significant improvements were similarly observed for subject-reported outcomes and satisfaction with botulinum toxin type A treatment, whereas treatment with any of the three topical creams did not result in a significant difference from placebo. Three adverse events occurred in three subjects who received StriVectin-SD. CONCLUSION Botulinum toxin type A provided significantly greater efficacy and patient satisfaction in the treatment of glabellar frown lines than StriVectin-SD, Wrinkle Relax, and HydroDerm, and in the objective measurements utilized, none of the topical preparations were better than Botox. 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