Tricomin: Melbourne Dermatology Skin Care


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	Tricomin Tricomin by ProCyte is based on the FDA-approved Iamin Hydrogel, a form of the antioxidant superoxide dismutase used in wound healing, with a noted side effect of hair growth stimulation. Superoxide dismutases are endogenous enzymes — proteins cofactored with copper, zinc, manganese, iron or nickel — which catalyze the disproportionation of superoxide into oxygen and hydrogen peroxide, forming a vital antioxidant defense for nearly all eukaryotic cells exposed to oxygen. Experimental studies in mice have shown that increasing cellular production of superoxide dismutase increases lifespan. This class of enzymes is also found in some skin care products aimed at preventing photodamage and preventing/treating hyperpigmentation (La Prairie Cellular Defense Shield, Vivité Vibrance Therapy, Citrix Antioxidant Body Lotion and SPF 30). Topical superoxide dismutase has been shown to reduce post-irradiation breast cancer fibrosis. Another ProCyte product, GraftCyte, comprising a concentrated superoxide dismutase spray and moist dressing, is FDA-approved to prevent transplanted hairs from entering the telogen phase. The telogen phase is the resting phase of the hair follicle. At any time 10-20% of all hairs are in the telogen phase. The telogen phase lasts for about 100 days on the scalp, and much longer for the eyebrows and eyelashes. The patented superoxide dismutase found in Tricomin (Alanine/Histidine/Lysine Polypeptide Copper HCI) is a copper peptide marketed for use in the treatment of hair loss and poor hair and scalp quality, and is also found in Neova Advanced Essential Lash, a product marketed for eyelash enhancement. A decrease in hair quality and a loss of hair can be due to decreased growth, increased shedding, breakage or the conversion of thick (terminal) hairs to thin (vellus) hairs. These scenarios can be as a result of medication intake, genetic and hormonal influences (including stress), internal conditions (iron or thyroid deficiency) and skin diseases or conditions (seborrheic dermatitis, atopic dermatitis) which injure the hair follicle. Copper helps inhibit 5A-Reductase which in turn reduces the formation of DHT (dihydrotestosterone), a cause of hormonal hair loss, and has been shown to stimulate collagen production, a reduction in which has been associated with less well nourished hair bulbs. Tricomin may be used to help maintain a healthy scalp and hair or in combination with proven hair loss therapies (Propecia, Minoxidil, Aminexil, Proxiphen and Retinoic Acid) with the aim of enhancing results and reducing scalp irritation (itchy scalp) which may occur with the use of topical hair loss medications. Tricomin Solution Follicle Therapy Spray is used in a manner similar to a leave-in conditioner, applied either to damp or dry hair and scalp. It is the most potent product containing the highest concentration of the Alanine/Histidine/Lysine Polypeptide Copper HCI antioxidant superoxide dismutase in an alcoholic base for deeper penetration. Tricomin Revitalizing Shampoo and Tricomin Restructuring Conditioner also contain Alanine/Histidine/Lysine Polypeptide Copper HCI in addition to hydrolyzed keratin and may be used in conjunction with Tricomin Solution Follicle Therapy Spray. Please note that Tricomin Deep Conditioning Treatment does not contain Alanine/Histidine/Lysine Polypeptide Copper HCI. Tricomin Solution Follicle Therapy Spray Tricomin Revitalizing Shampoo Tricomin Restructuring Conditioner Tricomin Conditioning Shampoo Tricomin Deep Conditioning Treatment Tricomin TriPack 1 3 Piece Tricomin TriPack 2 2 Piece *Tricomin* Before and After Picture Source: ProCyte. Superoxide Dismutase References for Tricomin Summary: McCord JM, Fridovich I (1988). "Superoxide dismutase: the first twenty years (1968-1988)". Free Radic. Biol. Med. 5 (5-6): 363—9. Tainer JA, Getzoff ED, Richardson JS, Richardson DC (1983). "Structure and mechanism of copper, zinc superoxide dismutase.". Nature (5940): 284-7. Li Y, Huang TT, Carlson EJ, Melov S, Ursell PC, Olson JL, Noble LJ, Yoshimura MP, Berger C, Chan PH, Wallace DC, Epstein CJ (December 1995). "Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase". Nat. Genet. 11 (4): 376—81. Elchuri S, Oberley TD, Qi W, Eisenstein RS, Jackson Roberts L, Van Remmen H, Epstein CJ, Huang TT (January 2005). "CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life". Oncogene 24 (3): 367—80. Sentman ML, Granström M, Jakobson H, Reaume A, Basu S, Marklund SL (March 2006). "Phenotypes of mice lacking extracellular superoxide dismutase and copper- and zinc-containing superoxide dismutase". J. Biol. Chem. 281 (11): 6904—9. Campana F, Zervoudis S, Perdereau B, Gez E, Fourquet A, Badiu C, Tsakiris G, Koulaloglou S (2004). "Topical superoxide dismutase reduces post-irradiation breast cancer fibrosis". J. Cell. Mol. Med. 8 (1): 109—16. Vozenin-Brotons MC, Sivan V, Gault N, Renard C, Geffrotin C, Delanian S, Lefaix JL, Martin M (January 2001). "Antifibrotic action of Cu/Zn SOD is mediated by TGF-beta1 repression and phenotypic reversion of myofibroblasts". Free Radic. Biol. Med. 30 (1): 30—42. File Tricomin for reference.	August 2010 Special Preparation / Special Order Items July 2010 SkinMedica Chemical Peels Nia24 Reference Manual June 2010 New Anthelios 45 Sunscreens for Face and Body Replenix Anti-Photoaging Sunscreen SPF 45 VitaMedica HA + A Program May 2010 New Skinceuticals Sheer Physical UV Defense SPF 50 Alyria Antioxidant Capsules (Vitamin C + E) IS Clinical Youth Complex April 2010 RevaleSkin — CoffeeBerry Extract Retin-A Gel Availability March 2010 RevaleSkin Day Cream SPF 15 Trehalose February 2010 Injuv Polyphenols Kinerase Pro+ C8 Peptide Intensive Treatment with Kinetin and Zeatin January 2010 La Roche-Posay Redermic December 2009 Anti-Aging Sunscreen Reminders November 2009 Complimentary Shipping The Sun Zinc: An Important Antioxidant for Skin La Roche-Posay Derm AOX Biomedic Potent-C 10.5 Concentrate Tocotrienols Skinceuticals Pigment Regulator SkinMedica Retinol Complex October 2009 The Connection Between Oxidative Stress and Aging Definition of Oxidative Stress Sources of Free Radical Damage Ozone Obagi Professional C Ingredients Citrix Antioxidant Body Lotion September 2009 Tricomin Erythema from Retinoids Carnosine Interleukin-6 (IL-6) Asiaticoside vs. Madecassoside for Collagen Synthesis New Elta MD UV Clear SPF 46 New DCL Super Sheer Sunscreen SPF 50+ PCA pHaze 16+ C-Strength 20% Arginine and Serine Chrysin August 2009 Glytone Lipo-Lift Serum Ergothioneine Ubiquinone (Co-Enzyme Q-10) Tetrahexyldecyl Ascorbate Hydrolyzed Hyaluronic Acid Polymorphous Light Eruption Saccharomyces Ferment (Filtrate Lysate) La Roche-Posay Effaclar AI Intensive Acne Spot Treatment New Skinceuticals Retexturing Activator New Vivite Defining Lip Plumper Neova Advanced Essential Lash July 2009 Ceramide 3 Oxido Reductases Cellex-C vs. Skinceuticals D-Tocopheryl Glucoside Human Fibroblast Conditioned Media Kinerase Pro+ Therapy Advanced Radiance Facial Peel June 2009 Pentapeptides Ineffective ReVivé Peau Magnifique Madecassoside Natural/Organic Instinct Products Contain Unlisted + Mislabelled Chemicals Neutrogena Amber Bar Sculpture La Roche-Posay, Vienne, France Obagi Rosaclear May 2009 Myristyl Nicotinate Topical Myristyl Nicotinate Creams Oxofulleram Benefits of Mexoryl SX Anthelios 60 Sunscreens Anthelios SX Daily Moisturizer RevaleSkin CoffeeBerry Kit April 2009 Biomedic Facial Shield SPF 20 IS Clinical Peptides Skin Care for Dry Body Skin Site Upgrades and Updates March 2009 Safety of Micronized Zinc Sunscreens Kinetin RevaleSkin — CoffeeBerry Extract Glycation Biomedic Collagenist Powder p53 Protein Expression Photoprotective (UVB) Salen-Manganese Complex (EUK-134) Clinique Medical Skin Care (Newly Available)