Skin Care and Treatments of Melbourne Dermatology - Clinical Skin Care Topics

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Clinical Skin Care Topics

Monday, 17 June 2013

Open Pores — Treatment and Prevention: 2007-2013 Archived Summary

Wednesday, 19 October 2016 — The preferred regular home treatment for visibly open pores is now available online. Visit the page for MD Rx Melbourne Dermatology Open Pores Overnight Solution for information.


Open Pores — Treatment, Prevention

"Open pores" are sometimes referred to as a "strawberry nose" however can occur anywhere on the face, back, chest or upper arms. Open pores are pathological rather than a clinical entity. Open pores are medically described as early as 1954.


Open Pores — Treatment and Prevention: 2007-2013 Archived Summary

Visibly open pores are one of the most common areas of concern in cosmetic patients.

Smack bang in the middle of the face, they have naturally high visibility and tend to make the nose appear larger than it actually is, simply by drawing attention to it, or rather to the brown, grey or black dotted-texture it wears when the follicles are filled with excess oxidized wax or sebum.

Clinically, absolutely optimal treatment of open pores varies according to skin type, condition, hormonal characteristics, gender and age, and can cost in excess of a thousand dollars.

Patients however express a desire for a relatively inexpensive quick fix.

While no quick-fix exists, long-term therapeutic salicylic acid and retinaldehyde use represents the next most appropriate solution not requiring extensive office visits.

Unfortunately and predictably, irrespective of cost, most patients leave effective treatment of open pores for an extended period of time (beyond one year) and will therefore always suffer from them even when (or if) congestion (in the form of blackheads, acne or hardened wax plugs) is addressed because their pores will have become permanently distended (stretched) by having to accommodate retained wastes.

Although the cosmetics industry has succeeded in suggesting a whole range of alternatives for visibly open pores (plant extracts, mild scrubs, facials administered by beauticians/aestheticians including dubious "extractions"), as always none of them provide any more than fleeting benefit because they address neither inflammation nor the clumping of cells within follicles which produce the aesthetic problem in the first place.

It's pointless to even try treating open pores without introducing salicylic acid and/or retinaldehyde use into pores in a manner which lasts the better part of each day because visibly open (distended) pores are representative of a chronic process. Visibly open pores simply do not respond favourably to physical and superficial treatments.

Clearing Open Pores — Treatment.

Patients who attempt to squeeze oxidized wax plugs from the pores may feel temporarily gratified by the sight of their own hardened sebum emerging from their nose, but they only succeed in lifting out the tops of plugs which block their pores — the follicular reservoirs will re-fill themselves within a day or less.

Open Pores — Treatment and Prevention: 2007-2013 Archived Summary

Effective resolution of visibly open pores also tends to fail where patients expect an overnight cure, complicate treatment with inappropriate supplementary skin care products (particularly cleansers, moisturisers and sunscreens) or become non-compliant in treatment at any time in the first year after commencement of therapy.

Most patients also disbelieve that open pores are as difficult to treat as severe, treatment-resistant acne, and will tend to (literally) wax and wane in their therapy for that reason, even when proof of their approach's failure is as plain as the clogged nose on their face.

Because time for effective treatment is extremely limited and because even effective treatments are slow, patients often lapse into chronic, futile yet all-knowing attempts to treat their own open pores.

The situation fosters perpetually disappointing self-treatment and the belief that "I just can't clear my open pores" becomes a self-fulfilling prophesy as they become progressively stretched.

Evidence also points to skin aging being mildly accelerated by the chronic presence of wax plugs because they signify an oxidative, free-radical process within the skin.

Patients with visibly open pores often have a highly similar syndrome occurring on their scalps, where it gives rise to an itchy scalp, scalp acne and reversible (at least for a period of time) hair loss.

Treatments (and Prevention) for Open Pores (sources of salicylic acid and retinol/retinaldehyde)

Day and Night Cleansers — Biomedic LHA Cleansing Gel, Biomedic Anti-Bac Acne Wash, Skinceuticals Clarifying Cleanser, Glycolix Gly/Sal 5-2 Cleanser or the stronger Glycolix Gly/Sal 10-2 Wash.

Toner — Glycolix Gly/Sal 5-2 Toning Pads or the stronger Glycolix Gly/Sal 10-2 Toning Pads.

Oil Control — OC Eight, Kinerase Clear Skin Treatment Serum.

Moisturizer/Treatments — La Roche Posay Effaclar K, Kinerase Clear Skin Moisture Light.

Nightly Treatments — Skinceuticals Retinol, Biomedic Retinol, Avene Retrinal.

Sunscreen — Biomedic Facial Shield SPF 30.

Masks — Skinceuticals Clarifying Clay Mask, Kinerase Clear Skin Regulating Mask.


Open Pores Information and Treatment Notes from 2007

What's the best solution to deal with open pores? Unfortunately there's no wonder cure for open pores, which are generally the result of excess sebum production or sun damage, where the skin loses elasticity around the pore.

Pores can enlarge from excess oil production, build up of dirt and debris, or from the breakdown of the collagen structure in the pore wall as we age.

Blackheads are a result of sebum and dirt blocking the pore.

Pollution and makeup need to be gently and regularly cleansed away for skin to remain clear.

Monday, 16 January 2012

Open Pores Overnight Solution Review: My Face Saver

I have been using this peel for more than a year. It has taken years off the appearance of my nose and cleared up my acne. It has also greatly improved the appearance of my forehead. I can't recommend this product highly enough.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Monday, 16 January 2012

Open Pores Overnight Solution Review: Clarifies and Refines My Skin and Pores

This peel clarifies and refines my pores but also my skin in general. Since using it the first time I have purchased it four more times and love to keep it in stock. It is the most effective product I have ever tried.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Monday, 16 January 2012

Open Pores Overnight Solution Review: Excellent Mini Peel for Open Pores with Few Side Effects

I have never tried a chemical peel before. I am very pleased with the result. This is real skin "care." I have used it three times and my skin is less dull, has more glow and most importantly has far less open pores. Side effects are redness and dryness but nothing unmanageable. You should probably be aware of this side effects prior to use so you don't become anxious. Several friends also purchased this peel and some of them experienced side effects while others did not. Some with sensitive skin didn't experience side effects so there probably is no reliable way to determine how any one will react without actually trying this product.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Monday, 16 January 2012

Open Pores Overnight Solution Review: Awesome Skin Refresher

This product was recommended to me by my dermatologist who had previously prescribed microdermabrasion and chemical peels. With this product you will get similar results to an office peel, but you do need to follow the instructions carefully. This is a very strong product so use with care and you will be ok. Over-zealous use can lead to dryness and redness. If this happens don't worry too much as they will clear up. When they do you will actually have superior results to a more gentle application. This product has allowed me to cut down on the number of professional chemical peels and microdermabrasion sessions I need in a given year. Possibly in the future with continued use of this product I may not really require them at all.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Monday, 16 January 2012

Open Pores Overnight Solution Review: Great for Smoothing Out Facial Pores

This is a quickly absorbed peel. It is easy to apply too much the first time, so follow the instructions for use carefully. It smoothes out facial pores very efficiently and I have also noticed less obvious freckles on my nose.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Monday, 16 January 2012

Open Pores Overnight Solution Review: Fantastic Product for Stretched Pores

I noticed a difference in my skin after three weeks (ie. three applications). I find it slightly irritation however I suspect this is the price to pay for it being so effective on stretched pores. Thankfully the irritation clears up quickly even without moisturizer. I prefer to use this at night a few days before any important event. I would be careful about using this peel for the first time within a few days of any even where you skin has to look its best, just to be safe. A fantastic product all round for stretch pores.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Monday, 16 January 2012

Open Pores Overnight Solution Review: Love the Result on Clogged Pores

The effect of this peel on clogged pores is amazing. I no longer have to have extractions or spend time in the mirror squeezing out the plugs only to see them looking the same within a day. With regular use I find my clogged pores are more consistently clear and my skin texture on my nose is more refined.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Monday, 16 January 2012

Open Pores Overnight Solution Review: Helps Prevent Acne

I have purchased this peel first in-office and then repeatedly online. Originally I purchased it to reduce my pore size, however I also find it prevents acne very effectively, more effectively than Proactiv and Jan Marini Bioclear. The peel also tightens skin.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Monday, 16 January 2012

Open Pores Overnight Solution Review: Inexpensive Chemical Peel for Open Pores

I have been getting mild chemical peels for more than a decade and it is very expensive. I believe this peel is similar to the in-clinic peels and is very specific to my problem of open pores. Highly recommended. I will continue to use this product indefinitely.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Monday, 16 January 2012

Open Pores Overnight Solution Review: Affordable Alternative to Expensive Professional Chemical Peels

I am glad I purchased this product although I was concerned it may be difficult to use. I believe it is an affordable alternative to chemical peels. I have been using it for two weeks and my pores look much tighter and are now clear of those solid oil plugs. I recommend this product to my friends, many of whom have asked about my skin!


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Monday, 16 January 2012

Open Pores Overnight Solution Review: Keeps Pores Fresh at Home

Peels normally cost around $100 which adds up to about $800 after a normal set. This product is slightly less than 1/8th the cost so the value is great. I feel I get the same results that I get from a clinic. Makes my pore size very small and keeps my skin fresh.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Monday, 16 January 2012

Open Pores Overnight Solution Review: 5 Minutes to Fresh Skin with Less Visible Pores

Easy to apply. Some stinging and irritation which clears up before long. Gives great smooth skin with less visible pores.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Monday, 16 January 2012

Open Pores Overnight Solution Review: Professional Strength Peel Treatment, Easy to Use

This is a very fine liquid which removes the very surface layers of the skin and removes debris from pores. I don't find it stings like some reviewers but I would agree that this is a very strong product. Pores definitely look smaller and more refined after use in a series, which is what this peel has been made for.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Monday, 16 January 2012

Open Pores Overnight Solution Review: Remarkable Results for a Home Use Product

I find this peel tingles a lot and can make my skin red and dry after use, however these problems soon clear up and I have refined pores. Despite the strength I think it is safe and easy to use. Also I save a lot of time and money using this at home instead of attending a clinic.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Monday, 16 January 2012

Open Pores Overnight Solution Review: Definitely Works on Ugly Pores

This product is a boon for ugly pores. It smoothes out their look and softens the nose so it is more beautiful.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Monday, 16 January 2012

Open Pores Overnight Solution Review: Helped with Open Pores as well as Acne

This peel really helped with my open pores and acne. I am really excited to see how good the results will be after eight weeks.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Monday, 16 January 2012

Open Pores Overnight Solution Review: Freshens and Renews Facial Appearance

I have used this product since before it was available online through the secure store. It gives you a glowing look free of very visible pores. There can be some redness and dryness as your skin is getting used to it. The glow you get from its use is without comparison, once your skin has adjusted to the strength of the peel. It is important for follow the instructions for use carefully.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Monday, 16 January 2012

Open Pores Overnight Solution Review: Professional-Like Results at Minimal Cost

This quick peel gives professional-like results at a fraction of the cost. Pores are much less obvious. The cost to benefit ratio between this peel and other products is huge. Also this is the only product which has seriously addressed the appearance of my pores.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Monday, 16 January 2012

Open Pores Overnight Solution Review: Effective but Not Without Side Effects

The first few times I used this product my skin became slightly red and dry and I experienced some acne. However after using the product for a little over a month my skin and my pores could hardly look more perfect. I no longer develop hormonal acne on my chin. Make up applies very smoothly.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Monday, 16 January 2012

Open Pores Overnight Solution Review: Amazing Inexpensive Treatment

I was slightly concerned when first trying this product for my open pores because my skin is very pale and delicate skin. I did find it quite potent however it did improve my skin a lot more than Obagi, Skinceuticals and Jan Marini.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Monday, 16 January 2012

Open Pores Overnight Solution Review: Mini Miracle for Open Pores

The Melbourne Dermatology Open Pores Peel is an extraordinary product. Each time I use it my pores become tighter and smoother, much much moreso than with anything else I have tried over the years.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Monday, 16 January 2012

Open Pores Overnight Solution Review: Great for Giving Rough Skin and New Glow

I really liked this product. My pores have smoothed out and look less open. My rough skin also smoothed out. I believe the product also gets rid of dead skin and I did experience some peeling. I would definitely recommend this product for people with open pores.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Monday, 16 January 2012

Open Pores Overnight Solution Review: Peel Away Appearance of Pores

This peel for open pores left my pores less visible and reduced my fine lines. After a few weeks I noticed a difference in my skin's texture. I also notice fewer breakouts.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Monday, 16 January 2012

Open Pores Overnight Solution Review: Best Way to Treat Open Pores

This is the best way to renew your skin. It is a strong product, but not too strong. I was recommended this product by my dermatologist and I am glad I tried it.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Sunday, 15 January 2012

Open Pores Overnight Solution Review: Great for Use at Home

I don't have time or sometimes the money to have professional peels in my dermatologist's office, so this is a fast and inexpensive alternative. I do find it especially effective on my open pores, which it is especially made for. I also find it improves my skin texture and some fine lines. The clarity of the skin also improves.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Sunday, 15 January 2012

Open Pores Overnight Solution Review: Recommended by my Dermatologist

My dermatologist recommended this peel to me as it was effective and contained pharmaceutical/medical grade ingredients. The product gives a huge improvement to skin and the look of my pores. It is not a regular skin care product. It is more effective than any other skin care or cosmeceutical product I have tried.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Sunday, 15 January 2012

Open Pores Overnight Solution Review: Inexpensive and Effective

This is a very light-weight peel that didn't irritate my sensitive skin. I think you have to use it more often than a professional peel however the results are easily worth the savings and the results are comparable.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Sunday, 15 January 2012

Open Pores Overnight Solution Review: Pores Banished

This is a strong product, so I wouldn't exceed the recommended application time. It leaves the skin super clear and the pores banished.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Sunday, 15 January 2012

Open Pores Overnight Solution Review: Favorite New Product

A fast and easy way to get an effective peel at home. When I use this in the evening I wake up in the morning with amazing skin and received compliments during the day. I recommend this to all my friends who complain about their pores.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Sunday, 15 January 2012

Open Pores Overnight Solution Review: Gentle and Effective

A great peel which you can use more often than recommended. Just five to ten minutes and skin comes away with a fresh glow and far less obvious pores. The results last.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Sunday, 15 January 2012

Open Pores Overnight Solution Review: Huge Reduction in Pore Size

I did not believe how much smaller this made my pores look.

There was some slight dryness, however nothing some moisturizer didn't help.


For further information see MD Rx Melbourne Dermatology Open Pores Overnight Solution, Instructions for Use and Ingredients. For general information, see Open Pores.


Thursday, 25 August 2011

RevaléSkin Coffeeberry Kit Available Again

June 8, 2011 — Sold out.

RevaléSkin Coffeeberry Kit Available Again

RevaléSkin Coffeeberry Kit Available Again

A limited quantity (125) of RevaléSkin CoffeeBerry skin care kits are available again.

RevaléSkin Coffeeberry Kit Available Again

RevaléSkin is a superior, stable antioxidant skin care range containing a diversity of antioxidants including ferulic acid and polyphenols similar to those found in green tea, however the antioxidant value (by ORAC measurement) is higher.

RevaléSkin also contains caffeine.

When used as prescribed, RevaléSkin reduces hyperpigmentation, brightens and lightens skin tone, and helps reduce some of the signs of photoaging.

Theoretically, the RevaléSkin collection should also help to prevent photoaging.

RevaléSkin is suited to most skins and does not seem to produce any of the skin sensitivity seen with some Vitamin C and retinoid products.

For further information, see the specific page for the RevaléSkin CoffeeBerry Kit and the sections for RevaléSkin and coffeeberry in general.

A RevaléSkin promotional video from 2008 is also available to be viewed online.

Thursday, 2 September 2010

Special Preparation / Special Order Items

Special Preparation / Special Order Items

American Podophyllin 20% 30 ml

American Podophyllin 25% 30 ml

American Podophyllin 40% 30 ml

American Podophyllin 50% 30 ml

Anthralin Powder BP 100 grams

Citric Acid Special Solution 30% 500 ml

Citric Acid Special Solution 50% 500 ml

DNCB 0.001% in Acetone 30 ml

DNCB 0.001% in Petrolatum 30 ml

DNCB 0.01% in Acetone 30 ml

DNCB 0.01% in Petrolatum 30 ml

DNCB 0.1% in Acetone 30 ml

DNCB 0.1% in Petrolatum 30 ml

DNCB 1% in Acetone 30 ml

DNCB 2% in Acetone 30 ml

DNCB 2% in Petrolatum 30 ml

DNCB 4% in Acetone 30 ml

Diphenylcyclopropenone 1 gram

Coal Tar Crude 500 ml

Dichloroacetic Acid (Bichloroacetic Acid) 30 ml and 60 ml

Ethanolic Coal Tar Solution 500 ml

Hetter Solution 30 ml

Hetter Solution 60 ml

Hetter Solution 500 ml

Hetter Light Solution 240 ml

Hetter Medium-Light Solution 240 ml

Hetter Medium-Heavy Solution 240 ml

Indian Podophyllin 20% 30 ml

Indian Podophyllin 25% 30 ml (in tincture of benzoin)

Indian Podophyllin 40% 30 ml

Indian Podophyllin 50% 30 ml

Kligman's Formula with Sunscreen and Vitamin C 30 ml (minimum order 6)

Kligman's Formula with Sunscreen and Vitamin C 60 ml (minimum order 6)

Kligman's Formula with Sunscreen and Vitamin C 120 ml (minimum order 6)

Kligman's Formula with Sunscreen and Vitamin C 240 ml (minimum order 6)

Kligman's Formula with Sunscreen, Vitamin C and Kojic Acid 60 ml (minimum order 6)

Kojic Acid Aquaphilic Ointment 30 ml (minimum order 6)

Leonard Formula Solution #1 30 ml

Leonard Formula Solution #2 30 ml

Mackenzie Special Formula 500 ml

Podophyllin USP 10% 30 ml (minimum order 6)

Podophyllin USP 30% 30 ml (minimum order 6)

Podophyllin USP 35% 30 ml (in tincture of benzoin) (minimum order 6)

Salicylic Acid 60% in Petrolatum

Stone Solutions — See below

Shum Special Formula 500 ml

Squaric Acid Dibutylester 1 gram

Swinehart's Paste 120 ml

Swinehart's Paste 240 ml

Thymol Iodides Powder 25 grams

Thymol Iodides Powder 125 grams

Unna's Paste 60 ml

Unna's Paste 120 ml

Zinc Oxide Paste with 10% Ichthammol 500 grams

Zinc Sulphate (Zinc Sulfate) 0.04% 15 ml

Stone Solutions

Stone II 500 ml

Stone II 240 ml

Stone #2 30 ml

Stone #4 30 ml

Stone #6 30 ml

Stone #19 30 ml

Stone #20 30 ml

Stone #21 30 ml

Stone #22 30 ml

Stone #23 30 ml

Stone Light Resorcinol 3 x 240 ml

Stone Venner-Kellson 83 ml

Wednesday, 28 July 2010

Nia24 Reference Manual

Nia24 Reference Manual

Nia24 (Niadyne, Inc.) contains a patented form of niacin known as Pro-Niacin (INCI: myristyl nicotinate) found throughout the company's own brand (manufactured and distributed by Mentorcorp, Johnson & Johnson) and licensed for use in a selection of products from Canyon Ranch and the hair care brand Frederic Fekkai.

A large body of evidence supports the use of niacin to increase collagen synthesis (to firm skin and reduce wrinkles) and ceramide biosynthesis (to relieve dryness, skin barrier function and reduce trans-epidermal water loss, sensitivity and stinging).

Niacin is also useful in inhibiting the transfer of melanosomes (making it useful in the treatment and prevention of hyperpigmentation) and in reducing inflammation in skin disorders such as acne and rosacea.

Topical niacin is thought to have beneficial effects on DNA metabolism which help prevent skin cancer and possibly skin aging.

The loss of chromosome ends termed telomeres has been shown to result in cellular aging of normal skin cells (senescence). Recent research implicates NAD (niacinamide adenine dinucleotide) in the maintenance of telomeres, suggesting niacinamide — and not topical telomeraseretards aging of skin cells.

Unlike Vitamin C and retinol, niacin formulas are generally non-irritating and effective. Perhaps as a consequence, the Nia24 range has become hugely popular online.

An increasing number of companies now include niacin (also referred to as Vitamin B3, niacinamide, nicotinic acid, myristyl nicotinate and nicotinamide) in their products. Olay Total Effects (Procter and Gamble) contains predominantly niacinamide, although it is marketed on the purported efficacy of its inactive peptides. Other products containing appreciable quantities of niacinamide include La Roche-Posay Rosaliac, B. Kamins Booster Blue Rosacea Masque, Elta MD UV Clear SPF 46 (Sunscreen for Acne-Prone Skin) and PCA Hydrating Serum.

The myristyl nicotinate form of niacin appears to be the most potent, producing a warmth and sometimes even homogenous blush when first used. In our experience this response is absent when other forms are used. Accordingly, extremely sensitive skin may require 7-10 days to adjust to myristyl nicotinate.

Nia24 Niacin (Myristyl Nicotinate) Reference Manual

Nia24 Reference Manual

Download the Nia24 Reference Manual.

Additional Nia24 Myristyl Nicotinate References

Cleaver JE and Crowley E. UV damage, DNA repair and skin carcinogenesis. Frontiers in Bioscience. April 2002;7:1024-1043.

Ullrich SE. Photoimmune suppression and photocarcinogenesis. Frontiers in Bioscience. March 2002;7:684-703.

Jacobson MK and Jacobson EL. Discovering new ADP-ribose polymer cycles: protecting the genome and more. Trends in Biochemical Sciences. 1999;24:415-417.

Jacobson EL, Giacomoni PU, Roberts MJ, Wondra GT and Jacobson MK. Optimizing the energy status of skin cells during solar radiation. Journal of Photochemistry and Photobiology B: Biology. 2001;63:141-147.

Kim H, Jacobson M, Kim M, Jacobson E and Qasem J. A topical niacin prodrug enhances wound healing by stimulation of leptin secretion. Journal of Investigative Dermatology. 2002;119:347(A840).

Higdon, J. Niacin. The Linus Pauling Institute’s Micronutrient Center. http://lpi.oregonstate.edu/infocenter/vitamins/niacin/printniacin.html.

Jacobson MK, Jacobson EL, Kim H, Kim M, Rizer RL and Trookman NS. Enhancement of human skin barrier integrity by nicotinic acid derivatives. Journal of Investigative Dermatology. 2004;122:58(A345).

Wednesday, 14 July 2010

Effect of Stress (Cortisol) on Skin

Chronic stress triggers a hormone called cortisol, which reduces the ability of the skin to retain water.

The result: a dull, dry complexion.

Sunday, 11 July 2010

SkinMedica Chemical Peel Overview of Ingredients

Sunday, 11 July 2010

SkinMedica Illuminize Peel

SkinMedica Illuminize Peel

SkinMedica Illuminize Peel is a very superficial chemical peel utilizing a newer generation of alpha-hydroxy acids (mandelic acid and malic acid) in combination with phytic acid and commonly used peeling agents (salicylic acid and resorcinol) to maximize skin rejuvenating effects with low irritation.

Similar to Skinceuticals Salicylic-Mandelic (SM) Peel, SkinMedica Illuminize Peel provides comparatively more skin tightening and improvement in skin clarity, skin colour and texture with little to no visible peeling.

The presence of resorcinol also greatly improves efficacy in treating hyperpigmentation.

SkinMedica Illuminize Peel is suitable for Fitzpatrick Skin Types I-VI.

Sunday, 11 July 2010

SkinMedica Vitalize Peel

SkinMedica Vitalize Peel

SkinMedica Vitalize Peel helps fight the effects of time, sun damage and environmental assaults.

This powerful yet gentle peel is an enhancement upon the traditional Jessner's Peel (although still containing resorcinol) and can take years off the appearance of aging skin.

SkinMedica Vitalize Peel:

  • Addresses various skin conditions, such as pigmentation abnormalities, post-inflammatory hyperpigmentation, melasma, and photodamage;

  • Achieves readily visible improvement after one treatment (generally superior to glycolic acid) and significant results after a series of treatments;

  • Can be customized for the treatment of each specific condition;

  • May be performed on Fitzpatrick skin types I-VI;

  • Requires little or no or down time;

  • May be combined with additional retinoic acid powder to create more exfoliation than other chemical peels targeting the same depth;

  • Is well-tolerated (minimum or no burning, peeling solution has pH 2-3, higher than most chemical peels);

  • Is inherently safe: does not require precise timing or neutralization and is anti-inflammatory.

Sunday, 11 July 2010

SkinMedica Rejuvenize Peel

SkinMedica Rejuvenize Peel

SkinMedica Rejuvenize Peel is a relatively deep form of Jessner's Peel combined with an anti-irritant and healing ingredients and a penetration enhancer which controls the rate and evenness of penetration.

SkinMedica Rejuvenize Peel is effective for use in instances of photodamage, melasma, hyperpigmentation and acne scarring.

The procedure produces great improvement after one session, although up to six are routinely recommended.

SkinMedica Rejuvenize Peel is suitable for Fitzpatrick Skin Types I-VI, however can be used on Skin Types V-VI after the patient has established tolerability to SkinMedica Vitalize Peel, or with physician consent.

The peel is well-tolerated and safe, not requiring very precise timing or neutralization.

Thursday, 27 May 2010

L'Oreal Lash Boosting Serum

L'Oreal Lash Boosting Serum contains madecassoside (an extract of centella asiatica), arginine and serine.

Tuesday, 25 May 2010

Anthelios 60 Melt-In Sunscreen Milk Patents

The sunscreen formulation of La Roche-Posay Anthelios 60 Melt-In Sunscreen Milk for Body is protected by US Patents 5576354, 5667765 and 5587150.

Tuesday, 25 May 2010

Anthelios 60 Melt-In Sunscreen Lotion Patents

The sunscreen formulation of La Roche-Posay Anthelios 60 Melt-In Sunscreen Lotion for Body is protected by US Patents 5576354, 5667765 and 5587150.

Tuesday, 25 May 2010

Anthelios 45 Ultra-Light Fluid for Body Sunscreen Patents

The sunscreen formulation of La Roche-Posay Anthelios 45 Ultra-Light Sunscreen Fluid for Body is protected by US Patents 5576354, 5667765 and 5587150.

Tuesday, 25 May 2010

Anthelios 45 Ultra-Light Fluid Sunscreen Patents

The sunscreen formulation of La Roche-Posay Anthelios 45 Ultra-Light Sunscreen Fluid is protected by US Patents 5576354, 5667765 and 5587150.

Sunday, 23 May 2010

Asiaticoside-induced elevation of antioxidant levels in healing wounds.

Abstract

Asiaticoside derived from the plant Centella asiatica is known to possess good wound healing activity. Enhanced healing activity has been attributed to increased collagen formation and angiogenesis. Since antioxidants have been reported to play a significant role in the wound healing process we studied the effect of asiaticoside on the levels of certain antioxidants in the wound so as to explore the possible involvement of such a mechanism in the asiaticoside induced wound healing. Asiaticoside application (0.2%, topical) twice daily for 7 days to excision-type cutaneous wounds in rats led to increased enzymatic and non-enzymatic antioxidants, namely superoxide dismutase (35%), catalase (67%), glutathione peroxidase (49%), vitamin E (77%) and ascorbic acid (36%) in newly formed tissues. It also resulted in a several fold decrease in lipid peroxide levels (69%) as measured in terms of thiobarbituric acid reactive substance. However, continued application for 14 days showed no significant difference in these antioxidants compared with their values in vehicle treated wound tissue. It appears from the present study that asiaticosides enhanced induction of antioxidant levels at an initial stage of healing which may be an important contributory factor in the healing properties of this substance.

Tuesday, 23 August 2011

How Does Prevage MD Work to Prevent Aging?

Mitochondria are structures located inside cells.

They produce energy necessary for cell functioning through an oxygen-dependent process named “cellular respiration.”

During cellular respiration, some toxic forms of oxygen, most commonly known as (oxygen) free radicals are produced.

These free radicals must be neutralised by other substances to the serious cell damage accompanying the appearance of skin aging and skin cancer.

The high concentration of deep-penetrating idebenone in Prevage MD acts as an "antioxidant" to neutralise these toxic forms of oxygen, consequently preventing cellular damage.

Most impressively, Prevage MD appears to target signs of aging other than photodamage.

Usually well tolerated, we combine Prevage MD with other topical and systemic antioxidants, sunscreens, retinoids and other agents in protocol suited to individual patient skin characteristics.

Monday, 17 May 2010

IS Clinical Youth Complex PDF

IS Clinical Youth Complex PDF

Monday, 17 May 2010

Alyria Antioxidant Capsule Vitamin C References

Mittal A, Elmets CA, Katiyar SK. Dietary feeding of proanthocyanidins from grape seeds prevents photocarcinogenesis in SKH-1 hairless mice: relationship to decreased fat and lipid peroxidation. Carcinogenesis 24(8):1379-88 (2003 Aug).

Mantena SK, Katiyar SK. Grape seed proanthocyanidins inhibit UV-radiation-induced oxidative stress and activation of MAPK and NF-kappaB signaling in human epidermal keratinocytes. Free Radic Biol Med. 40(9):1603-14 (2006 May).

Gil MI, Tomás-Barberán FA, Hess-Pierce B, et al. Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem 48(10):4581-9 (2000 Oct).

Chidambara Murthy KN, Jayaprakasha GK, Singh RP. Studies on antioxidant activity of pomegranate (Punica granatum) peel extract using in vivo models. J Agric Food Chem 50(17):4791-5 (2000 Oct).

Syed DN, Malik A, Hadi N, et al. Photochemopreventive effect of pomegranate fruit extract on UVA-mediated activation of cellular pathways in normal human epidermal keratinocytes. Photochem Photobiol 82(2):398-405 (2006 Mar-Apr).

Wei H, Cai Q, Rahn RO. Inhibition of UV light- and Fenton reaction-induced oxidative DNA damage by the soybean isoflavone genistein. Carcinogenesis 17:73-7 (1996).

Wei H, Saladi R, Lu Y, et al. Isoflavone genistein: photoprotection and clinical implications in dermatology. J Nutr 133(11 Suppl 1):3811S-3819S (2003 Nov).

Maziere C, Dantin F, Dubois F, et al. Biphasic effect of UVA radiation on STAT1 activity and tyrosine phosphorylation in cultured human keratinocytes. Free Radic Biol Med 28(9):1430-7 (2000 May).

Sime S, Reeve VE. Protection from inflammation, immunosuppression and carcinogenesis induced by UV radiation in mice by topical Pycnogenol. Photochem Photobiol 79(2):193-8 (2004 Feb).

Saturday, 8 May 2010

Facilitating facial retinization through barrier improvement

The utility of topical tretinoin as a treatment for improving the appearance of photodamaged skin is limited by irritation that occurs during the early phases of facial retinization. The observed side effects are consistent with stratum corneum barrier compromise. This paired double-blinded study was conducted to determine if preconditioning the skin with a barrier-enhancing cosmetic facial moisturizer before beginning tretinoin therapy and continuing moisturizer application during therapy would mitigate these side effects. Women with facial photodamage were recruited and randomly assigned to apply one cosmetic moisturizer to one side of the face and the other cosmetic moisturizer to the other side of the face twice daily for 10 weeks. One moisturizer contained a mixture of vitamins (niacinamide, panthenol, and tocopheryl acetate) to enhance stratum corneum barrier function, and the other moisturizer contained similar moisturizing ingredients but no vitamins. Daily full-face treatment with tretinoin cream 0.025% commenced 2 weeks into the study. Subjects' facial skin condition was monitored via investigator assessments, instrumental measurements, and subject self-assessments. The results show that improving stratum corneum barrier function before beginning topical tretinoin therapy and continuing use of a barrier-enhancing cosmetic moisturizer during therapy facilitates the early phase of facial retinization and augments the treatment response.

Draelos ZD, Ertel KD, Berge CA.

Tuesday, 4 May 2010

Retin-A Gel Availability

The Australian generic gel formulation of Retin-A appears to have been discontinued.

Retin-A Gel Availability

Thursday, 18 March 2010

Genistein Protects Against UVB-Induced Senescence-Like Characteristics in Human Dermal Fibroblast by p66Shc Down-Regulation

Background

Genistein, as an active compound of dietary antioxidants, has shown considerable promise as an effective agent against aging process. However, the effect of genistein on skin photoaging and the associated mechanism remain unclear.

Objective

To delineate the effect of genistein on UVB-induced senescence in human dermal fibroblasts (HDFs) with emphasis on the mechanism of oxidative pathway regulated by p66Shc involved in the events.

Methods

HDFs were induced to premature senescence by repetitive subcytotoxic doses of UVB irradiation. Cellular apoptosis and DNA cell cycle were analyzed using flow cytometry. Intracellular levels of superoxide dismutase (SOD) and malondialdehyde (MDA) were detected by ELISA. Mutation levels of two large deletions of mitochondrial DNA, 4977bp and 3895bp deletion, were determined by quantitative PCR. Western blot was applied to detect the expression and activation of p66Shc (the 66-kilodalton isoform of the growth factor adapter Shc) and FKHRL1 (a forkhead protein that is intimately linked with intracellular oxidation).

Results

Strong activity of senescence-associated beta-galactosidase (SA-?-gal), high percent of cell apoptosis as well as cell cycle arrest in G0/G1 phase, and increased intracellular oxidative stress were observed in HDFs irradiated by UVB. Genistein exerted dramatically protective effects on HDFs in a dose-dependent manner. Elevated copy numbers of large deletions in mitochondrial DNA were also inhibited by genistein. Down-regulation of total and phosphorylated p66Shc on Ser36, as well as FKHRL1 and its phosphorylation on Thr32, were observed after genistein treatment.

Conclusion

The results indicate that genistein protects UVB-induced senescence-like characteristics in HDFs via maintenance of antioxidant enzyme activities and modulation of mitochondrial oxidative stress through down-regulation of a p66Shc-dependent signaling pathway, which may provide potential prevention against skin aging and even photoaging.

Keywords: Genistein, Photoaging, UVB, p66Shc, FKHRL1

Yi Na Wanga1, Wei Wub1, Hong Chao Chena, Hong Fanga

Wednesday, 16 December 2009

Anti-Aging Sunscreen Reminders

Anti-Aging Sunscreen Reminders  Anti-Aging Sunscreen Reminders

Healthy vs. Unhealthy CollagenCollagen is one of the skin's major components protected by sunscreen.


While an increasing number of people are using sunscreens with the aim of preventing and reducing aging, unfortunately next to none do so in a manner which results in obvious clinical improvement.

Patients on good sunscreen regimens also have a tendency to lapse for months at a time, negating underlying positive changes before they are outwardly visible.

Follow these points to achieve major, permanent skincare success with sunscreens:

  • think daily without fail and long term — liken sunscreen for skin as fluoride for teeth, and not as just a beach or hot-weather product for occasional use;

  • if sunscreen is the only therapy used, don't expect much outwardly visible improvement for 8-12 months in the beginning;

  • apply even if indoors or making short tripsUVA penetrates glass and incremental exposure adds up;

  • use enough — the correct amount to ensure you reach the stated SPF is one teaspoon for the area the size of the face and neck (a 100g tube should last about 20 days);

  • apply correctly — cover all exposed areas to ensure even results: face, neck (all around), ears and hands;

  • for routine daily use, only use sunscreens containing Mexoryl or Zinc — with few exceptions, other sunscreens lose UVA protection within 30-60 minutes (as SPF only pertains to UVB and UVA protection isn't regulated in many regions, you must look for these ingredients);

  • for routine daily use, avoid heavy and greasy sunscreens — they don't come off completely at the end of the day, inhibiting absorption of evening skincare or requiring deleterious cleansing;

  • because no one sunscreen is perfect as yet, the "gold standard" in daily protection is a Mexoryl sunscreen underneath Zinc.

To bolster your sunscreen, you can also apply an antioxidant underneath during the day and a retinoid overnight (although retinoids initially make the skin more light-sensitive, they ultimately strengthen the skin's daytime response to light).

Anti-Aging Sunscreen Reminders

La Roche-Posay Anthelios SX is an excellent non-whitening, hypoallergenic sunscreen with a low chemical sunscreen content (14% vs. approximately 35% for a non-Mexoryl sunscreen) despite providing day-long UVA protection, making it ideal for once-daily use. Daily optimal use amounts to around $1.50/day. As a source of zinc oxide, Colorescience Sunforgettable may be brushed over the top for ultimate protection. Cotz is another alternative (used in smaller amounts).

Anti-Aging Sunscreen Reminders with Mexoryl

Friday, 14 May 2010

La Roche-Posay Derm AOX Study Notes

Based on in-vitro test. Source: Cossins et al., Biochem Mol Biol Int, 45:583-597, 1998 Packer et al., Free Rad Biol Med 27:704-724, 1999. Protocol: in-vitro test. Densitometric analysis for AGE production after Dot-Blot immunodentection *p<0.0001 **Protocol: ICL-S Technique (Induced Chemiluminescence of Human Skin); in-vivo measurement of photonic emission following UVA-induced oxidative stress on 24 subjects over 20 days; once daily application. *p<0.0001 ***Protocol: CHU Besancon, Clinical scoring tests conducted on 2 groups of 30 women aged 35 to 45, under dermatological supervision. Blind study DERM AOX Serum vs Placebo. Twice daily facial application for 6 months.

For further information, refer La Roche Posay Derm AOX (general product description) and La Roche Posay Derm AOX Ingredients.

Thursday, 19 November 2009

Complimentary Shipping

Throughout November and December 2009, shipping via USPS (Priority — All US territories and International) and Australia Post (Express Post — Australia) is complimentary for all orders, irrespective of size and delivery region (domestic or international).

Wednesday, 28 July 2010

UV Radiation-Induced Immunosuppression Is Greater in Men and Prevented by Topical Nicotinamide

UV radiation-induced immunosuppression augments cutaneous carcinogenesis.

The incidence of skin cancer continues to increase despite increased use of sunscreens, which are less effective at preventing immunosuppression than sunburn.

Using the Mantoux reaction as a model of skin immunity, we investigated the effects of solar-simulated (ss) UV and its component UVA and UVB wavebands and tested the ability of topical nicotinamide to protect from UV-induced immunosuppression.

Healthy, Mantoux-positive volunteers were UV-irradiated on their backs, with 5% nicotinamide or vehicle applied to different sites in a randomized, double-blinded manner. Subsequent Mantoux testing at irradiated and adjacent unirradiated sites enabled measurement of UV-induced immunosuppression with and without nicotinamide.

Suberythemal ssUV caused significant immunosuppression, although component UVB and UVA doses delivered independently did not.

Men were immunosuppressed by ssUV doses three times lower than those required to immunosuppress women.

This may be an important cause of the higher skin cancer incidence and mortality observed in men.

Topical nicotinamide prevented immunosuppression, with gene chip microarrays suggesting that the mechanisms of protection may include alterations in complement, energy metabolism and apoptosis pathways.

Nicotinamide is a safe and inexpensive compound that could be added to sunscreens or after-sun lotions to improve protection from immunosuppression.

Examples include Elta MD UV Clear SPF 46 and Nia 24 SPF 30.

Journal of Investigative Dermatology (2008) 128, 447—454; doi:10.1038/sj.jid.5701058.

Department of Dermatology, Melanoma and Skin Cancer Research Institute, Sydney Cancer Centre, University of Sydney, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia

Thursday, 8 July 2010

Obagi Professional C Ingredients

Obagi Professional C Ingredients

The Obagi Professional-C Serum line of serums is designed to deliver greater penetration of professional strength Vitamin C to the dermis and epidermis.

Obagi Professional-C Serum is clinically proven to provide up to two times more penetration than leading formulations and to remain stable for longer periods of time than other Vitamin C treatments.

Obagi Professional-C penetrates to where collagen synthesis occurs, delivering optimal firming skincare results.

Professional-C Serums are formulated to address all facial areas and skin types with four different concentrations of Ascorbic Acid — the form of Vitamin C that is most effectively absorbed by the skin — to give skin the ultimate protection it needs from exposure to the sun’s damaging rays as well as environmental assaults.

Vitamin C, one of nature’s most powerful antioxidants, neutralizes free radicals before they attack skin cells to prevent premature signs of aging, including fine lines and wrinkles; protects against future damage; contributes to collagen synthesis for firmer, more resilient skin; and lightens and brightens skin for a more even tone.

Obagi Professional-C Serums also helps to reduce inflammation, decrease transepidermal water loss and maintain normal cellular turnover, resulting in skin that looks and feels healthier.

Obagi Professional-C Serums are specially formulated to be used as a stand-alone product, or in conjunction with the Obagi Nu-Derm® System, and is available in four different concentrations:

Wednesday, 30 September 2009

Kinerase PhotoFacials Clinical Study

A dermatologist clinical study showed 89% of women using the revolutionary in-home Kinerase® PhotoFacials Sun Damage Reversal System experienced significant visible improvements in one or more of the most noticeable signs of sun damage in as little as 4 weeks:

  • 89% had improved appearance of overall photodamage
  • 96% showed increased radiance
  • 96% experienced decreased roughness
  • 80% showed significantly diminished fine lines
  • 76% showed more even skin tone and color
  • 53% had visibly minimized pores
  • 46% had significantly reduced appearance of uneven pigmentation
  • 43% showed significantly smoothed deep wrinkles.

Tuesday, 29 September 2009

Carnosine References

Wang AM, Ma C, Xie ZH, Shen F. Use of carnosine as a natural anti-senescence drug for human beings. Biochemistry (Mosc.). 2000 Jul;65(7):869-71.

Reddy VP, Garrett MR, Perry G, Smith MA (2005). "Carnosine: a versatile antioxidant and antiglycating agent". Sci Aging Knowledge Environ 2005 (18): pe12. doi:10.1126/sageke.2005.18.pe12. PMID 15872311.

Yuneva MO, Bulygina ER, Gallant SC, et al. Effect of carnosine on age-induced changes in senescence-accelerated mice. J Anti-Aging Med. 1999;2(4):337-42.

Guiotto A, Calderan A, Ruzza P, Borin G. Carnosine and carnosine-related antioxidants: a review. Curr Med Chem. 2005;12(20):2293-315.

Babizhayev MA, Seguin MC, Gueyne J, Evstigneeva RP, Ageyeva EA, Zheltukhina GA (1994). "L-carnosine (beta-alanyl-L-histidine) and carcinine (beta-alanylhistamine) act as natural antioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities". Biochem. J. 304 ( Pt 2): 509—16. PMID 7998987.

Hipkiss AR, Michaelis J, Syrris P. Non-enzymatic glycosylation of the dipeptide L-carnosine, a potential anti-protein-cross-linking agent. FEBS Lett. 1995 Aug 28;371(1):81-5.

Hipkiss AR (2006). "Does chronic glycolysis accelerate aging? Could this explain how dietary restriction works?". Ann. N. Y. Acad. Sci. 1067: 361—8. doi:10.1196/annals.1354.051. PMID 16804012.

Hipkiss AR. Carnosine, a protective, anti-ageing peptide? Int J Biochem Cell Biol. 1998 Aug;30(8):863-8.

Gallant S, Semyonova M, Yuneva M. Carnosine as a potential anti-senescence drug. Biochemistry (Mosc.). 2000 Jul;65(7):866-8.

Kohen R, Yamamoto Y, Cundy KC, Ames BN. Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain. Proc Natl Acad Sci USA. 1988 May;85(9):3175-9.

Monday, 21 September 2009

La Roche-Posay — Hair and Scalp Health and Hair Loss Video

La Roche-Posay Hair and Scalp Health and Hair Loss Video. Includes promotional information regarding La Roche-Posay Kerium Anti-Hair Loss.


La Roche-Posay Kerium is unavailable in the US and Australia. We recommend ProCyte Tricomin as an alternative.

Thursday, 10 September 2009

Erythema from Retinoids

Erythema from Retinoids

Erythema (superficial skin redness), usually in patches, is a common side effect of using retinoids in the treatment of photoaging and the most frequently cited reason for their discontinuation, however deriving maximum clinical improvement from retinoids need not be at the cost of injuring your skin.

To minimize and avoid erythema from retinoids:

Avoid the use of glycolic and ascorbic acid (Vitamin C), and any other ingredients such as essential oils which irritate your skin, unless you are already able to use them without provoking sensitivity.

Lipohydroxy acid, salicylic acid and sulfonic acids are suitable anti-inflammatory alternatives if you require additional superficial exfoliation.

If you have dry-prone, sensitive skin, avoid the use of foaming facial cleansers, or at the least those which contain sulfates.

Products containing niacinamide (such as Nia 24 and PCA Skin Hydrating Serum), ceramides (such as Kinerase Pro+, Replenix Dermal Restructuring Therapy PM) and cholesterol (RevaleSkin Day Cream) also seem to help reduce side effects.

Start by applying only a small amount of a lower-strength retinoid such as Alyria Intense Wrinkle Correction (0.1% Retinol), Neova Retinol ME 0.15% (0.15%) or Biomedic Retinol Cream 15 (0.15% Retinol) every third night.

After 2-3 weeks, increase use to once every second night, and after 3-4 weeks, increase your use to nightly, five nights per week (the maximum usage for many people).

Increase the strength of the retinoid you use over time if you have been able to tolerate a lower strength with little to no redness or irritation.

Ideally, you will need to acclimate your skin to the point of "Highest Strength Retinoids" and more potent options, as outlined below, although you should not persist with any strength which elicits considerable or prolonged erythema or dermatitis. With a measured approach, even individuals with extremely sensitive skin are able to benefit from the most potent and effective retinoids.

Lowest Potency Retinoids

Alyria Intense Wrinkle Correction

Biomedic Retinol Cream 15

Neova Retinol ME 0.15%

Replenix Retinol Plus Smoothing Serum 2x

Mid-Strength Retinoids

Biomedic Retinol Cream 30

Replenix Retinol Plus Smoothing Serum 3x

Neova Retinol ME 0.3%

Higher-Strength Retinoids

Biomedic Retinol Cream 60

Replenix Retinol Plus Smoothing Serum 5x

Highest Strength Retinoids

Replenix Retinol Plus Smoothing Serum 10x

Skinceuticals Retinol 1%

SkinMedica Retinol Complex

Higher-Potency High-Strength Retinoids

Avene Retrinal Cream 0.05%

Avene Retrinal Cream 0.1%

There is a considerable jump in the efficacy and potential for erythema from the retinoids in this category compared with the prior categories.

Highest-Potency Highest-Strength Retinoids — Rx Only

Tazorac, Differin, Retin-A and Retin-A Micro, Renova, Tri-Luma, Isotrex, Avage, Atralin, Avita.

These prescription retinoids are approximately 20 times more potent than the "highest strength retinoids."


All the above listed retinoids are formulated and packaged so as to avoid oxidation which reduces potency — please avoid retinoids packaged in open-top jars, droppers and in formulations containing alpha hydroxy acids.

Ultimately (after approximately one year), application three or four times a week is sufficient to maintain improvement, providing antioxidants and sunscreen are used during the day for the duration of treatment.

Tuesday, 8 September 2009

Asiaticoside vs. Madecassoside for Collagen Synthesis

Asiaticoside vs. Madecassoside for Collagen Synthesis

Skin aging is marked by a decrease in collagen synthesis and an increase in collagen breakdown effected by metalloproteinases.

The net loss in dermal collagen is thought to cause wrinkles.

Purified isolates of Centella Asiatica, such as asiaticoside and madecassoside, which have been shown to stimulate collagen production, are incorporated into some anti-aging products with the aim of preventing and reducing wrinkles.

Twenty-nine types of collagen have thus far been identified, however Type I and III collagens are the major components of the dermis, where wrinkling changes occur.

While both asiaticoside and madecassoside stimulate collagen Type I and III, thus far only madecassoside has been shown to significantly increase collagen III.

Skin care products containing asiaticoside and madecassoside such as La Roche-Posay Redermic may be used in addition to retinoids, Vitamin C and sunscreen for greater collagen synthesis.

Reference: Bonté F, Dumas M, Chaudagne C, Meybeck A. Ann Pharm Fr. 1995;53(1):38-42.

Monday, 24 August 2009

Oily Sensitive Skin

Wednesday, 26 May 2010

La Roche-Posay Effaclar AI Intensive Acne Spot Treatment Clinical Study

Test of La Roche-Posay Effaclar AI conducted on 30 subjects, from 18 to 45 years old, 50% with self-perceived sensitive skin.

Inclusion criteria:

At least 5 inflammatory and 10 retentional lesions.

Application of Effaclar AI to affected areas 1 to 3 times daily during 10 days.

Clinical evaluation: counting lesions + Overall Global Acne assessment + tolerance grading under dermatological control.

For further information, see the overview of L:a Roche-Posay Effaclar.

Monday, 22 August 2011

Selected Sunscreens

Sunscreens for daily facial use to help prevent photoaging — optimal sunscreen use is by far the most beneficial anti-aging topical therapy.

Apply one teaspoon of a cream, lotion or gel sunscreen daily to face, neck and hands.

Ideally, re-apply once or twice daily (Colorescience Sunforgettable SPF 30 Brushes are ideal for topping-up sunscreen quickly and easily).

Saturday, 8 August 2009

Moisturizer Archive

Monday, 3 August 2009

Combat Thinning Lashes with Essential Copper

Combat Thinning Lashes with Essential Copper

SAN FRANCISCO — (Business Wire):

PhotoMedex, Inc. (NASDAQ:PHMD) announced today that Procyte, a PhotoMedex company, has launched its new eyelash conditioner at the winter conference of the American Academy of Dermatology (AAD) in San Francisco this past weekend.

Neova Advanced Essential Lash, formulated with Procyte's patented AHK Copper Peptide Complex® technology, botanicals and essential amino acids, strengthens, conditions and hydrates thinning and brittle lashes.

It is clinically proven to promote the appearance of fuller, thicker and longer eyelashes in as little as three weeks*.

Safe and non-irritating, Essential Lash can be obtained through participating physicians without a prescription.

Procyte, the innovator of utilizing copper technology in skincare, brings the revolutionary benefits of the essential micronutrient to renew and restore health and vitality to natural eyelashes.

The third most abundant trace metal in the human body, copper is essential for hair health.

Procyte's patented AHK Copper Peptide Complex utilizes a unique delivery system that mimics the body's natural transport mechanisms to deeply nourish the hair follicle, resulting in eyelashes with a thicker, longer, darker appearance.

Jeff O`Donnell, President and Chief Executive Officer of PhotoMedex stated, "We are thrilled to be able to make this product available to our physician partners and their patients. We believe the market opportunity for Essential Lash, a safe and effective non-prescription product, will be significant."

The Science Behind Lush Lashes: AHK Copper Peptide Complex®

  • Proprietary AHK Copper Peptide Complex deeply nourishes and stimulates hairfollicles with patented copper tripeptides.
  • AHK Copper Peptide technology uses a unique delivery system that mimics the body's natural copper transport mechanisms.
  • AHK Copper Peptide technology provides a precise delivery of copper to the base of the eyelash follicles where it can stimulate cells responsible for production of substances such as collagens and various proteins.
  • AHK Copper Peptide technology stimulates the formation of extracellular matrix components which is important to the health of the hair follicle as it provides structural integrity, components and a nutrient supply.

Benefits of Essential Lash

  • Natural eyelashes will appear fuller, thicker and longer.
  • Strengthens and conditions eyelashes to protect from breakage.
  • Non-prescription formulation.
  • Does not contain prostaglandin.
  • Does not cause lid hyperpigmentation.
  • Does not cause iris discoloration.
  • Non-irritating; safe for sensitive eyes.
  • Hypoallergenic.
  • Physician tested; clinically tested.
  • Paraben free.

When applied nightly, Essential Lash (0.2 fl. oz.) will last approximately four to six months, averaging $28 per month - a considerably lower monthly cost compared to the market`s current prescription lash conditioner.

  • Data on file. Evaluator 8-week blinded study

PROCYTE

PhotoMedex is the market leader in developing proprietary excimer laser and fiber optic systems and techniques directed toward dermatological applications, with FDA 510(k) clearances to market the XTRAC® laser system for the treatment of psoriasis, vitiligo, atopic dermatitis.

PhotoMedex is also the market leader in developing and marketing products based on its patented, clinically proven Copper Peptide Complex® technology for skin health, hair care and wound care.

PhotoMedex sells directly to dermatologists, plastic and cosmetic surgeons, and medical spas.

The Company`s Procyte brands include Neova®, Ti-Silc®, Complex® Cu3, Tricomin®, GraftCyte®, Vitalcopper®, Simple Solutions® and AquaSante®.

Sunday, 2 August 2009

Decrease Fine Lines

Sunday, 2 August 2009

Build Collagen

Tuesday, 21 July 2009

Sagging Skin Protocol for Oily Sensitive Skin

AM Sagging Skin Protocol for Oily Sensitive Skin

Kinerase Clear Skin Treatment Serum or DCL High-Potency C-Scape Serum or Skinceuticals Serum 10 AOX+ or Cellex-C Sensitive Skin Serum or Obagi Professional-C Serum 10%.

La Roche-Posay Anthelios 60 Ultra-Light Fluid or Biomedic Facial Shield SPF 30 or Alyria Corrective Protection SPF 30 Oil-Free Lotion

PM Sagging Skin Protocol for Oily Sensitive Skin

Avene Retrinal Cream 0.05%

Tuesday, 21 July 2009

Sagging Skin Protocol for Oily Skin

AM Sagging Skin Protocol for Oily Skin

Skinceuticals Serum 20 AOX+ or IS Clinical Super Serum Advance+ or Cellex-C Avanced-C Serum or DCL High Potency C-Scape Serum or Obagi Professional-C Serum 15%

La Roche-Posay Anthelios 60 Ultra-Light Fluid or Biomedic Facial Shield SPF 30 or Alyria Corrective Protection SPF 30 Oil-Free Lotion

PM Sagging Skin Protocol for Oily Skin

Avene Retrinal Cream 0.1%

Sunday, 26 July 2009

Sagging Skin Protocol for Sensitive Dry Skin

AM Sagging Skin Protocol for Sensitive Dry Skin

Kinerase Pro+ C6 Peptide Intensive Treatment with Kinetin and Zeatin or Skinceuticals Serum 10 AOX+ or Skinceuticals CE Ferulic or Cellex-C Sensitive Skin Serum or Obagi Professional-C Serum 10%.

La Roche-Posay Redermic UV

PM Sagging Skin Protocol for Sensitive Dry Skin

Kinerase Pro+ C6 Peptide Intensive Treatment with Kinetin and Zeatin

SkinMedica TNS Recovery Complex

SkinMedica TNS Ceramide Treatment Cream or Nia24 Intensive Recovery Complex or Neova Creme De La Copper or La Roche-Posay Redermic for Dry Skin.

Monday, 27 July 2009

Sagging Skin Protocol for Dry Skin

AM Sagging Skin Protocol for Dry Skin

Citrix 15% Cell Rejuvenation Serum with Growth Factor or IS Clinical Super Serum Advance+ or Obagi Professional-C Serum 15%

La Roche-Posay Redermic UV

PM Sagging Skin Protocol for Dry Skin

Avene Retrinal Cream 0.1%

SkinMedica TNS Ceramide Treatment Cream or Skinceuticals Skin Firming Cream or Nia24 Intensive Recovery Complex or Neova Creme De La Copper or IS Clinical Firming Complex.

Tuesday, 21 July 2009

Sagging Skin Treatments — Arranged by Potency

Sagging skin treatments arranged by potency.

These treatments for sagging skin have been arranged in order of potency and are for use once or twice daily, with sunscreens always applied as a final layer during the day (La Roche-Posay Redermic UV includes sunscreen).

If you have sensitive skin prone to burning or stinging, do not use Skinceuticals Serum 20 AOX+, Avene Retrinal 0.1%, IS Clinical Super Serum Advance+, Citrix 20% CRS or Obagi Professional-C 20% except under specialist care, or alternatively start with lower-strength equivalents of these products (Skinceuticals Serum 10 AOX+, Avene Retrinal 0.025%, Citrix 10% CRS and Obagi Professional-C 10%) and increase concentration and the amount used over 4-6 months.

Monday, 20 July 2009

Neova GHK Copper and AHK Copper

ProCyte's GHK Copper and AHK copper, which are protected by ProCyte's patents, are the only true Copper peptides on the market.

Scientific studies have demonstrated that Copper plays a vital role in skin health.

It is a powerful collagen and elastin promoter and acts as an antioxidant.

The GHK Manganese Peptide Complex smooths and firms the skin reducing fine lines, wrinkles, and sagging skin.

Monday, 20 July 2009

About Neova by ProCyte

About Neova by ProCyte

Copper has long played an essential role in the body's healing processes, but little has it been recognized in the cosmetic world as playing a part as beneficial as zinc or iron.

Neova, a cosmetic line founded by the ProCyte Corporation, specializes in the development of products formulated with a special copper peptide formula, bringing the constructive, rejuvenating properties of copper to consumers.

As skin matures, surface layers tend to sag, form lines and wrinkles, and suffer from moisture loss.

Copper, a powerful antioxidant, stimulates the occurrence of cellular turnover, encourages tissue reformation and supports the production of collagen and elastin in the skin.

When used as part of a skin care regimen, copper is clinically proven to help the skin appear visibly younger and more radiant more expediently than with the use of other skin care products.

Over the course of 15 years, through advanced scientific and pharmaceutical modes of development,

Neova has patented two marvelously effective forms of copper peptides: GHK copper and AHK copper, the only two authentic forms available on the market.

Advanced amino acid technology in Neova's formula encapsulates the copper, binding it together until it reaches its proper dispersal area within the body.

This transfer method is modeled after the body's natural form of copper delivery.

The remarkable healing and beautifying effects of the copper are most significantly evident in Neova's GHK copper formula.

Through Neova, ProCyte is continuing to experiment with new approaches to copper peptide formulations to better suit human skin and all around well-being.

With the use of impressively effective, innovative ingredients, and a dedication to forming more concentrated and more beneficial compositions, Neova focuses its efforts on expanding its already comprehensive line of products.

Neova's wide range of products suit basic, everyday skin issues, like troublesome complexions, and more complicated issues, like the reduction of visible aging in skin.

Whether it's cleansers, sun protection, exfoliants, eye care, toners, moisturizers or general body care, the team behind Neova aspires to enhance their products for extreme effectiveness and immediately noticeable results.

Monday, 20 July 2009

Revitalash Example Before and After

Revitalash Example Before and After

Monday, 20 July 2009

Does the crème help scars or wrinkles?

Satisfied customers have indicated that new surgical scars have improved with the use of the crème.

Striae® Stretch Mark Crème can remove some of the redness of new scars if it is applied shortly after the wound heals.

Some clients have also reported success using the crème to remove small wrinkles.

Monday, 20 July 2009

Are there any side effects?

No. Many clients have found that their skin becomes smoother because of the moisturizing elements in the crème.

In a few cases, stretch marks may appear more red after the first few days of use.

Dr. Moy believes that this initial redness/reaction signals an active circulation in the damaged area and the start of the regeneration process.

Therefore, it is not necessary to cease application if this occurs.

We use only natural and botanical ingredients, so users should not experience an allergic reaction.

Monday, 20 July 2009

When should I stop using the crème?

Striae® Stretch Mark Crème continues to improve stretch marks with extended use.

The results you have with the crème are permanent; stopping its application will not undo the improvement.

Some of our customers have seen continued improvement after using Striae® Stretch Mark Crème for more than a year.

We therefore recommend that you continue to use the crème until you see no further improvement in the appearance of your stretch marks.

Monday, 20 July 2009

Why is the clinical study important?

There are many products on the market today that supposedly treat stretch marks.

The clinical study proves the effectiveness of Striae® Stretch Mark Crème in treating stretch marks.

You should not trust a product that does not have scientific support of its effectiveness.

Monday, 20 July 2009

Does it matter how old my stretch marks are?

Stretch marks that are less than 7 years old are more sensitive to Striae® Stretch Mark Crème, but the crème still works on older stretch marks.

These older marks will need a longer application, so if you have had your stretch marks for more than seven years, we recommend that you wait at least 6 weeks before expecting to see results.

Monday, 20 July 2009

Will my stretch marks disappear completely?

It is not possible to completely remove stretch marks because they are essentially small scars of torn skin.

It is possible, however, for the ridges to smooth out and the associated redness or whiteness to fade to the point that they are hardly visible.

Monday, 20 July 2009

How long does it take to see results?

For most users, it takes from 4 to 6 weeks to regenerate the weakened skin and see results.

Some clients have seen results after only a few days, but on average, it takes at least a month.

Monday, 20 July 2009

How and where do I apply the crème?

Twice a day, gently rub the crème into the skin. Please note that if you are a first time user, you should only apply the crème to a small test area to check for results. After 4 to 6 weeks, initial results should be visible.

Tip: Some users have found that the use of an exfoliating scrub (while bathing) improves the penetration of the crème into the skin. Other clients have told us that they have had faster results by applying the crème to the skin and leaving it there for five minutes before rubbing it in.

Monday, 20 July 2009

How does Striae® Stretch Mark Crème Work?

Striae® Stretch Mark Crème increases proteins (collagen) to reinforce weak skin and change the appearance of stretch marks.

The crème helps to undo the weakness associated with stretch marks.

After four weeks of continued use, the crème fades stretch mark redness and whiteness, smoothes out ridges, and strengthens and thickens surrounding skin.

The crème may also prevent future stretch marks from pregnancy and weight changes by keeping the skin supple.

Monday, 20 July 2009

VitaMedica Dry Skin Formula Indications

VitaMedica’s Dry Skin Formula is a nutritional supplement designed for individuals whose skin lacks hydrations and/or lubrication.

Sunday, 9 August 2009

Hyaluronic Acid for Hydration & Moisture-Retention

Hyaluronic Acid is one of the skin’s most important components for hydration and moisture-retention. Hyaluronic acid functions to maintain water balance in the dermis which provides support for essential dermal elements like collagen and elastin.

Each packet includes two softgel capsules containing Injuv, a patented, naturally-derived, low molecular weight hyaluronic acid with clinically proven absorption through oral administration.

Monday, 20 July 2009

Fish Oil for Skin Suppleness

Fish oil helps to promote formation of favorable prostaglandins, hormone-like compounds that play a role in reducing dermal inflammation. Each packet includes a one gram Super EPA/DHA Fish Oil capsule. This pharmaceutical-grade fish oil is molecularly distilled and ultra-refined to produce a high-potency product with negligible “fishy” aftertaste.

Monday, 20 July 2009

Flax Seed Oil for Dermal Lubrication

Flax seed oil is an excellent source of Omega-3 essential fatty acids (EFAs). EFAs are fundamental components of the cellular membrane of all skin cells. Because of the rapid turnover of cells in the dermis, an adequate supply of EFAs is essential for healthy, youthful looking skin. Each packet includes a one gram, carob-coated Flax Seed Oil capsule. The delicate oil is expeller-pressed at low temperatures to minimize exposure to damaging light, oxygen and reactive metals.

Thursday, 23 July 2009

VitaMedica Dry Skin Formula Further Information

Monday, 20 July 2009

VitaMedica Dry Skin Formula Contraindications

Nutritional supplements have an excellent safety track record. However, certain individuals should seek the advice of their doctor before beginning any nutritional supplement program particularly diabetics and pregnant or nursing women.

Monday, 20 July 2009

VitaMedica HA+A™ Program Indications

The HA+A Program is intended for individuals who need to hydrate and protect the skin from free-radical damage. The product is intended for everyday use but is also indicated post-surgically to help support healing.

Monday, 20 July 2009

VitaMedica HA+A™ Program: Convenience

The convenient, one-month HA+A Program kit provides you with quality, convenience and simplicity so you can streamline the number of products in your skin-care regimen.

Monday, 20 July 2009

VitaMedica HA+A™ Program: Designed for All Skin Types

VitaMedica's HA+A Program is designed for all skin types and provides significant dermal hydration and antioxidant protection.

Monday, 20 July 2009

VitaMedica HA+A™ Program: Promotes Youthful-Looking Skin

By providing these key ingredients both topically and internally - the so-called bi-directional approach - HA+A Program is designed to promote enhanced moisture retention, skin hydration, and elasticity providing a more youthful complexion.

Monday, 20 July 2009

VitaMedica HA+A™ Program: Antioxidant Protection Externally & Internally

Both products are also fortified with some of the most powerful dermal antioxidants currently available.

These include vitamins A, C and E, Green tea extract, CoQ10 and Pycnogenol®.

Antioxidants are vital for the management of reactive oxygen species which are widely-held to be one of the primary causes of aging.

Monday, 20 July 2009

VitaMedica HA+A™ Program: Hydration Externally & Internally

HA+A supplement and serum are designed to work together, in an integrated manner, with key ingredients common to both formulations. Hyaluronic acid, one of the skin's most important components for hydration and moisture-retention, is featured in each product.

Monday, 20 July 2009

VitaMedica HA+A™ Program Further Information

VitaMedica's HA+A Program is designed for all skin types and provides significant dermal hydration and antioxidant protection.

HA+A Program includes our HA+A Hydrating Nutraceutical for internal support and a HA+A Hydrating Serum for topical support.

HA+A Hydrating Nutraceutical and HA+A Hydrating Serum are designed to work together, in an integrated manner, with key ingredients common to both formulations. Hyaluronic acid, one of the skin's most important components for hydration and moisture-retention, is featured in each product.

Both products are also fortified with some of the most powerful dermal antioxidants currently available. These include vitamins A, C and E, Green tea extract, CoQ10 and Pycnogenol®. Antioxidants are vital for the management of reactive oxygen species (free-radicals) which are widely-held to be one of the primary causes of aging.

Monday, 20 July 2009

HA+A™ Hydrating Serum

Designed for all skin types. Provides significant dermal hydration and antioxidant protection. HA+A Serum features hyaluronic acid, one of the skin’s most important components for hydration and moisture-retention.

The product is intended for use as a humectant base to enhance the absorption and effectiveness of other topical products that are commonly used on the skin.

Key Features

Hyaluronic acid plus panthenol for hydration

Vitamins A, C & E for photo-protection

Potent antioxidants including Pycnogenol®, green tea leaf extract & CoQ10

Enhances the absorption and action of other topical products

Ideal for all skin types

Lot number and expiration date ensures product freshness and quality. Manufactured in the U.S. using Good Manufacturing Practices (GMPs).

Sunday, 9 August 2009

HA+A™ Hydrating Nutraceutical

HA+A features hyaluronic acid (HA), one of the body’s most important components for hydration and moisture-retention. Supplements the body’s natural store of HA which declines as we age, promoting dry skin and stiff joints. Formulated with Injuv®, a hyaluronic acid for better absorption.

Key Features

Features Injuv®, a patented, naturally-derived low-molecular weight hyaluronic acid

Formulated with natural vitamin E family & mixed carotenoids

Contains potent antioxidants including Pycnogenol®, green tea extract & CoQ10

Easy-to-swallow gel-caps

Lot number and expiration date ensures product freshness and quality. Manufactured in the U.S. using Good Manufacturing Practices (GMPs).

Monday, 20 July 2009

VitaMedica Healthy Skin Formula Contraindications

Nutritional supplements have an excellent safety track record. However, certain individuals should seek the advice of their doctor before beginning the program particularly diabetics, pregnant or lactating women. HEALTHY SKIN FORMULA contains Vitamin A. If you are presently taking Accutane® (isotretinoin) for the treatment of acne, please refrain from taking HEALTHY SKIN FORMULA until the end of the treatment cycle.

Monday, 20 July 2009

VitaMedica Healthy Skin Formula Indications

Healthy Skin Formula is indicated for patients with mild to moderate acne. The product is suitable for patients 12 years or older. This nutraceutical is ideal for individuals who do not eat a well-balanced diet on a consistent basis. Because of the poor dietary habits of people who are 15-30 years of age, Healthy Skin Formula is particularly well-suited for patients in this age group.

Monday, 20 July 2009

VitaMedica Healthy Skin Formula Capsule Formulation

Only two capsules are required per day, making the supplement easy to take, especially for younger patients who have a higher incidence of acne.

Monday, 20 July 2009

VitaMedica Healthy Skin Formula Herbs to Cleanse & Detoxify

Burdock, dandelion, Oregon grape and yellow dock are powerful herbs known for their potent cleansing properties of the skin and blood.

Monday, 20 July 2009

VitaMedica Healthy Skin Formula Nutrients to Support Inflammatory Control

Bromelain, an enzyme extracted from pineapple, and selenium both have anti-inflammatory properties.

Monday, 20 July 2009

VitaMedica Healthy Skin Formula Nutrients to Promote Skin Health

The formula contains Vitamin A, from both Palmitate and Betatene®, which reduces sebum production and the buildup of keratin in the follicle. The formulation also contains zinc, selenium, and chromium. Each of these nutrients has a significant role in skin health.

Monday, 20 July 2009

VitaMedica Healthy Skin Formula Further Information

VitaMedica's Healthy Skin Formula is a nutritional supplement that provides internal skin care by enhancing the body's natural systems for repairing, cleansing and healing. The supplement is intended as an adjunctive therapy to the topical products and/or treatments that skin care professionals recommend for acne patients.

Many topical treatments for the care of acne and inflammatory disorders of the skin are currently available. While effective, these regimens contain products that produce an action primarily on the outer layer of the skin. Although the topical approach represents the foundation of good skin care, it also makes sense to address what is going on internally. That's because what you put inside your body may be just as important as what you apply externally.

Other acne treatments, including prescription medications such as antibiotics and Accutane®, can display potent activity but may have significant side-effects. Natural medicines tend to be milder, safer and are far less likely to cause negative reactions.

Monday, 20 July 2009

Vitamedica Broad Spectrum Antioxidant Contraindications

Broad Spectrum Antioxidant has an excellent safety track record. However, certain individuals should seek the advice of their doctor before beginning the product particularly diabetics, pregnant or lactating women. Broad Spectrum Antioxidant should not be taken in conjunction with VitaMedica's Healthy Skin Formula .

Monday, 20 July 2009

VitaMedica Broad Spectrum Antioxidant Indications

Broad Spectrum Antioxidant is indicated for individuals who wish to provide internal protection from free-radical damage. For this reason, this product is ideally suited for individuals who are 35+ years of age or for those who spend a significant amount of time outdoors, with direct sunlight exposure.

Monday, 20 July 2009

VitaMedica Broad Spectrum Antioxidant Further Information

Today, we are consistently advised to eat a wide variety of colored fruits and vegetables. Plants contain protective botanical compounds called flavonoids that help to protect the plant from the sun's harmful rays. Fortuitously, by ingesting foods or supplements that contain these compounds, antioxidant protection is conferred to us. Given that most of Americans do not eat 5+ servings a day of these types of foods, supplementing the diet with a wide variety of antioxidants is prudent.

VitaMedica's Broad-Spectrum Antioxidant is a nutritional supplement that provides internal skin care by enhancing the body's natural systems for neutralizing and eliminating free-radicals. Other nutrients also help to protect, repair and heal the skin. The result is optimal skin health and appearance.

As we age, certain physical changes happen to our bodies that are part of the normal aging process. These changes are particularly evident in the skin and are largely due to the effects of the sun. In particular, two of the key building blocks of the skin, proteins called collagen and elastin, can be damaged. The result is skin with a thin, sagging appearance.

The damage caused by the sun's rays, along with environmental pollution, diet, and even normal biologic processes contribute to the development of free-radicals. Clinical studies indicate that free-radicals contribute to age-related illnesses like cancer, and heart-disease and to the aging process itself. Although our bodies have wonderful innate mechanisms for dealing with free-radicals, our bodies become less efficient with this process as we age.

BENEFITS

VitaMedica's Broad Spectrum Antioxidant offers a number of benefits including:

Potent, Antioxidant Blend for Better Protection Against Free-Radical Damage

The formulation includes a broad range of nutrients known for their potent antioxidant and protective benefits including vitamin A, vitamin C, vitamin E and alpha lipoic acid. The supplement also includes grape seed extract and green tea, whose antioxidant activity is 20-200 times more powerful than vitamin E or vitamin C. In clinical studies, green tea extract has also been shown to provide a protective role in skin cancer.

Natural Ingredients

The formulation includes d-alpha tocopheryl (natural vitamin E) and Betatene®, a natural mixed carotenoid blend. Research has shown that natural vitamins provide better absorption than their synthetic counterparts. Also, a broad range of carotenoids provides better antioxidant protection.

Nutrients to Support the Development of Collagen & Elastin

The formulation includes vitamin C, zinc and copper. Each of these nutrients plays a role in the formation of two important proteins found in the skin — collagen and elastin.

Natural Skin and Eye Protection

The formula includes Flora-GLO® a carotenoid blend of lutein and zeaxanthin. Studies have shown that these carotenoids, typically found in combination, provide antioxidant protection effects to skin cells. Lutein also reduces the risk of developing age-related macular degeneration (AMD), the leading cause of blindness in adults.

Formulated in Easy-to-Swallow Capsules

Only two capsules are required per day, making the supplement easy to take.

Sunday, 9 August 2009

VitaMedica Healthy Skin Formula MSM (MethylSulfonylMethane)

MethylSulfonylMethane, commonly referred to as MSM, is naturally occurring nutritional sulfur. Sulfur is found in the tissues of all plants and animals, and is the fourth most abundant mineral in the human body. It is stored in virtually every cell of the body with the highest concentrations in the skin, hair, nails. MSM combines with toxins in the body, facilitating their removal via urination. Dietary sulfur is an essential ingredient of protein necessary for collagen synthesis. Collagen is the most common protein in the body, and the main component of skin and bones. It is needed for the growth and repair of cells, gums, blood vessels, bones and teeth. Vitamin C, is an important regulator of collagen synthesis, and works synergistically with MSM. By keeping skin cells soft, MSM also allows skin to detoxify. MSM enhances tissue pliability and encourages the repair of damaged skin.

Monday, 20 July 2009

Protective Effects of (-)-Epigallocatechin-3-Gallate on UVA- and UVB-Induced Skin Damage

It has been known that green tea and its components possess significant chemopreventive effects against chemical carcinogens and photo-caused skin tumor formation. In this study, the protective effects of (-)-epigallocatechin-3-gallate (EGCG), a major green tea catechin, on the ultraviolet (UV)-induced skin damage (photoaging) were studied in guinea pigs, hairless mice and human dermal fibroblast cultures. The lipid peroxidation was significantly reduced in the EGCG-treated group. The amount of lipid peroxides produced in the control and EGCG treated group were 838 ± 144 and 286 ± 57 nmol/mg at 18 h after UV irradiation, respectively. UVB-induced erythema was also significantly reduced in the EGCG treated group. The erythema relative index of the control and the EGCG treated group were 311 ± 45 and 191 ± 49 at 16 h after UV irradiation, respectively. EGCG treatment reduced UVA-induced skin damage (roughness and sagginess) and protected from the decrease of dermal collagen in hairless mouse skin. EGCG treatment blocked the UV-induced increase of collagen secretion and collagenase mRNA level in fibroblast culture. The nuclear transcription factors NF-B and AP-1 binding activities were also inhibited by EGCG treatment.

Monday, 20 July 2009

Photoprotective effects of green tea polyphenols

Non-melanoma skin cancer is the most common malignancy in humans and is equivalent to the incidence of malignancies in all other organs combined in the United States. Current methods of prevention depend on sunscreens in humans, efficacy of which is largely undetermined for non-melanoma skin cancers. Green tea polyphenols have the greatest effect with respect to chemoprevention and have been found to be most potent at suppressing the carcinogenic activity of UV radiation. They protect against many of the other damaging effects of UV radiation such as UV-induced sunburn response, UV-induced immunosuppression and photoaging of the skin. They exert their photoprotective effects by various cellular, molecular and biochemical mechanisms in in vitro and in vivo systems. Green tea polyphenols thus have the potential, when used in conjunction with traditional sunscreens, to further protect the skin against the adverse effects of ultraviolet radiation.

Monday, 20 July 2009

Beneficial Effects of Green Tea—A Review

Tea is the most consumed drink in the world after water. Green tea is a ‘non-fermented’ tea, and contains more catechins, than black tea or oolong tea. Catechins are in vitro and in vivo strong antioxidants. In addition, its content of certain minerals and vitamins increases the antioxidant potential of this type of tea. Since ancient times, green tea has been considered by the traditional Chinese medicine as a healthful beverage. Recent human studies suggest that green tea may contribute to a reduction in the risk of cardiovascular disease and some forms of cancer, as well as to the promotion of oral health and other physiological functions such as anti-hypertensive effect, body weight control, antibacterial and antivirasic activity, solar ultraviolet protection, bone mineral density increase, anti-fibrotic properties, and neuroprotective power. Increasing interest in its health benefits has led to the inclusion of green tea in the group of beverages with functional properties. However, although all the evidence from research on green tea is very promising, future studies are necessary to fully understand its contributions to human health, and advise its regular consumption in Western diets, in which green tea consumption is nowadays limited and sporadic.

Monday, 20 July 2009

Skin photoprotection by green tea: antioxidant and immunomodulatory effects

Because of a characteristic aroma and health benefits, green tea is consumed worldwide as a popular beverage. The epicatechin derivatives, commonly called polyphenols, present in green tea possess antioxidant, anti-inflammatory and anti-carcinogenic properties. The major and most highly chemopreventive constituent in green tea responsible for the biochemical or pharmacological effects is (-)-epigallocatechin-3-gallate (EGCG). Epidemiological, clinical and biological studies have implicated that solar ultraviolet (UV) light is a complete carcinogen and repeated exposure can lead to the development of various skin disorders including melanoma and nonmelanoma skin cancers. We and others have shown that topical treatment or oral consumption of green tea polyphenols (GTP) inhibit chemical carcinogen- or UV radiation-induced skin carcinogenesis in different laboratory animal models. Topical treatment of GTP and EGCG or oral consumption of GTP resulted in prevention of UVB-induced inflammatory responses, immunosuppression and oxidative stress, which are the biomarkers of several skin disease states. Topical application of GTP and EGCG prior to exposure of UVB protects against UVB-induced local as well as systemic immune suppression in laboratory animals, which was associated with the inhibition of UVB-induced infiltration of inflammatory leukocytes. Prevention of UVB-induced suppression of immune responses by EGCG was also associated with the reduction in immunosuppressive cytokine interleukin (IL)-10 production at UV irradiated skin and draining lymph nodes, whereas IL-12 production was significantly enhanced in draining lymph nodes. Antioxidant and anti-inflammatory effects of green tea were also observed in human skin. Treatment of EGCG to human skin resulted in the inhibition of UVB-induced erythema, oxidative stress and infiltration of inflammatory leukocytes. We also showed that treatment of GTP to human skin prevents UVB-induced cyclobutane pyrimidine dimers formation, which are considered to be mediators of UVB-induced immune suppression and skin cancer induction. The in vitro and in vivo animal and human studies suggest that green tea polyphenols are photoprotective in nature, and can be used as pharmacological agents for the prevention of solar UVB light-induced skin disorders including photoaging, melanoma and nonmelanoma skin cancers after more clinical trials in humans.

Monday, 20 July 2009

Green Tea and Skin

Säntosh K. Katiyar, PhD; Nihal Ahmad, PhD; Hasan Mukhtar, PhD

Arch Dermatol. 2000;136:989-994.

Objective To discuss the current knowledge of polyphenolic compounds present in green tea as anti-inflammatory, antioxidant, and anticarcinogenic in skin.

Data Sources References identified from bibliographies of pertinent articles, including our work in related fields.

Study Selection and Data Extraction Articles were selected based on the use of green tea or its polyphenolic constituents for prevention against inflammation and cancer in the skin. Also discussed is the possible use of green tea to treat various inflammatory dermatoses.

Data Synthesis The polyphenolic compounds from green tea were tested against chemical carcinogenesis and photocarcinogenesis in murine skin. These green tea polyphenols were found to afford protection against chemical carcinogenesis as well as photocarcinogenesis in mouse skin. A few experimental studies were conducted in human skin in our laboratory. Analysis of published studies demonstrates that green tea polyphenols have anti-inflammatory and anticarcinogenic properties. These effects appear to correlate with antioxidant properties of green tea polyphenols.

Conclusions The outcome of the several experimental studies suggests that green tea possess anti-inflammatory and anticarcinogenic potential, which can be exploited against a variety of skin disorders. Although more clinical studies are needed, supplementation of skin care products with green tea may have a profound impact on various skin disorders in the years to come.

Tuesday, 13 October 2009

Green tea polyphenol (—)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress

The use of naturally occurring botanicals with substantial antioxidant activity to afford protection to human skin against UV damage is receiving increasing attention. The green tea constituent (—)-epigallocatechin-3-gallate (EGCG) is a potent antioxidant and has shown remarkable preventive effects against photocarcinogenesis and phototoxicity in mouse models. In this study we have investigated the effects of topical application of EGCG, the major polyphenol present in green tea, to human skin before UV irradiation on UV-induced markers of oxidative stress and antioxidant enzymes. Using immunohistochemistry and analytical enzyme assays, we found that application of EGCG (mg/cm2 skin) before a single UV exposure of 4x minimal erythema dose (MED) markedly decreases UV-induced production of hydrogen peroxide (68—90%, P < 0.025—0.005) and nitric oxide (30—100%, P < 0.025—0.005) in both epidermis and dermis in a time-dependent manner. EGCG pretreatment also inhibits UV-induced infiltration of inflammatory leukocytes, particularly CD11b+ cells (a surface marker of monocytes/macrophages and neutrophils), into the skin, which are considered to be the major producers of reactive oxygen species. EGCG treatment was also found to inhibit UV-induced epidermal lipid peroxidation at each time point studied (41—84%, P < 0.05). A single UV exposure of 4x MED to human skin was found to increase catalase activity (109—145%) and decrease glutathione peroxidase (GPx) activity (36—54%) and total glutathione (GSH) level (13—36%) at different time points studied. Pretreatment with EGCG was found to restore the UV-induced decrease in GSH level and afforded protection to the antioxidant enzyme GPx. Further studies are warranted to study the preventive effects of EGCG against multiple exposures to UV light of human skin.

Monday, 20 July 2009

Double-Blinded, Placebo-Controlled Trial of Green Tea Extracts in the Clinical and Histologic Appearance of Photoaging Skin

Background. Green tea extracts have gained popularity as ingredients in topical skin care preparations to treat aging skin. Green tea polyphenolic compounds have significant antioxidant and anti-inflammatory activities, and studies suggest that these extracts help mediate ultraviolet radiation damage.

Objective. To evaluate the effects of a combination regimen of topical and oral green tea supplementation on the clinical and histologic characteristics of photoaging.

Methods. Forty women with moderate photoaging were randomized to either a combination regimen of 10% green tea cream and 300 mg twice-daily green tea oral supplementation or a placebo regimen for 8 weeks.

Results. No significant differences in clinical grading were found between the green tea—treated and placebo groups, other than higher subjective scores of irritation in the green tea—treated group. Histologic grading of skin biopsies did show significant improvement in the elastic tissue content of treated specimens (p<.05).

Conclusion. Participants treated with a combination regimen of topical and oral green tea showed histologic improvement in elastic tissue content. Green tea polyphenols have been postulated to protect human skin from the cutaneous signs of photoaging, but clinically significant changes could not be detected. Longer supplementation may be required for clinically observable improvements.

Monday, 20 July 2009

Green Tea Polyphenols Prevent Ultraviolet Light-Induced Oxidative Damage and Matrix Metalloproteinases Expression in Mouse Skin

Chronic exposure of solar ultraviolet (UV) light to human skin results in photoaging. UV-induced oxidative damage and induction of matrix metalloproteinases (MMP) have been implicated in this process. Because polyphenols from green tea (GTP) prevent other cutaneous adverse effects of UV radiation we hypothesized that UV irradiation-induced oxidative damage and induction of MMP might be prevented in vivo in mouse skin by oral administration of GTP. GTP was administered in drinking water (0.2%, wt/vol) to SKH-1 hairless mice, which were then exposed to multiple doses of UVB (90 mJ per cm2, for 2 mo on alternate days) following in vivo photoaging animal protocol. Treatment of GTP resulted in inhibition of UVB-induced protein oxidation in vivo in mouse skin, a hallmark of photoaging, when analyzed biochemically, by immunoblotting, and immunohistochemistry. GTP treatment also inhibited UVB-induced protein oxidation in vitro in human skin fibroblast HS68 cells, which supports in vivo observations. Moreover, oral administration of GTP also resulted in inhibition of UVB-induced expression of matrix degrading MMP, such as MMP-2 (67%), MMP-3 (63%), MMP-7 (62%), and MMP-9 (60%) in hairless mouse skin. These data suggest that GTP as a dietary supplement could be useful to attenuate solar UVB light-induced premature skin aging.

Praveen K Vayalil, Anshu Mittal, Yukihiko Hara, Craig A Elmets and Santosh K Katiyar.

Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, USA

Department of Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA

Department of Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, USA

Center for Aging, University of Alabama at Birmingham, Birmingham, Alabama, USA

Tokyo Food Techno Co. Ltd., Shizuoka, Japan

Correspondence: Santosh K. Katiyar, Ph.D, Department of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard, Volker Hall 557, PO Box 202, Birmingham, AL 35294, USA. Email: skatiyar@uab.edu

Monday, 20 July 2009

Polyphenolic Antioxidant (-)-Epigallocatechin-3-Gallate from Green Tea Reduces UVB-lnduced Inflammatory Responses and Infiltration of Leukocytes in Human Skin

Identification of natural products capable of affording protection against UVB radiation-induced inflammatory responses and generation of oxidative stress may have important human health implications. The UVB exposure-induced skin injury and oxidative stress has been associated with a variety of skin disease conditions including photoaging, inflammation and cancer. Tea is a popular beverage consumed worldwide. In several mouse skin models, topical application as well as oral consumption of green tea has been shown to afford protection against chemical and UVB-induced carcinogenesis and inflammatory responses. In the present study, we investigated in human skin, whether topical application of (-)epigallocatechin-3-gallate (EGCG), the major polyphenolic constituent in green tea, inhibits UVB-induced infiltration of leukocytes (macrophage/neutrophils), a potential source of generation of reactive oxygen species (ROS), and generation of prostaglandin (PG) metabolites. Human subjects were UVB irradiated on sun-protected skin to four times their minimal erythema dosage (MED) and skin biopsies or keratomes were obtained either 24 h or 48 h later. We found that topical application of EGCG (3 mg/2.5 cm2) before UVB (4 MED) exposure to human skin significantly blocked UVB-induced infiltration of leukocytes and reduced myeloperoxidase activity. These infiltrating leukocytes are considered to be the major source of generation of ROS. In the same set of experiments we found that topical application of EGCG before UVB exposure decreased UVB-induced erythema. In additional experiments, we found that microsomes from EGCG pretreated human skin and exposed to UVB, compared to UVB exposure alone, produced significantly reduced PG metabolites, particularly PGE2. The PG metabolites play a critical role in free radical generation and skin tumor promotion in multistage skin carcinogenesis. Careful microscopic examination of skin sections, stained with hematoxylin and eosin, under higher magnification (x400) also revealed that EGCG pretreated and UVB exposed human skin contained fewer dead cells in the epidermis with comparison to nonpretreated UVB-exposed skin. Taken together, our data demonstrate that EGCG has the potential to block the UVB-induced infiltration of leukocytes and the subsequent generation of ROS in human skin. This may explain the possible mechanism involved in anti-inflammatory effects of green tea. We suggest that EGCG may be useful as a topical agent for protection against UVB-induced ROS-associated inflammatory dermatoses, photoaging and photocarcinogenesis. Further studies are warranted in this direction.

Santosh K. Katiyar 1 , Mary S. Matsui 2 , Craig A. Elmets 3 Hasan Mukhtar* , 1

1 Department of Dermatology, Case Western Reserve University, and University Hospitals of Cleveland, Cleveland, OH, USA 2 Biological Research Division, Estee Lauder Companies Inc., Research Park, Melville, NY, USA 3 Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA

Correspondence to *Department of Dermatology, Case Western Reserve University, 11100 Euclid A venue, Cleveland, OH 44106, USA. Fax: 216-368-0212: e-mail: hxm4@po.cwru.edu

Sunday, 9 August 2009

Alpha Hydroxy Acids with Antioxidant Benefits

Alpha

Gluconic (gluconolactone), citric, tartaric, malic and ascorbic acids are alpha hydroxy acids with antioxidant activity.

Tuesday, 14 July 2009

Using Skinceuticals Phloretin CF in place of Skinceuticals Eye Gel AOX+

Using Skinceuticals Phloretin CF in place of Skinceuticals Eye Gel AOX+

If you do not have a sensitive eye area prone to dehydration, or have used Skinceuticals Eye Gel AOX+ before without experiencing burning or stinging, you can use trial using Skinceuticals Phloretin CF (which contains flavonoids) in place of Skinceuticals Eye Gel AOX+.

If you can make this alteration, you'll see enhanced results from Skinceuticals A.G.E. Eye Complex.

Tuesday, 14 July 2009

Skinceuticals C E Ferulic vs. Skinceuticals Phloretin CF

Skinceuticals Phloretin CF is an alternative to Skinceuticals C E Ferulic for individuals with combination to oily skin and has been shown to provide identical photoprotection to Skinceuticals C E Ferulic.

However, Skinceuticals Phloretin CF has been shown to prevent elastase and enhance elastin production, while Skinceuticals C E Ferulic has not.

Distinct from Skinceuticals C E Ferulic, Skinceuticals Phloretin CF contains less firming antioxidant Vitamin C and no antioxidant Vitamin E (as alpha tocopherol), however includes phloretin — an antioxidant bioflavonoid and hormone — possessing anti-inflammatory, antibacterial, anti-fungal, anti-glycogen and sebum-regulating properties.

Although Skinceuticals Phloretin CF contains 5% less Vitamin C than Skinceuticals C E Ferulic, Skinceuticals Phloretin CF contains SD alcohol and is oil-free.

Phloretin itself is also claimed to be a penetration-enhancer.

These factors contribute to greater skin penetration, therefore the amount of Vitamin C delivered to the skin in both formulas is likely very similar.

If you would like to use Skinceuticals Phloretin CF for it's elastin-regenerating and elastin-protective properties, which are absent from Skinceuticals C E Ferulic, but would not like to forego the benefits of Vitamin E, or experience dryness from Skinceuticals Phloretin CF (which is intended for combination to oily skin), you can use Skinceuticals Phloretin CF in conjunction with a product containing tocopherol glucoside such as Glytone Vitaceutical Facial Serum. This combination will provide even greater general antioxidant and photoprotection than Skinceuticals C E Ferulic.

Tuesday, 14 July 2009

Skinceuticals Phloretin CF vs. Skinceuticals C E Ferulic

Skinceuticals Phloretin CF is an alternative to Skinceuticals C E Ferulic for individuals with combination to oily skin and has been shown to provide identical photoprotection to Skinceuticals C E Ferulic.

However, Skinceuticals Phloretin CF has been shown to prevent elastase and enhance elastin production, while Skinceuticals C E Ferulic has not.

Distinct from Skinceuticals C E Ferulic, Skinceuticals Phloretin CF contains less firming antioxidant Vitamin C and no antioxidant Vitamin E (as alpha tocopherol), however includes phloretin — an antioxidant bioflavonoid and hormone — possessing anti-inflammatory, antibacterial, anti-fungal, anti-glycogen and sebum-regulating properties.

Although Skinceuticals Phloretin CF contains 5% less Vitamin C than Skinceuticals C E Ferulic, Skinceuticals Phloretin CF contains SD alcohol and is oil-free.

Phloretin itself is also claimed to be a penetration-enhancer.

These factors contribute to greater skin penetration, therefore the amount of Vitamin C delivered to the skin in both formulas is likely very similar.

Tuesday, 14 July 2009

Skinceuticals Phloretin CF Marketing Blurb

"Skinceuticals Phloretin CF™ represents a new class of preventive and corrective topical antioxidant treatment.

After five years of extensive research, SkinCeuticals developed this patent-pending breakthrough technology combining the newly-discovered, broad-range power of phloretin with vitamin C and ferulic acid in a biodiverse formulation to divide and conquer sources of damage at every level.

Skinceuticals Phloretin CF ™, a broad-spectrum treatment, protects against not only free radicals, but the range of other reactive molecules known to cause damage and DNA mutations among the integral cell types.

In addition, it corrects existing damage by stimulating the synthesis of essential proteins and fibers and accelerating cell turnover.

The result — a strengthened support structure on the inside and a more youthful, firm, radiant appearance on the outside."

Tuesday, 14 July 2009

Skinceuticals Phloretin CF Further Information

Skin Care IngredientsPhloretin.

Mature Skin Analysis: Firmness and Elasticity of Healthy vs. Unhealthy Mature Skin.

Bioflavonoids.

Skin care products containing bioflavonoids.

Collagen.

Elastin.

Tuesday, 14 July 2009

Skinceuticals Phloretin CF, Botox and Other Injectables

If you are using Emla (or similar) prior to your procedure, cease using Skinceuticals Phloretin CF two days prior.

Tuesday, 14 July 2009

Skinceuticals Phloretin CF Vitamin C Content — Skin Firming and Acne

The concentration of Vitamin C available in Skinceuticals Phloretin CF is only 10% L-Ascorbic Acid, which is minimally firming when compared with 15%, 17.5% and 20% formulations, although the reduced concentration may be beneficial for those prone to acne and sensitivity, albeit only outside of ideal complementing skin care factors.

The propensity for Vitamin C (as ascorbic acid) to stimulate acne appeared to be reduced with the addition of ferulic acid to the original higher concentration vitamin C serums (Serum 15, Serum 20).

The minimized Vitamin C concentration in Skinceuticals Phloretin CF combined with ferulic acid and phloretin, known to be effective against acne, should further reduce the likelihood of acne in comparison with Skinceuticals Serum 10 and 10 AOX+, 15 and 15 AOX+, 20 and 20 AOX+, C E Ferulic, IS Clinical and Cellex-C Vitamin C Serums.

Skinceuticals Phloretin CF may provide more benefit than Skinceuticals C E Ferulic, particularly if you have predominantly oily skin and hyperpigmentation, however individual assessment and follow-up are essential in determining suitability.

Inappropriate use may produce lipid-dry skin.

Tuesday, 14 July 2009

Skinceuticals Phloretin CF and Limiting Elastase Activity

Phloretin has been shown to inhibit up to 80% of the skin's own paradoxically deleterious enzyme, elastase.

Elastase breaks down elastin, an elastic fiber whose levels (together with collagen) determine the mechanical properties of facial connective tissue, producing skin which is more or less:

  • bouncy, dense and full or
  • tired, flat and thinned-out.

The unwanted effects of elastase are especially noticeable around the eyes and neck, where near-total reduction in its activity would be highly desirable.

Amino acids contained within GERnétic Anti-Radical Eye Gel are marketed as "preventing elastase enzyme activity" and were previously available as a very generous set of 6 tubes (3 for day, 3 for night).

Although detailed information regarding their composition and action is unavailable and the original formulas abandoned in place of a single gel, the original product had been used on the neck (as well as around the eyes) with good effect.

Chantal Ethocyn, Prevage MD and Elastiderm (by Obagi Medical) are also marketed as capable of protecting and regenerating elastin.

Tuesday, 14 July 2009

Skinceuticals, Phloretin and Bioflavonoids

In recent times, bioflavonoids have been unavailable in Skinceuticals Vitamin C Serums (excepting C+AHA) but always present in those produced by IS Clinical, Jan Marini and Cellex-C among others.

Bioflavonoids were formerly regarded as vitamins — in French skin care they are still sometimes referenced as "Vitamin P", "PP" or "citrin", and are primarily derived from citrus fruits.

Skinceuticals have named their bioflavonoid specifically (phloretin), while IS Clinical, Jan Marini and Cellex-C do not publicly disclose theirs, and may in fact use combinations of bioflavonoids.

Monday, 6 July 2009

Oxidoreductase Reactions

An enzyme that catalyzed this reaction would be an oxidoreductase:

A— + B ... A + B—

In this example, A is the reductant (electron donor) and B is the oxidant (electron acceptor).

In biochemical reactions, the redox reactions are sometimes more difficult to see, such as this reaction from glycolysis:

Pi + glyceraldehyde-3-phosphate + NAD+ ... NADH + H+ + 1,3-bisphosphoglycerate

In this reaction, NAD+ is the oxidant (electron acceptor), and glyceraldehyde-3-phosphate is the reductant (electron donor).

Monday, 6 July 2009

Classification of Oxidoreductases

Oxidoreductases are classified as EC # in the EC (Enzyme Commission) number classification of enzymes.

Oxidoreductases can be further classified into 22 subclasses (EC #.#):

EC 1.1 includes oxidoreductases that act on the CH-OH group of donors (alcohol oxidoreductases);

EC 1.2 includes oxidoreductases that act on the aldehyde or oxo group of donors;

EC 1.3 includes oxidoreductases that act on the CH-CH group of donors (CH-CH oxidoreductases);

EC 1.4 includes oxidoreductases that act on the CH-NH2 group of donors (Amino acid oxidoreductases, Monoamine oxidase);

EC 1.5 includes oxidoreductases that act on CH-NH group of donors;

EC 1.6 includes oxidoreductases that act on NADH or NADPH;

EC 1.7 includes oxidoreductases that act on other nitrogenous compounds as donors;

EC 1.8 includes oxidoreductases that act on a sulfur group of donors;

EC 1.9 includes oxidoreductases that act on a heme group of donors;

EC 1.10 includes oxidoreductases that act on diphenols and related substances as donors;

EC 1.11 includes oxidoreductases that act on peroxide as an acceptor (peroxidases);

EC 1.12 includes oxidoreductases that act on hydrogen as donors;

EC 1.13 includes oxidoreductases that act on single donors with incorporation of molecular oxygen (oxygenases);

EC 1.14 includes oxidoreductases that act on paired donors with incorporation of molecular oxygen;

EC 1.15 includes oxidoreductases that act on superoxide radicals as acceptors;

EC 1.16 includes oxidoreductases that oxidize metal ions;

EC 1.17 includes oxidoreductases that act on CH or CH2 groups;

EC 1.18 includes oxidoreductases that act on iron-sulfur proteins as donors;

EC 1.19 includes oxidoreductases that act on reduced flavodoxin as a donor;

EC 1.20 includes oxidoreductases that act on phosphorus or arsenic in donors;

EC 1.21 includes oxidoreductases that act on X-H and Y-H to form an X-Y bond;

EC 1.97 includes other oxidoreductases.

Saturday, 15 August 2009

D-Tocopheryl Glucoside

D-Tocopheryl Glucoside

Like myristyl nicotinate which delivers topical niacin with greater efficacy than the Vitamin (B3) from which it is derived, d-tocopheryl-glucoside is a new prodrug developed to enhance the benefits of topical Vitamin E.


Vitamin E is found in many cosmeceutical skin care products (up to 1% in Skinceuticals C E Ferulic, IS Clinical C E Advance+ and IS Clinical Pro-Heal Advance+) and includes tocopherols and tocotrienols, among which d-alpha-tocopherol is the most active form.

As the skin's major lipid-phase antioxidant, delivered to the skin's surface through sebum, Vitamin E plays a role in protecting skin from photodamage.

While Vitamin E is obtained from the diet from vegetables, seeds, nuts and oils, topical supplementation increases skin levels far beyond that possible from diet alone and can help provide greater protection against photoaging in combination with other antioxidants.

Vitamin E Drops

Despite the benefit, topical application of higher concentrations of (pure) Vitamin E (as tocopherol) can provoke erythema, urticaria, and eczematous dermatitis.

Tocopherol is also unstable and poorly absorbed.

Even in the absence of conspicuous reactions, the global appearance and comfort of patients' skins often improves on cessation of products in which tocopherol is a primary ingredient.

Commonplace Vitamin E derivatives such as tocopherol succinate and tocopherol acetate, often marketed as "Vitamin E", are effective moisturizing agents, however provide little to no antioxidant activity due to their negligible or non-existent conversion into biologically active tocopherol in skin.

Comparative studies have shown that the Vitamin E derivatives tocopherol acetate and tocopherol succinate do not prevent photodamage.

Conversely, the Vitamin E derivative d-tocopheryl-glucoside is stable and converts progressively to active tocopherol in skin over several hours with anti-inflammatory and antioxidant effects which protect collagen and elastin.

Unlike pure tocopherol which can be irritating, d-tocopheryl-glucoside is now a primary active ingredient in products designed to help prevent and treat atopic and contact dermatitis which can occur in the course of Vitamin C (ascorbic acid), Vitamin A (retinoid) and alpha-hydroxy acid use.

D-tocopheryl-glucoside is found in a variety of Avene products for sensitive skin, including Avene Hydrance Optimal SPF 25 Hydrating Cream [ingredients], Soothing Eye Contour Cream [ingredients] and at a higher concentration in Glytone Vitaceutical Facial Serum [ingredients].

Monday, 16 January 2012

Kinetin + Niacinamide Superior to Niacinamide Alone

A double-blind, randomized, vehicle-controlled clinical trial conducted over twelve weeks shows that a combination of Kinetin (0.03%) and Niacinamide (4%) produced the following results:

Reduction in hyperpigmentation and erythema and increase in skin hydration were reported as statistically insignificant for the use of niacinamide alone.

The study report written by attending dermatologist Pin-Chi Chiu, M.D. concluded that "Kinetin, when combined with niacinamide, can be used as an adjunctive therapy for acne rosacea, xerosis and sensitive skin" and that "the effects of kinetin and niacinamide are additive when compared to niacinamide alone. Study data suggest that these compounds have the capacity to exert multiactive, multifunctional and pluripotent effects on the skin."

Patients can use a combination of Kinerase or Kinerase Pro+ (containing Kinetin) and Nia 24 products (containing the deepest-penetrating form of niacin) to achieve the synergistic benefits of these two ingredients.

Clinical study was conducted at the National Taiwan University Hospital.


Wednesday, 19 October 2016 — The preferred regular home treatment for visibly open pores is now available online. Visit the page for MD Rx Melbourne Dermatology Open Pores Overnight Solution for information.


Wednesday, 8 July 2009

Effective Peptide Products

Copper peptides are regarded as genuinely effective.

Among those currently included in our database (as of 29/6/09) are IS Clinical, La Roche-Posay Cicaplast, Hydraphase Light and Avene Cicalfate.

Thursday, 12 November 2009

La Roche-Posay — UV Exposure Video

Covers ultraviolet (UVB, UVA) and and free radicals (includes promotional information regarding Anthelios, Mexoryl and Senna Alata).

For further information, refer The Sun and photodamage.


To prevent photodamage and photoaging, practice sun avoidance, consume dietary and supplementary antioxidants, apply antioxidants underneath sunscreens in the morning and optionally at night after the application of retinoids.

Monday, 29 June 2009

Dry Mature Skin

Monday, 29 June 2009

La Roche-Posay Substiane Clinical Study

29% increase in skin fullness.

Number of subjects: 40.

Evaluation method: scoring of skin's fullness using a standard scale.

Length of treatment: 3 months.

Monday, 21 September 2009

La Roche-Posay — Mature Skin Video

La Roche-Posay Mature Skin Video (includes promotional information regarding Pro-Xylane).


Monday, 9 November 2009

Pathogenisis of Skin Aging

The pathogenesis of skin aging is well defined.

It is characterized by a decrease in collagen synthesis and an increase in collagen breakdown, mediated by metalloproteinases (Arch. Dermatol. 138[11]:1462-70, 2002).

This net loss in dermal collagen is believed to cause wrinkling.

Biologic factors that stimulate collagen production in wound healing might provide similar benefits for aging skin.

Accordingly, growth factors, peptide fragments, and other biologically active molecules are being incorporated into antiaging cosmeceuticals.

Monday, 29 June 2009

ASA Finding Quotations Regarding Pentapeptides

"The differences between the observed changes in the control product group and the peptide containing product group were small at all stages of the trial. "

"... changes [did not reach] a level of significance sufficient to support the claim that pentapeptides were effective at reducing the appearance of lines and wrinkles. "

"in the self-evaluation part of the study, the test subjects themselves overall reported no effect for the pentapeptide containing product."

"he did not consider those changes, measured by instruments, which were reported in favour of the pentapeptide containing product, were likely to be visually significant to the consumer."

Sunday, 28 June 2009

ReVivé Arrete Booster C

Tuesday, 30 June 2009

ReVivé Peau Magnifique

ReVivé Peau Magnifique

ReVivé Peau Magnifique — USD $1,500 / AUD $2,500.


ReVivé Peau Magnifique

Similar to Jan Marini Age Intervention Regeneration Booster, ReVivé Peau Magnifique contains Telomerase to "activate and differentiate dormant adult stem cells without surgical intervention and repair DNA fragmentation."

Telomerase is an an enzyme that adds nucleotides to telomeres, especially in cancer cells.

There is no evidence of effectiveness — or scientific rationale — behind topical telomerase.

Recent research does however implicate NAD in the maintenance of telomeres (refer niacin) to retard the aging of skin cells.

Revivé Peau Magnifique also contains the moisturizers Glycerin, Methylsilanol Mannuronate, Tocopherol Acetate and Panthenol, skin-healing Beta Glucan, antioxidant Vitamin E and Borage and firming Madecassoside.

Saturday, 27 June 2009

Jan Marini Age Intervention Peptide Extreme

Monday, 29 June 2009

Example Pentapeptide Products

Example Pentapeptide Products

Products featuring pentapeptides as a "skin care technology" include Gernetic Concentré Reparateur Serum, Jan Marini TGF, Age Intervention and Marini Lash, Olay Regenerist, StriVectin-SD and Strixaderm.

Although users often report improvement, the improvement is likely largely attributable to other ingredients and characteristics of these products.

Monday, 29 June 2009

Superior Alternatives to Pentapeptides

Consumers who have had poor experiences with other ingredients or are enthusiastic about new ingredients, are among those using the newest peptide products, sometimes to the relative detriment of their skins.

Where the pentapeptide products replace retinoids, alpha-hydroxy acids, better antioxidants and sunscreens, and even certain botanical extracts, the result can be greater expense for lesser result.

Monday, 27 July 2009

Pentapeptides Ineffective

Television advertisement for Olay Regenerist pentapeptides.


The UK's ASA (Advertising Standards Authority) has determined that pentapeptides, popular in an increasing number of newly released "anti-aging" skin care products, and one of the most expensive ingredients in skin care, are not effective at reducing the appearance of fine lines and wrinkles.

Pentapeptides are tiny strings of amino acids which are claimed to be able to communicate with skin cells in highly specific ways by directly improving or correcting instructions the cell needs in order to function properly so that they create younger-looking skin.

These latest peptides are held to outperform earlier versions by being even more specific in their pre-programmed actions, allowing for even greater skin repair or assistance.

After examining all available data, the ASA reached the conclusion that the magnitude of changes recorded by pentapeptides were so small that they were not sufficient to support claims of efficacy.

It is also not clear if pentapeptides penetrate skin, and if they do that they are used to beneficial effect rather than being broken down by the skin's enzymes for elimination.

Pentapeptides have reached the point of mass-market distribution. Assuming the mechanisms by which they are said to operate are true, prudent manufacturers may be formulating to ensure they do not penetrate skin or remain active in formulations to avoid side-effects or safety concerns.

Saturday, 27 June 2009

Obagi C-Effectives

Wednesday, 24 June 2009

Reduction in Severity of Rosacea using The Obagi Rosaclear System

Reduction in Severity of Rosacea using The Obagi Rosaclear System

Ninety percent of rosacea patients experienced at least a 1-grade reduction in rosacea symptoms by the second week of treatment (see example before and after pictures) with the Obagi Rosaclear System.

Wednesday, 24 June 2009

Obagi Rosaclear Before and After Pictures

Obagi Rosaclear Before and After Pictures

The upper pictures show before/after improvement in the skin of a rosacea patient after one week.

The lower pictures show before/after improvement in the skin of a rosacea patient after one month.

Wednesday, 24 June 2009

Alternatives to Madecassoside

Asiatic and madecassic acid and asiaticoside or combinations thereof (for example, TECA) are alternatives to madecassoside.

These isolates are mainly found in skin care from IS Clinical and to a lesser extent Skinceuticals.

Wednesday, 24 June 2009

Recommended Madecassoside Skin Care Protocols for Aging Skin

Incorporating madecassoside into a skin care protocol for aging skin that achieves additional benefits against sagging and wrinkles can be achieved as follows:

AM Madecassoside Skin Care Protocol for Aging Skin

After the application of any antioxidant serums (optional), apply La Roche-Posay Redermic Eyes and either La Roche-Posay Redermic for Combination Skin or La Roche-Posay Redermic for Dry Skin before the application of sunscreen.

Alternatively, use La Roche-Posay Redermic UV in place of any of the Redermic formulas for facial (excluding eye contour) skin and sunscreen.

PM Madecassoside Skin Care Protocol for Aging Skin

As per AM excluding sunscreen and not at the same time as retinoids.

Madecassoside Skin Care Notes

Ideally, wait several minutes when layering any products.

Saturday, 15 August 2009

Additional Uses for Madecassoside

Madecassoside acts upon different cutaneous mechanisms and can enhance skin healing, regulating the renewal and the differentiation of the epidermal tissues (keratinocytes), optimizing the organisation of the corneous layer and modulating skin inflammation.

Madecassoside enhances post procedure healing and improves the outcome of the inflammatory phase of hypertrophic scars and keloids.

Madecassoside may also assist the treatment of phlebitis, cellulitis, slow-healing wounds, scars and stretch marks.

Tuesday, 23 June 2009

Recommended Madecassoside Skin Care Products

Skin care products containing madecassoside are few.

La Roche-Posay Redermic formulas contain madecassoside in combination with Vitamin C as ascorbic acid, a combination which has been shown to be superior to either ingredient alone, however is best not applied at the same time as retinoids.

Use of La Roche-Posay Redermic has not been associated with contact sensitivity.

La Roche-Posay Cicaplast is a barrier repair product which contains madecassoside in addition to gluconates of copper, zinc and manganese.

Dermalogica Super Rich Repair (now discontinued) also contained madecassoside albeit without ascorbic acid and in small concentration.

Cellex-C Cellulite Smoothing Complex contains madecassoside as part of its Centella Asiatica content and may help prevent and reduce new stretch marks.

Madecassoside is also found in La Roche-Posay Kerium Anti-Hair Loss.

Monday, 17 May 2010

Effects of Madecassoside on Aging Skin

In skin, the major components are collagen type I and collagen type III.

Skin aging is inextricably linked with a decrease in type I collagen.

Studies dating back to the 1980s indicate that glycosides found in Centella Asiatica such as madecassoside increase collagen synthesis and that combinations of glycosides of Centella Asiatica combined with Vitamin C as ascorbic acid produce greater collagen type I synthesis than either alone.

In addition madecassoside reduces the activity of dermal matrix degrading enzymes (MMPs — Matrix MetalloProteinases of type I, 3 and 9) which break down the compounds occurring chiefly as components of connective tissue.

Madecassoside, particularly in combination with ascorbic acid, both enhances and protects the turgidity (bounce) of skin.

The clinical experience has been that skin care products containing significant concentrations of pure extracts of Centella Asiatica such as madecassoside provide obvious skin firming effects when used for at least six weeks.

The effectiveness of skin care products containing trace amounts of Centella Asiatica, and products not containing the isolated glycosides of Centella Asiatica, has either been poor or impossible to judge with any accuracy.

Skin care products containing healthy amounts of extracts of Centella Asiatica such as madecassoside can be expected to perform better than the popular implementations of peptides used in skin care.

Monday, 17 May 2010

TECA

TECA is a perfectly standardized extract of centella asiatica of pharmaceutical quality.

Isolated in purified fractions, free genins (asiatic and madecassic acids) and asiaticoside, these active ingredients are combined in constant proportions to guarantee optimal activity.

TECA was traditionally used in pharmaceutical applications.

Administered in ointments, powders, or in tablet form, TECA proved very successful in the treatment of burns, scars and wound healing defects.

Studies showed that wound chambers to which TECA had been applied were characterized by increased dry weight, DNA, total protein, collagen, and uronic acid contents. Peptidic hydroproline was also increased, showing an increased remodeling of the collagen matrix in the wound.

Asiaticoside exerted a preferential stimulation of collagen synthesis and was active at low doses only. In addition to collagen, the three components were also able to stimulate glycosaminoglycan synthesis (glycosaminoglycan synthesis was also shown in a study by DelVecchio et al, 1984).

Tuesday, 23 June 2009

Pierre Boiteau

Ch. Grimes (1939). Le traitement de la lèpre par l'Hydrocotyle asiatica. Bulletin de la Société de pathologie exotique, XXXII (6) : 692.

M. Bontemps (1942). Sur un Glucoside nouveau : l'Asiaticoside isolé à partir de Hydrocotyle asiatica (ombellifères). Gazette médicale de Madagascar n° 15 : 29-33.

J. Devanne & R. Razafimahery (1942). Glucoside et résine de l'Hydrocotyle asiatica. Gazette médicale de Madagascar : 15-34.

Ch. Grimes & P. Boiteau (1945). Rapport sur la thérapeutique de la lèpre. Huitième rapport annuel de la Société du Parc Botanique et Zoologique de Tsimbazaza, 1944.

P. Boiteau (1945).? Travaux sur l'Asiaticoside (étude botanique). Neuvième rapport annuel de la Société du Parc Botanique et Zoologique de Tsimbazaza.

P. Boiteau (1945). Travaux sur l'Asiaticoside. Rapport annuel du laboratoire de botanique et de technologie végétale : 26-40.

P. Boiteau (1947).? Contribution à l'étude du rôle des glucosides dans le métabolisme de la plante. Bulletin de la société de chimie biologique. XXIX (4-6) : 451-453.

P. Boiteau & R. Saracino (1948). Premiers essais au sujet de l'action de l'Asiaticoside sur les lupus érythémateux et sur certaines lésions produites par les bacilles de Hansen & Koch. Le médecin français. VIII (19), 10 oct. 1948.

P. Boiteau, A. Buzas, E. Lederer & J. Polonsky (1948).? Sur la constitution chimique de l'Asiaticoside. Nature, 163 : 258. London. Communication Congrès de Chimie biologique, oct. 1948.

P. Boiteau & A.R. Ratsimamanga (1956).? L'asiaticoside extrait de Centella asiatica et ses emplois thérapeutiques dans la cicatrisation des plaies expérimentales et rebelles (lèpre, tuberculose cutanée et lupus). Thérapie II (1) : 125-151.

A.R. Ratsimamanga & P. Boiteau (1964).? Propriétés thérapeutiques des extraits de Centella et de leurs constituants triterpéniques isolés. Annales de l'université de Madagascar. 2 : 101-107.

Tuesday, 23 June 2009

La Roche-Posay Redermic Dry Skin Study

La Roche-Posay Redermic Dry Skin produced a 33% average improvement in skin firmness over six months in 80% of patients, measured by clinical score assessed by a dermatologist.

Monday, 22 June 2009

Review of Antioxidant Skinceuticals Phloretin C F / Review of "Truth In Aging"

Review of Antioxidant Skinceuticals Phloretin C F / Review of

I came across a review of Skinceuticals Phloretin CF at a site called "Truth In Aging" which concluded the product was not worthwhile as follows:

For the last six weeks I have dabbed a little every day on the creases between my eyes. I thought I'd given it a pretty easy job because these wrinkles are comparatively new and tiny. Six weeks later, not one whit of difference. If anything, I found it extremely drying and dulling.

Can you please clarify whether or not I should bother using Skinceuticals Phloretin CF?


The review you mention, as per the Skinceuticals Retinol review at Truth In Aging, is a good example of poor advice leading people astray, increasing the likelihood of futile and incorrect treatment.

For the most part, and as they are most typically used, antioxidants are a long-term daily-use proposition to assist in preventing photodamage.

As antioxidants are not capable of treating pre-existing wrinkles, a different entity to photodamage prevention, the 6-week "reviewed and rejected" assessment made on Skinceuticals Phloretin CF's ability to treat wrinkles is invalid.

Skinceuticals Phloretin CF is intended for combination skin and may cause skin irritation in individuals with sensitive skin and additional dryness in individuals with dry skin.

Skinceuticals C E Ferulic is more suitable for dry skin.

It is not claimed to be an inherently superior alternative to Skinceuticals C E Ferulic as the review states ("Five years in the making, Phloretin CF is supposed to take CE Ferulic to new antioxidant heights").

Samples of products containing Vitamin C are also prone to heavy oxidation which affects efficacy.

Lastly, 6 weeks isn't long enough to judge the effects of any skin care — 6 months is a more telling, minimal period of time.

The document A Year of Photoprotection — Results from Topical Vitamin C (as Ascorbic Acid) and Sunscreen Use can give you a better idea of what you can realistically expect from long-term use of a ascorbic acid serum such as Skinceuticals Phloretin CF when combined with sunscreen.

You may also like to refer to the Skinceuticals C E Ferulic Dermatological Evaluation of Tolerance and Efficacy and Evaluation of Effects on Special Molecular Biomarkers of Oxidative Stress in Skin of Healthy Subjects After UVA 1 Irradiation.

Tuesday, 16 June 2009

Mineral Makeup with Very Few Minerals Present

Mineral Makeup with Very Few Minerals Present

Some mineral makeup brands apply the term “mineral makeup” to traditional makeup.

Ingredients that bubble or foam are not pure minerals.

Minerals that sink to the bottom are not properly processed.

Tuesday, 16 June 2009

Improperly/Inadquately Processed Mineral Makeup

Improperly/Inadquately Processed Mineral Makeup

Some makeup brands may put minerals in their products, but do not process them adequately to reduce cost, leaving impurities.

Ingredients that muddy the water are not pure minerals.

Monday, 22 June 2009

"High Integrity" Mineral Makeup

Real micronized minerals that are processed properly are completely waterproof and will not dissolve in water.

Therefore, they float to the top.

Tuesday, 16 June 2009

Poor Mineral Processing in Mineral Make-Up

Poor Mineral Processing in Mineral Make-Up

Ingredients that muddy the water are not pure minerals.

Tuesday, 16 June 2009

Extremely Low-Cost or Quality Mineral Make-Up Ingredients (Raw Materials)

Extremely Low-Cost or Quality Mineral Make-Up Ingredients (Raw Materials)

Minerals shown have “muddied” the water and were not processed for complete purity.

Tuesday, 16 June 2009

Quality and Refinement in Mineral Makeup Processing

Quality and Refinement in Mineral Makeup Processing

Only pure, high-quality micronized minerals float on water without causing cloudiness.

Tuesday, 25 August 2009

Colorescience Mineral Make-Up Benefits

Colorescience Mineral Make-Up Benefits

Fast application techniques with unique packaging.

Non-transfer finish resists rubbing off on clothes.

Highly concentrated.

Extremely silky texture.

Prolonged wear with minimal touch-up.

Very water-resistant.

Easy to blend and match.

Weightless feel, even with multiple layers.

Layering possibilities, including cream over powder.

Camouflage coverage without a "cakey" look.

SPF-rated mineral makeup offer virtually full-protection, highly photostable sun protection.

Tuesday, 16 June 2009

Mineral Makeups as Sunscreens

Mineral Makeups as Sunscreens

Pictured: Colorescience Almost Clear Sunforgettable SPF 30.


SPF-rated mineral makeup such as Colorescience and Jane Iredale can offer longer-lasting photostable sun protection, however should not be relied upon as sunscreens effective against photodamage on their own.

Studies have shown that photoprotection from makeup is negligible if used alone.

An SPF-rated mineral makeup (such as Colorescience Sunforgettable or Powder Brush Foundation) can be used after the application of a generous amount of sunscreen.

Monday, 22 June 2009

Colorescience vs. Other Mineral Makeups

Colorescience vs. Other Mineral Makeups

"The beauty industry has been inundated by new mineral makeup lines.

Some mineral makeups which originally had "ingredient integrity" have changed their formulas over time to use less expensive ingredients and processes.

Mineral makeup, as originally conceived by Diane Ranger, is free of oils, talcs, alcohols, dyes, binders, fillers and the need for heavy preservation.

If consumers are not educated about mineral makeup they will not see the results expected from a original mineral makeup, or worse, they could be applying product that can cause skin problems like acne.

The majority of mineral makeups reflect poorly on the original concept of mineral makeup."

Tuesday, 16 June 2009

Colorescience Founder: Diane Ranger

Colorescience Founder: Diane Ranger

Diane Ranger, founder of Colorescience, invented the mineral makeup concept and coined the term "mineral makeup" in 1977.

Diane Ranger's vision was to establish and maintain the highest level of ingredient integrity by focusing on the quality of the minerals in each formula, as well as the way in which the minerals were processed.

Colorescience products are popularly considered the standard by which all mineral makeup is judged.

Wednesday, 19 May 2010

La Roche-Posay Kerium Anti-Hair Loss

Hair loss is normal process, hair is like a tree, it grows, it thrives and dies.

When the hair arrive at the end of life, they fall out and are immediately replaced by an another.

The reasons are variables: genetic, hormonal, nutritional, or change of season.

And as different as if you are a man or a woman.

To fight this persistent hair loss, La Roche-Posay Laboratories have developed, in collaboration with dermatologists, KERIUM Anti-Hair Loss.

Properties: KERIUM Anti-Hair Loss contains:

  • Madecassoside - It's a substance extracted from Centella Asiatica, a plant used for thousands of years for its soothing and healing properties. As regard its action on the hair, it helps soothing the irritation of the scalp therefore prevents the effect on capillary bulb, which helps to nourish the hair.
  • Aminexil® - It's a substance that will help anchor the hair root within the scalp.
  • La Roche-Posay Thermal Spring Water - By its anti-free radicals and soothing virtues, help strengthen the bulb and hair.

Results:

KERIUM Anti-Hair Loss Treatment slows down hair loss while intensifying their growth.

Directions: KERIUM Treatment is used for 6 weeks at 1 application daily or at least 3 applications weekly, on cleansed and dried hair.

  • For women : use the long nozzle and apply on the scalp 3 sprays per section (4 different sections distributed throughout the head), then massage to diffuse the product.
  • For Men : Spray (excluding long nozzle) on the areas to be treated, then massage the scalp. Do not rinse. Size: 125 Ml bottle.

Tuesday, 25 May 2010

Anthelios 60 Ultra-Light Sunscreen Fluid Patents

The sunscreen formulation of La Roche-Posay Anthelios 60 Ultra-Light Sunscreen Fluid is protected by US Patents 5576354, 5667765 and 5587150.

Tuesday, 23 June 2009

Natural/Organic Instinct Products Contain Unlisted + Mislabelled Chemicals

Natural/Organic Instinct Products Contain Unlisted + Mislabelled Chemicals - Natural Instinct Skin Care Products

A regulatory inquiry has found that Natural and Organic Instinct products, identical expect for the slight variation in name and sold for several years through health food stores and chemists, contain an array of unlisted and mislabeled chemicals.

Despite their overt and foremost marketing claims of "no sodium laureth sulphate," "petroleum by-products" or "detergents", among other purportedly beneficial omissions, the products actually contained all of these, and more.

Although many chemicals have alternate names, Natural and Organic Instinct products contained actual sodium laureth sulphate, cocamide DEA, cetrimonium chloride and fragrance/perfume despite claiming to be free of these chemicals.

For example, the company had held that it didn't use sodium laureth sulphate and formulated with "sodium salt of sulphonated laureth" as an alternative. Similarly, they passed off added product fragrance as "preservative T."

Additionally, ingredients were not listed in declining order of concentration as expected by mandatory convention, giving the impression that these relatively inexpensive products contained exceptionally high concentrations of plants.

Some advertisements had stated the products were made from 100% plant oils and herbs. Natural and Organic Instinct's spokesperson states that "100% can be used loosely" despite it being an arithmetical value.

These blatant skin "care" inventions have abused end-users who need to avoid certain ingredients due to allergies, sensitivities or ethical reasons.

The belief that "organic" and "natural skin care" is superior seems to be rooted in a misunderstanding about the source of ingredients used in products.

There is no foreign matter for inclusion into skin care products available anywhere on Earth — there are only configurations of the same matter.

Plants contain chemicals, chemicals can be extracted from plants or made synthetically from chemicals which happen to also be found in plants (among other things), and those chemicals are identical:

Natural/Organic Instinct Products Contain Unlisted + Mislabelled Chemicals

"... the roots, when soaked and powdered, release saponin, a useful soap-like substance."

Royal Botanic Gardens Melbourne, South Yarra Californian Garden — July 10, 2007.


Certain skin care marketers, such as psychologist Dennis Gay who gave us Strivectin among the body of Basic Research's work, clearly understand how to manipulate apparently psychogenic concerns to their advantage.

For efficacy and even safety, it's generally best to give very small or recent personal care product manufacturers a wide berth until they prove they can provide genuine products over a long period of time.


Natural and Organic Instinct products are manufactured by Natural Products of Australia Pty Ltd in Victoria.

Tuesday, 16 June 2009

Neutrogena Amber Bar Sculpture

Danielle Julian-Norton's sculpture Ambrosia made from approximately 20,000 Neutrogena Amber Bars. Video source: Neutrogena. The video is also available in a larger format on the Youtube Channel.


The Neutrogena Facial Cleansing Bar, sometimes referred to simply as the "Amber Bar", has been around since 1954.

At a time when opaque animal-derived alkaline soaps were the only way to cleanse, Neutrogena's Amber Bar must have caused a sensation.

The understated product, visually no more than a more-or-less clear amber block and devoid of the manipulative marketing of the day, was made with gentler cleansers which produced less foam and were easier to rinse off, hydrating glycerin and a pH which didn't break down nearly as much of the skin's essential healthy barrier function.

When wet, the bar becomes more transparent.

Neutrogena's Amber Bar set the company's founder (Manny Stolaroff) a template for further skin care innovations.

Artist Danielle Julian-Norton has been inspired to create the sculpture Ambrosia comprising approximately 20,000 Neutrogena Amber Bars.

Forming 7-feet high walls and running 40 feet long, Ambrosia is installed at The Reeves Contemporary Art Gallery in New York City.

In Greek and Roman mythology, ambrosia refers to anything so pleasing in scent that it should appeal to The Gods. Danielle Julian-Norton writes:

"It is the clean identity, amber color, fresh scent, bodily reference, striking surface and translucent aesthetic that inspired me."

The scent of the installation can be detected from as far away as the street:

"It's kind of fun hearing people smell the piece before they even walk into the gallery, so they're trying to pinpoint the smell "what is it, what is it? Oh yeah I knew it was Neutrogena soap."

From helping establish Neutrogena in its role as a pioneer in bonafide skincare, to creating a cult following, to works of art, the "Amber Bar," has certainly come a long way.

Neutrogena

Sunday, 7 June 2009

Alyria Intense Wrinkle Correction/Strivectin SD Comparison

Alyria Intense Wrinkle Correction/Strivectin SD Comparison

In a recent article in the Journal of Cosmetic Dermatology there was a comparative study of efficacy between Alyria Intense Wrinkle Correction and Strivectin.

Alyria Intense Wrinkle Correction contains peptides which have been shown in the laboratory to produce collagen, elastin and hyaluronic acid.

Results showed greater visible improvement in the appearance of crow's feet and wrinkles, including less number, less area, and less depth in the subjects who used Alyria Intense Wrinkle Correction then those who used Strivectin.

Monday, 22 June 2009

La Roche-Posay Toleriane Soothing Protective Skincare Facial Cream Effectiveness

La Roche-Posay Toleriane Soothing Protective Skincare Facial Cream exhibited excellent tolerance tested on 512 patients with soothing and protective effects on all symptoms of intolerant skin (erythema/stinging and burning/tightness).

Saturday, 6 June 2009

La Roche-Posay Active C Study

In double blind clinical study.

This is a testing procedure designed to eliminate biased results in which the identity of those receiving a test treatment is concealed from both administrators and subjects until after the study is completed.

Friday, 10 July 2009

Decrease Wrinkles

Topical application of human growth factors, particularly Transforming Growth Factor, to photodamaged skin has been shown to thicken the epidermis, stimulate and protect new collagen production to decrease wrinkles [see Human Fibroblast Conditioned Media].

Friday, 5 June 2009

La Roche-Posay Introduction to Corrective Make-up

Teaching patients how to better conceal their scars or their skin conditions, for an improved quality of life.

Friday, 5 June 2009

La Roche-Posay Psychotherapeutic Help

Psychotherapeutic help is often essential to cope with the psychological aspect of skin conditions.

Sunday, 7 June 2009

La Roche-Posay Dermatological Wrap

This moisturizing and softening treatment for people suffering from acute dry skin conditions consists of applying La Roche-Posay Lipikar Baume cream and an occlusive film.

Friday, 5 June 2009

La Roche-Posay Functional Rehabilitation

Functional rehabilitation is arranged by a rehabilitation doctor in the city.

Sunday, 7 June 2009

La Roche-Posay Massages

Massages soften scars and other skin irregularities.

They can be performed on dry skin or with La Roche-Posay Thermal Spring Water and are performed by physiotherapist masseurs.

Tuesday, 16 June 2009

La Roche-Posay Pharmaceutical Product Range — Introduction

The mission of the La Roche-Posay laboratory is to provide dermatologists with hygiene, care and make-up products necessary to improve the effectiveness of prescribed treatments and patients' quality of life.

All the products contain La Roche-Posay Thermal Spring Water, the only thermal water to contain selenium with anti-free radical properties.

They benefit from the latest technological innovations and, in particular, patented active ingredients developed from cutting-edge fundamental scientific research.

The effectiveness of La Roche-Posay skin care products has been proven through clinical studies.

Thanks to a purified formulation, the products ensure maximum tolerance, tested on skins with disorders.

Formulated, made and tested according to the rigorous criteria of the pharmaceutical industry and sold in 38 countries, La Roche-Posay products accompany patients throughout the world for a better management of their skin disorders.

Sunday, 7 June 2009

La Roche-Posay Everyday Drink

In addition to the treatments, the La Roche-Posay Thermal Spring Water everyday drink cure is an essential therapeutic element.

Sunday, 7 June 2009

La Roche-Posay Baths

Simple or Jacuzzi-style La Roche-Posay Thermal Spring Water Baths, either local or general, have a decongesting and relaxing action.

Sunday, 7 June 2009

La Roche-Posay Pulverizations

Fine jets of pressurized La Roche-Posay Thermal Spring Water administered locally or over the entire body.

Pulverizations leave a calcium silicate dressing on the skin.

This treatment is particularly pleasant and soothing.

Sunday, 7 June 2009

La Roche-Posay Filiform Shower

The very first cure treatment is a high-pressure filiform shower of La Roche-Posay Thermal Spring Water.

It can be in the form of a light effleurage, a toning percussion that stimulates blood circulation or an exfoliation of the upper layers of the epidermis.

Friday, 5 June 2009

Immunomodulatory Effect of La Roche-Posay Thermal Spring Water

La Roche-Posay Thermal Spring Water slows down the stimulation of T lymphocytes, white corpuscles responsible for immune responses, provoked by Langerhans cells, which protect the skin's immune system.

Monday, 22 June 2009

Anti-Inflammatory Effect of La Roche-Posay Thermal Spring Water

The anti-inflammatory effect of La Roche-Posay Thermal Spring Water is translated by the in vitro reduction in the production of three keratinocyte cytokine molecules that carry signs of inflammation, and under the effect of UV aggression.

Additional reference: Selenium Inhibits Skin-Damaging UV-Induced Inflammatory Cytokines.

Monday, 15 June 2009

Anti-Irritant Effect of La Roche-Posay Thermal Spring Water

The anti-irritant effect is demonstrated in vivo by applying a gel containing La Roche-Posay Thermal Spring Water on the skin of healthy volunteers.

On top of this gel, a sodium lauryl sulfate irritant solution is applied under occlusion for 24 hours.

Monday, 22 June 2009

La Roche-Posay, Vienne, France

La Roche-Posay, Vienne, France

La Roche-Posay is a small town in the Vienne region, located on the borders of Berry, Touraine and Poitou.


La Roche-Posay is home to spring water that is very rich in selenium, a trace element with numerous therapeutic and dermatological benefits.

Legend has it that in the Middle Ages, the knight Bertrand Du Guesclin stopped near the spring to let his horse drink and to quench his own thirst.

The horse, who suffered from eczema, plunged into the water and came out cured…

The renown of the therapeutic qualities of La Roche-Posay thermal spring water continued to grow in the centuries to come.

In the 17th century, Pierre Milon, the doctor of Louis XIII, went to La Roche-Posay to analyze the water for the very first time. The newly-founded Académie des Sciences, sent researchers there from 1670.

At the beginning of the 19th century, Napoleon, upon his return from Egypt, had a thermal hospital built at La Roche-Posay to treat the skin diseases of his soldiers.

A notary writes about the spring in 1573

On Thursday, 13 August 1573, it was at La Roche-Posay where I bathed and drink the sulfured water of the fountain known as La Boette, that I was cured from a migraine and excruciating pain in my head and my gall from which I had been suffering, as were the majority of the sick people who drank it cured of whatever illnesses afflicted them. Having experienced it myself and seen it in many others, it seemed to me more akin to a miracle than an act of nature.

The reputation of the place reached so far that people were coming from Paris and I saw two to three thousand people there...

La Roche-Posay, Vienne, France Statistics

  • Elevation — 52—139 metres (170—460 feet), Average 73 m/240 ft.
  • Land Area — 35.31 square kilometres (13.63 sq mi).
  • Population — 1,522 (2006)
  • Population Density — 43/square kilometre (110 /square mile).

Monday, 15 June 2009

Anti-Aging, Soothing and Protective Properties of La Roche-Posay Thermal Spring Water

With anti-inflammatory and anti-free radical properties, La Roche-Posay Thermal Spring Water helps treat certain serious inflammatory skin conditions such as rosacea when used as a therapeutic complement.

La Roche-Posay Thermal Spring Water also helps to fight skin aging, and its dermatological benefits are recognized by the highest scientific and medical authorities.

Monday, 22 June 2009

Mineral Content of La Roche-Posay Eau Thermale

La Roche Posay Thermal Spring Water seeps slowly through chalky beds from the Turonian period and is drawn from depths of 30 to 80 metres.

With a low mineral content, La Roche Posay Thermal Spring Water is bicarbonated, calcic, silicated water containing selenium.

Its extraction temperature is 13°.

It has anti-inflammatory, anti-pruriginous, healing and anti-free radical properties.

La Roche Posay Thermal Spring Water lays a silicated calcic dressing on the skin that regenerates it.

This water is an essential component of the La Roche Posay pharmaceutical product range identical to that found at and used at the La Roche-Posay Thermal Dermatology Centre.

Precise Mineral Content of La Roche-Posay Eau Thermale

Bicarbonates — 387 mg/l

Calcium — 149 mg/l

Silicates — 31.6 mg/l

Magnesium — 4.4 mg/l

Selenium — 53 mg/l

Zinc — <5 mg/l

Dry Residue of La Roche-Posay Eau Thermale

Dry residue at 180 C: 595 mg/l

pH of La Roche-Posay Eau Thermale

Neutral pH: 7

Thursday, 4 June 2009

La Roche-Posay Hydraphase Physician Review

"I like to use products that are light enough (elegant and non-greasy) for patient compliance but still occlusive enough to bind with the skin and protect the skin’s lipid barrier. For the face I recommend Hydraphase for moderate dryness and Nutritic for severe dryness. I personally use Lipikar Balm (a fragrance-free emollient rich in shea butter) regularly because I wash my hands all day long when seeing patients."

Dr. Coyle S. Connolly, DO

President of Connolly Skin Care

New Jersey.

Wednesday, 24 June 2009

Biomedic Retinol Cream Physician Review

"I like to use the Biomedic line of La Roche-Posay because it is effective and well tolerated. In my practice, an overwhelming number of patients use products like the Biomedic Retinol 30 and the new Redermic (vitamin C) range to get great results with minimal downtime. These products are a perfect adjunct to all of our surgical procedures!"

Isaac Starker, MD

Board Certified Plastic Surgeon

The Peer Group

Florham Park, New Jersey.

Wednesday, 24 June 2009

La Roche-Posay Redermic Physician Review

"I like to use the Biomedic line of La Roche-Posay because it is effective and well tolerated. In my practice, an overwhelming number of patients use products like the Biomedic Retinol 30 and the new Redermic (vitamin C) range to get great results with minimal downtime. These products are a perfect adjunct to all of our surgical procedures!"

Isaac Starker, MD

Board Certified Plastic Surgeon

The Peer Group

Florham Park, New Jersey.

Wednesday, 26 May 2010

La Roche-Posay Effaclar K Acne Treatment Fluid Physician Review

"I believe in a twice-a-day regimen is key in ensuring that patients take an active role in their treatment. Using a gentle cleanser in the morning followed by an OTC acne treatment product with salicylic acid and then of course sunscreen is a great way to start. I completely trust La Roche-Posay products, like Effaclar K, to help me better control the overall treatment process to manage the acne and minimize any related side effects".

Dr. Alicia Barba, MD.

Board Certified Dermatologist. Miami, FL.

For further information, see the overview of L:a Roche-Posay Effaclar.

Sunday, 7 June 2009

La Roche-Posay Rosaliac Gelée Physician Review

"In my office, I recommend a gentle cleanser like Toleriane or Rosaliac Gelée along with an appropriate moisturizer depending on the patient’s skin type. The La Roche-Posay Thermal Spring Water is also a great addition to any skincare regimen because of it soothing and calming properties."

M. Elena Kendall, MD, P.A.

Miami, FL

Sunday, 7 June 2009

La Roche-Posay Toleriane Dermo Cleanser Physician Review

"In my office, I recommend a gentle cleanser like Toleriane or Rosaliac Gelée along with an appropriate moisturizer depending on the patient’s skin type. The La Roche-Posay Thermal Spring Water is also a great addition to any skincare regimen because of it soothing and calming properties."

M. Elena Kendall, MD, P.A.

Miami, FL

Sunday, 7 June 2009

La Roche-Posay Formulation Guidelines

La Roche-Posay skincare products are non-comedogenic and contain purified ingredients.

The La Roche-Posay Pharmaceutical Laboratory aims to maximize product tolerance and limit secondary effects (irritative, allergic or infectious).

Each La Roche-Posay product is formulated with water from the La Roche-Posay warm springs.

Raw materials are selected on the basis of:

  • Stringent criteria relative to innocuousness and the quality of analysis;
  • Knowledge acquired over time.

Products contain as few components as possible, and none that are unnecessary.

They also contain few combinations of active ingredients and avoid complex blends.

Microbiological cleanliness is ensured by choosing hygienic packagings (sterile individual doses, nozzle-end tubes, etc.), selecting preservatives with the highest tolerance levels for the specific area of product application and excluding jars (the jar is not a very hygienic packaging format and requires a high concentration of preservatives).

Microbiological control procedures are carried out at each stage of manufacturing.

As regards the formulas, total transparency is ensured by full labeling.

A "use by" date is indicated on the products.

Thursday, 1 April 2010

Madecassoside

Madecassoside

The pentacyclic triterpenoid glycoside Madecassoside is the latest purified isolate of Centella Asiatica with healthy effects against aging skin, scars, stretch marks and psoriasis.


Centella Asiatica is a pantropical (umbelliferous) plant with a millennium-long medicinal history, used for over 2000 years in India, as shown in Sanscrit manuscripts and, later, in Ayurvedic medicine.

Centella Asiatica appeared relatively late in modern Western medicine, making its entrance in the Codex only in 1884.

The first dry extract was not produced until 1941, three years before the triterpenoids were isolated by Pierre Boiteau, who used it for its soothing and healing properties.

The beneficial properties of the molecules asiatic and madecassic acid, followed by asiaticoside, were discovered first and marketed from 1959 as TECA and are used today in products such as Skinceuticals Epidermal Repair and IS Clinical Body Complex.

Madecassoside was discovered in 1973 but only isolated and purified (at 95%+) in 2003 with advances in separation and purification made possible by new chromatography techniques.

A high level of purity is required to guarantee efficacy and skin tolerance.

Monday, 1 June 2009

New in June from La Roche-Posay

Substiane Eyes

Kerium Anti-Hairloss

Substiane XL

Rosaliac XL Riche

Hydreane Teinte

Effaclar M

Physiological Ultra-Fine Scrub

Monday, 1 June 2009

Sederma Matrixyl "Anti-Wrinkle Effects" Study

Sederma Inc. announced two recent company studies support claims about the anti-wrinkle effect of the non-irritating peptide Matrixyl™.

In the first study, 16 volunteers applied a cream with 3 percent Matrixyl or a cream with 0.07 percent retinol.

Study subjects applied the cream daily for two months and then twice daily for two months.

Both treatments showed similar results in reducing wrinkle depth, wrinkle surface and wrinkle length.

Skin thickness increased by 6.5 percent after two months and 8.6 percent after four months with Matrixyl; retinol increased skin thickness by 4.0 percent after two months and 8.7 percent after four months.

The second study included two groups of 30 volunteers, who used a 5 percent Matrixyl cream or a placebo cream twice daily on face and décolleté for four months.

A 13-percent net decrease in roughness was obtained with Matrixyl after four months, compared to no change with placebo.

In addition, after four months, Matrixyl had a 27-percent improvement in wrinkle mean depth and 36-percent improvement in wrinkle volume.

Monday, 1 June 2009

Matrixyl's Mode of Action

According to Sederma (Sederma.fr), Matrixyl stimulates fibroblasts to synthesize collagen I, collagen IV, fibronectin and glycosaminoglycans, restoring the matrix and epidermal-dermal junction to reduce wrinkles.

Thursday, 28 May 2009

Sun Stick "Moist" SPF 15 Precautions

For external use only.

Avoid contact with eyes.

Should contact occur, flush eyes with cool water.

Discontinue use if irritation develops.

Sunday, 9 August 2009

Ti-Tan Sunless Tanning Lotion Precautions

Wash hands thoroughly after applying, especially knuckles, cuticles and under nails.

Thursday, 28 May 2009

Ti-Silc Scalp Defense SPF 20 Precautions

For external use only.

Avoid contact with eyes.

Should contact occur, flush eyes with cool water.

Discontinue use if rash develops.

Do not use on children under six months of age.

In case of accidental ingestion, seek professional assistance or contact a Poison Control Center immediately.

Thursday, 28 May 2009

Z-Silc SPF 30 Precautions

For external use only.

Avoid contact with eyes.

Should contact occur, flush eyes with cool water.

Discontinue use if rash develops.

Do not use on children under six months of age.

In case of accidental ingestion, seek professional assistance or contact a Poison Control Center immediately.

Thursday, 28 May 2009

Z-Silc Plus SPF 30+ Precautions

For external use only.

Avoid contact with eyes.

Should contact occur, flush eyes with cool water.

Discontinue use if rash develops.

Do not use on children under six months of age.

In case of accidental ingestion, seek professional assistance or contact a Poison Control Center immediately.

Thursday, 28 May 2009

Ti-Silc Untinted SPF 45 Precautions

For external use only.

Avoid contact with eyes.

Should contact occur, flush eyes with cool water.

Discontinue use if rash develops.

Do not use on children under six months of age.

In case of accidental ingestion, seek professional assistance or contact a Poison Control Center immediately.

Thursday, 28 May 2009

Ti-Silc Sheer SPF 45 Precautions

For external use only.

Avoid contact with eyes.

Should contact occur, flush eyes with cool water.

Discontinue use if rash develops.

Do not use on children under six months of age.

In case of accidental ingestion, seek professional assistance or contact a Poison Control Center immediately.

Thursday, 28 May 2009

Ti-Silc GT Sunblock SPF 60+ Precautions

For external use only.

Avoid contact with eyes.

Should contact occur, flush eyes with cool water.

Discontinue use if rash develops.

Do not use on children under six months of age.

In case of accidental ingestion, seek professional assistance or contact a Poison Control Center immediately.

Monday, 25 May 2009

Replenix Retinol Plus Smoothing Serum 10X Warnings

For external use only.

Avoid contact with eyes and mucous membranes.

If you get product in the eyes, rinse thoroughly with water.

If irritation develops, discontinue use and consult your physician.

Keep out of reach of children.

Use of this product during pregnancy is not recommended.

Consult your physician before use if you are pregnant.

Monday, 25 May 2009

Replenix Retinol Plus Smoothing Serum 5X Warnings

For external use only.

Avoid contact with eyes and mucous membranes.

If you get product in the eyes, rinse thoroughly with water.

If irritation develops, discontinue use and consult your physician.

Keep out of reach of children.

Use of this product during pregnancy is not recommended.

Consult your physician before use if you are pregnant.

Monday, 25 May 2009

Replenix Retinol Plus Smoothing Serum 3X Warnings

For external use only.

Avoid contact with eyes and mucous membranes.

If you get product in the eyes, rinse thoroughly with water.

If irritation develops, discontinue use and consult your physician.

Keep out of reach of children.

Use of this product during pregnancy is not recommended.

Consult your physician before use if you are pregnant.

Monday, 25 May 2009

Replenix Retinol Plus Smoothing Serum 2X Warnings

For external use only.

Avoid contact with eyes and mucous membranes.

If you get product in the eyes, rinse thoroughly with water.

If irritation develops, discontinue use and consult your physician.

Keep out of reach of children.

Use of this product during pregnancy is not recommended.

Consult your physician before use if you are pregnant.

Sunday, 24 May 2009

Replenix Anti-Photoaging Sunscreen SPF 45 — Ectoin Content

The findings of a recent in-vitro study suggest that the combination of antioxidants Bisabolol and Ectoin may ''inhibit relevant cellular oxidative damage occurring during carcinogenesis and aging in the human skin,'' meaning your skin will be incredibly well protected.

Thursday, 21 May 2009

Is NIA 24™ Suitable for People with Rosacea?

Is NIA 24™ Suitable for People with Rosacea?

Are NIA 24™ products suitable for people with rosacea?

Yes.

While no clinical trials have been published using NIA 24™ products to treat rosacea, individuals with rosacea have reported reduced redness with use of the NIA 24™ products.

Thursday, 21 May 2009

Simultaneous Use of NIA 24™ and IPL

Simultaneous Use of NIA 24™ and IPL

Is it safe to use the NIA 24™ products while undergoing Intense Pulse Light (IPL) treatment?

Yes.

It is safe to use the NIA 24™ products both before and after IPL treatment.

Pre-treatment usage is best 30 days prior to IPL but any amount of usage will provide benefit.

Post-treatment protocol recommends abstaining from use of the Physical Cleansing Scrub for 2-3 weeks as the skin barrier can become quite compromised during IPL treatment.

A clinical study examining this combination was completed in January 2006 and will be available for review on the NIA 24™ website in the summer of 2006.

Thursday, 21 May 2009

Does NIA 24™ Affect Oral Supplements?

Does NIA 24™ Affect Oral Supplements?

Does the Niacin in the NIA 24™ products affect the Niacin that I am taking in a multi-vitamin or B complex vitamin?

The bioavailability and metabolic pathways are different for vitamins which are applied topically versus those administered orally.

Because the NIA 24™ products are topically applied, the absorption of Pro-Niacin™ into the cells is localized primarily to the skin.

In addition, there should be no concern about Niacin toxicity because Niacin is water-soluble and doses found in multi-vitamins or in B-complex are typically low.

Thursday, 21 May 2009

Time to Results

Time to Results

When can I expect to see results from using the NIA 24™ products?

Improvements in tone, texture and brightness can usually be seen within the first several weeks, though individual results may vary.

Depending on the degree of sun damage, improvements in sun damage and hyperpigmentation can take up to six months.

Thursday, 21 May 2009

Allergy Testing

Allergy Testing

What does "allergy tested" mean?

All NIA 24™ Skin Therapy products have been tested on humans in a controlled laboratory study under exaggerated circumstances to confirm their safety.

In formulating the NIA 24™ products, no ingredients known to cause allergic reactions were used.

Thursday, 21 May 2009

Nut Allergies

Nut Allergies

Can an individual take the NIA 24™ products if they have an allergy to nuts?

The Physical Cleansing Scrub contains Macadamia Seed Oil.

The Skin Strengthening Complex contains Walnut Seed Extract.

Individuals with an allergy to nuts may experience an adverse reaction to either of these products; therefore, it is recommended to consult their physician prior to using these products.

Friday, 26 June 2009

Chemical vs. Physical

Chemical vs. Physical

What is the difference between the "chemical" and "physical" applications?

NIA 24™ offers both a physical scrub and a physical sunscreen.

In a physical scrub, exfoliation is achieved through some type of particle (walnut shells, apricot pits, etc.).

They allow you to control the degree of exfoliation based on manual manipulation, therefore, tend to be less irritating and drying.

Thursday, 21 May 2009

Non-Comedogenicity

Non-Comedogenicity

What does "non-comedogenic" mean?

Non-comedogenic means that the product does not block pores or induce skin breakout causing white heads and/or black heads.

Each of the NIA 24™ products has been tested and was found to be non-comedogenic.

Tuesday, 23 June 2009

Benefits of Fragrance-Free Formulation

Benefits of Fragrance-Free Formulation

What are the benefits of "fragrance free" products?

Many customers feel that added fragrance can irritate skin; therefore, NIA 24™ products contain no added fragrance.

The slight aroma that you may detect in the products is the natural aroma of the ingredients themselves.

Thursday, 21 May 2009

Fragrance, Colour and Dye

Fragrance, Colour and Dye

Why are the NIA 24™ products fragrance, color and dye free?

Many customers feel that fragrance, color and dye additives are unnecessary ingredients and can irritate the skin.

Thus, the NIA 24™ products do not contain added colors, fragrances or dyes.

Thursday, 21 May 2009

pH Level of NIA 24™ Products

pH Level of NIA 24™ Products

What are the pH levels of the NIA 24™ products?

Physical Cleansing Scrub: 6.0 — 6.6

Skin Strengthening Complex: 6.0 — 7.0

Sun Damage Prevention 100% Mineral Sunscreen: Not Applicable

Tuesday, 23 June 2009

Mineral Oil and Petroleum

Mineral Oil and Petroleum

Do any of the NIA 24™ products contain mineral oil or petroleum?

No.

None of the NIA 24™ products contains mineral oil or petroleum.

Thursday, 21 May 2009

NIA 24™ and Skin Thickness

NIA 24™ and Skin Thickness

If the NIA 24™ products increase the skin barrier, does this mean that my skin will appear thicker?

Increasing the skin barrier means that the very thin layer of skin cells on the top of the skin are increased, but the difference in skin barrier thickness will not be visible to the eye.

An enhanced barrier means better skin structure, which will produce a positive visible difference in the texture and tone of the skin.

Thursday, 21 May 2009

Using a Single NIA 24™ Product for Benefit

Using a Single NIA 24™ Product for Benefit

Can you benefit from using only one of the NIA 24™ products? If so, which should you use?

The NIA 24™ products are multi-functional, providing specific benefits from each product.

Thus, a combination is best.

However, all products contain the Pro-Niacin™ molecule and delivery of this molecule is the primary benefit of all of the NIA 24™ products.

If an individual is only interested in purchasing one product, the Skin Strengthening Complex is recommended because it is a leave-on treatment that contains 5% of the Pro-Niacin™ molecule and can be used twice daily.

Thursday, 21 May 2009

Simultaneous Use of NIA 24™ and Vitamin C Serums

Simultaneous Use of NIA 24™ and Vitamin C Serums

Can Vitamin C serums be used with the NIA 24™ products?

Yes.

You can layer a Vitamin C serum underneath the Skin Strengthening Complex or Sun Damage Prevention 100% Mineral Sunscreen SPF 30 because of the consistency of serums versus moisturizers and creams.

However, when using NIA 24™ products in conjunction with other non-prescribed products, NIA 24™ products should be applied first because of their very efficient penetration properties and to ensure maximum efficacy.

Thursday, 21 May 2009

Antioxidant Content of NIA 24™ Products

Antioxidant Content of NIA 24™ Products

Do the NIA 24™ products contain antioxidants?

Yes. In addition to the powerful antioxidant benefits of Pro-Niacin™, the Skin Strengthening Complex also contains Wheat Germ Oil, Retinyl Palmitate, Green Tea and Rosemary extracts. The Sun Damage Prevention 100% Mineral Sunscreen SPF 30 and Physical Cleansing Scrub both contain Vitamin E.

Thursday, 21 May 2009

Simultaneous Use of NIA 24™ and Statins

Simultaneous Use of NIA 24™ and Statins

Can the NIA 24™ products be used with Lipitor® or other statin drugs?

There are no known drug interactions between Niacin and statins.

The FDA has approved a regime that includes combining Niaspan® (Niacin extended-release tablets), indicated for the treatment of cholesterol, and Lovistatin (a generic cholesterol lowering drug) which are both oral medications. Using the NIA 24™ products should therefore, be safe.

If an individual experiences flushing, this may be due to a weak stratum corneum, rather than a drug interaction. In this case, it is recommended that you gradually introduce the NIA 24™ products to your daily skin care regimen over the course of 10 days and this should relieve the problem.

Lipitor® is a registered trademark of Pfizer, Inc., Niaspan® is a registered trademark of Kos Pharmaceuticals.]

Thursday, 21 May 2009

Simultaneous Use of NIA 24™ and Hydroquinone

Simultaneous Use of NIA 24™ and Hydroquinone

Can the NIA 24™ products be used with hydroquinones?

Yes. Patients have seen successful results using NIA 24 ™ in combination with hydroquinone.

However, because of the very efficient penetration properties of the Pro-Niacin™molecule, it's important to remember to apply the NIA 24™ products first, waiting several minutes prior to applying hydroquinone to ensure maximum efficacy of the Pro-Niacin™ molecule and to avoid irritation.

Thursday, 21 May 2009

Simultaneous Use of NIA 24™ and Retinol

Simultaneous Use of NIA 24™ and Retinol

Can the NIA 24™ products be used with tretinoins such as Retin A®/Renova®?

Yes. Patients have seen successful results using the NIA 24™ products in combination with tretinoins and have found that the efficacy of the NIA 24™ products enables them to reduce the dosage of the prescription drug, while still achieving the same result and minimizing irritation.

Apply the NIA 24™ products after application of the tretinoin therapy at night and the NIA 24™ products alone in the morning to ensure 24-hour delivery of the Pro-Niacin™ molecule.

Thursday, 21 May 2009

Use of NIA 24™ on Open Wounds

Use of NIA 24™ on Open Wounds

Can you use NIA 24™ with open wounds?

NIA 24™ products are topical skin care products to be used once a patient has started the healing process and are not to be ingested or used on open wounds.

Release of leptin has been shown to improve wound healing but studies conducted on NIA 24™ products and actual wound healing have not been conducted.

Thursday, 21 May 2009

NIA 24™ and Chemotherapy/Radiation

NIA 24™ and Chemotherapy/Radiation

Can you use the NIA 24™ products if you are using chemotherapy or radiation?

Clinical studies have not been conducted on patients undergoing chemotherapy or radiation while using the NIA 24™ products.

Patients undergoing such treatments are recommended to refer to their oncologists/physicians prior to using the NIA 24™ products.

Thursday, 21 May 2009

NIA 24™ and Ultrasound

NIA 24™ and Ultrasound

Can I use the NIA 24™ products in conjunction with ultrasound?

Because of the chemical structure of the Pro-Niacin™ molecule, a continuous delivery system of Niacin to the skin is already built in - allowing penetration of the molecule through the epidermis at a slow, continuous rate that is optimal for avoiding vasodilation and providing a continuous supply of NAD to living skin cells below.

Therefore, ultrasound is not needed to provide better penetration of the Pro-Niacin™ molecule.

Use of ultrasound with the NIA 24™ products could result in faster residence times and hyperabsorption of the Pro-Niacin™ molecule and result in vasodilation or skin irritation and therefore, is not recommended.

Thursday, 21 May 2009

Shelf Life of NIA 24™ Products

Shelf Life of NIA 24™ Products

What is the shelf life of the NIA 24™ products?

The shelf life of the Physical Cleansing Scrub and the Skin Strengthening Complex is 3 years.

The Sun Damage Prevention 100% Mineral Sunscreen SPF 30 has a 2-year expiration date because of its classification as an over-the-counter (OTC) drug.

Thursday, 21 May 2009

Safety of NIA 24™ During Pregnancy and Breastfeeding

Safety of NIA 24™ During Pregnancy and Breastfeeding

Can I use the NIA 24™ products while pregnant or breastfeeding?

Although the products have been tested rigorously for safety, use of the NIA 24™ products during pregnancy or while breastfeeding is left to the discretion of your physician.

Thursday, 21 May 2009

Can NIA 24™ Remove Brown Spots?

Can NIA 24™ Remove Brown Spots?

Will the NIA 24™ products help remove brown spots?

Yes.

Clinical trials have demonstrated that the Pro-Niacin™ molecule helps to reduce the appearance of hyperpigmentation.

Thursday, 21 May 2009

Will NIA 24™ Cause Blushing or Redness?

Will NIA 24™ Cause Blushing or Redness?

Will the NIA 24™ products cause blushing or redness?

In some individuals, applying the NIA 24™ products to the skin may initially create a warm sensation that can accelerate into mild blushing or even red, itchy skin.

If this happens, apply a cold compress to soothe the skin.

The redness and itchiness should subside within several hours.

To limit the effects of a first blush, it is recommended that you gradually introduce the NIA 24™ products to your daily skin care regimen over the course of 10 days.

Thursday, 21 May 2009

Does NIA 24™ Help Treat Acne?

Does NIA 24™ Help Treat Acne?

Will the NIA 24™ products help with acne/blemished skin?

No.

The NIA 24™ products are not intended as acne treatment products.

However, with promotion of a healthier, stronger skin barrier, bacteria cannot invade as easily and blemishes aggravated by bacteria can be improved (clinical trials not yet conducted on anti-bacterial effects).

Thursday, 21 May 2009

Can NIA 24™ Cause Breakouts?

Can NIA 24™ Cause Breakouts?

Will the NIA 24™ products cause my skin to break out?

NIA 24™ products are non-comedogenic; however, increased NAD within the skin cells can initially cause excess sebum production in some individuals.

To limit the effects of a breakout, it is recommended that you gradually introduce the NIA 24™ products to your daily skin care regimen over the course of 10 days.

Thursday, 21 May 2009

Is NIA 24™ Suitable for Acne-Prone Skin?

Is NIA 24™ Suitable for Acne-Prone Skin?

Will the NIA 24™ products clog pores and/or aggravate acne?

No.

The NIA 24™ products were tested and found to be non-comedogenic, which as stated by the FDA, means that the products do not contain common pore-clogging ingredients that could lead to acne.

Thursday, 21 May 2009

Is NIA 24™ Suitable for Oily Skin?

Is NIA 24™ Suitable for Oily Skin?

Can I use the NIA 24™ products if I have oily skin?

Yes.

You may find that strengthening the skin barrier with the NIA 24™ products may help to control oil production. Each product also has additional individual benefits for oily skin.

The Physical Cleansing Scrub helps remove dead skin cells that can clog pores and create blemishes.

The Skin Strengthening Complex helps moisturize and nourish the skin, as even oily skin needs hydration or moisturization.

The Sun Damage Prevention 100% Mineral Sunscreen SPF 30 is an oil-free formula that provides natural sunscreen protection from harmful UVA/UVB rays.

Sunday, 9 August 2009

Is NIA 24™ Suitable for Sensitive Skin?

Is NIA 24™ Suitable for Sensitive Skin?

Are the NIA 24™ products suitable for sensitive skin?

Yes.

NIA 24™ products do not contain added fragrances, colors or dyes which can be potential irritants.

The Sun Damage Prevention 100% Mineral Sunscreen SPF 30 is also oil and PABA-free and is a physical sunscreen which causes less irritation than chemical sunscreens to sensitive skin.

Monday, 22 June 2009

Does NIA 24™ Skin Care Cause Dryness?

Does NIA 24™ Skin Care Cause Dryness?

Will the NIA 24™ products cause dryness?

The skin barrier's ability to retain moisture and resist damage can make the surface of the skin feel dry.

To limit the effects of dryness, use a humectant or additional moisturizer to help hold water on top of the skin, applying the NIA 24™ products first.

Thursday, 21 May 2009

Using NIA 24™ on Dry Skin

Using NIA 24™ on Dry Skin

Which NIA 24™ products can I use if I have dry skin?

All NIA 24™ Skin Therapy products can be used with dry skin.

In fact, the Physical Cleansing Scrub is a physical scrub that can be less irritating than chemical exfoliants to dry skin that is red and irritated.

Furthermore, the natural sunscreens in the Sun Damage Prevention 100% Mineral Sunscreen SPF 30 are also known to be less irritating than chemical sunscreens to dry skin.

Thursday, 21 May 2009

NIA 24™ Around the Eyes

NIA 24™ Around the Eyes

Can the NIA 24™ products be used around the eye (orbital) area?

Yes.

Application of the Skin Strengthening Complex and Sun Damage Prevention 100% Mineral Sunscreen SPF 30 can be extended to the orbital bone.

However, as with all products, avoid eye contact.

Thursday, 21 May 2009

NIA 24™ for Body Use

NIA 24™ for Body Use

Can I use the NIA 24™ products for other areas of the body?

Yes.

NIA 24™ products are ideal for use on areas of the face, neck, chest and hands.

Thursday, 21 May 2009

Compatability of NIA 24™ with Foundations

Compatability of NIA 24™ with Foundations

Are NIA 24™ products compatible with most foundations?

Yes.

Apply the Skin Strengthening Complex and/or Sun Damage Prevention 100% Mineral Sunscreen SPF 30 first and allow several minutes for the products to absorb prior to make-up application.

Thursday, 21 May 2009

Using Additional Moisturizer with NIA 24™

Using Additional Moisturizer with NIA 24™

Can I use an additional moisturizer with the NIA 24™ products? If, so which should I use first?

Yes. While the Skin Strengthening Complex is an excellent moisturizer, some individuals may require more intensive moisturization.

Apply the Skin Strengthening Complex first to ensure maximum efficacy of the Pro-Niacin™ molecule, then follow with your desired moisturizer.

Thursday, 21 May 2009

Layering NIA 24™ Sun Damage Prevention 100% Mineral Sunscreen SPF

Layering NIA 24™ Sun Damage Prevention 100% Mineral Sunscreen SPF

Can I layer the NIA 24™ Sun Damage Prevention 100% Mineral Sunscreen SPF 30 with the NIA 24™ Skin Strengthening Complex and if so, which product should I use first?

Yes, NIA 24™ products can be layered. Apply the Skin Strengthening Complex first, followed by the Sun Damage Prevention 100% Mineral Sunscreen SPF 30 to ensure that the sunscreen benefits are not diluted.

Allow several minutes for the SPF 30 to be absorbed prior to make-up application.

By layering the NIA 24™ Skin Strengthening Complex along with the NIA 24™ Sun Damage Prevention 100% Mineral Sunscreen SPF 30, will I be getting too much Pro-Niacin™, the active ingredient?

No. The extensive clinical and safety testing conducted on the Pro-Niacin™ molecule and NIA 24™ products have shown no unexpected side effects or reactions.

Instead, clinical studies have shown dramatic improvements in skin health with use of the NIA 24™ products.

Thursday, 21 May 2009

NIA 24™ for Atopic Skin

NIA 24™ for Atopic Skin

How does Pro-Niacin™ assist in improving atopic skin?

Pro-Niacin™ has been clinically proven to strengthen the skin barrier through increasing the content of NAD within the skin cells and generating the growth and maturation of healthy skin cells from the inside-out.

A stronger skin barrier improves atopic skin by providing better protection against environmental toxins, bacteria, etc. from aggravating the living skin cells beneath.

Wednesday, 28 July 2010

Nicotinamide Extends Replicative Lifespan of Human Cells

We found that an ongoing application of nicotinamide to normal human fibroblasts not only attenuated expression of the aging phenotype but also increased their replicative lifespan, causing a greater than 1.6-fold increase in the number of population doublings.

Although nicotinamide by itself does not act as an antioxidant, the cells cultured in the presence of nicotinamide exhibited reduced levels of reactive oxygen species (ROS) and oxidative damage products associated with cellular senescence, and a decelerated telomere shortening rate without a detectable increase in telomerase activity.

Furthermore, in the treated cells growing beyond the original Hayflick limit, the levels of p53, p21WAF1, and phospho-Rb proteins were similar to those in actively proliferating cells.

The nicotinamide treatment caused a decrease in ATP levels, which was stably maintained until the delayed senescence point.

Nicotinamide-treated cells also maintained high mitochondrial membrane potential but a lower respiration rate and superoxide anion level.

Taken together, in contrast to its demonstrated pro-aging effect in yeast, nicotinamide extends the lifespan of human fibroblasts, possibly through reduction in mitochondrial activity and ROS production.

Department of Life Science, University of Seoul, Dongdaemungu, Jeonnongdong, Seoul, Korea.

Kang HT, Lee HI, Hwang ES.

Sunday, 7 June 2009

Topical Niacinamide Reduces Yellowing, Wrinkling, Red Blotchiness and Hyperpigmented Spots in Aging Facial Skin

Previous clinical testing of topical niacinamide (vitamin B3) has revealed a broad array of improvements in the appearance of aging facial skin.

The study reported here was done to confirm some of those previous observations and to evaluate additional end points such as skin anti-yellowing.

Caucasian female subjects (n = 50, aged 40—60 years) participated in a 12-week, double-blind, placebo-controlled, split-face, left—right randomized clinical study assessing two topical products: moisturizer control product versus the same moisturizer product containing 5% niacinamide.

Niacinamide was well tolerated by the skin and provided significant improvements versus control in end points evaluated previously: fine lines/wrinkles, hyperpigmentation spots, texture, and red blotchiness.

In addition, skin yellowing (sallowness) versus control was significantly improved. The mechanism by which this array of benefits is achieved with niacinamide is discussed.

International Journal of Cosmetic Science 26 (5) , 231—238 doi:10.1111/j.1467-2494.2004.00228.x.

D. L. Bissett, K. Miyamoto, P. Sun, J. Li, C. A. Berge (2004).

Wednesday, 14 October 2009

A Pilot Study Evaluating The Efficacy of Topically Applied Niacin Derivatives for Treatment of Female Pattern Alopecia

Background:

Female pattern alopecia is a common dermatologic condition that manifests after puberty. The only approved drug treatment for this condition is 2% minoxidil for topical application.

Aims:

This pilot study examined the effect of topical application of two niacin derivatives, octyl nicotinate and tetradecyl nicotinate, on hair fullness in female alopecia.

Patients/methods:

Sixty female subjects with Ludwig types I-III female pattern hair loss were evaluated in a double-blinded, placebo-controlled (40 active, 20 placebo) design using standardized 35-mm photographic analyses for assessment of efficacy after 6 months of application.

Results:

The niacin derivatives demonstrated a statistically significant increase in hair fullness (P = 0.04 compared to the placebo).

Conclusion:

Whereas evaluation of hair growth in women is challenging, this 6-month pilot study demonstrated statistically significant increase in hair fullness on blinded 35-mm photographic analysis. Long-term topical application of nicotinic acid derivatives offers promise for providing benefit in female alopecia and warrants further study.

Journal of Cosmetic Dermatology. 4(4):258-261, December 2005.

Draelos, Zoe Diana 1; Jacobson, Elaine L. 2,3; Kim, Hyuntae 2; Kim, Moonsun 2; Jacobson, Myron K 2,3

Thursday, 21 May 2009

Nicotinic Acid vs. Niacinamide

Nicotinic acid has been clinically proven to affect hyperpigmentation reduction pathways through receptors found within skin.

Conversely, niacinamide has not been shown to have such effects.

Nicotinic acid stimulates mechanisms not stimulated by niacinamide.

Source: NIA 24.

Sunday, 9 August 2009

Formulation Compatibility of Myristyl Nicotinate with Drugs Used to Treat Dermatological Conditions Involving an Impaired Skin Barrier

A number of dermatology conditions including skin photodamage, atopic dermatitis, and rosacea involve skin barrier impairment and first line therapies for these conditions including retinoids and steroids further impair skin barrier function.

We have evaluated the compatibility of myristyl nicotinate, an agent that enhances skin barrier function, with drugs used to treat conditions where skin barrier impairment is present including photodamage (retinoic acid), atopic dermatitis (hydrocortisone, triamcinolone acetonide), rosacea (metronidazole), and seborrheic dermatitis (ketoconazole).

Myristyl nicotinate was found to be compatible with each of the drugs examined when formulated together and also was shown to be photocompatible with retinoic acid.

Our results suggest that the combination of myristyl nicotinate with these drugs is a feasible therapeutic development strategy.

Drug development and industrial pharmacy.

2007, vol. 33, no11, pp. 1176-1182 [7 page(s) (article)] (1/4 p.)

Wednesday, 28 July 2010

Topical Myristyl Nicotinate Creams

Topical Myristyl Nicotinate Creams

Nia 24 contains the ester prodrug myristyl nicotinate (MN), a lipophilic nicotinic acid derivative with potential chemopreventive activity.

Upon topical application, myristyl nicotinate penetrates into the epidermis where the agent is cleaved and is converted into nicotinic acid (also known as niacin and nicotinamide).

Nicotinic acid then diffuses into cells where it is converted to nicotinamide adenine dinucleotide (NAD).

NAD may stimulate poly(ADP-ribose) polymerase-1 (PARP-1), enhance skin cell turnover and epidermal differentiation and strengthen skin barrier function.

NAD is a coenzyme that plays a crucial role in many redox reactions.

PARP-1 is an enzyme that plays an important role in DNA repair.

Thursday, 21 May 2009

Analysis and Stability Study of Myristyl Nicotinate in Dermatological Preparations by High-Performance Liquid Chromatography

Myristyl nicotinate is an ester prodrug under development for delivery of nicotinic acid to skin for treatment and prevention of conditions that involve skin barrier impairment such as chronic photodamage and atopic dermatitis or for mitigating skin barrier impairment that results from therapy such as retinoids or steroids.

The formulation stability of myristyl nicotinate is crucial because even small amounts of free nicotinic acid cause skin flushing, an effect that is not harmful but would severely limit tolerability.

We report here reversed-phase HPLC methods for the rapid analysis of myristyl nicotinate and nicotinic acid in dermatological preparations [see NIA 24].

Because of the large differences in polarity, myristyl nicotinate and nicotinic acid were analyzed by different chromatographic conditions, but they can be rapidly extracted from cream formulations using HPLC mobile phase as a solvent followed by HPLC analysis in less than 10 min.

The methods were validated in terms of linearity, precision and accuracy and mean recovery of myristyl nicotinate from topical creams ranged from 97.0-101.2%. Nicotinic acid at levels of 0.01% in the formulations could be quantified.

Stability studies show that myristyl nicotinate formulations are stable at room temperature for 3 years with less than 0.05% conversion to nicotinic acid. These methods will be effective for routine analysis of myristyl nicotinate stability in dermatological formulations [see NIA 24].

J Pharm Biomed Anal. 2007 Feb 19;43(3):893-9. Epub 2006 Oct 16.

Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.

Tashtoush BM, Qasem J, Williams JD, DeWald TP, Jacobson EL, Jacobson MK.

Wednesday, 28 July 2010

Simultaneous Determination of Myristyl Nicotinate, Nicotinic Acid and Nicotinamide in Rabbit Plasma by Liquid Chromatography—Tandem Mass Spectrometry Using Methyl Ethyl Ketone as a Deproteinization Solvent

Myristyl nicotinate (Nia-114) is an ester prodrug being developed for delivery of nicotinic acid (NIC) into the skin for prevention of actinic keratosis and its progression to skin cancer.

To facilitate dermal studies of Nia-114, a novel liquid chromatography—tandem mass spectrometry (LC—MS/MS) method using methyl ethyl ketone (MEK) as a deproteinization solvent was developed and validated for the simultaneous determination of Nia-114, NIC, and nicotinamide (NAM) in rabbit plasma.

NAM is the principal metabolite of NIC, which is also expected to have chemopreventive properties. The analytes were chromatographically separated using a Spherisorb Cyano column under isocratic conditions, and detected by multiple reaction monitoring (MRM) in positive-ion electrospray ionization mode with a run time of 9 min.

The method utilized a plasma sample volume of 0.2 ml and isotope-labeled D4 forms of each analyte as internal standards. The method was linear over the concentration range of 2—1000, 8—1000, and 75—1000 ng/ml, for Nia-114, NIC, and NAM, respectively.

The intra- and inter-day assay accuracy and precision were within ±15% for all analytes at low, medium, and high quality control standard levels.

The relatively high value for the lower limit of quantitation (LLOQ) of NAM was demonstrated to be due to the high level of endogenous NAM in the rabbit plasma (about 350 ng/ml). Endogenous levels of NIC and NAM in human, dog, rat, and mouse plasma were also determined, and mean values ranged from <2 ng/ml NIC and 38.3 ng/ml NAM in human, to 233 ng/ml NIC and 622 ng/ml NAM in mouse. Nia-114 was generally unstable in rabbit plasma, as evidenced by loss of 44—50% at room temperature by 2 h, and loss of 64—70% upon storage at ?20 °C for 1 week, whereas it was stable (<7% loss) upon storage at ?80 °C for 1 month.

Journal of Chromatography.

Volume 829, Issues 1-2, 27 December 2005, Pages 123-135

Paul Catza, Walter Shinna, Izet M. Kapetanovicb, Hyuntae Kimc, Moonsun Kimc, Elaine L. Jacobsonc, Myron K. Jacobsonc and Carol E. Greena, ,

a Toxicology and Metabolism Laboratory, SRI International, 333 Ravenswood Ave. Menlo Park, CA 94025, USA

b Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, Executive Plaza North, Room 2116, 6130 Executive Blvd., Bethesda, MD 20892-7322, USA

c Department of Pharmacology and Toxicology, College of Pharmacy and Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA

Wednesday, 28 July 2010

Study: Topical Myristyl Nicotinate Cream on the Skin of Healthy Volunteers

University of Arizona

National Cancer Institute (NCI)

ClinicalTrials.gov Identifier: NCT00619060


Chemoprevention is the use of certain drugs to keep cancer from forming.

The use of topical myristyl nicotinate cream may stop skin cancer from forming.

This randomized phase I trial is studying the side effects and best way to give topical myristyl nicotinate cream on the skin of healthy volunteers.

Study placed in the following topic categories:

Antimetabolites

Vasodilator Agents

Niacinamide

Vitamin B Complex

Skin Diseases

Antilipemic Agents

Trace Elements

Healthy

Cardiovascular Agents

Skin Neoplasms

Nicotinamide

Nicotinic Acids

Vitamin B3

Vitamins

Micronutrients

Nicotinic Acid

Niacin

Wednesday, 28 July 2010

The Mechanisms of Action of Nicotinamide and Zinc in Inflammatory Skin Disease

Nicotinamide (niacinamide), a physiologically active form of niacin (nicotinic acid), in combination with zinc is being assessed in clinical studies for the treatment of inflammatory skin diseases such as acne vulgaris and bullous pemphigoid.

The basis for these investigations is the variety of potential mechanisms of action of nicotinamide and zinc, including an anti-inflammatory effect via inhibition of leukocyte chemotaxis, lysosomal enzyme release, lymphocytic transformation, mast cell degranulation, bacteriostatic effect against Propionibacterium acnes, inhibition of vasoactive amines, preservation of intracellular coenzyme homeostasis, and decreased sebum production.

Other possible mechanisms involve suppression of vascular permeability and inflammatory cell accumulation, as well as protection against DNA damage.

The goal of this paper is to review the pathophysiology of inflammatory skin diseases and discuss the role, mechanisms of action, and safety of nicotinamide and zinc as therapeutic options for these disorders.

Cutis. 2006 Jan;77(1 Suppl):5-10.

Fivenson DP.

Wednesday, 28 July 2010

Nicotinic Acid/Niacinamide and The Skin

Nicotinic acid (also generally known as niacin) and niacinamide (also known as nicotinamide) are similarly effective as a vitamin because they can be converted into each other within the organism.

The blanket term vitamin B(3) is used for both.

Niacinamide is a component of important coenzymes involved in hydrogen transfer.

Here, the two codehydrogenases, nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) are of central importance.

Topical application of niacinamide has a stabilizing effect on epidermal barrier function, seen as a reduction in transepidermal water loss and an improvement in the moisture content of the horny layer.

Niacinamide leads to an increase in protein synthesis (e.g. keratin), has a stimulating effect on ceramide synthesis, speeds up the differentiation of keratinocytes, and raises intracellular NADP levels.

In ageing skin, topical application of niacinamide improves the surface structure, smoothes out wrinkles and inhibits photocarcinogenesis.

It is possible to demonstrate anti-inflammatory effects in acne, rosacea and nitrogen mustard-induced irritation.

Because of its verifiable beneficial effects, niacinamide would be a suitable component in cosmetic products for use in disorders of epidermal barrier function, for aging skin, for improving pigmentary disorders [hyperpigmentation /hypopigmentation] and for use on skin prone to acne.

Hautklinik am Klinikum der Stadt Karlsruhe, Karlsruhe, Germany.

Gehring W.

Wednesday, 20 May 2009

Nicotinic Acid: An Unjustly Neglected Remedy

In human organism, the administration of nicotinic acid (niacin) leads to two types of effects.

Within the physiological range (approximately = 20 mg/day), niacin has a vitamin-like role as pellagra preventing factor.

The pharmacological dosage (approximately 0,5-4,5 g/day) substantially influences the plasma lipid and lipoprotein concentrations: decreases VLDL and LDL concentrations, changes the profile of LDL subfractions towards the larger particles as well as particles with lower density; it also profoundly increases the concentration of HDL-C in consequence of elevated concentration of HDL2 subfraction.

Niacin as the only hypolipidemic drug [which] reduces the lipoprotein(a) concentration.

The hypolipidemic mechanism of niacin is different from that of other hypolipidemic drugs.

On the basis of clinically controlled trials (both interventional epidemiological and angiographical), which satisfy the criteria of evidence-based medicine, it is possible to conclude that niacin falls unambiguously into the class of hypolipidemic drugs with proven beneficial effect not only on cardiovascular mortality and morbidity, but also on total mortality.

Therefore, niacin should have an indisputable role in the pharmacological control of dyslipidemias.

With the respect of basic mechanism (inhibition of the lipolysis of adipose tissue) with subsequent decrease in the concentration of free fatty acids and their flux to liver, niacin fulfils the criteria for pathogenetic treatment of atherogenic dyslipidemia in metabolic syndrome.

The prerequisite condition for the niacin treatment is the respect for serious adverse effects and possible health hazards of administration (skin flush, hepatotoxicity and deterioration of glucose homeostasis).

Recently discovered extrahypolipidemic effects of niacin (antioxidative activity, facilitation of reverse cholesterol transport, activation of PPAR-gamma, antithrombotic effects) and the introduction of drug forms with sustained (extended resp.) release of active compound (that minimizes the adverse effects and administration hazards) form together the basis for [the] firm statement that the derivatives of nicotinic acid should be introduced to the clinical practice in Czech Republic.

IV. interní klinika 1. LF UK a VFN, Praha. azak@vfn.cz

Zák A, Zeman M, Vecka M, Tvrzická E.

Wednesday, 20 May 2009

Niacin Skin Test Response in Dyslexia

The niacin skin test reflects a flush and oedema owing to the production of prostaglandin D2 from arachidonic acid.

A diminished response may indicate abnormalities in the phospholipid metabolism, which has been shown in schizophrenia.

There is evidence that dyslexia might also involve phospholipid abnormalities, therefore we examined the skin response in 51 dyslexics and 45 controls.

Four concentrations of aqueous methyl nicotinate were applied topically to the forearm.

Flushing was rated using a seven-point scale at 3 min intervals over 21 min.

Repeated measures ANOVA for the four concentrations across all seven time-points showed no significant effect of subject group, but when analyses were confined to the first 9 min, flushing was reduced in dyslexics.

Significant group differences were also found for the lowest niacin concentration (0.0001M) across six out of seven time-points.

The results indicate a slightly reduced and delayed response to niacin in dyslexia.

Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Oxford, UK. eva.cyhlarova@physiol.ox.ac.uk

Cyhlarova E, Montgomery P, Ross MA, Richardson AJ.

Saturday, 15 August 2009

Impaired Flush Response to Niacin Skin Patch among Schizophrenia Patients and their Nonpsychotic Relatives: The Effect of Genetic Loading

We previously reported familial aggregation in flush response to niacin skin patch among schizophrenia patients and their nonpsychotic relatives.

However, little is known about whether this abnormal skin response is associated with genetic loading for schizophrenia.

This study compared the niacin flush response in subjects from families with only one member affected with schizophrenia (simplex families) with those from families having a sib-pair with schizophrenia (multiplex families).

Subjects were patients with schizophrenia and their nonpsychotic first-degree relatives from simplex families (176 probands, 260 parents, and 80 siblings) and multiplex families (311 probands, 180 parents, and 52 siblings) as well as 94 healthy controls.

Niacin patches of 3 concentrations (0.001M, 0.01M, and 0.1M) were applied to forearm skin, and the flush response was rated at 5, 10, and 15 minutes, respectively, with a 4-point scale.

More attenuated flush response to topical niacin was shown in schizophrenia probands and their relatives from multiplex families than in their counterparts from simplex families, and the differentiation was better revealed using 0.1M concentration of niacin than 0.01M or 0.001M.

For the highest concentration of 0.1M and the longest time lag of 15 minutes, a subgroup of probands (23%), parents (27%), and siblings (19%) still exhibited nonflush response.

Flush response to niacin skin patch is more impaired in schizophrenia patients and their relatives from families with higher genetic loading for schizophrenia, and this finding has implications for future genetic dissection of schizophrenia.

Ju Shan Hospital, Taoyuan, Taiwan.

Chang SS, Liu CM, Lin SH, Hwu HG, Hwang TJ, Liu SK, Hsieh MH, Guo SC, Chen WJ.

Wednesday, 20 May 2009

Protective Effects of B Vitamins and Antioxidants on the Risk of Arsenic-Related Skin Lesions in Bangladesh

BACKGROUND:

An estimated 25-40 million of the 127 million people of Bangladesh have been exposed to high levels of naturally occurring arsenic from drinking groundwater.

The mitigating effects of diet on arsenic-related premalignant skin lesions are largely unknown.

OBJECTIVES:

The purpose of this study was to clarify the effects of the vitamin B group (thiamin, riboflavin, niacin, pyridoxine, and cobalamin) and antioxidants (vitamins A, C, and E) on arsenic-related skin lesions.

METHODS:

We performed a cross-sectional study using baseline data from the Health Effects of Arsenic Longitudinal Study (HEALS), 2000-2002, with individual-level, time-weighted measures of arsenic exposure from drinking water.

A total of 14,828 individuals meeting a set of eligibility criteria were identified among 65,876 users of all 5,996 tube wells in the 25-km(2) area of Araihazar, Bangladesh; 11,746 were recruited into the study.

This analysis is based on 10,628 subjects (90.5%) with nonmissing dietary data.

Skin lesions were identified according to a structured clinical protocol during screening and confirmed with further clinical review.

RESULTS:

Riboflavin, pyridoxine, folic acid, and vitamins A, C, and E significantly modified risk of arsenic-related skin lesions.

The deleterious effect of ingested arsenic, at a given exposure level, was significantly reduced (ranging from 46% reduction for pyridoxine to 68% for vitamin C) for persons in the highest quintiles of vitamin intake.

CONCLUSIONS:

Intakes of B-vitamins and antioxidants, at doses greater than the current recommended daily amounts for the country, may reduce the risk of arsenic-related skin lesions in Bangladesh.

Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.

Zablotska LB, Chen Y, Graziano JH, Parvez F, van Geen A, Howe GR, Ahsan H.

Monday, 24 August 2009

Niacin and Carcinogenesis

The dietary status of niacin (vitamin B3) has the potential to influence DNA repair, genomic stability, and the immune system, eventually having an impact on cancer risk, as well as the side effects of chemotherapy in the cancer patient.

In addition to its well-known redox functions in energy metabolism, niacin, in the form of NAD, participates in a wide variety of ADP-ribosylation reactions.

Poly(ADP-ribose) is a negatively charged polymer synthesized, predominantly on nuclear proteins, by at least seven different enzymes.

Poly(ADP-ribose) polymerase-1 (PARP-1) is responsible for the majority of polymer synthesis and plays important roles in DNA damage responses, including repair, maintenance of genomic stability, and signaling events for stress responses such as apoptosis.

NAD is also used in the synthesis of mono(ADP-ribose), often on G proteins, with poorly understood roles in signal transduction.

Last, NAD and NADP are required for the synthesis of cyclic ADP-ribose and nicotinic acid adenine dinucleotide (NAADP), two mediators of intracellular calcium signaling pathways.

Disruption of any of these processes has the potential to impair genomic stability and deregulate cell division, leading to enhanced cancer risk.

There are various sources of evidence that niacin status does have an impact on cancer risk, including animal models of leukemogenesis and skin cancer, as well as epidemiological data from human populations.

Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.

Kirkland JB.

Saturday, 15 August 2009

NAD in Skin: Therapeutic Approaches for Niacin

The maintenance and regulation of cellular NAD(P)(H) content and its influence on cell function involves many metabolic pathways, some of which remain poorly understood.

Niacin deficiency in humans, which leads to low NAD status, causes sun sensitivity in skin, indicative of deficiencies in responding to UV damage.

Animal models of niacin deficiency demonstrate genomic instability and increased cancer development in sensitive tissues including skin.

Cell culture models of niacin deficiency have allowed the identification of NAD-dependent signaling events critical in early skin carcinogenesis.

Niacin restriction in immortalized keratinocytes leads to an increased expression and activity of NADPH oxidase resulting in an accumulation of ROS, providing a potential survival mechanism as has been shown to occur in cancer cells.

Niacin deficient keratinocytes are more sensitive to photodamage, as both poly(ADP-ribose) polymerases and sirtuins are inhibited by the unavailability of their substrate, NAD+, leading to unrepaired DNA damage upon photodamage and a subsequent increase in cell death.

Furthermore, the identification of the nicotinic acid receptor in human skin keratinocytes provides a further link to niacin's role as a potential skin cancer prevention agent and suggests the nicotinic acid receptor as a potential target for skin cancer prevention agents.

The new roles for niacin as a modulator of differentiation and photo-immune suppression and niacin status as a critical resistance factor for UV damaged skin cells are reviewed here.

Department of Pharmacology & Toxicology, College of Pharmacy and Arizona Cancer Center, The University of Arizona, Tucson, AZ 85724, USA.

Benavente CA, Jacobson MK, Jacobson EL.

Wednesday, 28 July 2010

Niacin Restriction Upregulates NADPH Oxidase and Reactive Oxygen Species (ROS) in Human Keratinocytes

NAD(+) is a substrate for many enzymes, including poly(ADP-ribose) polymerases and sirtuins, which are involved in fundamental cellular processes including DNA repair, stress responses, signaling, transcription, apoptosis, metabolism, differentiation, chromatin structure, and life span.

Because these molecular processes are important early in cancer development, we developed a model to identify critical NAD-dependent pathways potentially important in early skin carcinogenesis.

Removal of niacin from the cell culture medium allowed control of intracellular NAD.

Unlike many nonimmortalized human cells, HaCaT keratinocytes, which are immortalized and have a mutant p53 and aberrant NF-kB activity, become severely NAD depleted but divide indefinitely under these conditions.

Niacin-deficient HaCaTs develop a decreased growth rate due to an increase in apoptotic cells and an arrest in the G(2)/M phase of the cell cycle.

Long-term survival mechanisms in niacin-deficient HaCats involve accumulation of reactive oxygen species and increased DNA damage.

These alterations result, at least in part, from increased expression and activity of NADPH oxidase, whose downstream effects can be reversed by nicotinamide or NADPH oxidase inhibitors.

Our data support the hypothesis that glutamine is a likely alternative energy source during niacin deficiency and we suggest a model for NADPH generation important in ROS production.

Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA.

Benavente CA, Jacobson EL.

Wednesday, 28 July 2010

A Topical Lipophilic Niacin Derivative Increases NAD, Epidermal Differentiation and Barrier Function in Photodamaged Skin

The effects of myristyl nicotinate (MN), a nicotinic acid derivative designed to deliver nicotinic acid to skin without vasodilatation, on subjects with photodamaged skin have been studied.

Myristyl nicotinate increased skin cell nicotinamide adenine dinucleotide (NAD) by 25% (P = 0.001) demonstrating effective delivery of nicotinic acid to skin.

Relative to placebo, myristyl nicotinate treatment of photodamaged facial skin increased stratum corneum thickness by approximately 70% (P = 0.0001) and increased epidermal thickness by approximately 20% (P = 0.001).

In two separate studies, myristyl nicotinate treatment increased rates of epidermal renewal by 6% (P = 0.003) to 11% (P = 0.001) and increased the minimal erythemal dose by 8.9 (P = 0.07) and 10% (P = 0.05) relative to placebo. M

Myristyl nicotinate treatment resulted in reductions in the rates of transepidermal water loss (TEWL) of approximately 20% relative to placebo on cheeks (P = 0.012) and arms (P = 0.017) of study subjects.

Results of a tape stripping challenge before and after myristyl nicotinate treatment demonstrated a significant correlation (P = 0.03) between increased skin NAD content and resistance to changes in TEWL for myristyl nicotinate treated but not placebo subjects.

Rates of TEWL changed more rapidly and to a greater extent in atopic subjects compared with normal subjects.

The results indicate that myristyl nicotinate enhances epidermal differentiation and barrier function in skin, suggesting that this method of nicotinic acid delivery may prove useful in limiting progression of actinic skin damage and possibly in treating other conditions involving skin barrier impairment.

Department of Pharmacology and Toxicology, College of Pharmacy, Tucson, AZ 85724, USA. elaine.jacobson@pharmacy.arizona.edu

Jacobson EL, Kim H, Kim M, Williams JD, Coyle DL, Coyle WR, Grove G, Rizer RL, Stratton MS, Jacobson MK.

Wednesday, 14 October 2009

Effect of Myristyl Nicotinate on Retinoic Acid Therapy for Facial Photodamage

Based on the hypothesis that skin barrier impairment is a contributor to side-effects associated with retinoic acid therapy, a double-blind, placebo-controlled pilot study examined the combined use of retinoic acid with myristyl nicotinate (MN), a lipophilic derivative of niacin that enhances skin barrier function, in female subjects with mild to moderate facial photodamage.

The study involved a 1-month run-in period with placebo or MN prior to initiation of retinoic acid therapy for 3 months. Analysis of skin biopsies revealed that retinoic acid therapy resulted in stratum corneum thinning of approximately 25% (P = 0.006 versus baseline) that was ameliorated by myristyl nicotinate use (P < 0.005).

Therapy resulted in an increased rate of transepidermal water loss (TEWL) of approximately 45% (P = 0.001 versus baseline) and use of myristyl nicotinate protected against the increase in TEWL with the strongest protection provided by prior use of myristyl nicotinate (P = 0.056 versus placebo).

Myristyl nicotinate use reduced the incidence of side-effects of the therapy and again prior use provided the greatest reduction of side-effects.

Subjects showed statistically significant clinical improvement (P < 0.05 versus baseline) during the study.

Myristyl nicotinate use did not interfere with any clinical improvement parameters and improved effects on temple laxity (P = 0.01 versus placebo).

Analysis of changes in epidermal thickness, Ki67-positive cells and intensity of loricrin staining demonstrated that MN either improved or did not interfere with retinoic acid efficacy.

These results show that prior and concurrent use of myristyl nicotinate can mitigate barrier impairment and improve the tolerability of retinoic acid therapy for facial photodamage without interfering with efficacy.

Department of Pharmacology & Toxicology, College of Pharmacy, and Arizona Cancer Center, University of Arizona, Niadyne Development Inc.,Tucson, AZ 85724, USA. mjacobson@pharmacy.arizona.edu

Jacobson MK, Kim H, Coyle WR, Kim M, Coyle DL, Rizer RL, Jacobson EL.

Tuesday, 19 May 2009

Revaléskin Replenishing Eye Therapy

Revaléskin Replenishing Eye Therapy

For information on Revaléskin Replenishing Eye Therapy, please see the new skin care and treatment section under RevaleSkin Replenishing Eye Therapy (including RevaleSkin Replenishing Eye Therapy Ingredients and RevaleSkin Replenishing Eye Therapy Instructions for Use).

Revaléskin Replenishing Eye Therapy Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Tuesday, 19 May 2009

Revaléskin Replenishing Eye

Revaléskin Replenishing Eye

One Revaléskin Replenishing Eye treatment product is available.

For further information, including replenishing eye ingredients and replenishing eye instructions for use, please see the main skin care and treatment section at RevaleSkin Replenishing Eye Therapy.

Revaléskin Replenishing Eye Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Tuesday, 19 May 2009

Revaléskin Replenishing

Revaléskin Replenishing

One Revaléskin Replenishing product is available, known as RevaleSkin Replenishing Eye Therapy (also see replenishing instructions for use and replenishing ingredients).

Revaléskin Replenishing Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Tuesday, 19 May 2009

Revaléskin Intense Recovery Treatment

Revaléskin Intense Recovery Treatment

One Revaléskin Intense Recovery Treatment is available, for further information, including ingredients and usage instructions, please see the main skin care and treatment section at RevaleSkin Intensive Recovery Therapy.

Revaléskin Intense Recovery Treatment Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Tuesday, 19 May 2009

Revaléskin Intense Recovery

Revaléskin Intense Recovery

One Revaléskin Intense Recovery product is available, known as RevaleSkin Intense Recovery Therapy (also see ingredients and usage instructions).

Revaléskin Intense Recovery Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Tuesday, 19 May 2009

Revaléskin Intense

Revaléskin Intense

One Revaléskin Intense formulation is available, known as RevaleSkin Intense Recovery Therapy.

Revaléskin Intense Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Tuesday, 19 May 2009

Revaléskin Facial Cleanser

Revaléskin Facial Cleanser

One Revaléskin Facial Cleanser is available, for further information, ingredients and usage instructions, please see the new skin care information and notes at RevaleSkin Facial Cleanser.

Revaléskin Facial Cleanser Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Tuesday, 19 May 2009

Revaléskin Eye Therapy

Revaléskin Eye Therapy

For information, usage instructions and ingredients for Revaléskin Eye Therapy, please see the new skin care information and notes at RevaleSkin Replenishing Eye Therapy.

Revaléskin Eye Therapy Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Tuesday, 19 May 2009

Revaléskin Eye Cream

Revaléskin Eye Cream

One Revaléskin Eye Cream is available, known as RevaleSkin Replenishing Eye Therapy.

Revaléskin Eye Cream Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Tuesday, 19 May 2009

Revaléskin Eye

Revaléskin Eye

One Revaléskin eye formulation is available overviewed under RevaleSkin Replenishing Eye Therapy.

Revaléskin Eye Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Tuesday, 19 May 2009

Revaléskin Ingredients

Revaléskin Ingredients

For Revaléskin ingredients see Revaleskin Ingredients.

Revaléskin Ingredients Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Tuesday, 19 May 2009

Buy Revaléskin

Buy Revaléskin

To buy Revaléskin, please see the relevant product sections: RevaleSkin Facial Cleanser, RevaleSkin Replenishing Eye Therapy, RevaleSkin Intense Recovery Therapy, Revaleskin Day Cream SPF 15 and RevaleSkin Night Cream.

Buy Revaléskin Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Tuesday, 19 May 2009

Revaléskin Review

Revaléskin Review

For Revaléskin reviews please see http://www.derm.net.au/discussions/.

Revaléskin Review Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Tuesday, 19 May 2009

Revaléskin Products

Revaléskin Products

For an overview of the Revaléskin products and their primary active ingredients and moisturizing ingredients, please see the main skin care section on Revaléskin.

Revaléskin Products Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Tuesday, 19 May 2009

Revaléskin Facial

Revaléskin Facial

For information on the Revaléskin Facial protocols, please contact Melbourne Dermatology.

Revaléskin Facial Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Tuesday, 19 May 2009

Revaléskin Coffeeberry Night

Revaléskin Coffeeberry Night

For information on Revaléskin Coffeeberry, please see the new skin care and treatment section for RevaleSkin Night Cream.

Revaléskin Coffeeberry Night Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Tuesday, 19 May 2009

Revaléskin Reviews

Revaléskin Reviews

For Revaléskin reviews please see http://www.derm.net.au/discussions/.

Revaléskin Reviews Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Tuesday, 19 May 2009

Revaléskin Cleanser

Revaléskin Cleanser

One Revaléskin Cleanser is available — please see the new skin care and treatment section at RevaleSkin Facial Cleanser.

Revaléskin Cleanser Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Tuesday, 19 May 2009

Revaléskin Care

Revaléskin Care

For further information on Revaléskin care, please see the RevaleSkin ORAC Antioxidant Comparison and RevaleSkin Video.

Revaléskin Care Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Tuesday, 19 May 2009

Revaléskin Coffeeberry Night Cream

Revaléskin Coffeeberry Night Cream

One Revaléskin Coffeeberry Night Cream is available, for further information, or to purchase, please see the new main skin care and treatment section at Revaleskin Night Cream.

Revaléskin Coffeeberry Night Cream Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Tuesday, 19 May 2009

Revaléskin Night Cream

Revaléskin Night Cream

For information or to purchase Revaléskin Night Cream, please see the new main skin care and treatment section at RevaleSkin Night Cream.

Revaléskin Night Cream Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Tuesday, 19 May 2009

Revaléskin Night

Revaléskin Night

Three Revaléskin night use products are available: RevaleSkin Intense Recovery Therapy, Revaleskin Replenishing Eye Therapy and Revaleskin Night Cream.

Revaléskin Night Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Tuesday, 19 May 2009

Revaléskin Day Cream

Revaléskin Day Cream

Two Revaléskin day creams are available: RevaleSkin Day Cream and Revaleskin Day Cream SPF 15.

Revaléskin Day Cream Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Tuesday, 19 May 2009

Revaléskin Day

Revaléskin Day

Four Revaléskin day use products are available — RevaleSkin Intense Recovery Therapy, RevaleSkin Day Cream, RevaleSkin Day Cream SPF 15 and RevaleSkin Replenishing Eye Therapy.

Revaléskin Day Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Tuesday, 19 May 2009

Revaléskin Coffeeberry

Revaléskin Coffeeberry

Revaléskin Coffeeberry is available in all RevaleSkin skin care products.

The highest concentration of Revaléskin Coffeeberry is found in RevaleSkin Intense Recovery Therapy at 1.5%.

Revaléskin Coffeeberry Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Monday, 20 July 2009

Revaléskin Cream

Revaléskin Cream

Three Revaléskin Cream are available — RevaleSkin Day Cream, RevaleSkin Day Cream SPF 15 and RevaleSkin Night Cream.

Revaléskin Cream Further General Information

See the skin care section on Revaleskin by Stiefel and Coffeeberry.

A RevaleSkin ORAC Antioxidant Comparison and Video are also available.

See the skin care products and topics for coffeeberry.

Coffeeberry is available in products from Revaleskin (Stiefel) and Priori.

For a listing of ingredients used, see Revaleskin Ingredients.

Monday, 11 May 2009

Bull Frog Quick Gel SPF 36 Warnings

Bull Frog Quick Gel SPF 36 is for external use only.

When using Bull Frog Quick Gel SPF 36 keep out of eyes. Rinse with water to remove.

Stop use and ask a doctor if rash or irritation develops and lasts.

Flammable.

Keep away from fire or flame.

Keep Bull Frog Quick Gel SPF 36 and similar products of reach of children.

If swallowed, get medical help or contact a Poison Control Center right away.

Bull Frog Quick Gel SPF 36 Warnings — Storage/Handling

Store in a cool, dry place in tightly closed container.

If empty, do not reuse this container. Place in rubbish, or offer for recycling.

If partly filled, call you local solid waste agency or 1-800-Cleanup for disposal instructions.

Never place unused product down any indoor or outdoor drain.

Monday, 11 May 2009

Bull Frog Quick Gel Sport Spray SPF 36 Warnings

Bull Frog Quick Gel Sport Spray SPF 36 is for external use only.

When using Bull Frog Quick Gel Sport Spray SPF 36 keep out of eyes. Rinse with water to remove.

Stop use and ask a doctor if rash or irritation develops and lasts.

Flammable.

Keep away from fire or flame.

Keep Bull Frog Quick Gel Sport Spray SPF 36 out of reach of children.

If swallowed, get medical help or contact a Poison Control Center right away.

Bull Frog Quick Gel Sport Spray SPF 36 Warnings — Storage/Handling

Store in a cool, dry place in tightly closed container.

If empty, do not reuse this container. Place in rubbish, or offer for recycling.

If partly filled, call you local solid waste agency or 1-800-Cleanup for disposal instructions.

Never place unused product down any indoor or outdoor drain.

Monday, 11 May 2009

Bull Frog Mosquito Coast SPF 30 Warnings

Bull Frog Mosquito Coast SPF 30 is for external use only.

Bull Frog Mosquito Coast SPF 30 can cause moderate eye irritation — do not get in eyes.

Use on children under 6 months of age only with the advice of a physician.

Bull Frog Mosquito Coast SPF 30 is flammable. Keep away from fire.

If swallowed, get medical help or contact a Poison Control Center right away.

Bull Frog Mosquito Coast SPF 30 Warnings — Storage/Handling

Store in a cool, dry place in tightly closed container.

If empty, do not reuse this container. Place in rubbish, or offer for recycling.

If partly filled, call you local solid waste agency or 1-800-Cleanup for disposal instructions.

Never place unused product down any indoor or outdoor drain.

Monday, 11 May 2009

B. Kamins Maple Treatment Hand Cream SPF 20 Warnings

B. Kamins Maple Treatment Hand Cream SPF 20 is for external use only.

Avoid contact with eyes.

Discontinue use of B. Kamins Maple Treatment Hand Cream if signs of irritation appear.

Keep out of children's reach.

Sunday, 10 May 2009

B. Kamins Maple Sugar Body Scrub Common Sense Caution

Do not use B. Kamins Maple Sugar Body Scrub on face or around eye area.

Be aware of slippery shower or bath surface.

Friday, 8 May 2009

DCL High Potency C Scape Serum Cautions

For external use only.

Keep out of reach of children.

Avoid contact with eyes.

If irritation develops, discontinue use.

Friday, 8 May 2009

DCL AHA Revitalizing Lotion 20 Cautions

For external use only.

Keep out of the reach of children.

Avoid contact with eyes or mucous membranes.

A mild, transient tingling may occur in people with sentitive skin.

If irritation develops, discontinue use.

Friday, 8 May 2009

DCL AHA Revitalizing Lotion 15 Cautions

For external use only.

Keep out of the reach of children.

Avoid contact with eyes or mucous membranes.

A mild, transient tingling may occur in people with sentitive skin.

If irritation develops, discontinue use.

Friday, 8 May 2009

DCL AHA Revitalizing Lotion 10 Cautions

For external use only.

Keep out of the reach of children.

Avoid contact with eyes or mucous membranes.

A mild, transient tingling may occur in people with sentitive skin.

If irritation develops, discontinue use.

Friday, 8 May 2009

DCL AHA Revitalizing Gel 15 Cautions

For external use only.

Keep out of the reach of children.

Avoid contact with eyes or mucous membranes.

A mild, transient tingling may occur in people with sentitive skin.

If irritation develops, discontinue use.

Thursday, 7 May 2009

Additional Introductory Clarisonic Information

The average person spends on 20 seconds cleansing daily.

Clarisonic is clinically proven to eliminate six times the dirt, debris and makeup of manual cleansing.

Clarisonic targets and alleviates excessive oil, patchiness, imperfections and discoloration while refining pore size and leaving skin soft and smooth.

The Clarisonic system cleanses and exfoliates skin thoroughly by penetrating areas of the skin that manual cleansing methods just can’t reach.

With Clarisonic, you're able to achieve the clearer, healthier skin of which you've always dreamed.

Thursday, 7 May 2009

How does Mexoryl SX Work?

MEXORYL™ SX protects the skin by absorbing the energy of the sun’s short UVA rays.

MEXORYL™ SX acts as a normal filter, but becomes highly energized by absorbing the energy of a UV photon.

MEXORYL™ SX protects against UVA photons penetrating your skin, deactivates and releases the absorbed energy to the environment as harmless energy, then repeats the process over and over.

Thursday, 7 May 2009

Benefits of Mexoryl SX

When UVA and UVB inorganic protective filters were first introduced using cosmetically acceptable concentrations, they provided minimal protection against UVA rays.

Though the UVA ray filter molecule Avobenzone (Parsol 1789) was approved for drug store and apothecary use in 1992, it has been discovered that Avobenzone (Parsol 1789) degrades when exposed to the sun, thereby reducing its UVA protection efficacy.

MEXORYL™ SX is photostable on its own and is the most effective approved organic filter designed to protect against short UVA rays.

Formulations containing MEXORYL™ SX and L’Oreal’s patented photostable association of Octocrylene and Avobenzone provide complete broad spectrum UV protection, with a high level of protection across the UVA spectrum — particularly short UVA rays in the range of UVA 320-340nm.

Thursday, 7 May 2009

What is Photostability?

Photostability means the ability to stabilize under sunlight.

The process of photostability is a key factor in sunscreen protection efficacy.

High photostability means the sunscreen will maintain a higher UVA protective barrier, which is important because sunscreen users typically apply less sunscreen than recommended, less frequently than recommended.

A single daily application of sunscreen, which is the usual practice for facial skin care, is unlikely to provide substantial actual protection against photodamage (photoaging).

Sunscreens containing Mexoryl exhibit exceptionally high photostability and are especially recommended.

Thursday, 7 May 2009

What is Mexoryl SX?

MEXORYL™ SX is the most effective FDA-approved organic filter designed to protect against short UVA rays (maximum absorption at 344nm) with high photostability, a key factor in sunscreen protection efficacy.

This high photostability means the sunscreen will maintain a higher UVA protective ability longer and not degrade as quickly as other FDA approved UVA filters such as avobenzone when exposed to the sun.

Wednesday, 11 November 2009

Anthelios 60 Sunscreens

Anthelios 60 Sunscreens

Three new Anthelios Sunscreens have been released by La Roche Posay.


Specifically formulated for outdoor use, Anthelios 60 sunscreens provide unprecedented non-whitening protection against UVA radiation (PFA 26) — the radiation primarily responsible for premature skin aging and sun allergies and against which traditional non-whitening sunscreens provide only very short-lived protection.

Anthelios 60 sunscreens include a new photoprotective technology, "Cell-Ox Shield" comprising an antioxidant complex derived from Senna Alata, a tropical leaf extract proven to help defend skin cells against UV.

Anthelios 60 sunscreens provide the highest level of consistent protection against UVA radiation responsible for premature skin aging and sun allergies (photoallergy).

Anthelios 60 Ultra-Light Sunscreen Fluid

Anthelios 60 Ultra-Light Sunscreen Fluid

Anthelios 60 Ultra-Light Sunscreen Fluid is a new matte-finish sunscreen for facial use, especially suited to normal combination skin, for outdoor/beach use. It is especially beneficial for those extremely prone to hyperpigmentation (dark spots).

Anthelios 60 Ultra-Light Sunscreen Fluid features the same light, non-greasy, non-whitening and rapidly absorbed texture as Anthelios 15 but with quadruple the SPF.

The Complete Anthelios 60 Sunscreen Formulas

Anthelios 60 Ultra-Light Sunscreen Fluid — for normal to combination facial skin, provides a matte finish.

Anthelios 60 Melt-In Sunscreen Lotion — for normal to dry facial skin, provides a sheer finish.

Anthelios 60 Melt-In Sunscreen Milk — for normal to dry face and body skin, provides a velvety finish.

Further Information

For further information and an overview of all Anthelios Sunscreens, refer Anthelios.

Saturday, 2 May 2009

Difference Between Dermatix and Dermatix Ultra Gels

What a is the difference between Dermatix Gel and Dermatix Ultra Gel ?


Dermatix Ultra (Advanced Scar Treatment) Gel contains Vitamin C (as the derivative Tetrahexyldecyl Ascorbate) which helps with healing skin and lightening uneven skin tone which is often an issue with scars.

Regular Dermatix does not contain Vitamin C.

You may also use Scarguard, which some feel is more effective than Dermatix.

I would use Dermatix Ultra Gel in preference to regular (original) Dermatix Gel.

Monday, 3 August 2009

IS Clinical Peptides

IS Clinical Peptides

IS Clinical Vitamin C Serums now contain copper tripeptides in addition to Vitamin C and zinc sulfate for an enhanced smoothing effect on fine lines and wrinkles (when compared with the original formulas).

IS Clinical Vitamin C Serums containg Peptides

IS Clinical Eye Advance+

IS Clinical C & E Serum Advance+

IS Clinical C-15 Serum Advance+

IS Clinical Super Serum Advance+

IS Clinical Pro-Heal Serum Advance+

Tuesday, 28 April 2009

Great Lips Rx Caution

FOR EXTERNAL USE ONLY.

Keep out of reach of children.

Avoid contact with eyes.

A slight tingling sensation is normal when this product is applied.

If excessive irritation develops, discontinue use and consult a physician.

Friday, 2 October 2009

Jan Marini C-ESTA Serum vs. Skinceuticals C E Ferulic

Skinceuticals C E Ferulic     Jan Marini C-ESTA Serum

I was wondering if you could tell me the difference between Jan Marini C-ESTA Serum and Skin Ceuticals C E Ferulic acid?

Plus which one would be better for a younger skin in their early 20's?


Jan Marini C-ESTA Serum contains ascorbyl palmitate and deanol and Skinceuticals C E Ferulic contains ascorbic acid, tocopherol and ferulic acid.

It should be noted that there are some concerns over the safety and suitability of large concentrations of ascorbyl palmitate and deanol.

In recent times, some manufacturers have removed or replaced ascorbyl palmitate from their products.

This includes the "Ester-C" products marketed by Dr. Nicholas Perricone's N.V. Perricone Cosmeceuticals, from which Jan Marini C-ESTA is said to be derived.

Skinceuticals C E Ferulic is a more effective protective product in theory however most people use oxidized versions of Vitamin C products which are useless or possibly harmful.

It was once thought that ascorbyl palmitate was more stable than ascorbic acid, however testing has confirmed that in fact both are inherently prone to considerable oxidation, therefore the claimed shelf-life and superior antioxidant advantage of Jan Marini C-ESTA over Skinceuticals C E Ferulic and similar products may not actually exist.

It is true that Jan Marini C-ESTA Cream is less prone to discolouration (oxidation) when refrigerated so it seems likely it is not stable.

People generally report more immediate skin firming with Jan Marini C-ESTA than Skinceuticals C E Ferulic however long-term firming results are likely to be different.

Skinceuticals C E Ferulic may irritate sensitive skin and stimulate acne in prone individuals while Jan Marini C-ESTA is generally well-tolerated.

If you'd like to try using a Vitamin C product, rather than use either of these, it is better to start with Alyria Antioxidant Capsules, the 10% Vitamin C content of which does not oxidize prior to use by virtue of a combination of formulation and packaging, and which is gentle enough to safely and comfortably test suitability on virtually any skin type or condition.

For additional advice it would be best to ask actual users including specialists at: http://www.derm.net.au/discussions/.


Jan Marini C-ESTA Serum vs. Skinceuticals C E Ferulic

Wednesday, 1 April 2009

Account Login

Thursday, 2 April 2009

Site Upgrades and Updates

Site Upgrades and Updates

Please be advised that due to upgrades required to implement new features, you may experience brief periods of downtime (where pages will not load) not exceeding 15 minutes per three days during April.

Some information, links and ordering functionality may also be temporarily unavailable or will move, although links will not be permanently broken.

If you require new login details as a result of the upgrade process, these will be e-mailed to you in due course.

Upgrades are being made to increase capacity and performance, add support for new features and to accomodate online ordering in additional regions.

Access from some internet service providers and countries including China and Russia will be blocked to help eliminate spam and persistent automated downloading. In these instances access will no longer be available.

We apologize for any inconvenience caused.

Recommended Web Browsers

These latest browsers, released in the last 6 months, provide optimal support and features, however may only function acceptably on faster computers.

Safari 4 — for Windows and Macintosh.

Internet Explorer 8 — for Windows.

Tuesday, 31 March 2009

Vaseline Intensive Rescue Relief and Repair Balm

Combines petrolatum with starch for greater acceptability.

Thursday, 9 July 2009

Skin Care for Dry Body Skin

Skin Care for Dry Body Skin

All body moisturizers are not created equal. Graph compares Vaseline Intensive Rescue Relief and Repair Balm against Aquaphor Ointment, E45 Cream, Neutrogena Comfort Balm and control. Data from Vaseline by Unilever. Efficacy is affected by ingredient and formulation characteristics, as well as the method of use.


The low humidity of cold weather and dry indoor heat (or conventional, non-evaporative air conditioning) can result in dry body skin due to a weakened skin barrier.

In winter, almost everyone has drier skin, particularly where temperatures are lower (and indoor heating more intense).

For those prone to eczema, low humidity can also produce the worst flare-ups.

Optimal body skin hydration results in more healthy, comfortable and also flexible skin, which gives the appearance of greater firmness and elasticity.

If you have dry skin, you can help prevent and limit body skin dryness by making daily use of the following tips:

If dry/itchy skin persists after 1-2 weeks of regular moisturizing, seek medical advice.

Body Washes for Dry Body Skin

La Roche Posay Lipikar Syndet Soap-Free Cleansing Gel

La Roche Posay Lipikar Surgras Body Wash (for extremely dry skin)

Avene Trixera+ Selectiose Emollient Cleansing Gel

Avene Cold Cream Emollient Cleansing Gel

CeraVe Hydrating Cleanser

Ego QV Re-Hydrate Gentle Wash

Bath Oils

Always use a hydrating product in bath water:

Avene Trixera+ Selectiose Emollient Cleansing Bath

La Roche Posay Lipikar Bath Oil

Ego QV Bath Oil

Body Lotions/Creams/Balms for Dry Body Skin

La Roche Posay Lipikar Body Emollient

La Roche Posay Lipikar Body Balm

Avene Akerat

Avene Trixera+ Selectiose Emollient Cream

Avene Trixera+ Selectiose Emollient Balm

Avene Cold Cream Body Lotion

Neostrata NeoCeuticals PDS Regular Strength Cream

Vaseline Intensive Rescue Relief and Repair Balm

CeraVe Hydrating Moisturizing Lotion

CeraVe Hydrating Moisturizing Cream

Skinceuticals Primacy Hydra Balm (extremely dry, hairless skin)

Cetaphil Moisturizing Cream

Supplements for Dry Body Skin

Blackmores Fish Oil

Nordic Naturals Norweigan Fish Oil

Information on Mercury in Fish

See Food Standards Australia and New Zealand.

Sunday, 21 June 2009

Is Skinceuticals Phloretin CF Effective?

Is Skinceuticals Phloretin CF Effective?

Does research indicate if Skinceuticals Phloretin CF works?


As is usually the case, this product has not been tested independently and there is little reported experience in its use.

However the ingredients are thought to be functional antioxidants and this product most likely is better than the majority of products purporting genuinely useful antioxidant effects.

The formula was reported on in Protective Effects of a Topical Antioxidant Mixture Containing Vitamin C, Ferulic Acid and Phloretin Against Ultraviolet-Induced Photodamage in Human Skin.

This antioxidant is not suitable for all skin types and conditions so please check suitability with a bonafide professional before and during use.

Sunday, 26 April 2009

Sodium ascorbyl phosphate and magnesium ascorbyl phosphate are more stable than ascorbyl palmitate

The stability of ascorbyl palmitate, sodium ascorbyl phosphate and magnesium ascorbyl phosphate in topical formulations was investigated by direct reverse phase high performance liquid chromatography after sample dilution with a suitable buffer — organic solvent mixture. Ascorbyl palmitate, sodium ascorbyl phosphate and magnesium ascorbyl phosphate are derivatives of ascorbic acid which differ in hydrolipophilic properties. They are widely used in cosmetic and pharmaceutical preparations. According to the results, ascorbyl esters showed significant differences: sodium ascorbyl phosphate and magnesium ascorbyl phosphate are more stable derivatives of vitamin C than ascorbyl palmitate and may be easily used in cosmetic products.

Reference:

AU: A. I. Segall, M. A. Moyano

TI: Stability of vitamin C derivatives in topical formulations containing lipoic acid, vitamins A and E

SO: International Journal of Cosmetic Science

VL: 30

NO: 6

PG: 453-458

YR: 2008

CP: © 2008 The Authors. Journal compilation. © 2008 Society of Cosmetic Scientists and the SociÈtÈ FranÁaise de CosmÈtologie

ON: 1468-2494

PN: 0142-5463

AD: Ctedra de Control de Calidad de Medicamentos, Facultad de Farmacia y Bioqumica, Universidad de Buenos Aires, Junn 956, 1113 Buenos Aires, Argentina

DOI: 10.1111/j.1468-2494.2008.00473.x

Saturday, 18 July 2009

Ascorbyl palmitate is not significantly effective against inhibiting UVB induced skin erythema

This paper assesses the suitability of UVB induced skin erythema measured by reflectance spectrophotometry in humans as a model for differentiating topical efficacy of free radical scavengers. Two different formulations (aqueous gels and O/W emulsions) of each active compound (tocopherol, tocopherol acetate, superoxide dismutase (SOD), glutathione, ascorbyl palmitate) were tested on healthy human volunteers before and after skin exposure to UVB radiation. Skin erythema was monitored by calculating erythema index values from the skin spectral data obtained using a reflectance spectrophotometer. The free radical scavengers tested were not able to inhibit UVB induced skin erythema from both formulations when they were topically applied before UVB irradiation. Applying the free radical scavenger formulations after skin exposure to UVB radiation, glutathione and SOD showed the best ability in inhibiting the induced erythema (percentage inhibition 53.3 and 41.6%, respectively from gels). Tocopherol and tocopherol acetate inhibited UVB skin erythema by 27% while ascorbyl palmitate showed a poor efficacy. For all the active compounds tested, no significant difference was observed comparing the results obtained from gels to those from emulsions. Liposomal gel formulations containing the free radical scavengers which showed the best activity (SOD and glutathione) were prepared and topically applied after skin exposure to UVB radiation. SOD and glutathione liposomal formulations were more effective than the corresponding conventional gels. The proposed model, if validated by further studies, could be useful for differentiating the effectiveness of free radical scavengers in inhibiting photoaging due to long-term sunlight skin exposure.

Reference:

AU: L. MONTENEGRO, F. BONINA, L. RIGANO, S. GIOGILLI, S. SIRIGU

TI: Protective effect evaluation of free radical scavengers on UVB induced human cutaneous erythema by skin reflectance spectrophotometry

SO: International Journal of Cosmetic Science

VL: 17

NO: 3

PG: 91-103

YR: 1995

ON: 1468-2494

PN: 0142-5463

AD: Institute of Pharmaceutical Chemistry, University of Catania, V. le A. Doria 6, 95125 Catania, Italy and ISPE, via Civerchio 4, 20159, Milano, Italy

DOI: 10.1111/j.1467-2494.1995.tb00113.x

Wednesday, 19 August 2009

Safety of Micronized Zinc Sunscreens

Safety of Micronized Zinc Sunscreens

Lately there has been increased concern that the particles of sunscreens containing micronized zinc oxide ("invisible zinc") penetrate skin, cause free radical damage to cells and lead to alteration of skin's DNA.

Sunscreens containing micronized zinc have been generally preferred over others because they block the greatest gamut of ultraviolet, are less likely to irritate skin, less prone to wearing away during the day, and are markedly less whitening than traditional zinc sunscreens.

The concern that microfine zinc sunscreens could do more harm than good was raised more than a decade ago.

Subsequent studies have shown that micronized zinc can pass through the skin in areas affected by acne, sunburn, eczema or shaving.

Studies have shown that micronized zinc exposed to ultraviolet produces free radical damage.

In light of the growing evidence that micronized zinc may be harmful, and because nanoparticles in sunscreens are not regulated, caution should be exercised when using ultrafine zinc sunscreens.

Studies have shown that micronized zinc coated in dimethicone, a form of silicone used as a primary ingredient in many moisturizers, forms a barrier to help prevent zinc from penetrating skin or reacting with light in ways which can be harmful.

Dimethicone-coated microfine zinc is a proprietary substance more expensive than uncoated zinc and is therefore not available in all sunscreens.

It is also usually unsuitable for application to large areas due to cost.

For daily face, neck, ear and hand protection against photodamage (skin cancer, wrinkles, dark blotches/hyperpigmentation, freckles, leathery skin texture, yellowed colouring and a loss of elasticity), micronized dimethicone zinc sunscreens nevertheless remain the most efficacious.

Recommended Ultrafine Zinc Sunscreens

Contain dimethicone-coated and micronized rather than nanoparticle zinc at a concentration of 8% or higher and are suitable for daily use on the face, neck, hands and ears:

Note: SPF regulation and numbers differ by region. US SPF figures are quoted.

Supplementary Sun Protection

Dietary, supplementary and topically applied antioxidants such as lutein, green tea, zeatin, Heliocare and chlorogenic acid can enhance the protection offered by sunscreens, however should not be used in place of sunscreens.

Wednesday, 11 November 2009

Heliocare News: Sun Protection in a Pill

From Allure Magazine, October 2005.

Even L. Ron Hubbard wouldn’t dispute the merits of these pills — they’re the only oral supplements proven to make skin more resistant to sun damage.

They contain a fern extract called polypodium leucotomos, which, in a 2004 study published in the Journal of the American Academy of Dermatology, was found to significantly reduce the number of sunburned cells in the skin after UV exposure.

A similar product was briefly available online under the name Sun Vitamines.

The extract appears to minimize sun damage by reducing the activity of enzymes that cause collagen breakdown, explains William Eaglstein, president of IVAX Dermatologicals, Heliocare’s distributor.

The effects kick in half an hour after taking a dose. Studies have documented only two and a half hours of sun protection, but the benefits may last much longer.

Salvador Gonzalez, a Harvard University researcher who has studied Heliocare, still advises slathering on broad-spectrum sunscreen for extended or intense exposure to the sun, but says that “when you walk from work to home or engage in basic outdoor activities, the pill would be sufficient.”

“There is strong scientific evidence that this fern extract prevents sunburn as well as the sun damage that leads to both wrinkles and cancer,” says James Spencer, a clinical professor of dermatology at Mount Sinai Hospital in New York City.

We took them on a recent Caribbean vacation, along with our usual potent sunscreen, and didn’t turn even the slightest shade of pink.

Monday, 23 March 2009

Heliocare News: Suntan Pill Might Help Prevent Skin Cancer

Each Year More Than One Million Skin Cancers Are Diagnosed In The United States

While sunscreen has been your best protection against harmful UV rays, some doctors are now saying you may want to add a little pill to your arsenal.

"We call it kind of a photo modulating pill where it gives us added protection but it's all over since we are taking it orally," explains Dr. Angela Bowers, Dermatologist.

Heliocare® is a dietary supplement Europeans have used for years to treat psoriasis and eczema.

It's not FDA regulated, but Harvard researchers have found it increases your skin's tolerance to the sun and provides an anti-oxidant protective effect on skin cells.

"It helps correct that before it damages the DNA," says Dr. Bowers.

"Like most young women I spent a lot of time in sun trying to get tan" says Sandra Brown, Heliocare Consumer.

Sandra Brown tried Heliocare after a skin cancer scare.

"They were basal skin cells, so they were just surface-based cancer cells. I've since had probably seven removed surgically," says Brown.

She takes one pill a day, and she says she can see the difference.

"Usually, even with sunscreen, if I am out in the sun a lot and I don't re-apply I'll get pink or redish. I have spent a couple of days in the sun where I haven't had the opportunity to re-apply sunscreen and I haven't noticed as much pink or red," explains Brown.

Critics argue that a good sunscreen alone should be enough to protect you, but Dr. Bowers disagrees.

"One thing we know in dermatology, that we've actually studied, is that patients never apply enough sunscreen. So when they think they are getting SPF 15 they are probably only getting about an SPF of 5," says Dr. Bowers. Sandra pays about 0.90 cents a pill for Heliocare. She says she'd rather pay it now, than face another cancer scare later.

Dr. Bowers says Heliocare has no known side effects. It can also be taken by children over twelve and is available online and at some health food stores and pharmacies.

Monday, 23 March 2009

PDF: Vitiligo Treatment with UVA and Heliocare

PDF: Vitiligo Treatment with UVA and Heliocare

Monday, 23 March 2009

PDF: Heliocare Inhibits UV-Induced TNF and INOS Expression

PDF: Heliocare Inhibits UV-Induced TNF and INOS Expression

Monday, 23 March 2009

PDF: Photoprotective Properties of Neutraceutical Heliocare Extract

PDF: Photoprotective Properties of Neutraceutical Heliocare Extract

Monday, 23 March 2009

PDF: Photoprotective Properties of Heliocare

PDF: Photoprotective Properties of Heliocare

Monday, 23 March 2009

PDF: Vitiligo Treatment with UVB and Heliocare

PDF: Vitiligo Treatment with UVB and Heliocare

Wednesday, 11 November 2009

Antioxidant Properties of Heliocare and Kojic Acid

The antioxidant action of Polypodium leucotomos extract and kojic acid: reactions with reactive oxygen species.

Gomes AJ, Lunardi CN, Gonzalez S, Tedesco AC.

Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes, 3900, 14040-901 Ribeirão Preto, SP, Brazil.

Two natural products Polypodium leucotomos extract (PL) and kojic acid (KA) were tested for their ability to scavenge reactive oxygen species (.OH,.O2-, H2O2, 1O2) in phosphate buffer.

Hydroxyl radicals were generated by the Fenton reaction, and the rate constants of scavenging were 1.6 x 10(9) M-1 s-1 for KA and 1.0 x 10(9) M-1 s-1 for PL, similar to that of ethanol (1.4 x 10(9) M-1 s-1).

With superoxide anions generated by the xanthine/hypoxanthine system, KA and PL (0.2-1.0 mg/ml) inhibited.O2-dependent reduction of nitroblue tetrazolium by up to 30 and 31%, respectively.

In the detection of 1O2 by rose bengal irradiation, PL at 1.0 mg/ml quenched singlet oxygen by 43% relative to azide and KA by 36%.

The present study demonstrates that PL showed an antioxidant effect, scavenging three of four reactive oxygen species tested here.

Unlike KA, PL did not significantly scavenge hydrogen peroxide.

Wednesday, 11 November 2009

Photoprotective Properties of Heliocare

Photoprotective properties of a hydrophilic extract of the fern Polypodium leucotomos on human skin cells.

Alonso-Lebrero JL, Domínguez-Jiménez C, Tejedor R, Brieva A, Pivel JP.

R&D Department, Industrial Farmaceútica Cantabria S.A., Madrid, Spain.

The effect of a hydrophilic extract of the fern Polypodium leucotomos (PLE) has been investigated in terms of photoprotection against UV-induced cell damage.

PLE efficiently preserved human fibroblast survival and restored their proliferative capability when the cells were exposed to UVA light.

This effect was specific and dose-dependent.

Photoprotection was not restricted to fibroblasts, as demonstrated by its effect on survival and proliferation of the human keratinocyte cell line HaCat.

Finally, treatment of the cells with PLE prevented UV-induced morphological changes in human fibroblasts, namely disorganisation of F-actin-based cytoskeletal structures, coalescence of the tubulin cytoskeleton and mislocalization of adhesion molecules such as cadherins and integrins.

Our in vitro results demonstrate the photoprotective effect of PLE on human cells and support its use in the preventive treatment of sunburning and skin pathologies associated with UV-mediated damage.

Wednesday, 11 November 2009

Heliocare May Limit and Reverse Extrinsic and Intrinsic Elastin Destruction

Predominant effects of Polypodium leucotomos on membrane integrity, lipid peroxidation, and expression of elastin and matrixmetalloproteinase-1 in ultraviolet radiation exposed fibroblasts, and keratinocytes.

Philips N, Smith J, Keller T, Gonzalez S.

Departments of Biology and Chemistry/Biochemistry, Georgian Court College, Lakewood, NJ, USA. philips@georgian.edu

Polypodium leucotomos has been reported to have antioxidant, anti-inflammatory and photoprotective properties.

Exposure of skin to ultraviolet (UV) radiation can lead to deposition of excessive elastotic material, reduction in collagen, and increased expression of matrix metalloproteinases (MMPs).

The goal of this research was to determine the effects of P. leucotomos in the absence or presence of UVA or UVB radiation on membrane damage, lipid peroxidation, and expression of elastin and MMP-1 in fibroblasts and keratinocytes, respectively.

Fibroblasts and keratinocytes, respectively, were irradiated by a single exposure to UVA (0.6, 1.8 or 3.6 J) or UVB radiation (0.75, 2.5 or 7.5 mJ), and then incubated with, or without, P. leucotomos (0.01, 0.1 and 1%) and examined for membrane damage, lipid peroxidation, expression of elastin (protein levels) and MMP-1 (protein levels or MMP-1 promoter activity).

UV radiation did not significantly alter membrane integrity, lipid peroxidation or MMP-1 expression, but increased elastin expression. P. leucotomos significantly improved membrane integrity, inhibited lipid peroxidation, increased elastin expression, and inhibited MMP-1 expression in both fibroblasts, and keratinocytes.

The effects of P. leucotomos predominated in the presence of UVA or UVB in both fibroblasts and keratinocytes, respectively, with the exception of inhibition of MMP-1 protein levels in fibroblasts only in combination with UV radiation.

Lower concentration of P. leucotomos (lower than 0.1%), may be beneficial in preventing photoaging by improving membrane integrity and inhibiting MMP-1, without increasing elastin expression. Higher concentration (greater than 0.1%) of P. leucotomos may reverse the loss of normal elastic fibers associated with intrinsic aging.

Wednesday, 11 November 2009

Heliocare Limits UV-Induced Free Radical Skin Damage

Inhibition of ultraviolet-induced formation of reactive oxygen species, lipid peroxidation, erythema and skin photosensitization by polypodium leucotomos.

González S, Pathak MA.

Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.

The acute reactions of human skin to solar ultraviolet radiation (290-400 nm) are recognized as a form of inflammation reactions that are mediated by several possible mechanisms including (a) direct action of photons on DNA, (b) generation of reactive free radicals and reactive oxygen species involving the formation of O2.-, 1O2, H2O2, OH, etc., (c) generation of prostaglandins (PGD2, PGE2, etc.), histamine, leucotrienes, and other inflammatory mediators.

It is conceivable that UV-induced reactions represent oxidative stress mediated by the formation of free radicals, reactive oxygen, lipid peroxidation, liberation of membrane phospholipids, and subsequent formation of prostaglandins by cyclo-oxygenase pathway.

In this study, we examined the role of reactive oxygen species and lipid peroxidation in in vitro reactions as well as in vivo skin inflammation reactions induced by (a) UVB radiation (290-320 nm), and (b) skin photosensitization reaction by PUVA treatment involving 8-methoxypsoralen and UVA (320-400 nm) radiation and presented data for the generation of superoxide anion O2.-) and lipid peroxides.

We have also evaluated, both in vitro as well as in vivo systems, the quenching or the inhibition of O2.- by a plant extract known as Polypodium leucotomos.

The P. leucotomos extract was found to exhibit interesting antioxidant and anti-inflammatory as well as photoprotective properties against photo-oxidative stress involving the generation of reactive oxygen, lipid peroxidation under in vitro reactions as well as in vivo experimental conditions.

Significant inhibition of UVB-induced erythemal response, and 8-methoxypsoralen plus UVA-induced phototoxic reaction after topical application or oral administration of the photosensitizer could be demonstrated in guinea pig skin and human skin following the topical application of P. leucotomos extract.

The photoprotective mechanism of P.leucotomos involving interaction with reactive oxygen species or free radicals appears to have potential clinical usefulness in preventing sunburn and inhibiting phototoxic reaction.

Wednesday, 11 November 2009

Heliocare Appears to Minimize Photoaging Changes

An extract of Polypodium leucotomos appears to minimize certain photoaging changes in a hairless albino mouse animal model. A pilot study.

Alcaraz MV, Pathak MA, Rius F, Kollias N, González S.

Dept. of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA.

Chronic ultraviolet B (UVB) exposure of human or murine skin is known to induce cutaneous photoaging and enhanced carcinogenic risk.

An extract of Polypodium leucotomos (PL), a tropical fern plant, has been known to exhibit interesting antioxidant and photoprotective properties against acute exposure to ultraviolet radiation.

The objective of this preliminary (or pilot) study was to determine the photoprotective role of topically applied Polypodium leucotomos extract in the prevention or amelioration of cutaneous changes of photoaging in hairless mice.

PL-treated mice showed significant reduction of skinfold thickness than those observed in PL-untreated controls.

Additionally, PL-treated mice showed a significantly lower degree of histologic parameters of photoaging damage, including dermal elastosis, compared with positive control mice.

Interestingly, PL treatment also showed reduction in the number of mice showing skin tumors at 8 weeks after the cessation of the UVB exposure protocol.

The results of this preliminary study illustrate that PL treatment helped to ameliorate and to partially inhibit some of the histologic damage associated with photoaging of skin and appeared to contribute to a decrease in the prevalence of UVB-induced skin tumors in mice.

Wednesday, 11 November 2009

Heliocare Exhibits Anti-Angiogenic Activities In Vivo

An extract of the fern Polypodium leucotomos (Difur) modulates Th1/Th2 cytokines balance in vitro and appears to exhibit anti-angiogenic activities in vivo: pathogenic relationships and therapeutic implications.

Gonzalez S, Alcaraz MV, Cuevas J, Perez M, Jaen P, Alvarez-Mon M, Villarrubia VG.

Wellman Laboratories of Photomedicine, Harvard Medical School, Boston, MA, USA.

In the present study we show the capacity of an extract of the fern Polypodium leucotomos (PLE) [Heliocare] to partially inhibit the production of cytokines showing a Th1 pattern (IL-2, IFN-gamma and TNF-alpha) in human PHA-stimulated peripheral blood mononuclear cells.

The percentage of inhibition was 24% for IL-2, 72% for INF-gamma and 53% for TNF-alpha.

With regard to Th2 cytokines, the addition of PLE resulted in a significant increase (33%) in IL-10 production.

Surprisingly, the production of the inflammatory cytokine IL-6 was completely abolished (100% inhibition) by PLE [Heliocare] at all doses tested. In a second experiment in vivo we show that, the topical application of PLE to the skin of hairless albino mice (Skh-1) significantly diminished the mast cell infiltrate as well as the number of blood vessels triggered by chronic ultraviolet B (UVB) irradiation.

These data show that PLE [Heliocare] moderately inhibits the immunological Th1 responses, thus explaining the immunosuppressive as well as the anti-inflammatory and antioxidant activities reported in other studies carried out with PLE.

The clear inhibitory effect on TFN-alpha and IL-6 production strongly suggest that this may be the mechanism by which PLE: (a) inhibits angiogenesis in vivo in the mouse model described here, and (b) prevents Langerhans' cells depletion caused by solar irradiation in humans.

Taken together, these data suggest that PLE [Heliocare] works through the induction of suppressive/anti-inflammatory cytokines such as IL-10 and/or TGF-beta which in turn appear to allow the partial deactivation of macrophages or other accessory cells.

These features suggest that PLE [Heliocare] could be useful in the treatment of autoaggressive/inflammatory conditions due to an exacerbation of Th1 responses.

Wednesday, 11 November 2009

Heliocare Prevents Sunburn, Phototoxic Reactions and Langerhans Cell Depletion in Human Skin

Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in human skin.

González S, Pathak MA, Cuevas J, Villarrubia VG, Fitzpatrick TB.

Department of Dermatology, Massachusetts General Hospital, Boston 02114, USA.

Sunburn, immune suppression, photoaging, and skin cancers result from uncontrolled overexposure of human skin to solar ultraviolet radiation (UVR).

Preventive measures, including photoprotection, are helpful and can be achieved by topical sunscreening agents.

Polypodium leucotomos (PL) has been used for the treatment of inflammatory diseases and has shown some in vitro and in vivo inmunomodulating properties.

Its beneficial photoprotective effects in the treatment of vitiligo and its antioxidant properties encouraged us to evaluate in vivo the potentially useful photoprotective property of natural extract of PL after topical application or oral ingestion.

Twenty-one healthy volunteers [either untreated or treated with oral psoralens (8-MOP or 5-MOP)] were enrolled in this study and exposed to solar radiation for evaluation of the following clinical parameters: immediate pigment darkening (IPD), minimal erythema dose (MED), minimal melanogenic dose (MMD), and minimal phototoxic dose (MPD) before and after topical or oral administration of PL.

Immunohistochemical assessment of CD1a-expressing epidermal cells were also performed.

PL was found to be photoprotective after topical application as well as oral administration.

PL increased UV dose required for IPD (P < 0.01), MED (P < 0.001) and MPD (P < 0.001).

After oral administration of PL, MED increased 2.8 +/- 0.59 times and MPD increased 2.75 +/- 0.5 and 6.8 +/- 1.3 times depending upon the type of psoralen used.

Immunohistochemical study revealed photoprotection of Langherhans cells by oral as well as topical PL.

The observed photoprotective activities of oral or topical PL reveal a new avenue in examining the potentially useful field of systemic photoprotection and suggests that PL can be used as adjunct treatment and can make photochemotherapy and phototherapy possibly safe and effective when the control of cutaneous phototoxicity to PUVA or UVB is a limiting factor in such phototherapies.

Wednesday, 11 November 2009

Heliocare Decreases UVA Damage of Human Skin

Orally administered Polypodium leucotomos extract decreases psoralen-UVA-induced phototoxicity, pigmentation, and damage of human skin.

Middelkamp-Hup MA, Pathak MA, Parrado C, Garcia-Caballero T, Rius-Díaz F, Fitzpatrick TB, González S.

Wellman Laboratories of Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.

The use of psoralen-UVA (PUVA) in patients of skin phototype I to II is limited by side effects of acute phototoxicity and possible long-term carcinogenesis.

We sought to assess oral Polypodium leucotomos (PL) extract in decreasing PUVA-induced phototoxicity of human skin on a clinical and histologic level.

A total of 10 healthy patients with skin phototypes II to III were exposed to PUVA alone (using 0.6 mg/kg oral 8-methoxypsoralen) and to PUVA with 7.5 mg/kg of oral PL.

Clinically, phototoxicity was always lower in PL-treated skin after 48 to 72 hours (P<.005), and pigmentation was also reduced 4 months later. Histologically, PL-treated skin showed a significant numeric reduction of sunburn cells (P=.05), preservation of Langerhans cells (P< or =.01), decrease of tryptase-positive mast cell infiltration (P<.05), and decrease of vasodilation (P< or =.01). No differences were found in Ki-67+ proliferating cells.

PL is an effective chemophotoprotector against PUVA-induced skin phototoxicity and leads to substantial benefits of skin protection against damaging effects of PUVA as evidenced by histology.

Wednesday, 11 November 2009

Heliocare Decreases UV Damage of Human Skin

Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin

Middelkamp-Hup MA, Pathak MA, Parrado C, Goukassian D, Rius-Díaz F, Mihm MC, Fitzpatrick TB, González S.

Wellman Laboratories of Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

UV radiation induces damage to human skin. Protection of skin by an oral photoprotective agent would have substantial benefits.

We investigated the photoprotective effect of oral administration of an extract of the natural antioxidant Polypodium leucotomos (PL).

A total of 9 healthy participants of skin types II to III were exposed to varying doses of artificial UV radiation without and after oral administration of PL (7.5 mg/kg). At 24 hours after exposure the erythema reaction was assessed and paired biopsy specimens were obtained from PL-treated and untreated skin.

A significant decrease in erythema was found in PL-treated skin (P < .01). Histologically, PL-treated biopsy specimens showed less sunburn cells (P < .05), cyclobutane pyrimidine dimers (P < .001), proliferating epidermal cells (P < .001), and dermal mast cell infiltration (P < .05). A trend toward Langerhans cell preservation was seen.

Oral administration of PL is an effective systemic chemophotoprotective agent leading to significant protection of skin against UV radiation.

Monday, 23 March 2009

Heliocare Research

Importantly, over 12 years of research has confirmed the antioxidant and photoprotectant properties of Heliocare.

Research has shown that the agent is effective when taken in capsule form or used on the skin.

Research has also confirmed that the capsule form has no known harmful side effects.

Oral photoprotection is now the focus of much attention, and has been hailed as the 'photoprotection of the future'.

Monday, 23 March 2009

Extent of Protection from Heliocare

Heliocare works as a potent oral antioxidant. UV [from the sun or from a sun lamp] has many detrimental effects on the skin: it can directly cause DNA damage, and it can create so-called 'reactive oxygen species' (ROS) or 'free radicals'. ROS are high energy molecules that collide with proteins and lipids in the cell and cause direct cellular damage.

This damage is responsible for the effects of UV on skin: premature aging.

Heliocare contains antioxidants which are shown to mop up free radicals before they damage important cellular proteins.

Heliocare is taken daily and is active within half an hour of the first dose (unlike many oral antioxidants which take months to build up sufficient levels).

Also, because Heliocare is taken orally it is effective in protecting cells deep in the skin - topical antioxidants are usually ineffective in protecting cells at this level.

Damage to these deeper cells is responsible for many of the signs of photoaging (e.g. wrinkles).

Monday, 23 March 2009

Heliocare Studies

Studies reveal that the antioxidants in Heliocare work against the harmful effects of ultraviolet radiation to decrease sunburn response, including a significant reduction in the number of ultraviolet induced sunburn cells and DNA damage.

Monday, 23 March 2009

Heliocare's Main Effects

The main effects of Heliocare are to:

  • inhibit the infiltration of mast cells after ultraviolet exposure;
  • protect collagen and elastin by inhibiting the formation of MMPs;
  • protect the epidermal immune system by preserving the cells of Langerhans;
  • protect DNA by inhibiting the formation of thymine dimers.

Monday, 23 March 2009

Heliocare vs. Sunscreen

Heliocare pills are not a substitute for optimal sunscreens and protective clothing.

If used in combination with these products, Heliocare pills will lend added sun protection.

Heliocare is very useful for people with sensitive skin, who have had skin treatments or who wish to lessen photoaging (wrinkles, discoloration or susceptibility to cancer).

Heliocare pills will not reverse sun damage, they will help minimize it.

Wednesday, 16 September 2009

Avene Cold Cream Lip Balm Study

Avene Cold Cream Lip Balm is clinically proven to remain on the lips for up to 8 hours.

8 a.m.

Fluorescence appears immediately after application of Avène Cold Cream Lip Balm.

11 a.m.

Fluorescence of Avène Cold Cream Lip Balm has not changed.

1 p.m.

Slight decrease of fluorescence of Avène Cold Cream Lip Balm after a light meal.

5 p.m.

Slight decrease but persistent good level of protection from Avène Cold Cream Lip Balm.

Avene Cold Cream Lip Balm Study Results:

Evaluation of the cosmetic residual effect of Avene lipstick with cold cream under actual conditions of use.

V. Bosquet, M.T. Borrel, Y. Gall.

Number of volunteers — 5 volunteers.

Inclusion criteria — Volunteers with unbroken skin on the lips or mouth.

Study duration — 8 hours.

Application modalities — A lipophilic markers (stinging nettle extract) incorporated into the lipstick because of its red fluorescence under UVA light; single application of Avène Cold Cream Lip Balm.

Measures carried out — evaluation of duration of residual effect of fluorecent marker observed under UVA light.

Sunday, 22 March 2009

Avene Emollient Soap-Free Cleansing Bar Usage Test (Self-Evaluation)

Usage test (self-evaluation):

60 patients

Use of the balm for 10 days.

Study Results:

Study objective — Evaluation of the repairing effect

Study type — Clinical study

Number of volunteers — 50 volunteers

Study duration — 7 days

Application modalities — 4 applications per day

Measures carried out — Auto assessment of dryness, roughness, rednesses, cracking, pruritus and skin suppleness.

Sunday, 22 March 2009

Avene Cold Cream Body Lotion Efficacy Study

Efficacy study:

32 subjects with dry to very dry body skin.

Application of the cream for 21 days.

Reduction in skin roughness:

Sunday, 22 March 2009

Avene Cold Cream Clinical Evaluation (Results)

Tolerability and acceptability study:

87 subjects with marked skin dryness. Application of the cream for two weeks.

Tolerability:

Tolerability was judged as being good to very good in 95.4% of cases.

Global effectiveness:

Global effectiveness was judged as being satisfactory to very satisfactory in 81% of cases by the investigator.

Tuesday, 24 March 2009

Avene Cicalfate Clinical Results

Guerrero D, Mengeaud V, Verrière F, Nocera T: Efficacy and tolerability of an association with copper, zinc and sucralfate in dermatology. Nouv. Dermatolo. 2002; 21: Suppl. 2:20-23..

Clinically proven effective in the skin recovery process.

A technologically advanced skin restorative cream that helps maintain an optimal healing environment during the skin recovery process. A unique formulation that contains both anti-bacterial and healing properies in one cream.

Saturday, 21 March 2009

Comments from Nu Skin regarding ArNox

"We know that arNOX, which is an internal source of ageing, generates damaging superoxide free radicals at a rate that accelerates as we age... This latest research correlates arNOX activity with an increase in cross links in the skin, leading us to the conclusion that arNOX is indeed a contributor to the breakdown of collagen and elastin, which contributes to the appearance of lines and wrinkles and other signs of aging skin."

Joe Chang, chief scientific officer at Nu Skin.

Monday, 16 January 2012

What is the difference between the Kinerase Core, Pro+ and Clear Skin Collections?

All Kinerase products have been developed to work together to enhance your skin's overall texture and appearance — you do not need to use the products from any one single Kinerase range.

About the Kinerase Core (Original) Collection of Skin Care Products

The Kinerase Core Collection contains kinetin, a plant-based extract found in the blue anemone flower that helps visibly improve the appearance of aging and sun-damaged skin.

About Kinerase Pro+ Therapy

Recently released to complement the Kinerase Core (Original) Collection of products, Kinerase Pro+Therapy contains kinetin as well as zeatin — a next generation plant-based extract derived from plant RNA that is proprietary to Valeant.

The original Kinerase products contain kinetin only.

The advanced treatment options of Kinerase Pro+Therapy are designed to help break topical cosmetic plateaus and take results to the next level.

Pro+Therapy products are only available at dermatologist and plastic surgeon offices.

About Kinerase Clear Skin

Kinerase Clear Skin provides the benefits of kinetin to those with acne-prone, oily skin as well as those with blackheads, open pores and whiteheads.


Wednesday, 19 October 2016 — The preferred regular home treatment for visibly open pores is now available online. Visit the page for MD Rx Melbourne Dermatology Open Pores Overnight Solution for information.


Thursday, 19 March 2009

Does Kinerase cause my skin to be extra sensitive to the sun?

Not for the most part.

Kinerase peels and Kinerase Clear Skin Blemish Dissolver all contain AHAs, which may increase a person's sensitivity to the sun.

Other than the products that contain AHAs, Kinerase products do not cause photo-sensitivity.

However, avoiding sun exposure is highly recommended for those with sun-damaged skin who want to help prevent UV damage.

Kinerase Cream with SPF 30 and Kinerase Lotion with SPF 30 are available and offer the benefits of Kinerase, plus added sun protection.

Thursday, 19 March 2009

Can I use Kinerase on compromised skin?

The following Kinerase products that should not be used on compromised skin:

Thursday, 19 March 2009

Can I use Kinerase in combination with procedures?

Most Kinerase products are ideal to be used pre- and post- procedure (microdermabrasion, chemical peel, Botox) or other treatments because Kinerase is formulated specifically to be effective, yet gentle enough for all skin types.

Kinerase is well tolerated by sensitive skin and can be used by people who cannot tolerate more invasive treatments.

Thursday, 19 March 2009

Do I need a doctor's prescription for Kinerase?

No.

Even though Kinerase is available through many dermatologist and plastic surgeon offices, a prescription is not necessary for the Kinerase products discussed on this web site.

Regular dermatologist appointments are recommended to optimize the overall health of your skin.

Thursday, 19 March 2009

How do I know which Kinerase products are right for me?

Visit the Kinerase Online Regimen Consultant to discover the best Kinerase regimen for your personal skin type.

Thursday, 19 March 2009

About Kinerase Pro+ Therapy

The Kinerase® Pro+Therapy Collection features zeatin—a next generation plant-based technology derived from RNA, available exclusively to the Kinerase Pro+Therapy collection.

Studies have shown that zeatin improves the appearance of fine lines and wrinkles, skin roughness and hyperpigmentation.

Zeatin and kinetin, when used together as part of the Kinerase skin care regimen, have a scientifically significant impact on the appearance of the more severe signs of skin aging.

Kinerase Pro+Therapy products are available exclusively through physicians.

The Kinerase Pro+Therapy Collection—Skin Smoothing Cleanser, Advanced Repair Serum and Ultra Rich Night Repair—are formulated to complement the Kinerase Core Collection.

Thursday, 19 March 2009

How Is Kinerase Pronounced?

Pronounce the long "i" in kin (like kind), plus erase.

An easy way to remember how to pronounce Kinerase is to think, "Kinerase kindly erases the appearance of wrinkles."

Monday, 22 June 2009

What Is Kinerase?

Kinerase is a gentle, yet effective skin care regimen scientifically shown to improve the appearance of skin aging, sun damage, blotchiness and roughness.

The power behind Kinerase is kinetin* — a plant-based extract that helps visibly improve the appearance of aging and sun-damaged skin.

Kinetin is the substance that actually prevents plant leaves from drying out and withering.

Kinerase formulations deliver the remarkable restorative powers of kinetin directly to the skin— improving skin's ability to retain moisture.

The latest innovation from Kinerase is Pro+Therapy.

Designed to work with the core products, Pro+Therapy is available exclusively through physicians.

The Pro+Therapy difference is zeatin  — a next generation plant-based extract derived from plant RNA that is proprietary to Valeant.

The advanced treatment options of Kinerase Pro+Therapy are designed to help break topical cosmetic plateaus and take results to the next level.

Kinerase's complete regimen of products works synergistically to reveal more radiant, visibly tighter skin.

Notes on Kinetin Content in Kinerase Skin Care Products

Kinetin is available in Kinerase Lotion, Cream, Cream with SPF 15, Lotion with SPF 30 and Cream with SPF 30 all of which contain 0.1% kinetin.

Kinerase Intensive Eye Cream, Under Eye Rescue and Lip Treatment contain 0.125% kinetin.

Notes on Kinetin and Zeatin Content in Kinerase Skin Care Products

Kinerase Pro+Therapy Ultra Rich Night Repair and Kinerase Pro+ C8 Peptide Intensive Treatment contain 0.1% zeatin and 0.1% kinetin.

Kinerase Pro+ Therapy Advanced Repair Serum contains 0.1% zeatin.

Thursday, 19 March 2009

Kinerase Pro+ Before and After

Before Kinerase Pro+Therapy and after 8 weeks of twice-daily application of 0.1% zeatin.

Photos were taken using the Canfield Scientific Photography System for maximum consistency in lighting, camera position, and film development.

Before and after photos are not retouched.

Thursday, 19 March 2009

Kinerase Skin Type Suitability

Kinerase is suitable for all skin types (normal, oily, dry amd combinations of these).

Because Kinerase is suitable for sensitive and allergic skin, it is an especially good option for those with sensitive skin, rosacea, compromised or post-procedure skin (please note the exceptions).

The Kinerase Clear Skin Collection is an optimal solution for sensitive, aging skin suffering from acne.

Monday, 22 June 2009

Kinerase's Effects on Skin Moisturization

As your skin ages, its abililty to retain moisture naturally decreases.

Kinerase is scientifically proven to improve skin's ability to retain moisture:

  • 15% more moisture after just 12 weeks;
  • 25% more moisture after just 24 weeks.

Thursday, 19 March 2009

Kinerase Results Chart

Kinerase gives you results you can measure and improvement in the appearance of:

Percentage of participants reporting improvements after 24 weeks of using Kinerase Lotion (0.1% kinetin).

Thursday, 19 March 2009

Kinerase Before and After

Photos were taken using the Canfield Scientific Photography System for maximum consistency in lighting, camera position, and film development.

Before and after photos are not retouched.

Tuesday, 23 June 2009

About Kinerase

The Kinerase, Kinerase Pro+Therapy and Kinerase Clear Skin Collections were developed by Valeant Pharmaceuticals, a company with 20+ years of experience in dermatology.

Kinerase works differently than most skin care brands — it nourishes the skin by delivering important nutrients that moisturize, rejuvenate and protect.

In contrast, some skin care products use ingredients that break down and irritate the skin.

Kinerase products are hypoallergenic, dye-free, non-comedogenic, and fragrance-free, making Kinerase suitable for even the most sensitive skin types.

Thursday, 19 March 2009

Kinerase Pro+ Results Chart

Kinerase Pro+Therapy gives you results you can measure and improvement in the appearance of:

Average % improvement in the visible signs of skin aging.

Expert assessment from a 12-week study of 30 participants with twice daily application of 0.1% zeatin in a cream vehicle.

Monday, 22 June 2009

About Kinetin

Kinetin (N6-furfuryladenine) has been shown to improve the appearance of skin aging with little or no irritation.

Wednesday, 24 June 2009

Zinc Oxide Sunscreens are Usually Superior

Only zinc oxide blocks the full spectrum of UVA and UVB rays while being hypoallergenic.

Sunscreens not containing zinc oxide are not optimally effective against photoaging and skin cancer.

For further information, see:

Wednesday, 18 March 2009

Blue Lizard Pregnancy/Baby Pediatric Sunscreen Poster

Blue Lizard Pregnancy/Baby Pediatric Sunscreen Poster

Wednesday, 18 March 2009

Blue Lizard Chemical Free Sunscreens Poster

Blue Lizard Chemical Free Sunscreens Poster

Wednesday, 18 March 2009

Blue Lizard Sport Sunscreen Poster

Blue Lizard Sport Sunscreen Poster

Tuesday, 24 March 2009

Blue Lizard SPF 30 Regular Sunscreen Poster

Blue Lizard SPF 30 Regular Sunscreen Poster

Note: SPF regulation and numbers differ by region. US SPF figures are quoted.

Wednesday, 18 March 2009

In-Vitro Sunscreen Performance Evaluations

In-Vitro Sunscreen Performance Evaluations

Thursday, 19 March 2009

The Evolution of Sunscreens

Skin cancer is the number one cancer in mankind.

People at risk are primarily Caucasians but even dark skinned individuals have shown an increasing incidence of skin cancer.

There are three main reasons for this phenomenon.

The first can be traced to fair skinned Europeans colonizing areas of the world with higher ultraviolet exposure profile. Whether this is a move to areas that are closer to the equator, or areas that are higher in altitude, being fair skinned definitely predisposes one to a greater chance of skin cancer.

The second major cause is the increase in longevity. Modern medicine has extended the lives of our population and this coupled with many immune suppressive drugs used for arthritis and organ transplants, have led to an explosion of skin cancers.

The third causes the change in habits where bronzed skin is prized and people willingly expose themselves to more ultraviolet radiation in the form of sunbathing or tanning bed exposure.

Four generations ago, our great-grandmothers knew that wearing a bonnet or covering up with long sleeve clothing was vitally important.

They saw people in their communities whose noses, ears or cheeks were literally eaten away by skin cancer before the advent of good local anesthetics.

It's hard to imagine that one severe sunburn before the age of 18 doubles ones lifetime risk of skin cancer but this is unfortunately true. The time from exposure to the consequences of that exposure can be 50 or 60 years.

Recognition of the need to block the ultraviolet spectrum was made in the 1960's and 1970's. Late in the 1960's the first sunscreens appeared. They were crude and not very effective, however, improvements continued to be made. In the 1970's, the labeling of an SPF or sun protection factor was introduced in the United States.

This was then and is still today basically only the parameter to block a very narrow band of ultraviolet radiation, which is ultraviolet-B radiation.

This narrow band of ultraviolet radiation is 290 nanometers to 320 nanometers.

Unfortunately, it is not just ultraviolet-B that caused damage and the evolution of skin cancer.

Early in the 1980's, using mouse studies, it was shown that ultraviolet-B range light is the initiator for most skin cancers. Less notice was taken that the same time it was discovered that ultraviolet-A or those rays between 320 nanometers and 360 nanometers are cancer promoters whereas these were initially studies performed on laboratory mice.

This has been confirmed clinically by the increasing incidence of squamous cell cancer relative to basal cell cancer over the last 50 years. Numerous studies document the increased number of squamous cancers induced in patients receiving ultraviolet-A light for psoriasis (PUVA treatment).

In the 1990's Australia reported that there was a higher incidence of malignant melanoma in persons who use sunscreens when matched to persons who didn't use them. Unfortunately, this was interpreted by the popular press that sunscreens are not needed or might actually cause skin cancer.

Nothing could be farther from the truth.

Many of these sunscreens contained weak ultraviolet-A blockers that are ineffective. Unfortunately there is no numbering system for UVA blockers. Evidence is mounting that the higher incidence of melanoma as well as squamous cell cancers is due to ultraviolet-A exposure.

The 1990's saw improved ultraviolet-A blocker with the introduction of a more effective blocker Parsol. Physicians recommended Parsol to be used by their photosensitive patients, especially patients with diseases such as lupus. Unfortunately, this still was not a very good solution.

It was not until the middle of the 1990's when ultramicronized zinc and titanium oxide was incorporated in many sunscreens.

Unfortunately, these products containing zinc oxide and titanium oxide are still not as cosmetically acceptable as the formulations that do not contain then.

It is also more difficult and less cosmetically acceptable to produce sunscreen that is waterproof or sweat proof but this is highly desirable for people who engage in outdoor activities. This ability to withstand wash off or sweat off is known as substantivity.

Australia is the melanoma and skin cancer capital of the world. This is due to the fact that it was predominately colonized by very fair Brits, Scots and Irish. Different countries have different parameters for defining sunscreen as being waterproof.

The US has a rather lax standard, which is that the ultraviolet-B blocking effectiveness is tested after 30 minutes in standing water.

The Australian standard is far more rigorous and sunscreens must demonstrate their ability to prevent wash off or sweat off after two hours of rapidly moving water.

It is for this reason that American made sunscreens are not sold in Australia.

Our antiquated method of labeling sunscreen measured only by an SPF value is no longer in the best interest of persons who use sunscreen and lulls us into a false sense of security.

The Food and Drug Administration in the United States has not yet revised this standard although the American Academy of Dermatology has urged them to do this for many years.

This policy is probably not in the best interest of Americans as some more reasonable system needs to be adopted, which recognizes the detrimental effects of ultraviolet-A light as a cancer promoter.

Manufacturers of popular sunscreens without zinc or titanium dioxide are not likely to incorporate effective ultraviolet-A blockers until there is either a public outcry or a change in the standards by the Food and Drug Administration.

Chasing the highest number on your sunscreen can no longer be relied upon as a measure of safety.

When possible, persons in the spring, summer and fall should avoid sun activities during the peak hours of sun exposure and those are 10am to 1pm standard time or 11am to 3pm daylight savings time.

Waterproof sunscreens with an SPF of 15 or greater, containing either zinc oxide or titanium oxide should be applied liberally before the body is overheated or water exposure by at least 20 minutes so that they may bind to the skin.

Persons should also wear a hat and cover as much of the body as is reasonable for the planned activity.

Currently the most substantive sunscreen with the broadest range of ultraviolet blocking activity I have been able to find to BLUE LIZARD sunscreen, manufactured by Del-Ray Dermatologicals.

This is the sunscreen which both my family and I use daily.

We encourage our patients to also use this sunscreen.

Thursday, 19 March 2009

Sunscreens and Blue Light Sensitivity

Sunscreens and Blue Light Sensitivity

Wednesday, 18 March 2009

Video: Blue Lizard on ABC News (20/20)

A dermatologist recommends the Blue Lizard Australian Sunscreen SPF 30+, which she uses on her own children, because the formula provides great protection against UVA and UVB rays.

Wednesday, 18 March 2009

Video: Bottle Changes Color — Blue Lizard on the Rachael Ray TV Show

Colby Donaldson demonstrates how the Blue Lizard Australian Sunscreen SPF 30+ bottle turns color on the Rachael Ray TV show.

Wednesday, 18 March 2009

Video: Blue Lizard on WJHL 11 - Tri Cities #2

"85% of sunscreens are inadequate."

Wednesday, 18 March 2009

Video: Blue Lizard on WJHL 11 - Tri Cities #1

"85% of sunscreens are inadequate."

Wednesday, 18 March 2009

Video: Blue Lizard — Dr. Kenneth Macknett

Wednesday, 18 March 2009

Video: Blue Lizard on the Ellen TV Show

Tuesday, 17 March 2009

Prevage MD Patient Information (PDF)

Prevage MD Patient Information (PDF)

Tuesday, 17 March 2009

Photoprotective Effect of Prevage MD Idebenone

In a scientific study, idebenone 1% was shown to slow up the formation of sunburn cells caused by exposure to UV radiation from the sun or tanning salon.

In a laboratory study, idebenone 1% demonstrated the ability to slow up the damage that exposure to UVB causes to keratinocytes, which are the cells that primarily make up the outermost layer of the skin (epidermis).

Sunday, 11 October 2009

Effect of Air Pollution on The Atmosphere and Skin

Air pollution depletes the ozone layer in the atmosphere, allowing harmful UVA/UVB rays from the sun to affect your skin's layers, impairing its ability to repair itself.

Repeated exposure to UVA/UVB causes injury resulting in aging skin.

Tuesday, 17 March 2009

Effect of UV Radiation on Skin

Ultraviolet (UVA, UVB, UVC) radiation penetrates into the middle layer of skin (the dermis).

UV radiation breaks down collagen, impairs the development of new collagen and attacks elastin.

Tuesday, 17 March 2009

Laser Resurfacing

The principal uses of lasers in facial skin rejuvenation are reduction or removal of fine lines, wrinkles, and age spots.

Aftereffects and recovery times vary with different laser procedures.

Tuesday, 17 March 2009

Prevage MD Healthy Skin Tip: Manage Sun Exposure

While you need some sun exposure to help your body generate Vitamin D, too much can be very harmful.

Sun exposure is a top cause of every skin problem, whether it’s fine lines and wrinkles or something as serious as skin cancer.

Limit your exposure to the sun and its harmful UV rays whenever possible.

Tuesday, 17 March 2009

Prevage MD Healthy Skin Tip: Reduce Alcohol Consumption

For the same reason that water is so important for healthy skin, too much alcohol can have the opposite effect.

Alcohol dehydrates you, and depletes your vitamin and mineral levels.

Tuesday, 17 March 2009

Prevage MD Healthy Skin Tip: Drink Enough Water

Your body loses almost three quarts of water every day.

Staying hydrated is essential for healthy skin, keeping it supple, clear, and moisturized.

Everyone should drink at least two quarts of water every day.

Tuesday, 17 March 2009

Prevage MD Healthy Skin Tip: Take Vitamins

Boosting your diet with vitamins and minerals that work on your skin is an easy way to help prevent problems down the road.

Some examples include Beta Carotene, Vitamin C and E, Selenium, Zinc, and Flaxseed Oil.

Talk to your doctor or nutritionist to learn more.

Refer Nordic Naturals for additional information on supplements which can help your skin.

Tuesday, 17 March 2009

Prevage MD Healthy Skin Tip: Follow a Healthy Diet

What you eat has an impact on how well your skin can heal itself.

Whenever possible, choose foods that are fresh and unprocessed.

Sunday, 11 October 2009

FAQ: Prevage MD vs. Alpha Hydroxy Acids (AHAs)

AHAs are obtained from fruits, sugar cane, and sour milk and are found in a variety of skin care products including moisturizers, cleansers, and sunscreens.

AHAs act primarily as exfoliants, helping to shed the outermost layer of the skin to make it look smoother and less wrinkled.

PREVAGE® MD anti-aging treatment works differently.

It contains idebenone, an antioxidant that scavenges harmful free radicals in the cells of your skin and protects it from damage from external environmental stressors such as UV light, air pollution, ozone, and cigarette smoke, to name a few.

PREVAGE® MD also reduces the appearance of fine lines and wrinkles, as well as skin roughness and dryness, and evens skin tone to restore youthful-looking skin.

Tuesday, 17 March 2009

FAQ: Prevage MD and Retinoids

If you are using retinoids or other products dispensed or prescribed by your doctor, ask about the appropriate use of these products in combination with PREVAGE® MD.

Tuesday, 17 March 2009

FAQ: Can I use Prevage MD in combination with other products?

Skin reactions to PREVAGE® MD anti-aging treatment may be more common in individuals who are using multiple skin care products.

If you are currently on an aggressive skin care regimen, your skin may become more sensitive to PREVAGE® MD.

In general, apply PREVAGE® MD directly after cleansing your skin and before applying any other products.

Tuesday, 17 March 2009

FAQ: Prevage MD vs. Sunscreen

Even though PREVAGE® MD anti-aging treatment protects your skin against environmental stressors, it is not a substitute for sunscreen.

Always use a sunscreen with a minimum of SPF 15 providing comprehensive UVA and UVB protection every day.

Tuesday, 25 August 2009

About Prevage MD and Skin Sensitivity

If you have normal skin sensitivity, after following the “Test usage of PREVAGE® MD” instructions and if no reactions are seen, begin using PREVAGE® MD anti-aging treatment once a day for the first week, and, if tolerated, twice a day from then on.

If any itching, burning, redness, or swelling occurs at any time while using the product, wash the product off, discontinue use, and consult your dispensing physician as needed.

Skin reactions may be more likely in individuals with very sensitive skin, eczema, or allergies to cosmetics, hair dyes (para-phenylenediamine (PPD), bleaching agents (hydroquinones), sulfa compounds, or jewelry.

Monday, 13 July 2009

Skin Reactions to Prevage MD

Skin reactions to PREVAGE® MD anti-aging treatment may be more likely to occur within the first several days of using the product.

For this reason, before beginning to use PREVAGE® MD on a regular basis, apply a small amount of product (less than one pump) daily for several days to a small area of skin in the area you plan to use the product.

Skin reactions to PREVAGE® MD may be more common in individuals who have recently had certain medical skin care procedures. If you have recently undergone laser resurfacing, dermabrasion, medium to deep chemical peels, or any other aggressive skin therapies, you should wait 7 to 10 days before starting to use PREVAGE® MD.

If any itching, burning, redness, or swelling occurs during this trial period, wash the product off and discontinue use.

Contact your dispensing physician to discuss your reaction and to receive a refund.

If no reactions occur, follow the Prevage MD instructions for use and supplementary directions under Optimizing Results from Prevage MD.

Also see FAQ: Can I use Prevage MD in combination with other products?

Tuesday, 17 March 2009

FAQ: Prevage vs. Prevage MD

Prevage MD contains double the concentration of idebenone found in Prevage, however is only available from doctors.

Tuesday, 17 March 2009

FAQ: What can idebenone 1% do for my skin?

Idebenone 1% anti-aging treatment helps correct the skin damage that you already have and also protects your skin from future damage.

The antioxidative power of PREVAGE® MD has been clinically shown to reduce the signs of skin aging in only 4 weeks.

In a recent survey of 18 subjects with severe to moderate photodamage:

  • 72% of subjects reported reduction in the appearance of fine lines and wrinkles;
  • 78% of subjects reported reduction in roughness and dryness;
  • 78% of subjects reported improvement in skin softness and smoothness;
  • 61% of subjects reported improvement in firmness, tightness, and elasticity;
  • 67% of subjects reported improvement in overall appearance.

In addition, a majority of subjects reported an overall improvement in their skin’s healthy appearance after just 4 weeks of use.

Fine lines and wrinkles, roughness and dryness, and a lack of firmness and elasticity are generally regarded as signs of sun damage.

Further information:

Oxidative Stress and Free Radical Damage.

The Connection Between Oxidative Stress and Aging.

Prevage MD Reference

Data on file, Allergan, Inc. DiNardo JC. Four-week clinical expert grader evaluation of PREVAGE® MD (1.0% idebenone) for the treatment of photodamage. 2005.

Tuesday, 17 March 2009

FAQ: Does Prevage MD anti-aging treatment work better than other topical antioxidants?

According to the makers of PREVAGE® MD, idebenone, found in PREVAGE® MD [1% Idebenone], is scientifically shown to be more effective than other topical antioxidants in protecting your skin against environmental stressors known to cause skin aging.

These other antioxidants include kinetin (used in Kinerase®), coenzyme Q10 (Q10 Plus Wrinkle Control products from Nivea® and other products), lipoic acid (used in N.V. Perricone M.D. Cosmeceuticals®), vitamin C, and vitamin E (both found in many anti-aging products such as Skinceuticals C E Ferulic and IS Clinical C + E).

Prevage MD Reference

McDaniel DH, Neudecker BA, DiNardo JC, Lewis JA II, Maibach HI. Idebenone: a new antioxidant: Part I. A relative assessment of oxidative stress protection capacity compared to commonly known antioxidants. J Cosm Derm. 2005;4(1):10-17.

Tuesday, 17 March 2009

About EPF Antioxidant Measurement

EPF® stands for "Environmental Protection Factor" and is a measure of antioxidant protection.

You are probably familiar with Sun Protection Factor or SPF, a measure of sunscreen protection.

Sunscreens protect against UV radiation, but do not neutralize free radicals.

You need to use a topical antioxidant to form a skin-protective shield distinct from SPF.

For everyday protection, you need both high SPF and high EPF® on your skin.

EPF® is the measure of effectiveness of an antioxidant shield.

In a clinical comparison with other commonly used antioxidants, the 1% concentration of idebenone found in PREVAGE® MD was proven to be more effective (see Prevage MD reference below).

These other antioxidants include kinetin (found in Kinerase®), coenzyme Q10 (found in products such as Q10 Advanced Wrinkle Reducer products from Nivea®), lipoic acid (found in N.V. Perricone M.D. Cosmeceuticals®), vitamin C, and vitamin E (both found in many anti-aging products such as Skinceuticals C E Ferulic and IS Clinical C + E).

Idebenone demonstrated the highest EPF® activity of any antioxidant tested: 95 out of 100.

Idebenone is what makes PREVAGE® MD so effective.

Prevage MD Reference

McDaniel DH, Neudecker BA, DiNardo JC, Lewis JA II, Maibach HI. Idebenone: a new antioxidant: Part I. A relative assessment of oxidative stress protection capacity compared to commonly known antioxidants. J Cosm Derm. 2005;4(1):10-17.

Thursday, 16 July 2009

Optimizing Results from Prevage MD

For best results, start low and go slow:

  • Start with a Skin Patch Test behind ear or on forearm, near the inside of your elbow;
  • One pea-size amount covers the entire face and neck;
  • Week 1: once a day every other day;
  • Week 2: once a day every day;
  • Then build up to morning and night every day;

The recommended cosmetic sequence: cleanse, tone, apply PREVAGE® MD, moisturize, apply sunscreen, apply makeup.

PREVAGE® MD is also used with retinoids, alpha hydroxy acids, other skin care ingredients and antioxidants.

Also see skin reactions to Prevage MD.

Tuesday, 17 March 2009

What Idebenone 1% Does for Skin

What Idebenone 1% Does for Skin

Idebenone corrects and protects skin cells, resulting in healthier, rejuvenated skin.

In a survey among patients using PREVAGE® MD anti-aging treatment, after just 4 weeks of use:

  • 72% reported a reduction in the appearance of fine lines and wrinkles;
  • 78% reported reduction in roughness and dryness;
  • 94% reported improvement in skin softness and smoothness;
  • 61% reported improvement in firmness, tightness, and elasticity;
  • 78% reported improvement in overall appearance.

Wednesday, 5 August 2009

Idebenone: The "Super Antioxidant" Molecule

Idebenone: The

Idebenone is a relatively small molecule, which allows for its deep penetration into the skin.

Idebenone embeds itself in skin membranes and then it has a double action:

Tuesday, 17 March 2009

Protecting Against Free-Radical Damage in the Skin

Protecting Against Free-Radical Damage in the Skin Protecting Against Free-Radical Damage in the Skin

The effects of stressors on your skin cannot be combated with simple cleansing.

To remove free radicals, you need a topical antioxidant like PREVAGE® MD anti-aging treatment, which helps protect against skin damage by chemically trapping and neutralizing each free radical it touches.

Think of antioxidants as guardians of your skin cells, protecting them from free radicals and allowing the production of healthier cells.

Prevage MD Reference

McDaniel DH, Neudecker BA, DiNardo JC, Lewis JA II, Maibach HI. Idebenone: a new antioxidant: Part I. A relative assessment of oxidative stress protection capacity compared to commonly known antioxidants. J Cosm Derm. 2005;4(1):10-17.

Sunday, 11 October 2009

The Connection Between Oxidative Stress and Aging

The Connection Between Oxidative Stress and Aging

Oxidative stress is a major cause of skin aging.

It results from the buildup of destructive free radicals in the skin.

The source of the free radicals may be external (from the environment, such as UV light, air pollution, ozone, cigarette smoke, and even oxygen) or internal (from cell activity).

The body does produce its own antioxidants that help keep free radicals in check.

However, the level of oxidative stress in which we live is beyond what the body can handle.

Left untreated, the result of accumulated free-radical damage in the skin is accelerated aging.

The Connection Between Oxidative Stress and Aging

In skin, the signs of aging due to oxidative stress include wrinkles, uneven skin tone, and the loss of skin elasticity.

Prevage MD Reference

McDaniel DH, Neudecker BA, DiNardo JC, Lewis JA II, Maibach HI. Idebenone: a new antioxidant: Part I. A relative assessment of oxidative stress protection capacity compared to commonly known antioxidants. J Cosm Derm. 2005;4(1):10-17.

Sunday, 11 October 2009

Additional Prevage MD Information

"PREVAGE MD anti-aging treatment, an innovative cosmetic by Allergan, represents the next generation of topical antioxidants and contains 1% idebenone, a revolutionary, potent, and effective antioxidant. This formula is available though doctors, dermatologists and cosmetic surgeons.

Idebenone, the active ingredient in PREVAGE MD, is the first clinically tested and proven topical antioxidant that both corrects and protects the skin. PREVAGE MD anti-aging treatment, with one percent idebenone, reduces the appearance of uneven skin tone, fine lines and wrinkles.

Idebenone is the most potent and effective topical antioxidant compound when compared to other commonly known antioxidants. Idebenone was found to be more effective than other antioxidants, including: kinetin, coenzyme Q10, lipoic acid, vitamin C, and vitamin E.

In a recent clinical trial with 17 participants, patients found that PREVAGE MD reduced the signs of skin aging in just four weeks. Seventy-two percent of patients reported a reduction in the appearance of fine lines and wrinkles, and 78 percent reported an improvement in skin softness and smoothness.

After eight weeks of product use, the following were observed:

  • 86 percent reduction in skin roughness and dryness;
  • 75 percent increase in skin firmness; and,
  • 59 percent improvement in overall appearance.

PREVAGE MD anti-aging treatment helps protect the skin from oxidative stress induced by environmental stressors known to cause skin aging, including:

2004 AAD Poster Exhibt: Antioxidants Compared in a New Protocol to Measure Protective Capacity against Oxidative Stress, Part II; DiNardo, J. Lewis, J. Neudecker, B. Dimitar, B. Wieland, E. Maibach, H.

Six Week Clinical Evalution of Prevage For the Treatment of PhotoAging; J.C. DiNardo

2005 Allergan data on file.

To protect skin from UV radiation, a combination of idebenone and sunscreen (SPF15 or greater) is recommended. "

Tuesday, 17 March 2009

Prevage MD Before and After Case #2

A 35-year-old woman with uneven skin tone, brown patches, freckling, and scaling on the cheeks.

Prevage MD Before and After Case #2

This photograph shows the results achieved in a 6-week study using the previous formulation of idebenone 1%.

A more even skin tone, and less freckling, scaling, and dryness were noted at the completion of the study.

Photographic results of a study utilizing the new formulation of idebenone 1% ("Prevage MD") are not yet available.

Photographs are completely unretouched.

Results may vary.

Tuesday, 17 March 2009

Prevage MD Before and After Case #1

A 55-year-old woman with fine lines and wrinkles around the eyes as well as uneven skin tone.

Prevage MD Before and After Case #1

This photograph shows the results achieved in a 6-week study using the previous formulation of idebenone 1%.

Reduced appearance of fine lines and wrinkles and a more even skin tone were noted at the completion of the study.

Photographic results of a study utilizing the new formulation of idebenone 1% ("Prevage MD 1%") are not yet available.

Photographs are completely unretouched.

Results may vary.

Sunday, 15 March 2009

Ineffective: Olay Regenerist's Pentapeptides

Do Olay Regenerist's peptides work?

No... and that's hardly suprising.

Back in 2005, the results of Olay Regenerist's peptides were published in the International Journal of Cosmetic Science.

The published study found that most users reported no effect on lines and wrinkles.

Nevertheless, Olay went on to advertise that their product's peptides reduce the appearance of fine lines and wrinkles and masses of women believe the lies of Olay Regenerist's benefits.

Olay Regnerist does next to nothing to treat the "seven signs of aging" and moreover, when you use it, it's likely getting in the way of you using something more beneficial.

From this perspective an argument can be made that Olay Regenerist supports the "seven signs of aging" by getting in the way of better — and less expensive — care.

We have never seen good results from peptides, and for the most part you can and should give them a pass.

I cannot remember a time when someone has "maxed out" improvement to the point where peptides should get in the way.

In reality, skin care products containing peptides create their transient effects by means not involving peptides.

Olay Regenerist is a moisturizer above all else, and not a very good moisturizer at that.

People flock to and recommend peptides by word of mouth to their and their friends' detriment, and unfortunately, appear to enjoy these products.

Olay Regenerist signifies skin care failure.

You can refer to the full peptide skin care ingredients list to find other products in which the peptide content makes little to no skin care difference.

Tuesday, 19 May 2009

RevaleSkin Video

Thursday, 28 May 2009

RevaleSkin Terry Cloth Cosmetic Bag

RevaleSkin Terry Cloth Cosmetic Bag

Available when all three original RevaléSkin products — Facial Cleanser, Day Cream SPF 15 and Night Cream — are purchased at once.

Limited stock.

Wednesday, 11 March 2009

Alyria Skin Care Complete Ingredient Listing

Wednesday, 11 March 2009

Chromaveil Photoprotection for Hair

Chromaveil is a patented broad spectrum ultraviolet (UV) absorber for hair care products.

Chromaveil is a UV absorbing quaternium compound delivering UVA and UVB protection to the hair, preserving the integrity of the hair fiber, with the added bonus of protecting hair color.

Lab tests have shown the ability of Chromaveil to absorb UVA and UVB radiation, maintaining color after UV exposure and maintaining hair strength.

It is available in an easy-to-use liquid that can be incorporated into cold process and hot process formulations, and is stable in low to neutral pH environments.

As a 75 percent active ingredient, formulators can incorporate Chromaveil without high loads of diluents or solvents.

Tuesday, 13 October 2009

Photoprotective (UVB) Salen-Manganese Complex (EUK-134)

EUK-134 Salen-Manganese Complex is a UVB photoprotective agent, for supplementary use with sunscreens, available in Alyria Corrective Protection SPF 30 Lotion.


Salen-manganese complexes exhibit powerful superoxide dismutase and catalase activity, with pharmacologic efficacy in several oxidative-stress-associated disease models.

Ultraviolet UVB not only induces direct DNA damage, but also generates oxidative stress.

EUK-134, a salen-manganese complex, might therefore confer a direct protection against UVB-induced oxidative stress and consequently alleviate UVB-damage-induced signal transduction.

We investigated the effect of EUK-134 on the UVB-induced accumulation and stabilization of the p53 protein.

Cells treated with EUK-134 before UVB irradiation showed a significantly lower accumulation of the p53 protein in a concentration-dependent fashion.

Furthermore, EUK-134 severely reduced N-terminal phosphorylation of p53.

The extracellular signal-regulated kinase ERK and the stress-activated kinases JNK and p38 have been implicated in the UVB-induced N-terminal phosphorylation and accumulation of p53.

Pre-treatment with EUK-134 inhibited the UVB-induced activation of these mitogen-activated protein kinase (MAPK) pathways.

We hypothesize that EUK-134, by direct protection of the membrane from UVB-induced oxidative damage, reduces oxidative stress induced MAPK signaling and consequently lowers the level of p53 induction.

The protection conferred by EUK-134 resulted in a significant increase in cell survival following UVB irradiation.


A Synthetic Superoxide Dismutase/Catalase Mimetic (EUK-134) Inhibits Membrane-Damage-Induced Activation of Mitogen-Activated Protein Kinase Pathways and Reduces p53 Accumulation in Ultraviolet B-Exposed Primary Human Keratinocytes

David Decraene*, Katrien Smaers*, David Gan , Tom Mammone , Mary Matsui , Daniel Maes , Lieve Declercqà and Marjan Garmyn*

Department of Dermatology, University of Leuven, Leuven, Belgium

 Estée Lauder Companies, Melville, New York, USA

àEstée Lauder Coordination Center, Oevel, Belgium

Correspondence: Marjan Garmyn, Department of Dermatology, UZ St. Rafaël, Kapucijnenvoer 33, B-3000 Leuven, Belgium. Email: Marjan.Garmyn@med.kuleuven.ac.be

Received 14 February 2003; Revised 4 August 2003; Accepted 22 October 2003; Published online 12 February 2004.

Keywords: oxidative stress, skin, p53 phosphorylation, manganese compounds, hydrogen peroxide.

Abbreviations: AAPH, 2,2'-azobis(2-amidinopropane)dihydrochloride; ERK, extracellular signal-regulated kinase; JNK/SAPK, c-Jun N-terminal kinase/stress-activated protein kinase; MAPK, mitogen-activated protein kinase; ROS, reactive oxygen species; SOD, superoxide dismutase; UV, ultraviolet.

Sunday, 9 August 2009

Protective Effects of a Topical Antioxidant Mixture Containing Vitamin C, Ferulic Acid and Phloretin Against Ultraviolet-Induced Photodamage in Human Skin

This study confirms the protective role of a unique mixture of antioxidants containing vitamin C, ferulic acid, and phloretin on human skin from the harmful effects of UV irradiation.

Phloretin, in addition to being a potent antioxidant, may stabilize and increase the skin availability of topically applied vitamin C and ferulic acid.

We propose that antioxidant mixture will complement and synergize with sunscreens in providing photoprotection for human skin.


Ultraviolet (UV) irradiation of the skin leads to acute inflammatory reactions, such as erythema, sunburn, and chronic reactions, including premature skin aging and skin cancer.

In this study, the effects of a topical antioxidant mixture consisting of vitamin C, ferulic acid, and phloretin on attenuating the harmful effects of UV irradiation on normal healthy volunteers were studied using biomarkers of skin damage.

Ten subjects (age, 18—60 years; Fitzpatrick skin types II and III) were randomized and treated with antioxidant product or vehicle control on the lower back for four consecutive days. On day 3, the minimal erythema dose (MED) was determined for each subject at a different site on the back. On day 4, the two test sites received solar-simulated UV irradiation 1—5? MED at 1? MED intervals. On day 5, digital images were taken, and 4-mm punch biopsies were collected from the two 5? MED test sites and a control site from each subject for morphology and immunohistochemical studies.

UV irradiation significantly increased the erythema of human skin in a linear manner from 1? to 5? MED. As early as 24 h after exposure to 5? MEDs of UV irradiation, there were significant increases in sunburn cell formation, thymine dimer formation, matrix metalloproteinase-9 expression, and p53 protein expression. All these changes were attenuated by the antioxidant composition. UV irradiation also suppressed the amount of CD1a-expressing Langerhans cells, indicating immunosuppressive effects of a single 5? MED dose of UV irradiation. Pretreatment of skin with the antioxidant composition blocked this effect.


Christian Oresajo, PhD 1 , Thomas Stephens, PhD 3 , Peter D Hino, MD 4 , Robert M Law, MD 5 , Margarita Yatskayer, MS 1 , Peter Foltis, MS 1 , Sreekumar Pillai, PhD 1 , & Sheldon R Pinnell, MD 2

1 L'Oreal USA, Clark, NJ

2 Duke University Medical Center, Durham, NC

3 Thomas J. Stephens & Associates, Inc., Dallas Research Center, Carrollton, TX

4 Presbyterian Medical Center, Dallas, TX

5 ProPath Services, Dallas, TX

Correspondence: Christian Oresajo, PhD, L'Oreal USA, 30 L'Oreal Way, Clark, NJ 07066. E-mail: coresajo@rd.us.loreal.com

Conflict of Interest. Dr. Sheldon Pinnell is a consultant for SkinCeuticals/L'Oreal. Drs. Thomas Stephens, Peter Hino, and Robert Law are independent contractors for the study. The other authors are employees of L'Oreal USA, who is the sponsor of the study.

KEYWORDS

antioxidant • ferulic acid • Langerhans cells • MED • MMP-9 • p53 • photodamage • phloretin • sunburn cells • thymine dimer • UV protection • vitamin C

Tuesday, 3 March 2009

Latisse Safety

Latisse has a good safetly profile.

The FDA study shows only a 4% chance for side effects.

Approximately 5% is absorbed into the eye.

Sunday, 9 August 2009

Radiance

Monday, 2 March 2009

Comparison: Clinique Medical IPL Treatment Study for Enhanced Outcomes

In IPL treatments, Clinique Medical significantly improved results vs control. 

Comparison: Clinique Medical IPL Treatment Study for Enhanced Outcomes

 A randomized, double-blind controlled study was conducted over the course of 12 weeks to demonstrate the effectiveness of the Clinique Medical Optimizing Regimen on the outcome of IPL treatments. Changes were demonstrated after 2 IPL treatments and Clinique Medical product usage as compared to control. Treatments were 6 weeks apart, with measurement readings taken at 1 week and 4 weeks post treatment.

Participants were female, between the ages of 35 and 65, who had never had a TCA peel (n=28), IPL treatment (n=29), or any other non-surgical cosmetic procedure.

Control group used standard skin care products (eg, mild liquid cleanser, skin protectant oil, water moisturizer and same level SPF).

1 P=0.0001, 2 P=0.0327, 3 P=0.0001, 4 P=0.0580, 5 P<0.0001, 6 P=0.0004, 7 P=0.0004, 8 P<0.0001, 9 P<0.0001, 10 P=0.0347, 11 P<0.0001, 12 P=0.0120, 13 P<0.0001, 14 P<0.0001, 15 P=0.0009, 16 P<0.0001

Monday, 2 March 2009

Comparison: Clinique Medical TCA Peel Treatment Study for Enhanced Outcomes

In TCA peels, Clinique Medical significantly improved results vs control. 

Comparison: Clinique Medical TCA Peel Treatment Study for Enhanced Outcomes

 A randomized, double-blind controlled study was conducted over the course of 12 weeks to demonstrate the effectiveness of the Clinique Medical Optimizing Regimen on the outcome of TCA peels. Changes were demonstrated after 2 TCA peels and Clinique Medical product usage as compared to control. Treatments were 6 weeks apart, with measurement readings taken at 1 week and 4 weeks post treatment.

Participants were female, between the ages of 35 and 65, who had never had a TCA peel (n=28), IPL treatment (n=29), or any other non-surgical cosmetic procedure.

Control group used standard skin care products (eg, mild liquid cleanser, skin protectant oil, water moisturizer and same level SPF).

1 P=0.0002, 2 P=0.0857, 3 P<0.0001, 4 P=0.0082, 5 P<0.0001, 6 P<0.0001, 7 P=0.0002, 8 P<0.0001, 9 P<0.0001, 10 P=0.0305, 11 P<0.0001, 12 P<0.0001, 13 P<0.0001, 14 P<0.0001, 15 P=0.0004, 16 P<0.0001

Monday, 2 March 2009

Before/After: Clinique Medical TCA Peel Treatment Study for Enhanced Outcomes

Results with Clinique Medical Optimizing Regimen.

Before/After: Clinique Medical TCA Peel Treatment Study for Enhanced Outcomes

Monday, 2 March 2009

Before/After: Clinique Medical IPL Treatment Study for Enhanced Outcomes

Results with Clinique Medical Optimizing Regimen.

Before/After: Clinique Medical IPL Treatment Study for Enhanced Outcomes

Monday, 2 March 2009

Clinique Medical TCA Peel Treatment Study for Enhanced Healing

"Clinical proof that after 12 weeks, Clinique Medical significantly reduced unintended visible effects post procedure in TCA peels as compared to control.*"

Clinique Medical TCA Peel Treatment Study for Enhanced Healing
  • Controlled study consisted of 12 weeks total testing time. Changes were demonstrated after 2 TCA peels and Clinique Medical product usage as compared to control and 2 IPL treatments and Clinique Medical product usage as compared to control. Treatments were 6 weeks apart, with measurement readings taken at 1 week and 4 weeks post treatment (Cycle 1 = treatment 1; Cycle 2 = treatment 2).

Participants were female, between the ages of 35 and 65, who had never had a TCA peel (n=28), IPL treatment (n=29), or any other non-surgical cosmetic procedure.

Control group used standard skin care products (eg, mild liquid cleanser, skin protectant oil, water moisturizer and same level SPF).

1 P=0.0002, 2 P=0.0596, 3 P=0.0107, 4 P=0.0231, 5 P=0.1834, 6 P=0.0010, 7 P=0.0034, 8 P=0.0001, 9 P<0.0001, 10 P=0.0002, 11 P<0.0001, 12 P<0.0001

Monday, 2 March 2009

Clinique Medical IPL Treatment Study for Enhanced Healing

"Clinical proof that after 12 weeks, Clinique Medical significantly reduced unintended visible effects post procedure in IPL treatments as compared to control.*"

Clinique Medical IPL Treatment Study for Enhanced Healing
  • Controlled study consisted of 12 weeks total testing time. Changes were demonstrated after 2 TCA peels and Clinique Medical product usage as compared to control and 2 IPL treatments and Clinique Medical product usage as compared to control. Treatments were 6 weeks apart, with measurement readings taken at 1 week and 4 weeks post treatment (Cycle 1 = treatment 1; Cycle 2 = treatment 2).

Participants were female, between the ages of 35 and 65, who had never had a TCA peel (n=28), IPL treatment (n=29), or any other non-surgical cosmetic procedure.

Control group used standard skin care products (eg, mild liquid cleanser, skin protectant oil, water moisturizer and same level SPF).

13 P=0.0566, 14 P=0.1419, 15 P=0.0145, 16 P=0.0967, 17 P=0.0046, 18 P<0.0001, 19 P=0.0059, 20 P<0.0001, 21 P<0.0001, 22 P=0.0023, 23 P<0.0001,

24 P=0.0004

Monday, 2 March 2009

Clinique Medical Clinical Data: Healing Process

Clinique Medical Clinical Data: Healing Process

"Minimize unintended effects of procedures"

Two randomized, double-blind controlled studies were conducted to demonstrate the effectiveness of the Optimizing Regimen on the outcome of TCA peel and IPL treatments.

The Optimizing Regimen has been clinically proven to help significantly reduce the unintended visible effects following a procedure and complement the outcomes, as compared to control.

Patients treated used the Optimizing Regimen, including Probiotic Cleanser, Skin Conditioning Treatment, Recovery Week Complex, Optimizing Treatment Cream, and Daily SPF 38.

The control group used standard skin care products (eg, mild liquid cleanser, skin protectant oil, water moisturizer and same level SPF).

Refer Clinique Medical IPL Treatment Results and TCA Peel Treatment Results.

Monday, 2 March 2009

About Ongoing Skin Maintenance

Long-term maintenance is important to healthy skin during a cycle of non-surgical cosmetic procedures and essential to keeping skin condition optimized and strong.

Patients undergoing dermatological procedures must constantly manage their skin's condition to help complement the outcome of procedures, bolster skin and help prevent the onset of the visible signs of aging.

Tuesday, 23 June 2009

About Post-Procedure Skin Care

Immediately following a cosmetic procedure, it is important to manage irritation and visible redness of the skin.

There are three distinct phases of the skin healing process. These phases may be important to the long-term recovery process and key to optimizing the outcome of cosmetic procedures.

The first phase begins immediately post procedure.

Because any injury to the skin elicits an inflammatory response, skin may be irritated, red, tight, dry and tender.

Irritation is skin's expected and productive reaction to initiate proper healing support and fend off infection.

In the second phase, skin is stimulated to rebuild the tissue and collagen required for healthy skin.

This vital function bolsters skin's ability to protect itself from further damage as it heals.

The third phase involves further collagen restructuring to strengthen skin and help prolong the benefits of cosmetic procedures.

This restructuring helps to create a more even skin tone and reduce the appearance of visible lines and wrinkles.

Shortening recovery time, yet not disrupting the natural wound healing process of the skin, can reduce discomfort such as dryness, irritation, itching and tightness.

Monday, 2 March 2009

The Importance of Pre & Post Proecedure Skin Care

Cleaning is an important step prior to any daily skin care routine as well as immediately prior to a non-ablative cosmetic procedure.

It's important to remove every trace of makeup and surface debris to help ensure even and effective penetration of the treatment.

Additionally, skin should be prepped to optimally receive the benefits of cosmetic procedures through enhanced exfoliation.

This will help keep skin strong and will also help improve the healing process.

Saturday, 14 March 2009

Clinique Medical Skin Care (Newly Available)

Clinique Medical Skin Care (Newly Available)

About Clinique Medical Skin Care

"Clinique Medical is an innovative alliance between Clinique®, a leader in cosmetic skin care, and Allergan®, a leader in medical aesthetics."

"Together, Clinique® and Allergan® have developed a line products containing no preservatives and which are 100% fragrance/perfume-free and allergy tested to the highest standards."

Clinique Medical In-House Studies

Clinique Medical submits before and after results for TCA Peels and IPL Treatment in combination with the Clinique Medical Optimizing Regimen and evidence for enhanced healing for TCA Peels and IPL Treatment.

Clinique Medical Skin Care Formulae

Probiotic Cleanser

"This formula helps thoroughly remove debris and the most tenacious makeup while replenishing lipids to help support the healing process."

Skin Conditioning Treatment

"This lightweight formula helps condition and prepare skin pre procedure by exfoliating without irritation."

Recovery Week Complex

"This soothing formula helps manage visible redness and irritation and inhibit the appearance of skin discoloration post procedure."

Optimizing Treatment Cream

"This hydrating formula complements the benefits of a procedure by reducing the appearance of visible lines and wrinkles and improving brightness and radiance."

Daily SPF 38 (SPF 15 in Australia)

"This non-irritating formula can be used daily to help protect against UVA and UVB rays and visibly repair and protect from damage caused by external aggressors."

Clinique Medical Skin Care Ingredients

Refer the complete ingredient listing under Clinique Medical Optimizing Regimen.

Monday, 2 March 2009

Clinique Medical Press Release

ALLERGAN, INC., THE #1 GLOBAL MEDICAL AESTHETICS COMPANY, AND CLINIQUE, THE #1 PRESTIGE COSMETICS BRAND IN THE UNITED STATES, FORM STRATEGIC COLLABORATION TO DEVELOP NEW SKIN CARE LINE

(IRVINE, Calif. and NEW YORK, New York, January 24, 2008) — Allergan, Inc. (NYSE: AGN) and Clinique Laboratories, LLC, today announced a strategic collaboration which combines Clinique's expertise in product development and formulation with Allergan's leadership in the medical aesthetics market. The new skin care line, which will incorporate the Clinique brand name, will offer clinically proven skin care products to complement in-office aesthetic procedures. It will be sold exclusively in physicians' offices in the United States and is expected to launch in the fall of 2008.

Over the past ten years, non-surgical aesthetic procedures have increased nearly 750 percent, with consumers in the United States spending more than $12 billion on cosmetic procedures in 20061. The top five non-surgical aesthetic treatments in 2006, administered in the physician's office, included BOTOX® Cosmetic and hyaluronic acid dermal fillers such as JUVÉDERM®, laser hair removal, microdermabrasion and laser skin resurfacing. As more patients seek advice and treatments from aesthetic specialty physicians, there is a similar, growing trend of consumers purchasing skin care products in the physician's office. Allergan and Clinique expect to pioneer a new category of best-in-class skin care products sold exclusively in physicians' offices that will be Allergy Tested and 100% Fragrance Free.

"In collaboration with Clinique, our goal is to establish a leadership position in physician-dispensed skin care by offering a one-stop approach to specialized skin care products under a brand name that is trusted by consumers and backed by science on which physicians can rely," said David E.I. Pyott, Allergan's Chairman of the Board and Chief Executive Officer. "The collaboration combines Allergan's leadership in medical aesthetics and our deep understanding of the physician channel based on our Total Facial Rejuvenation portfolio - including BOTOX® Cosmetic, JUVÉDERM® and our skin care product line, with Clinique's history of formulating leading consumer skin care products guided by dermatologists. Together with our complementary strengths, we expect Clinique and Allergan to grow this market."

"Clinique's promise to our consumers has always been to create dermatologist guided, Allergy Tested, 100% Fragrance Free products that address skin care needs. Today we are entering a new phase of our relationship with the medical community," said Lynne Greene, Global President, Clinique Laboratories. "By joining forces with Allergan, the number one medical aesthetics company, we are now able to service consumers who are under the care of a physician with this completely new class of products."

"Clinique's rich dermatological heritage dates back 40 years," said William P. Lauder, President and Chief Executive Officer, The Estée Lauder Companies Inc. "This new skin care line, created in collaboration with Allergan, is the next generation of the expression of Clinique's unique position delivered through one of the fastest growing channels today, physicians' offices."

As part of the agreement, Clinique will be responsible for formulating, developing and manufacturing the new product line. Clinique will sell products to Allergan while Allergan will record sales to physicians and handle consumer and professional marketing and distribution. The agreement with Clinique will allow Allergan to expand the size of its current sales force dedicated to physician-dispensed skin care. Clinique and Allergan may also conduct clinical trials and work with the physician community to ensure the success of the new skin care line.

  1. # #

Important BOTOX® Cosmetic (Botulinum Toxin Type A) Information

BOTOX® Cosmetic is indicated for the temporary improvement in the appearance of moderate to severe frown lines between the brows in people 18 to 65 years of age.

Important BOTOX® Cosmetic (Botulinum Toxin Type A) Safety Information

Serious heart problems and serious allergic reactions have been reported rarely. If you think you are having an allergic reaction or other unusual symptoms, such as difficulty swallowing, speaking or breathing, call your doctor immediately. The most common side effects following injection include temporary eyelid droop and nausea. Localized pain, infection, inflammation, tenderness, swelling, redness and/or bleeding/bruising may be associated with the injection. Patients with certain neuromuscular disorders such as ALS, myasthenia gravis or Lambert-Eaton syndrome may be at increased risk of serious side effects. For full prescribing information, please visit www.botoxcosmetic.com.

Important JUVÉDERM® Safety Information

JUVÉDERM® is indicated for injection into the mid to deep dermis for correction of moderate to severe facial wrinkles and folds (such as nasolabial folds), and is generally well tolerated. In clinical studies, adverse events were usually mild to moderate in nature, did not require intervention and lasted seven days or less. The most common side effects included temporary injection site reactions including redness, pain/tenderness, firmness, swelling, lumps and bumps and bruising. For complete patient safety and prescribing information, please visit www.Juvederm.com.

About Allergan, Inc. (NYSE: AGN)

Founded in 1950, Allergan, Inc., with headquarters in Irvine, California, is a multi-specialty health care company that discovers, develops and commercializes innovative pharmaceuticals, biologics and medical devices that enable people to live life to its greatest potential — to see more clearly, move more freely, express themselves more fully. The Company employs more than 7,500 people worldwide and operates state-of-the-art R&D facilities and world-class manufacturing plants. In addition to its discovery-to-development research organization, Allergan has global marketing and sales capabilities with a presence in more than 100 countries.

About Clinique

Introduced in 1968, Clinique was the first ever dermatologist-created, prestige cosmetic brand. Clinique's mission has always been to provide the highest quality and most effective line of products to enhance every skin type and tone. The brand's customized approach and quality products ? all meticulously tested and carefully formulated with the latest science — have made Clinique one of the leading skin care authorities in the world. All makeup and skin care products are Allergy Tested and 100% Fragrance Free. Clinique offers products for men and women of all ages and ethnicities. Clinique is sold in more than 135 countries and territories, 17,000 sales locations and on www.clinique.com.

About the The Estée Lauder Companies Inc. (NYSE:EL)

Founded in 1946, The Estée Lauder Companies Inc. is one of the world's leading manufacturers and marketers of quality skin care, makeup, fragrance and hair care products. The Company's products are sold in over 135 countries and territories under well-recognized brand names, including Estée Lauder, Aramis, Clinique, Prescriptives, Lab Series, Origins, M•A•C, Bobbi Brown, Tommy Hilfiger, La Mer, Donna Karan, Aveda, Jo Malone, Bumble and bumble, Darphin, Michael Kors, American Beauty, Flirt!, Good Skin™, Grassroots, Sean John, Missoni, Daisy Fuentes, Tom Ford Beauty, Mustang, Coach and Ojon.

Allergan and The Estée Lauder Companies Inc. Forward-Looking Statements

This press release contains "forward-looking statements," including the statements by Mr. Pyott, Mr. Lauder and Ms. Greene and other statements regarding the market potential associated with the new product line. These statements are based on current expectations of future events. If underlying assumptions prove inaccurate or unknown risks or uncertainties materialize, actual results could vary materially from Allergan's or The Estée Lauder Companies Inc.'s expectations and projections. Risks and uncertainties include, among other things, general industry and professional skin care channel conditions; technological advances and patents attained by competitors; challenges inherent in the research and development and regulatory processes; challenges related to product marketing, such as the unpredictability of market acceptance for new skin care products; inconsistency of treatment results among patients; the potential for product failures; potential difficulties in manufacturing new products; governmental laws and regulations affecting domestic and foreign operations and the ongoing success of the collaboration. Allergan and the The Estée Lauder Companies Inc. expressly disclaim any intent or obligation to update these forward-looking statements except as required to do so by law.

Additional information concerning these and other risk factors can be found in press releases issued by Allergan, as well as Allergan's public periodic filings with the Securities and Exchange Commission, including the discussion under the heading "Risk Factors" in Allergan's 2006 Form 10-K and Allergan's Form 10-Q for the quarter ended September 28, 2007. Copies of Allergan's press releases and additional information about Allergan are available on the World Wide Web at www.allergan.com or you can contact the Allergan Investor Relations Department by calling (714) 246-4636.

Additional information concerning these and other risk factors can also be found in press releases issued by The Estée Lauder Companies Inc., as well as in its filings with the Securities and Exchange Commission, including the discussion under the heading "Risk Factors" in The Estée Lauder Companies Inc. Form 10-K for the fiscal year ended June 30, 2007. Copies of The Estée Lauder Companies Inc. press releases, filings as well as additional information about the company, are available at www.elcompanies.com or you can contact The Estée Lauder Companies Inc. Investor Relations Department by calling (212) 572-4184.

Allergan Contacts

Jim Hindman (714) 246-4636 (investors)

Joann Bradley (714) 246-4766 (investors)

Emil Schultz (714) 246-4474 (investors)

Caroline Van Hove (714) 246-5134 (media)

Leslie Bryant (714) 246-6948 (media)

The Estée Lauder Companies Inc. Contacts

Dennis D'Andrea (212) 572-4384 (investors)

Clinique Laboratories Contacts

Sheila Munguia (212) 572-6810 (media)

ALLERGAN and BOTOX are registered trademarks of Allergan, Inc.

JUVÉDERM is a registered trademark of Allergan Industrie, SAS

The other trademarks in this press release are owned or licensed by subsidiaries of The Estée Lauder Companies Inc.

1 American Society for Aesthetic Plastic Surgery (ASAPS), 2006 Statistics on Cosmetic Surgery, www.surgery.org (January 24, 2008)

Monday, 2 March 2009

Where Can I Find Clinique Medical?

Clinique Medical is available in selected physician offices.

For more information or to locate a provider near you, please visit www.cliniquemedical.com

Monday, 2 March 2009

Who Is Clinique Medical For?

Anyone who is planning to undergo a non-surgical cosmetic procedure or taking certain prescription medications.

Ask your physician if Clinique Medical products could benefit you.

Monday, 2 March 2009

What Are The Benefits of Clinique Medical?

With your physician’s guidance, a Clinique Medical regimen can improve your recuperative experience, minimize predictable discomfort and disruptive visible side effects, and keep skin primed for optimal results.

Monday, 2 March 2009

What Is In The Clinique Medical Product Lineup?

Clinique Medical offers a daily-use, pre, post and ongoing regimen designed to optimize the results of non-surgical cosmetic procedures.

The Clinique Medical collection also includes a treatment for the drying effects of certain prescription medications.

Monday, 2 March 2009

What’s So Different About Clinique Medical?

Physician involvement in development and testing means Clinique Medical products are designed to work synergistically to help strengthen skin, minimize unintended effects and support recovery.

In addition, all products are filled in a pharmaceutically-designated environment, offering purity assurance for compromised skins.

Monday, 2 March 2009

What Is Clinique Medical?

Clinique Medical is an innovative line of exclusive products available only from your physician.

Clinique Medical formulas care for skin’s heightened needs before and after non-surgical cosmetic procedures —including various laser treatments and chemical peels — and provide an exceptional level of ongoing care.

Monday, 2 March 2009

Pre- and Probiotics for Human Skin (Jean Krutmann)

Current research on the complex interplay between the microbiota, the barrier function and the innate immune system of the skin indicates that the skin's microbiota have a beneficial role, much like that of the gut microflora.

As a consequence, interest in strategies beyond antibiotica that allow a more selective modulation of the skin microflora is constantly growing.

This review will briefly summarize our current understanding of the cutaneous microbiota and summarize existing information on pre- and probiotic strategies for skin.


Journal of Dermatological Science

1 April 2009

Volume 54, Issue 1

Pages 1-5

DOI: 10.1016/j.jdermsci.2009.01.002)

Thursday, 18 February 2010

RevaleSkin Coffeeberry (Newly Available)

RevaleSkin Coffeeberry (Newly Available)

February 2009.

We are pleased to announce the availability of RevaléSkin Coffeeberry skin care products (manufactured by Stiefel Laboratories) containing extract of Coffea arabica, a rich source of photoprotective antioxidant ferulic acid, quinic acid, chlorogenic acid and condensed proanthocyanidins.

Using the ORAC (Oxygen Radical Absorbance Capacity) assay as a guide, the proprietary Coffea arabica extract used in RevaléSkin ("CoffeeBerry") exhibits approximately 10 times the antioxidant capacity of green tea, and therefore higher than pomegranate, blueberries, white tea, black tea and strawberries.

Research from Stiefel indicates significant lessening of hyperpigmentation, fine lines, wrinkles and an overall improvement in the appearance of skin over a six week period of use.

Studies indicate ferulic and chlorogenic acids inhibit cutaneous tumours (Cancer Research 48:5941-5946, 1988) and that a combination of these substances is likely more effective than either alone.

The antioxidant constituents of Coffea arabica provide these protective substances in addition to others.

RevaléSkin Coffeeberry skin care products contain up to 1.5% CoffeeBerry.

It will be interesting to see how these products compare with pre-existing ferulic acid formulations (mainly Skinceuticals Serums) and the numerous predominantly very low-concentration Camellia sinensis and Camellia oleifera-containing skin care products.

CoffeeBerry is a proprietary extract of coffee fruit used under license by Stiefel in RevaléSkin and is also available in "functional foods" and supplements.

For further information you may like to refer to http://www.coffeeberry.org.

Friday, 20 February 2009

More About Tx Systems Afirm Retinol

Afirm acts directly on the epidermis to restore the natural process by which healthy, new cells gradually work their way to the surface to replace older, less vital cells. This improved renewal process is how your skin texture is refined and pores become less noticeable. The color becomes more uniform, and your skin actually takes on a new radiance.

This easy-to-use, fragrance free formula spreads evenly on your face.

Afirm is greaseless, non-comedogenic and non-acnegenic.

Afirm is offered in three strengths:

  • 1x (0.15% retinol) for sensitive skin
  • 2x (0.30% retinol) for normal skin
  • 3x (0.60% retinol) for more tolerant skin

Sunday, 8 March 2009

The Ultraviolet Garden

Excerpt from the 1991 Royal Institution Christmas Lectures discussing chemically powerful ultraviolet (UVA, UVB) light, invisible to the human eye (although harmful to human skin and eyes), yet visible and beneficial to bees (and other species) in their search for nectar and pollen.

Video requires Apple Quicktime. Streaming file size: 18 mb.


For those species that are able to perceive it, ultraviolet light reveals instructional patterns and colours which the human eye sees only as solid colour.

This type of light has been named "ultra"violet because it exists at frequencies higher than violet, the last colour we see in the rainbow sequence comprising red, orange, yellow, green, blue, indigo and violet, first proven in a colour theory by Isaac Newton in 1666, which when combined are white.

Astronomer and composer Frederick William Herschel discovered infrared (heat) rays in 1800. Just a year later physicist and chemist Johann Wilhelm Ritter discovered invisible ultraviolet rays.

Isaac Newton's deconstruction of the colours of the rainbow is said to have caused John Keats to write Lamia:

Do not all charms fly
At the mere touch of cold philosophy?
There was an awful rainbow once in heaven:
We know her woof, her texture; she is given
In the dull catalogue of common things.
Philosophy will clip an Angel's wings,
Conquer all mysteries by rule and line,
Empty the haunted air, and gnomed mine —
Unweave a rainbow

Notwithstanding the angst evoked and disease provoked by the sun, a better understanding of it's light (it's photons) has enabled people to avoid considerable previously inadvertent harm, and to benefit from technologies that have emerged from this understanding (phototherapy, laser, sunscreens and photoprotective antioxidants).

Ultraviolet (and Infrared) Patterns Exposed in Flowers

Photographer Bjørn Rørslett has photographed flowers so as to reveal their fluorescent UV and infrared patterns:

Potentilla anserina.

Coreopsis (from the Aster family of plants).

Crepis biennis (from the Aster family of plants).

Jasione montana.

Oenothera biennis.

Ranunculus ficaria (showing UV and IR).

Angelica sylvestris.

Ultraviolet Skin Image

Ultraviolet Skin Image.

Refer photoprotection and photoaging.

Further Information

The Sun.

Light.

Ultraviolet.

Radiation.

Rainbow.

Colours.

Sunday, 8 March 2009

Optics

Optics is the scientific study of sight and the behavior of light, or the properties of transmission and deflection of other forms of radiation.

Sunday, 8 March 2009

The Sub-Atomic Source of Perceived Optical Properties

Electrons are minute negatively-charged particles of matter that orbit the positively-charged nuclei of atoms, they are responsible for binding atoms together in molecules and for the optical properties of solids. An atom is roughly 10 to the minus 8 centimetres in diametre.

Wednesday, 11 November 2009

Georges Seurat

Prior to the first (1938, red petroleum) sunscreen...

A Sunday Afternoon on the Island of La Grande Jatte — Un Dimanche Après-Midi à l'Île de la Grande Jatte, 1883

A Sunday Afternoon on the Island of La Grande Jatte — Georges Seurat's most famous work.

Georges Seurat's most famous work, motivated by study in optical and colour theory.

As in Bathers at Asnières below, the painstaking pointillist dots of primary colours give the human eye the impression of a single vibrant hue.

Bathers at Asnières — Une Baignade, Asnières, 1884

Bathers at Asnières.x

Simple forms and regular shapes defined by daylight, comprised of dots of contrasting colour to create a vibrant, luminous effect.

For example, dots of brown, pink and orange comprise the dog's coat.

Rainbow Arc-en-ciel, 1883

Rainbow — A study for Bathers at Asnières.

One of several studies leading up to Bathers at Asnières.

Additional Information

Optics.

The Particle Source of Perceived Optical Properties.

Light.

Colours.

Ultraviolet.

The Ultraviolet Garden.

Sunday, 21 December 2008

Collagen Protects Brain from Alzheimer’s Disease

Researchers have discovered that a certain type of collagen, collagen VI, protects brain cells against amyloid-beta protein, the accumulation of which is thought to cause Alzheimer’s disease.

The researchers discovered that the source of collagen VI in the brain was, in fact, neurons — the very same cells which are destroyed by Alzheimer’s disease.

Source: A special type of collagen may help protect the brain against Alzheimer's disease. Gladstone Institutes. December 10th 2008.

Further Information

Collagenase.

Friday, 13 March 2009

Oxidative Stress/Damage Theory of Aging Disproven by Study

The National Institute of Health recognizes 20-30 different theories of aging, among which the "Free Radical" and "Neurohumoral" theories have been given the most support.

Supplement, food and cosmetics industries (a category encompassing cosmeceutical brands) and their consumers have come to regard the Free Radical Theory of Aging as universally accepted.

This acceptance has led to rapid expansion and uptake of products and services with little or no realization that the mechanisms by which antioxidants may work are all still classed as theories.

In reality, science increasingly disproves the current free radical theory of aging and moreover has pointed to harmful effects of some antioxidant use.

Antioxidant skin care use is sometimes clearly deleterious, yet users will maintain their use due to some degree of inattention, reliance on poor or inadequate information, unrealistic product passion, peer factors or a plain inability to equate a relatively high purchase price with uselessness for skin.

One of the prime dermatologic proponents of the free radical theory of aging and moreover it's role in inflammation is Dr. Nicholas Perricone, founder of N.V. Perricone Cosmeceuticals and author of The Wrinkle Cure, among a growing collection of books.

The Free Radical Theory holds that, with accumulated free radical damage and oxidative stress, biochemical and cellular processes begin to do more "incorrect" things as aging damage accumulates.

Researched published by Dr. David Gems of University College London's Ageing Laboratory in the Journal of Genes and Development (see below) finds that antioxidants themselves are not "anti-aging".

In contrast with the universal acceptance of the free radical theory of aging, Dr. Gems states that:

"The fact is that we don't understand much about the fundamental mechanisms of ageing... The free radical theory of ageing has filled a knowledge vacuum for over fifty years now, but it just doesn't stand up to the evidence... One of the hallmarks of ageing is the accumulation of molecular damage, but what causes this damage?... It's clear that if superoxide is involved, it only plays a small part in the story. Oxidative damage is clearly not a universal, major driver of the ageing process. Other factors, such as chemical reactions involving sugars in our body, clearly play a role... It really demonstrates finally that trying to boost your antioxidant levels is very unlikely to have any effect on ageing."

Examples of Superoxide-Scavenging Antioxidants

Skin care products, supplements and foods containing alpha-tocopherol (Vitamin E), ascorbic acid (Vitamin C), propyl gallate and Trolox. (Vitamin E Analogue).

Some Recommendations for Antioxidant Skin Care Use

  • Antioxidants do not reverse aging and increasingly do not appear to prevent aging by themselves, however optimal, careful and managed use may help stimulate your skin's own defenses;

  • If using antioxidants, avoid over-emphasizing the use of any one kind (for example, do not apply a serum containing only Vitamin E or C alone, as these can increase damage) — this usually means using a variety of brands, rather than just one or two;

  • Analogues and derivatives of naturally-occurring antioxidants increasingly appear to be of much less value than nature-identical forms;

  • Avoid use of oxidized antioxidant skin care products — unfortunately, these appear to comprise a significant proportion of those used (stock should be fresh, packaging should omit air — many Vitamin C products should be used within weeks of manufacture, not months);

  • Keep in mind that commonplace use of antioxidant skin care products do not replicate, or only very mildly and transiently reproduce the results of trials published into the ingredients contained within said products;

  • Avoid excessive antioxidant or cosmeceutical skin care use unless your skin is scientifically assessed for irritation (laser doppler allows for this measurement);

  • Never attempt to make your own antioxidant skin care products by purchasing raw materials and combining them into bland base creams or other products — more or stronger is not necessarily better.

Further Information

Antioxidants "Cannot Slow Ageing" — BBC.

Dr. David Gems of University College London's Ageing Laboratory.

A Year of Photoprotection — Results from Topical Vitamin C (as Ascorbic Acid) and Sunscreen Use.

Against the oxidative damage theory of aging

Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans

Doonan R, McElwee JJ, Matthijssens F, Walker GA, Houthoofd K, Back P, Matscheski A, Vanfleteren JR, Gems D.

Institute of Healthy Ageing and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom;

The superoxide radical (O(2)(-)) has long been considered a major cause of aging. O(2)(-) in cytosolic, extracellular, and mitochondrial pools is detoxified by dedicated superoxide dismutase (SOD) isoforms. We tested the impact of each SOD isoform in Caenorhabditis elegans by manipulating its five sod genes and saw no major effects on life span. sod genes are not required for daf-2 insulin/IGF-1 receptor mutant longevity. However, loss of the extracellular Cu/ZnSOD sod-4 enhances daf-2 longevity and constitutive diapause, suggesting a signaling role for sod-4. Overall, these findings imply that O(2)(-) is not a major determinant of aging in C. elegans.

PMID: 19056880

Thursday, 18 December 2008

Why Protect Against UVA Exposure?

Why Protect Against UVA Exposure?

Sunscreen SPF numbers pertain to UVB protection only, however different sunscreen ingredients and brands actually provide different protection.

Optimal protection against both UVA and UVB rays is important.

While UVB is primarily responsible for basal and squamous cell carcinomas, malignant melanomas and actinic keratoses, UVA threatens:

  • decreased immune response against skin cancer;

  • more dyspigmentation than UVB;

  • dermal damage, including permanent wrinkling changes (vimentin);

  • oxidative DNA damage, leading to mutations.

For further information, see the Recommended Sunscreens, Optimal Sunscreen Use and The Truth About Sunscreens).

Thursday, 18 December 2008

Shortcomings of Avobenzone

Avobenzone is a popular chemical sunscreen ingredient which offers some protection against UVA and is popular due to its cosmetically elegant texture.

Its primary shortcomings are as follows:

  • It is less effective the greater the UV exposure and the less frequent the application (as an "anti-aging" sunscreen it provides no great day-long protection against aging UVA rays, yet users commonly presume once-daily application is substantially effective against photoaging);

  • It is more stable when combined with octocrylene, nevertheless it remains far from perfect in this combination.

If you use a sunscreen containing avobenzone, it should also ideally contain octocrylene (for further information, see the Recommended Sunscreens, Optimal Sunscreen Use and The Truth About Sunscreens).

In addition, if your Fitzpatrick Skin Type is I or II, and you opt to use a sunscreen with avobenzone, it should be SPF 30+.

Thursday, 7 May 2009

Sunscreen/Sun Exposure/Photoprotection

Sunscreen/Sun Exposure/Photoprotection

Better sunscreens and sunscreen use provide more optimal photoprotection for reduced photoaging, actinic keratoses, basal cell carcinomas, squamous cell carcinomas and melanomas.

Thursday, 18 December 2008

Don't Forget Vitamin D

Don't Forget Vitamin D

Thursday, 18 December 2008

Your Skin and The Sun

Your Skin and The Sun

Friday, 26 August 2011

Optimal Sunscreen Use

Optimal Sunscreen Use

Better sunscreens and sunscreen use provide more optimal photoprotection for reduced photoaging, actinic keratoses, basal cell carcinomas, squamous cell carcinomas and melanomas.

Tuesday, 17 March 2009

The Truth About Sunscreens

The Truth About Sunscreens

Better sunscreens and sunscreen use provide more optimal photoprotection for reduced photoaging, actinic keratoses, basal cell carcinomas, squamous cell carcinomas and melanomas.

Thursday, 18 December 2008

Tanning

Tanning

Friday, 26 August 2011

Recommended Sunscreens

Recommended Sunscreens

Better sunscreens and sunscreen use provide more optimal photoprotection for reduced photoaging, actinic keratoses, basal cell carcinomas, squamous cell carcinomas and melanomas.

Thursday, 18 December 2008

How To Minimize Exposure

How To Minimize Exposure

Thursday, 18 December 2008

Safety Concerns Over High-Tech (Nanotechnology) Sunscreens

Video Source: ABC 7:30 Report, 17/12/2008. Reporter: Kirstin Murray. Requires Apple Quicktime.


Nanotechnology has been a revolutionary science utilised to improve water supplies, screen for viruses and increase durability in food among its other uses.

Nanoscience has also been used to produce products such as stain resistant clothing and is often found in cosmetic products such as anti-ageing creams and sunscreen.

With this technology being so widely used, questions are being raised as to how safe nanotechnology is in products that are rubbed directly onto human skin.

Titanium dioxide and zinc oxide nanotechnology sunscreens are covered in this report.

Current

Titanium dioxide nanoparticles been used since at least 1990 and zinc oxide nanoparticles since 1999.

There is no evidence that sunscreens containing these materials pose any risk to the people using them.

A theoretical concern has been raised that if zinc oxide or titanium dioxide in nanoparticle form are absorbed into skin cells they could possibly interact with sunlight to increase the risk of damage to these cells. However, initial studies are limited in number and have proved inconclusive.

The most recent review (2006) by the Australian TGA found that there is evidence from isolated cell experiments that zinc oxide and titanium dioxide can induce free radical formation in the presence of light and that this may damage these cells (photo-mutagenicity with zinc oxide).

However, this would only be of concern in people using sunscreens if the zinc oxide and titanium dioxide penetrated into viable skin cells.

The weight of current evidence is that they remain on the surface of the skin and in the outer dead layer (stratum corneum) of the skin.

Further Information

Nanotechnology.

A review of the scientific literature on the safety of nanoparticulate titanium dioxide or zinc oxide in sunscreens — PDF, Australian TGA.

A purportedly Safe Sunscreen Guide — Friends of The Earth.

Updated and extended sunscreen comparisons.

General Sunscreen Information

Recommended Sunscreens.

Tanning.

The Truth About Sunscreens.

How To Minimize Exposure.

Optimal Sunscreen Use.

Your Skin and The Sun.

Don't Forget Vitamin D.

Tuesday, 25 November 2008

Leading Therapeutic Approaches in Antioxidant Skincare Protocols

Leading Therapeutic Approaches in Antioxidant Skincare Protocols

Thursday, 18 December 2008

Extended Comparison of Sunscreens

Extended Comparison of Sunscreens

Better sunscreens and sunscreen use provide more optimal photoprotection for reduced photoaging, actinic keratoses, basal cell carcinomas, squamous cell carcinomas and melanomas.

Saturday, 18 July 2009

Tetrahexyldecyl Ascorbate replaces Ascorbyl Palmitate in N.V. Perricone Products

N.V. Perricone have replaced ascorbyl palmitate with tetrahexyldecyl ascorbate — both forms of lipid-soluble "Vitamin C" — also found in Strivectin SD and Strivectin Facial Antioxidant.

Tuesday, 16 August 2016

Algorithm for Optimal Sustained Exfoliation: Glycolic Acid

Generates highly individualised AM and PM home skin care protocols for glycolic acid lasting four months with the aim of extracting maximum results (results up to the point of net negative side effects).

Exfoliation is maximized according to the individual's precise skin characteristics, side effect tolerance, extent of daily UV exposure and whether or not they smoke or take skin-sensitizing medications.

Permutations

Normal/Oily/Dry +/- Sensitive +/- Hyperpigmented +/- Retinaldehyde 0.01% Gel/0.05% Cream/Retinol 0.3%/0.5%/1% +/- Ascorbic Acid 10/15/17.5/20% for Forehead/Neck/Cheeks/Nose/Nasolabial/Periocular.

Settings

Side Effect Tolerance, Sun Exposure, Smoking, Medications.

Prerequisites

Notes

Does not take into account the effects of hormones, including stress, diet, or the effects of additional cosmetic procedures or cosmetics.

Monday, 13 July 2009

Skinceuticals Phloretin C F Press Release: How to Use Phloretin CF

Skinceuticals Phloretin CF is ideal for oily, problematic and normal skin types and for those who are concerned with hyperpigmentation, erythema, uneven skin tone, loss of elasticity, mottled appearance or photo-damage.

After cleansing and before moisturising, apply 4 or 5 drops of Skinceuticals Phloretin CF to face, neck and chest once daily using fingertips.

Monday, 3 August 2009

Skinceuticals Phloretin C F Press Release: Key Ingredients

2% Phloretin


10% L-Ascorbic Acid (Vitamin C)


0.5% Ferulic Acid


Monday, 13 July 2009

Skinceuticals Phloretin C F Press Release: How does Phloretin Work?

"After extensive research, SkinCeuticals has identified Phloretin as a powerful molecule that works in synergy with Vitamin C and ferulic acid to provide broad spectrum antioxidant protection.

This patent-pending technology and unsurpassed combination of key ingredients helps protect not only against free radicals, but the range of Reactive Oxygen Species.

Further, Skinceuticals Phloretin CF helps correct existing damage by stimulating the synthesis of essential proteins and fibres and accelerating cell turnover.

The broad-spectrum action of Skinceuticals Phloretin CF delivers powerful, optimised photoprotection, penetrating the skin at every level to help protect integral cell types and prevent cell mutation by shielding the skin’s DNA from ROS and antioxidants.

The skin’s natural immunity against DNA impairment is strengthened, to preserve cellular integrity and help prevent serious skin conditions.

Cell renewal is accelerated, the support structure of the skin is boosted and UV-induced discolorations [hyperpigmentation] are inhibited.

On an aesthetic level, age spots are diminished, skin tone is dramatically improved for a firmer, stronger re-textured complexion.

The skin appears healthy, radiant and younger looking."

Monday, 13 July 2009

Skinceuticals Phloretin C F Press Release: What is Phloretin

"This innovative ingredient is derived from apples and the root bark of fruit trees including apple, grapefruit and pear.

Classified as a dihydrochalcone, Phloretin is known to prevent immunosuppression and for anti-inflammatory, antifungal and anticancer properties."

Wednesday, 11 March 2009

Skinceuticals Phloretin C F Press Release: Why Use an Antioxidant?

"Daily exposure to damaging environmental elements accelerates the ageing process by causing molecules in the skin to become highly reactive. These unstable molecules produce damaging reactive oxygen species (ROS) such as free radicals, oxygen ions and peroxides.

Increased ROS levels can result in damaging DNA mutations, a slow down in cell regeneration and signs of photodamage including fine lines, wrinkles, loss of elasticity, discoloration and even skin cancer.

The use of a topical antioxidant application such as PHLORETIN CF fights against ROS to protect the skin from premature ageing."

Saturday, 25 October 2008

About "Lavender"

Lavender is a small aromatic evergreen shrub of the mint family, with narrow leaves and bluish-purple flowers.

Lavender has been widely used in perfumery and medicine since ancient times.

Lavender's genus is Lavandula and its family is Labiatae.

Flowers and stalks of of the shrub are dried and used to give a pleasant smell to clothes and bed linens.

Lavender also refers to the scented oil distilled from lavender flowers.

Lavender is also a dated reference to refinement or gentility, as in "she had a certain lavender charm."

Lavender also refers to the pale blue color with a trace of mauve.

"Perfume with lavender."

The word originates from Middle English, from Anglo-Norman French lavendre, based on medieval Latin lavandula.

Saturday, 25 October 2008

Cytotoxicity of Lavender Oil and its Major Components to Human Skin Cells

Lavender (Lavandula angustifolia) oil, chiefly composed of linalyl acetate (51%) and linalool (35%), is considered to be one of the mildest of known plant essential oils and has a history in wound healing.

Concerns are building about the potential for irritant or allergenic skin reactions with the use of lavender oil.

This study has demonstrated that lavender oil is cytotoxic to human skin cells in vitro (endothelial cells and fibroblasts) at a concentration of 0.25% (v/v) in all cell types tested (HMEC-1, HNDF and 153BR).

The major components of the oil, linalyl acetate and linalool, were also assayed under similar conditions for their cytotoxicity.

The activity of linalool reflected that of the whole oil, indicating that linalool may be the active component of lavender oil.

Linalyl acetate cytotoxicity was higher than that of the oil itself, suggesting suppression of its activity by an unknown factor in the oil.

Membrane damage is proposed as the possible mechanism of action.


View skin care products and topics for lavender.


Cell Proliferation.

Volume 37 Issue 3, Pages 221 - 229.

AU: A. Prashar, I. C. Locke, C. S. Evans

TI: Cytotoxicity of lavender oil and its major components to human skin cells

SO: Cell Proliferation

VL: 37

NO: 3

PG: 221-229

YR: 2004

ON: 1365-2184

PN: 0960-7722

AD: School of Biosciences, University of Westminster, London, UK

DOI: 10.1111/j.1365-2184.2004.00307.x

US: http://dx.doi.org/10.1111/j.1365-2184.2004.00307.x

A. Prashar , I. C. Locke and C. S. Evans

School of Biosciences, University of Westminster, London, UK

Correspondence to Dr I. C. Locke, School of Biosciences, University of Westminster, 115 New Cavendish Street, London, W1W 6UW, UK. Tel.: + 44-20-7911-5000; Fax: + 44-20-7911-5087; E-mail: i.c.locke@westminster.ac.uk

Tuesday, 23 June 2009

Bakel Skin Care

The new "cosmeceutical" Italian skin care brand Bakel appears to be a disappointment.

Refer Bakel.


From the Press Release:

In a bid to bring scientific know-how and skincare expertise to a brand reputed as artsy, Australian makeup artist brand Becca has entered a distribution tie-up with new Italian skincare company Bakel Technology. The deal will see the new six-sku Bakel skincare range sold in all 120 of Becca's points-of-sale worldwide, Becca ceo Steven Schapera tells CosmeticNews.

Developed by Italian skincare chemist Raffaella Gregoris of the University of Milan, the Bakel range comprises six fluid serums containing no preservatives, fragrance or petroleum-based ingredients, and composed exclusively of active ingredients, including star anti-aging ingredient hyaluronic acid. “In technological terms, [Bakel] has made a huge leap. Because the products are fluid, they're absorbed much more easily by the skin, and Bakel has eliminated unnecessary ingredients that don't provide any benefits,” Schapera claims. “We're makeup experts and not skincare experts, so we need to bring in this expertise from outside,” he continues. “It makes for a good marriage, [combining] their scientific orientation with our creative [one].”

The Bakel line will be exclusively available at Becca's points-of-sale in the markets where the latter brand is distributed. In markets outside Becca's distribution network, including Italy, Germany and Russia, the Italian brand will be available in other retail doors. Becca will initially launch the skincare range in the UK market next month, at its flagship store in London and at high-end department store Harvey Nichols, before rolling it out to doors in Australia and New Zealand, the Middle East and Asia later this year. The brand will be introduced to Becca's North American doors either by the end of this year or in early 2009, Schapera says.

Becca and Bakel will be merchandised alongside each other in-store, with skincare specialists slated to join Becca's makeup artists in points-of-sale to advise customers. The tie-up should also result in Becca launching a series of reformulated and new products in collaboration with Bakel, Schapera reveals. “We’ve been trying to find skincare technology that we can use in our products, and now that we have access to [Bakel's] expertise we're looking to work with them on our products.”

The tie-up comes as Becca, currently available in 21 countries, is gearing up to expand into new markets. The brand will enter Poland within the next few weeks, where it will be exclusively distributed at specialty store Galilu. It will then enter Dubai by the end of this year, and Taiwan and Japan sometime in the next year, Schapera says. He confirms that Becca is planning to open its first standalone outside the London flagship in Dubai by the end of 2009. “If the economic circumstances were different [in the US], we would have chosen to open our [first standalone abroad] in New York City or Los Angeles, but Dubai is a more logical choice at this time,” he comments.

Sunday, 9 August 2009

Bakel Malic "Lightening Solution"

This formula may lessen hyperpigmentation, but it will do so at a glacial rate and at far greater cost than more effective alternatives.

Ironically this, Bakel's most potentially beneficial product, is it's cheapest @ $135.00.


Innovative fluid solution containing:

malic acid, mandelic acid, tartaric acid, kojic acid, all acting synergically for thoroughly removing dead skin cells and acquire new brightness. They prevent skin spots and improve skin complexion; glycerine and pentylene glycol help maintaining an ideal moisturizing level; vegetable hydrocellulose with its protective action adds a gel formula thus improving its application; ammonium hydroxyde which instantly dabbing the acid pH of this solution, helps respecting skin physiologica balance.

This solution does not need to be rinsed, therefore you can leave it on your skin to boost its effects.

INGREDIENTS:

aqua, glycerin, pentylene glycol, malic acid, mandelic acid, tartaric acid, kojic acid, hydroxyethylcellulose, ammonium hydroxide

NOT CONTAIN:

perfumes, colouring agents, preservatives, oil-derivatives, silicones, alcohol, PEG, PPG.

Thursday, 18 December 2008

Bakel Vit. E-A "Nutritive Formula"

Used during the day, you can expect Bakel's Vit. E-A, priced @ $175.00 per 30 mL, to potentially increase free radical damage.


Oily fluid containing:

Vitamin E with its important anti-free radicals action for a perfect anti-age function; Vitamin A which together with Vitamin E slows considerably down the ageing process typical of dry skin, and reduces skin thickening; sweet almond oil with its outstanding emollient, nourishing and softening properties; silica with a renewing action.

INGREDIENTS:

prunus amygdalus dulcis oil, tocopheryl acetate, retinyl palmitate, silica

NOT CONTAIN:

perfumes, colouring agents, preservatives, oil-derivatives, silicones, alcohol, PEG, PPG.

Thursday, 16 October 2008

Bakel Q10-B5 "Cellular Revitalizer"

The only aspect of this formulation which is remotely unique is that it contains ubiquinone (Co-Enzyme Q10).

The ingredient is also available in Nivea Co-Enzyme Q10 products.

In any event, unlike some antioxidants, ubiquinone is presently thought better supplied to the skin by diet than topical application.


Innovative fluid containing:

Q10 coenzyme which prevents and slows down skin ageing at a cellular level; panthenol with its soothing and compacting action; aloe and vegetable glycerine with their synergic rehydrating properties.

INGREDIENTS:

aloe barbadensis gel, glycerin, panthenol, ubiquinone

NOT CONTAIN:

perfumes, colouring agents, preservatives, oil-derivatives, silicones, alcohol, PEG, PPG.

Saturday, 18 July 2009

Bakel Collagen "Firming Formula"

The formula, priced at $190.00 per 30 mL, simply does nothing to actually firm skin by increasing collagen production.


Innovative fluid containing:

natto gum, with its high-elasticity and firming properties keeps your skin young and well-nourished; panthenol with its soothing and compacting activity; vegetable glycerine with its crucial moisturizing property.

IINGREDIENTS:

glycerin, natto gum, panthenol

NOT CONTAIN:

perfumes, colouring agents, preservatives, oil-derivatives, silicones, alcohol, PEG, PPG.

Saturday, 15 August 2009

Bakel Jaluronic "Instant Replenishment"

If ever there were a formulation as boring as monochrome, this is it.

Priced at $190.00 Bakel Jaluronic contains only water and hyaluronic acid.

One would expect this product to dehydrate and challenge the skin's barrier in air-conditioned and other dry climates due to its plainly hydroscopic nature.

Hyaluronic acid is a less effective moisturizer than many other ingredients required for a healthy skin barrier.

Skin penetration by topical hyaluronic acid is poor and not high as claimed.

The suggested use "before any other treatment" would impair absorption of beneficial ingredients, including critical sunscreens.


Innovative fluid containing pure hyaluronic acid which thanks to its low molecular weight boasts high penetration performance. It ensures perfect tone, elasticity and cutaneous turgor, together with an ideal moisturizing level.

It produces an immediate lifting effect and gives your skin visible brightness.

INGREDIENTS:

aqua, sodium hyaluronate

NOT CONTAIN:

perfumes, colouring agents, preservatives, oil-derivatives, silicones, alcohol, PEG, PPG

Sunday, 9 August 2009

Bakel Lactobionic "Antioxidant" Formula

Contains glycerin, lactobionic acid, gluconolactone.

This purported antioxidant is an exceedingly ordinary moisturizer priced at $225.00


Innovative fluid exclusively containing 3 active agents giving great and proven effects.

Lactobionic acid able to improve cutaneous turgor thanks to its powerful anti-ageing and anti-wrinkle action.

Gluconolactone, which protects your skin against spots and ageing due to sun exposure, and improves your skin tonicity.

Vegetable glycerine with its moisturizing action.

Does not contain perfumes, colouring agents, preservatives, oil-derivatives, silicones, alcohol, PEG, PPG.

Thursday, 26 November 2009

Skinceuticals Claimed Benefits of A.G.E. Interrupter

Thursday, 26 November 2009

Skinceuticals A.G.E. Interrupter Product Description

A.G.E. Interrupter is specifically formulated to improve the creping, thinning appearance of mature skin caused by intrinsic or internal aging processes such as glycation.

Glycation occurs when excess glucose molecules stick to collagen and elastin fibers, eventually binding them together and leading to the formation of Advanced Glycation End-products (A.G.E.).

Glycated collagen and elastin fibers lose the ability to function normally, and the body cannot break them down and replace them, which leads to severe wrinkling of the skin.

A.G.E. Interrupter is a unique treatment formulated with 4% blueberry extract, 30% Pro-Xylane™, and 0.2% phytosphingosine to help prevent the glycation process and correct severe signs of intrinsic aging in mature skin.

Wednesday, 15 October 2008

Vivité Vibrance Therapy Description from Allergan

Vibrance Therapy uses botanicals, antioxidants and glycolic compound to diminish the appearance of hyperpigmentation.

The hydroquinone-free formula also smoothes fine lines and wrinkles, promotes the production of collagen and epidermal growth factor, and increases hydration within the skin. Licorice, mulberry, retinol, green tea and methyl dihydroxybenzoate reduce the appearance of brown spots, sun spots, melasma and other forms of hyperpigmentation.

Antioxidants neutralize free radicals to prevent the formation of visible signs of aging. The complexion becomes bright, evenly toned, gorgeously translucent and youthful in both tone and texture.

Wednesday, 3 June 2009

Skinceuticals A.G.E. Interrupter Technology

Multi-faceted formulation containing 4% blueberry extract, 30% Pro-Xylane™, and 0.2% phytosphingosine to prevent and correct the most visible signs of intrinsic aging.

Sunday, 14 June 2009

Joan Crawford's Deleterious Facial Cleansing Protocol

Facial Cleansing Scene from Mommy Dearest.

Faye Dunaway as Joan Crawford.
Music by Henry Mancini.
Directed by Frank Perry.
Paramount Pictures, 1981. Video requires Apple Quicktime.


The American Film Institute regards Joan Crawford (1905—1977) as the "tenth greatest female star" of the last one-hundred years.

If reports from those close to her are accurate, Joan Crawford practiced a range of extreme skin care protocols likely driven by paranoid and hypomanic symptoms.

Ms. Crawford's morning facial cleansing protocol reportedly comprised readying coffee while giving her essentially clean skin a stern brush with copious amounts of too-alkaline soap and too-hot water before plunging it into perfumed ice kept refrigerated under the sink.

One could hardly do more to foster an un-healthy skin barrier.

Her face-immobilising bands are not, however, such a bad "anti-aging" idea.

The medical understanding of what constitutes ideal cleansing has advanced considerably over time, yet relatively and plainly deleterious facial cleansing remains remarkably popular.

Sub-par facial cleansers are to be found across many skin care brands, be they "natural," "French," "cosmeceutical" or other and the temptation (or is it a drive?) to over-cleanse or strip non-existent dirt is perennial.

The Clinique 3-Step System hails from the time of Joan Crawford.

Monday, 15 June 2009

Beauty Product Consumers like Old Sailors (The Old Sailor, by A. A. Milne)

Beauty Product Consumers like Old Sailors (The Old Sailor, by A. A. Milne)

Beauty product consumers like Old Sailors ... never starting in the right place, never finishing what is begun, producing aging in the name of anti-aging for no good reason at all.


There was once an old sailor my grandfather knew
Who had so many things which he wanted to do
That, whenever he thought it was time to begin,
He couldn't because of the state he was in.

He was shipwrecked, and lived on a island for weeks,
And he wanted a hat, and he wanted some breeks;
And he wanted some nets, or a line and some hooks
For the turtles and things which you read of in books.

And, thinking of this, he remembered a thing
Which he wanted (for water) and that was a spring;
And he thought that to talk to he'd look for, and keep
(If he found it) a goat, or some chickens and sheep.

Then, because of the weather, he wanted a hut
With a door (to come in by) which opened and shut
(With a jerk, which was useful if snakes were about),
And a very strong lock to keep savages out.

He began on the fish-hooks, and when he'd begun
He decided he couldn't because of the sun.
So he knew what he ought to begin with, and that
Was to find, or to make, a large sun-stopping hat.

He was making the hat with some leaves from a tree,
When he thought, "I'm as hot as a body can be,
And I've nothing to take for my terrible thirst;
So I'll look for a spring, and I'll look for it first."

Then he thought as he started, "Oh, dear and oh, dear!
I'll be lonely tomorrow with nobody here!"
So he made in his note-book a couple of notes:
"I must first find some chickens" and "No, I mean goats."

He had just seen a goat (which he knew by the shape)
When he thought, "But I must have a boat for escape.
But a boat means a sail, which means needles and thread;
So I'd better sit down and make needles instead."

He began on a needle, but thought as he worked,
That, if this was an island where savages lurked,
Sitting safe in his hut he'd have nothing to fear,
Whereas now they might suddenly breathe in his ear!

So he thought of his hut ... and he thought of his boat,
And his hat and his breeks, and his chickens and goat,
And the hooks (for his food) and the spring (for his thirst) ...
But he never could think which he ought to do first.

And so in the end he did nothing at all,
But basked on the shingle wrapped up in a shawl.
And I think it was dreadful the way he behaved -
He did nothing but bask until he was saved!


6/10/08 — Skin Care Failure: Do Everything At Once / Never Complete A Single Treatment.

Sunday, 12 July 2009

Do Everything At Once / Never Complete A Single Treatment

Inattention, endless sampling and shopping for products (either barely used or used for inadequate periods of time) are among the shortcomings representative of wasted effort, relatively careless detriment and unnecessary aging.

As A. A. Milne's hapless Old Sailor remains shipwrecked and star-crossed without concern for the ultimate consequences, the cosmetic user whom remains mindless can find him or herself simultaneously:

  • in possession of an abundance of products;

  • and without positive actual results and progress, let alone prolonged momentum, to their skin's care and treatment.

For better actual care of skin, avoid approaches to skin care derived from individual brands, mass-market trends and advertising.

Tuesday, 17 March 2009

Collagen Types

Collagen is a protein that makes up most of the dermis, the middle layer of the skin. Collagen forms a network of fibers that provides a framework for the growth of cells and blood vessels, and also acts as the support structure for the skin. In young skin, the collagen framework is intact and the skin remains moisturized and elastic. Over time, collagen fibers loosen and unravel, and skin loses its elasticity.

Wednesday, 14 October 2009

Topical Estrogens Repaired Photodamaged Mouse Skin

Topical estrogens: their effects on connective tissue synthesis in hairless mouse skin

Gerard J. Gendimenico, Vincent J. Mack, Paul A. Siock, James A. Mezick.

Arch Dermatol Res. 2002 Jul;294(5):231-6. 2002 Jun 7.

Skin is an important target organ for estrogens. The major reported effects of estrogens are as regulators of connective tissue molecules, namely collagen and hyaluronic acid. We investigated the regulation of connective tissue synthesis by topical estrogens in a hairless mouse model of photodamaged skin, which has been previously shown to respond to topical retinoids. The naturally occurring estrogen, 17#-estradiol (17#-E) and a close stereoisomer, 17!-estradiol (17!-E), were found to be as effective as all-trans-retinoic acid in stimulating the development of new connective repair zones in photodamaged skin. Furthermore, 17#-E and 17!-E caused a skin thickening response in normal hairless mouse skin after three daily treatments. Skin thickening is due to water accumulation as a result of estrogen-induced hyaluronan synthesis. Our results show that topical estrogens are important regulators of connective tissue synthesis in photodamaged skin as well as normal skin. These findings are consistent with reports from human studies in which estrogen has been found to stimulate collagen production. We also demonstrated that 17!-E, previously thought to be a weak or inactive estrogen, is less potent than 17#-E, but nonetheless topically effective in stimulating connective tissue synthesis.

Tuesday, 16 September 2008

Within five years of menopause, c. 30% skin collagen is lost

Br. Med. J. [Clin. Res. Ed.] 287[6402]:1337-38, 1983.

Wednesday, 31 March 2010

Induction of Collagen by Topical Estradiol

Induction of Collagen by Topical Estradiol — Estrogen- and Soy-Containing Skin Care Products.

The basis for systemic and topical estrogen study and use originates in findings that link estrogen depletion and chronologic skin aging.

Decreases in skin thickness following menopause are to be expected without hormone replacement.

Collagen, elastin and dermal hyaluronic acid appear to be highly sensitive to and dependent on hormonal levels — their reduction produces skin dryness, losses in elasticity and volume.

One early study found that within five years of menopause, a large amount (approximately one third) of skin collagen is lost, although other factors — notably free radical damage — are implicated in aging.

Conversely, a controversial trial of a hormone replacement medication ceased in 2002 on grounds it increased the risk of breast cancer, cardiovascular and thromboembolic disease.

Evidence suggests estrogens are stronger antioxidants than Vitamin C and E and that female face and chest skin are especially estrogen-receptive.

Estrogen normally works by signaling genes in cells to be switched on or off, however this recent study has found that sun-damaged skin isn't improved by topical estradiol (Topical 17-beta estradiol in ethanol/propylene glycol (ETOH/PG).

Topical estradiol is included in products such as prescription topical Premarin and OTC Jan Marini Age Intervention (Serum and Cream).

Because photo-aging is superimposed on natural aging in sun-exposed areas of the skin, the results suggest that alterations induced by long-term sun exposure hinder the ability of topical estradiol to stimulate collagen production in aged human skin in vivo.

Comments from Study Co-Author Laure Rittié, PhD

"Frankly, we were very surprised to find that stimulation of collagen production by topical estrogen treatment was restricted to skin not chronically exposed to sunlight. These results suggest that sun exposure alters the ability of skin to respond to topical estrogen, and point out how difficult it is to repair photoaged skin."

An earlier study had found that topical estrogen did repair photodamaged mouse skin.

Estrogens and Phytoestrogens in Skin Care

Topical estrogens (such as estradiol) are more potent than phytoestrogens (found in soy-containing skin care products), however they have a tendency to cause allergies in around a quarter of post-menopausal women.

If you are already taking hormone replacement medication, topical estrogens should not be used without medical attention.

Although they may be purchased through online pharmacies and retailers, neither should topical estrogens be used without medical attention as contraindications exist.

Topically applied soy isoflavones (phytoestrogens) — weaker than estrogens although mimicking their effects — are available in soy-containing foods and many products among which are Skinceuticals Face Cream, Eye Balm, Advanced Body Firming Lotion, Darphin Rose Aromatic Care, Arovita C Cream, Stimulskin Plus Cream, Gernetic Hydra-Men, IS Clinical Youth Complex, Nivea Visage Triple Action Soy, Neutrogena Anti-Aging Hand Cream and J&J's Aveeno Positively Radiant.

Studies in mice suggested systemic and topical soy prevents skin cancer in mice, with the optimal effect reached through a combination of systemic and topical phytoestrogen supplementation, however they are now unlikely to be of any considerable benefit for chronically sun-damaged skin and to be lesser-effective than pure estradiol in any event.

The key components of soy isoflavones are the chemicals genistein and diadzein and are enhanced in the presence of ascorbic acid.

Prescription topical and systemic estrogens, diets and skin care products containing soy may enhance the natural moisturisation, firmness, thickness and antioxidant defenses of post-menopausal female skin in areas of the body which have been consistently photoprotected.

Soy and estradiol-containing skin care formulated to penetrate skin effectively are likely to deliver greater benefit to body skin than facial and hand skin, which more often than not end up chronically photodamaged.

Lifelong photoprotection can enhance skin's positive response to systemic and topical estrogen and soy isoflavones.

Collagen Study Objective

To evaluate the effectiveness of topical estradiol in stimulating collagen I and collagen III production in naturally aged and photoaged human skin of postmenopausal women and age-matched men.

Collagen Study Design

Vehicle-controlled treatment followed by biochemical and immunohistochemical analyses of skin biopsy specimens.

Collagen Study Setting

Academic referral center.

Collagen Study Participants

Seventy healthy volunteers (40 postmenopausal women with a mean age of 75 years, and 30 men with a mean age of 75 years) with photodamaged skin.

Interventions

Topical application of estradiol, 0.01%, 0.1%, 1%, or 2.5% or vehicle on aged or photoaged skin, with biopsy specimens taken after last treatment.

Main Outcome Measures

De novo synthesis of collagen by quantitative polymerase chain reaction, immunohistochemistry, and enzyme-linked immunosorbent assay.

Collagen Study Results

Topical estradiol increased procollagen I and III messenger RNA and collagen I protein levels in sun-protected aged hip skin in postmenopausal women and, to a lesser extent, in age-matched men.

Surprisingly, no significant changes in production were observed in women or men after 2-week estradiol treatment of photoaged forearm or face skin, despite similar expression of estrogen receptors (ER-, ER-?, and GPR30) in aged and photoaged skin.

Estradiol treatment induced the estrogen-responsive gene GREB1, indicating that penetration of topical estradiol and genomic response to estrogen were similar in the 3 anatomic sites.

Collagen Study Conculsions

Two-week topical estradiol treatment stimulates collagen production in sun-protected hip skin, but not in photoaged forearm or face skin, in postmenopausal women and aged-matched men.

These findings suggest that menopause-associated estrogen decline is involved in reduced collagen production in sun-protected skin.

Interestingly, alterations induced by long-term sun exposure hinder the ability of topical 2-week estradiol to stimulate collagen production in aged skin.

Related Collagen and Estradiol Studies

Skin collagen changes in post-menopausal women receiving oestradiol gel.

Brincat M, Versi E, O'Dowd T, Moniz CF, Magos A, Kabalan S, Studd JW.

Maturitas. 1987; 9:1-5.

Sixteen post-menopausal women who had never previously received any hormonal treatment applied Oestrogel cream 1.5 mg/day percutaneously for 1 yr. Skin biopsies were taken from the abdomen and from the lateral aspect of the thigh at 0, 3, 6 and 12 mth, and the changes in skin collagen content were noted. The abdominal skin collagen content increased significantly (P less than 0.001) over the 1-yr treatment period. The thigh skin collagen content also increased, but did not reach significant levels. There was a strong correlation between the change in skin collagen content (in both the abdomen and the thigh) and the original skin collagen content, indicating that the change in collagen content in response to oestrogen therapy is dependent on the original level. There is no further increase once an 'optimum' skin collagen level has been reached.

The effect of topical oestradiol on skin collagen of postmenopausal women

Eero Varila, Immo Rantala, Aarne Oikarinen, Juha Risteli, Timo Reunala, Hanna Oksanen, Reijo Punnonen.

BJOG: An International Journal of Obstetrics & Gynaecology. 1995; 102(12):985-989

Topical oestradiol treatment increases the amount of skin collagen. The increase in the level of PICP and PIIINP in skin blister fluid indicates that oestradiol treatment stimulates collagen synthesis. Furthermore, our results show that topical ostradiol treatment has a greater influence on the amount than on the quality of skin collagen. On the contrary, in elastic tissue the oestradiol treatment will only result in morphologic improvement.

Estradiol-17beta as an antioxidant: some distinct features when compared with common fat-soluble antioxidants.

Ayres, S : Tang, M : Subbiah, M T

J-Lab-Clin-Med. 1996 Oct; 128(4): 367-75

Estrogens are potent antioxidants both in vitro and in vivo. In this study the antioxidant affect of estradiol-17beta (estradiol) was compared with those of fat-soluble antioxidants (alpha-tocopherol and beta-carotene) in terms of both fatty acid (thiobarbituric acid-reactive substances and diene conjugation) and cholesterol oxidation (oxysterols). The addition of alpha-tocopherol (54 micromol/L) inhibited low-density lipoprotein (LDL) oxidation by 92.6% and high-density lipoprotein (HDL) oxidation by 76.5%. In similar experiments, estradiol (54 micromol/L) inhibited LDL oxidation by 77.5% but inhibited HDL oxidation by only 55.4%. Beta-carotene had no antioxidant effect. Lag times (diene conjugation method) for alpha-tocopherol and beta-carotene increased by 175% and 125%, respectively. Estradiol markedly reduced the maximum formation of diene conjugates as compared with results with alpha-tocopherol and beta-carotene, and it exhibited a linear curve (no change in lag time). In terms of cholesterol oxidation, estradiol was far more effective than alpha-tocopherol or beta-carotene in inhibiting oxysterol formation (microg/ml plasma) (control = 24.56 +/- 2.31, beta-carotene = 20.59 +/- 3.32, alpha-tocopherol = 20.19 +/- 1.58, estradiol = 14.38 +/- 0.70). This study shows that estradiol is as effective an antioxidant as alpha-tocopherol in terms of fatty acid peroxidation but is far more effective than alpha-tocopherol in terms of cholesterol peroxidation.

Estradiol as an antioxidant: incompatible with its physiological concentrations and function.

Santanam N, Shern-Brewer R, McClatchey R, Castellano PZ, Murphy AA, Voelkel S, Parthasarathy S.

Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA 30322, USA.

Estradiol has been documented to inhibit the oxidation of low density lipoprotein (LDL). We show that physiological concentrations of estradiol do not inhibit the oxidation of LDL by copper. LDL samples isolated from a) premenopausal and postmenopausal women and from b) women at different time periods during their menstrual cycle, who differ vastly in plasma estradiol levels, were also oxidized at the same rates by copper. In contrast, LDL samples isolated from c) women who were hyperstimulated during in vitro fertilization (IVF), with estradiol concentrations above 2000 pg/ml, were resistant to oxidation by copper. However, these LDL samples were also oxidized at a higher rate by peroxidases. More importantly, subjects with high estradiol levels also showed an increase in myeloperoxidase (MPO) protein in the plasma. Based on these results, we conclude that at physiologic concentrations, it is unlikely that estradiol could act as an antioxidant. In fact, the ability of estradiol to induce MPO and become a prooxidant might instead suggest that MPO-mediated oxidative clearance of LDL from plasma by liver might favorably influence the outcome of atherosclerosis.

Topical estrogens: their effects on connective tissue synthesis in hairless mouse skin

Gerard J. Gendimenico, Vincent J. Mack, Paul A. Siock, James A. Mezick.

Arch Dermatol Res. 2002 Jul;294(5):231-6. 2002 Jun 7.

Skin is an important target organ for estrogens. The major reported effects of estrogens are as regulators of connective tissue molecules, namely collagen and hyaluronic acid. We investigated the regulation of connective tissue synthesis by topical estrogens in a hairless mouse model of photodamaged skin, which has been previously shown to respond to topical retinoids. The naturally occurring estrogen, 17#-estradiol (17#-E) and a close stereoisomer, 17!-estradiol (17!-E), were found to be as effective as all-trans-retinoic acid in stimulating the development of new connective repair zones in photodamaged skin. Furthermore, 17#-E and 17!-E caused a skin thickening response in normal hairless mouse skin after three daily treatments. Skin thickening is due to water accumulation as a result of estrogen-induced hyaluronan synthesis. Our results show that topical estrogens are important regulators of connective tissue synthesis in photodamaged skin as well as normal skin. These findings are consistent with reports from human studies in which estrogen has been found to stimulate collagen production. We also demonstrated that 17!-E, previously thought to be a weak or inactive estrogen, is less potent than 17#-E, but nonetheless topically effective in stimulating connective tissue synthesis.


Induction of Collagen by Estradiol — Authors

Laure Rittié, PhD; Sewon Kang, MD; John J. Voorhees, MD; Gary J. Fisher, PhD

Arch Dermatol. 2008;144(9):1129-1140.

Trial Registration Identifier: NCT00113100

Collagen Study Authors

Laure Rittié, PhD

Laure Rittié is a Research Investigator in the Department of Dermatology Photoaging and Aging Research Program at the University of Michigan in Ann Arbor. Dr. Rittié received her Ph.D. in Biochemistry and Molecular Biology from the Université de Reims Champagne-Ardenne, France in 2001 and her Master of Science in Cell Biology from the Université de Reims Champagne-Ardenne, France in 1996. Dr. Rittié received postdoctoral training at the Université de Reims Champagne, France and at the University of Michigan, Department of Dermatology. She was recruited to join the Dermatology Department faculty in 2006.

Sewon Kang, MD

Clinical Interests: Skin aging, psoriasis, atopic dermatitis, scleroderma, acne and rosacea. Research Interests: Pharmacology of retinoids and immunosuppression. Photomedicine and photoaging.

John J. Voorhees, MD

Dr. Voorhees' research focuses on psoriasis and premature aging of the skin.

Gary J. Fisher, PhD

Dr. Fisher's research studies the molecular mechanisms of sun-induced premature skin aging and the molecular mechanisms of chronological skin aging focusing on four major areas: procollagen biosynthesis, collagen degradation, signal transduction, and inflammation.


Author Affiliations: Department of Dermatology, University of Michigan Medical School, Ann Arbor.

Wednesday, 3 September 2008

Decipering of Telomerase Structure Opens Door To New Cancer, Aging Treatments

Researchers at The Wistar Institute have deciphered the structure of the active region of telomerase, an enzyme that plays a major role in the development of nearly all human cancers. The landmark achievement opens the door to the creation of new, broadly effective cancer drugs, as well as anti-aging therapies.

Researchers have attempted for more than a decade to find drugs that shut down telomerase - widely considered the No. 1 target for the development of new cancer treatments - but have been hampered in large part by a lack of knowledge of the enzyme's structure.

The findings, published online August 31 in Nature, should help researchers in their efforts to design effective telomerase inhibitors, says Emmanuel Skordalakes, Ph.D., assistant professor in Wistar's Gene Expression and Regulation Program, who led the study.

"Telomerase is an ideal target for chemotherapy because it is active in almost all human tumors, but inactive in most normal cells," Skordalakes says. "That means a drug that deactivates telomerase would likely work against all cancers, with few side effects."

The study elucidates the active region of telomerase and provides the first full-length view of the telomerase molecule's critical protein component. It reveals surprising details, at the atomic level, of the enzyme's configuration and how it works to replicate the ends of chromosomes - a process critical to both tumor development and the aging process.

Achieving immortality

In humans, telomerase adds multiple repeats of a short DNA sequence to the ends of chromosomes, known as telomeres, thus preventing damage and the loss of genetic information during cell division.

When telomerase is dormant, telomeres shorten each time a cell divides, leading eventually to genetic instability and cell death. By preserving chromosomes' integrity, telomerase allows cells to continue living and dividing. The enzyme is active in cells that multiply frequently, such as embryonic stem cells, but is switched off almost entirely in normal adult cells to prevent the dangers of runaway cell proliferation.

Cancer cells, however, often regain the ability to activate telomerase, which has been implicated in 90 percent of human tumors. The enzyme permits cells to replicate indefinitely and achieve the cellular "immortality" that is the hallmark of cancer. Deactivating telomerase would stop tumor growth.

In addition to its role in cancer, telomerase holds significant implications for the development of therapies to combat aging and other age-related diseases. Finding ways to activate telomerase under controlled conditions and allow some cells to begin dividing again could result in healthier, younger-looking tissue that lives longer.

An elusive enzyme

Telomerase is a complex structure made up of multiple protein domains and a stretch of RNA, which contains the template the enzyme uses to synthesize telomeres.

Last year, Skordalakes and his team solved the structure of a key segment of the molecule - the so-called TRBD domain, where RNA binding occurs. However, the complexity of telomerase has proved a roadblock to determining the enzyme's overall architecture - a goal pursued by researchers worldwide for more than 15 years.

To perform the necessary studies, scientists first must gather large quantities of the enzyme in a specific conformation. Because the complex structure of telomerase most likely allows it to change configuration, that process has been challenging, Skordalakes says.

To find sufficient quantities of the enzyme for the study, Skordalakes and his team looked beyond commonly relied-on sources such as humans and yeast. By screening a wide variety of organisms, including protozoa and insects, they discovered that a gene from the red flour beetle could produce telomerase in copious amounts, and a stable form.

"That was really the breakthrough," Skordalakes says. "Once we found that the gene from this organism expressed the protein in the quantities we needed, we were able to move quickly."

The researchers used X-ray crystallography, a technique that analyzes the diffraction patterns of X-rays beamed at crystals of a molecule, to determine the three-dimensional structure of the enzyme's active region - the catalytic component called telomerase reverse transcriptase protein, or TERT.

The study revealed surprising features, including the fact that the molecule's three domains are organized into a doughnut shape, an unexpected configuration. Knowledge of the structure allowed the researchers to create a model of the enzyme's function.

"It's extremely exciting," Skordalakes says. "For the first time, we can see how telomerase assembles at the end of chromosomes to initiate telomere replication."

Looking ahead

Skordalakes plans to further study TERT and search for new telomerase inhibitors that could become cancer therapies. He also will look at modifying existing drugs. Previous attempts to target telomerase have fallen flat, but knowledge of the enzyme's structure will help researchers to determine the limitations of existing agents and make them more effective.

Skordalakes began his studies of telomerase when he joined The Wistar Institute in 2006 and established his first laboratory. "I've always been interested in understanding, on a molecular level, the function of protein nucleic acid assemblies and using that information in the treatment of human disease," he says. "Telomerase, because of its important role in cancer and aging, was an obvious target for me."

He says though the process was frustrating at times, his team was determined to solve the structure. "It required a lot of perseverance and effort, but we really wanted to do this," he says.

----------------------------

Article adapted by Medical News Today from original press release.

----------------------------

Wistar's Andrew J. Gillis and Anthony P. Schuller assisted with the study.

The research was supported in part by the Commonwealth Universal Research Enhancement Program of the Pennsylvania Department of Health and the Ellison Medical Foundation.

The Wistar Institute is an international leader in biomedical research with special expertise in cancer research and vaccine development. Founded in 1892 as the first independent nonprofit biomedical research institute in the country, Wistar has long held the prestigious Cancer Center designation from the National Cancer Institute. The Institute works actively to ensure that research advances move from the laboratory to the clinic as quickly as possible. The Wistar Institute: Today's Discoveries -Tomorrow's Cures. On the Web at The Wistar Institute.

Monday, 1 September 2008

Changes to Skin Care Support

Melbourne Dermatology Skin Care — Changes to Support.

Please be advised that skin care and treatment support — including clinical dermatology documents, advanced usage documents, reviews, studies and results and other specialist materials or assistance, including support by e-mail or telephone — are henceforth (1/9/08) only available where an individual presents for ongoing care in-person and where considerable changes to skincare are not made without prior dermatological consultation.

The minimum periodic assessment schedule (associated with optimal care of skin) is once every four months.

Considerable ongoing, cumulative benefit within the realm of chronic cosmetic skin complaints and "anti-aging" is entirely unrealistic outside of these conditions and appears to lend credence to poor, inappropriate or even deleterious skin care practices, brands and protocols entrenched in beauty therapy, spa and skin clinics while generating a pointless burden on the two practices.

Please note that product information and discussion available online is provided "as is" for general information only and that "suitability, safety and performance" of any skin care product or treatment, medical or otherwise, is "not guaranteed outside of an ongoing individualised protocol."

Related:

Skin Care Failure.

Tuesday, 14 July 2009

Obagi Medical Products Presents In Vitro Data Showing Its Topical Vitamin C Serums Provide Greater Absorption and Stability Than a Leading Competitor

Obagi Medical Products Presents In Vitro Data Showing Its Topical Vitamin C Serums Provide Greater Absorption and Stability Than a Leading Competitor

Obagi Professional-C Serum and Obagi-C(R) Rx Serum Provide Advanced Topical Vitamin C to Prevent Premature Signs of Aging and Protect Against Future Damage

Obagi Medical Products, Inc. (Nasdaq:OMPI), a leader in topical aesthetic and therapeutic skin health systems, announced the results of an in vitro study of their Obagi Professional-C and Obagi-C Rx Serums today at the American Academy of Dermatology's Summer Academy Meeting in Chicago.

The data show that Obagi-C Rx Serum (4% hydroquinone, 10% L-ascorbic acid) provided a more than 10-fold greater absorption of vitamin C than the leading competitive product, Skinceuticals 20%.

The Obagi Professional-C Serum (20%) resulted in a more than 5-fold greater absorption of vitamin C than the leading competitive product.

In addition, both Obagi Medical Vitamin C Serums were proven to have greater stability than the leading competitor, which is important given that topical vitamin C products can be unstable thus potentially making them less efficacious.

"Vitamin C is an important antioxidant and is essential for collagen production, which keeps skin looking young and healthy. It's also very sensitive to numerous external conditions, so it is important to use a formulation that has a high level of penetration and is stable," said Harry Agahigian, lead investigator of the study. "The studies showed that the Obagi Medical vitamin C formulations provide much better absorption and greater stability versus the competitive product."

Obagi vs. Skinceuticals Key Findings — Absorption

Investigators sought to evaluate the absorption and stability of the three serums and the Obagi serums performed better in each objective of the study.

In an in vitro test evaluating absorption of vitamin C, each of the three serums (Obagi-C Rx Serum, Obagi Professional-C 20% Serum and the 20% L-ascorbic acid-based leading competitor product) was tested by being applied to cadaver skin for a period of 19 hours at 37 degrees C.

Obagi vs. Skinceuticals Skin Penetration.

The total absorption of vitamin C in each product was:

Total absorption was calculated by adding amounts of L-ascorbic in the reservoir, determined at .5, 1.5, 3.0, 6.0, 10.5 and 19 hours.

When compared to Skinceuticals vitamin C serum in a recent study, the vitamin C serum in the Obagi-C Rx System provided 50% more penetration into the layers of the skin to provide greater antioxidant therapy and effectiveness."

Obagi vs. Skinceuticals Key Findings — Stability

In a stability test, the serums, Obagi-C Rx Serum (4% hydroquinone, 10% L-ascorbic acid), Obagi Professional-C Serum (20% L-ascorbic acid), and leading competitor 20% L-ascorbic acid, were stored at 40 degrees C and the vitamin C content was measured at 1 and 3 months.

An additional stability test was performed by storing the products at 45 degrees C for 1 month.

Here, vitamin C content was also measured.

Obagi vs Skinceuticals In Vitro Data.

"We are proud that our vitamin C products provide such clinically significant advantages over the competitive product," said Steven Carlson, Chief Executive Officer of Obagi Medical Products. "Obagi Medical's top priority is to provide highly effective differentiated skin care products that are based in real science. We do that by working closely with the top experts in the skin care field."


Source: Obagi Medical Products via Wire — July 31, 2008.

NB: Patients should not change their skincare outside of individual dermatological attention.

Obagi Professional C Serums

Skinceuticals Skin-Penetration Data

Vitamin C Serum - Absorption by Percentage Concentration

Tuesday, 25 August 2009

Skinceuticals C + E vs Skinceuticals C E Ferulic

   

The newer formula lacks zinc sulphate and bioflavonoids, however ferulic acid, propylene glycol and glycerin are now present and SD alcohol absent.

Propylene glycol consistently causes irritation in oilier skin types and SD alcohol generally enhances product penetration and therefore beneficial activity, including firming and antioxidant protection.

The original C + E formula likely produced better (deeper) Vitamin C and E penetration than the newer C E Ferulic formulation however was less stable, less photoprotective and more likely to stimulate acne.

Monday, 9 November 2009

Only Use One Brand

Less an overt skin care failure than the result of brand evangelism, it is almost invariably a mistake to use the products of one brand only.

A single skin care brand will typically provide 1-3 products of potential benefit to some, supplemented by additional products which are of more benefit to the companies' bottom lines than to your skin.

The more popular or well-established a brand, the more likely it is to be loaded with products which will do nothing to support the health of your skin, and which more than likely get in the way of better care.

Brands such as Cetaphil, which provide (and promise) no more than basic cleansing and moisturisation of your skin are largely exempt from this phenomenon, however other brands — be they drugstore/chemist, salon/spa or cosmeceutical — are usually not.

A typical optimal daily skin care protocol will encompass 3+ brands at an average cost up to 75% less than one constructed from 1-2 brands, for far greater immediate and long-term benefit.

The either/or approach to the use of skin care is largely attributable to the dermatologically unaware and commercially-derived ideas and needs of quasi-medi-spas, beauty therapy, the department stores and media.

Tuesday, 10 March 2009

Use Excess Antioxidants

Inappropriate antioxidant use can have deleterious effects.

Friday, 26 August 2011

New Darphin Vitalprotection SPF 15 Sunscreen

New Darphin Vitalprotection SPF 15 Sunscreen

The new Darphin Vitalprotection Sunscreen contains Titanium Dioxide and Zinc Oxide.


"Delightful, daily age-defying lotion helps preserve skin from environmental aggressors known to cause premature skin ageing.

Hydrating formula combines powerful antioxidants with physical filters in order to help reduce oxidative- and photo-ageing.

Its light, fluid texture makes it an ideal make-up base. "

Darphin Vitalprotection SPF 15 Sunscreen is suitable for all skin types.

  • Helps guard against detrimental photo-ageing due to environmental aggressions.
  • Helps protect skin’s natural barrier and strengthens its natural defences.
  • Helps reduce the appearance of redness.
  • Ideal make-up base.

Key Ingredients

Edelweiss extract;

Venuceane™;

Transluce;

Natural filters (Titanium Dioxide and Zinc Oxide).

Use in the morning after the appropriate Serum and Cream as often as needed.

Apply a small amount to face, neck and décolleté.

Massage gently in upward motions.

Can be used as make-up base.

Please Note: in case of broken capillaries, the preferred sunscreen is Melbourne Dermatology Broken Capillaries Sunscreen SPF 30+.

Sunday, 15 March 2009

RevaleSkin ORAC Antioxidant Comparison

RevaleSkin ORAC Antioxidant Comparison

The RevaléSkin CoffeeBerry Oxygen Radical Absorbance Capacity (ORAC) score is between 15,000 and 17,000 higher than other known naturally occurring antioxidants.

Thursday, 31 July 2008

Antioxidants Can Be Harmful

Antioxidants Can Be Harmful

Antioxidants can potentially prevent the cellular cycle of free radical damage to skin that produces skin cancer, visible symptoms of aging skin (mainly photoaging) and a variety of other skin diseases.

Oral and topical antioxidant supplements are popularly thought beneficial or harmless, however a mounting body of evidence and clinical experience suggests non-dietary and topical antioxidants can indeed be harmful.

Raising antioxidant levels in the skin and body can be pro-oxidant, accelerating aging, damage and the likelihood of cancer, yet increasing numbers of consumers believe ingesting and applying more antioxidants to their skins can only be better:

By any measure, some individuals utilizing purportedly antioxidant skin care regimes have some of the worst skin we have ever seen — skin that improves when said regimes are stopped.

Whether their skin be visibly and chronically red, dull, unusually reactive or appearing different or unusual but not better, individuals often persist in using unsuitable antioxidant skin care products.

Beauty therapy, word of mouth, overly simplistic cosmetic analyses and mass media advertising's endless propagation of false ideas about skin and aging are the root source of antioxidant-stimulated skin problems which would never have otherwise emerged.

In the past, beauty therapy and the department store's niche had been to spend an exorbitant amount of time and effort spinning their clients' wheels in the mud with nonsensical ineffective treatments that were made to ring true due to their expense, luxurious, clinical or international flavour.

Luckily, most of the "treatment" supplied was not actively harmful, but it did distract skincare users enough to prevent them from ever attaining actual care of their skin, securing technically unnecessary, permanent deterioration under an ever-changing, disingenuous guise of "skin care."

In the present day, clinics often push cosmeceuticals and antioxidants as the latest penultimate and universally-suitable thing, despite the unchanging organic nature of skin, and despite a flagrant (usually total) lack of expertise required to avoid harm.

Similarly, consumers find "clinically-trialled" and apparently scientific products desirable, however the real-world efficacy of even medically trialled products is often below popular expectations.

Trials and comparisons surrounding idebenone, for example, are inherently flawed — Allergan's Prevage frequently causes acne and irritation, and CosmeceuTechs' Priori are unable to prove actual and consistently superior antioxidant protection.

The skin disease of people applying oxidized and home-made antioxidant skincare is a niche epidemic among obsessive skincare users — fostered online — that is yet to be fully appreciated.

Undesirable effects may not be visible to the untrained eye because topical antioxidant formulas can also produce exfoliation and moisturisation which can mask underlying changes.

Indeed, many cosmetics users are happy to see any change occurring and are often told that temporarily worse skin is a requirement to progress, however not all side effects are appropriate.

Strivectin's Facial Antioxidant marketing claims "facial anti-oxidants can virtually reverse the hands of time" however antioxidants simply do not treat existing skin damage, such as wrinkles.

Guidelines for Antioxidant Use

  • Avoid indiscriminate oral antioxidant supplementation — speak to your health care provider before taking supplements to treat or prevent any condition or disease.

  • Topical antioxidants do not actively reverse existing skin aging and cannot replace sunscreens to prevent aging.

  • Compounding biologically active antioxidants (or other ingredients) at home for topical application is a foolhardy practice.

  • Most mild and low-dose topical purported antioxidants are not irritating, however their users don't appear to avert considerable aging either — particularly if antioxidants are chosen by brand rather than individual relevance or if use is inconsistent.

  • Effective use of topical antioxidants generally requires higher concentrations of multiple antioxidant ingredients and is highly dependent on:

    • skin type;

    • condition;

    • the nature of the patient's environmental exposure;

    • overall skin care and procedure use;

    • initial specialist analysis and ongoing follow up.

Realising more than a small degree of benefit and avoiding undesirable effects from antioxidants requires ongoing specialist assessment and care.

Considerably effective antioxidant skin care protocols are substantially revised over time and make use of multiple brands — a practice which greatly increases results while typically lowering cost.

Until more is known, medically unmonitored use of antioxidants in skin care should be restricted to one gentle formula amidst sunscreen.

Thursday, 10 July 2008

ASA Rules Against Amatokin by Strivectin's Basic Research

Amatokin

Empty-vessel Amatokin from "Voss Laboratories" by Strivectin's Basic Research has been comprehensively reprimanded by the UK's ASA after the Harley Medical Group filed an official complaint against the manufacturer's promotional practices.

The ASA now requires the degenerate group responsible for Voss (Heather Hurst, Gina Gay, among others) to submit all advertising for review prior to publishing.

The following points regarding Amatokin were made clear:

Basic Research Products are widely available and blindly promoted by department stores and beauty salons of all descriptions.

If you'd like to try Amatokin, Olay's Regenerist Range offers the same ingredient's paucity of results at lesser cost and greater respect for your intelligence, although not your skin.

Thursday, 3 July 2008

Combining Use of Ascorbic Acid with Mineral-Rich Skin Care

Combining use of ascorbic acid with especially mineral-rich skin care (for example Phytomer or Gernetic GER-Lift) often appears to be pro-oxidant, producing noticeable "greying" of the skin, although not erythema.

Skin care products containing small amounts of minerals may also therefore be contraindicated when used simultaneously with viable ascorbic acid.

Thursday, 3 July 2008

L'Oreal and Nivea Sunscreens Fail to Provide Stated SPFs

L'Oreal and Nivea Sunscreens Fail to Provide Stated SPFs

A recent analysis of sunscreens made by L'Oreal and Nivea (among other manufacturers), including those containing Mexoryl, has shown that they fail to provide their stated SPFs.

One formula, Marks and Spencer's Sun Formula Lotion, was found to provide an SPF less than half its advertised protection.

As a general rule, you cannot indiscriminately rely on any sunscreen to provide considerable protection against aging or skin cancer.

These facts are reflected in:

Typically, individuals use sunscreens which are inadequately protective both by virtue of their formulation (the responsibility or work of the manufacturer) and their application (the responsibility of the user, whom routinely applies around one fifth the required quantity).

A comparison of the photoprotective ability of 33 sunscreens from a range of makers including Decleor, Dermalogica, Clinique, Yonka, Pevonia, Ego, La Prairie, Jan Marini, Skinceuticals and IS Clinical is made in the Comparison of 33 Sunscreens Document.

Individuals should not generally and automatically rely on or expect considerable skin cancer or aging prevention just by possessing sunscreens.

The majority of people are using sunscreens with the impression that they are extremely effective (no matter which formula is chosen or how much is used), yet they achieve:

Individuals living in Northern Australia, where UV is more intense, may do better to not use photosensitizing skin care if they are unable to verify their sunscreen use is beyond reproach.

Unfortunately, the latent benefits of regular sunscreen use remain largely theoretical.

Popular Hamilton sunscreens are always a poor choice.

For further information, refer photoprotection, photoaging, sunscreens, cowardly photoprotection, mature skin analysis, sunscreen around the eyes and different sunscreens provide different skin protection.

Friday, 27 June 2008

Retinoic Acid Peels

Tuesday, 25 November 2008

(Photo)Protection of Hair

(Photo)Protection of Hair

Even on a cloudy day, the quality of hair — a kind of skin — deteriorates in the presence of daylight and oxygen, becoming permanently more rough, dry and less naturally glossy.

Combing, brushing and hot air drying are further deleterious actions which roughen, strip and dehydrate, resulting in hair much weaker and duller than it need ever have become.

Bona fide hair care is a cosmetic concern because the appearance of hair downplays the success of cosmetic procedures and ideal skincare.

While shampoos containing silicone and trace quantities of Provitamin B-5 — most popularly Pantene — temporarily smooth-out hair's damaged structure and texture, shampoos containing sodium laureth sulphate and sodium pareth sulphate remove their fleeting benefit with each application while leaching hair's naturally-protective nutrients.

While the skin may be made to renew itself in as little as 3 months (or much sooner where dermatological procedures such as retinoic acid peels are employed), a full head of medium or longer-length hair is a seven year affair.

In reality, the original health of hair as it emerges is greatly reduced within days of mainstream hair-care.

Within weeks, the hair loses the intensity of its original hue, and the lustre of being moist from within.

Despite the massive volume of shampoos, conditioners and various sprays available in supermarkets and hair salons, products barely differ and essentially what is supplied is the following:

  • detergent cleansers (sodium laureth sulphate, sodium pareth sulphate among other sulphates);

  • rudimentary temporary moisturizers/conditioners (predominantly cetyl alcohol) and oils which smooth the hair by coating it, but always at the expense of volume due to their physical weight on the hair;

  • a variety of silicones which smooth hair, but with a tendency to render it with a sterile appearance, particularly if dry or brittle underneath, and which have emerged as an environmental hazard to water-based organisms.

To enhance and protect the original quality of your hair, particularly with the aim of amplifying or matching your facial appearance:

Wednesday, 18 June 2008

Comments from Anne Campoamor regarding Darphin Photoprotection

"Our creams don't offer any protection (against the sun and environmental aggressions), and knowing that over 80% of aging is a result of these factors, the idea was to protect the skin with a shield applied over the cream."

Darphin will provide Vitalprotection Age-Defying Protective Lotion and Vitalprotection Age-Defying Soothing Lotion, in June 2008.

The introduction of these products will complete Darphin's 3D skincare concept, which includes a daily serum, aromatic oil and moisturizing cream.

Darphin's SPF 15 protective lotion offers UVA-UVB protection.

The soothing lotion deals with the treatment of skin that has been exposed to sun or environmental damages.

Darphin intends to expand the Vitalprotection range with a bodycare line in 2009.

Refer photoprotection, photoaging, sunscreens and photoprotective antioxidants.

Wednesday, 18 June 2008

Darphin Intral Candles

Darphin Intral Candles

The light pink Darphin Intral aromatic candle creates a soothing atmosphere.


Just as the Darphin Intral skincare collection soothes sensitive skin with the calming aromas of peony, chamomile, orchid and hawthorn, this candle envelopes the home in fragrance to sooth the senses.

Limited availability.

Wednesday, 18 June 2008

La Prairie Skin Caviar Luxe Body Cream Review

This luxurious body cream instantly drenches skin in rich, extravagant moisture. It lightly exfoliates and smoothes uneven skin tone and protects against free radical damage. The cream lifts, firms and energizes leaving your body as smooth and plump as your face.

Wednesday, 18 June 2008

La Mer The Body Cream (Creme)

Saturate the skin in a wave of long-lasting hydration with this sumptuous moisturizer. Think of it as a seaweed wrap in a jar, infusing skin with moisture to help break the cycle of dryness and dehydration. An exclusive Micro-Algae Complex comforts and renews skin on contact, calming and cushioning even the driest of skin as it is enveloped in the therapeutic effects of the sea.

Wednesday, 18 June 2008

Elemis Pro-Collagen Radiantly Smooth Body Cream

This British brand is best known for its cult-favorite Pro-Collagen Marine Cream. Now it takes on anti-aging body care with the launch of the Pro-Collagen Radiantly Smooth Body Cream. It combines a luxurious soufflé texture with iridescent sheen and the aromas of rose and mimosa. This body cream deeply hydrates the skin while smoothing out crepe-like skin texture and leaving it with a youthful glow.

Wednesday, 18 June 2008

Skinceuticals AOX Body Treatment Review

This three-in-one product exfoliates while adding antioxidants and moisturizers to your skin through Vitamin E and purified grape polyphenols. Typically, these ingredients are found in facial skin-care products, but now SkinCeuticals is applying them to the body as well. This body treatment helps protect against damaging environmental aggressors, lightly exfoliates dead skin cells and deeply moisturizes dehydrated areas for smoother, healthier-looking skin.

Monday, 13 July 2009

Skinceuticals Ploretin CF Summary of Claimed Benefits

Skinceuticals Phloretin CF:

  • Prevents premature signs of aging and corrects existing photodamage.
  • Divides and conquers the range of reactive oxygen species (ROS) throughout the skin;
  • Prevents cell mutation by shielding skin’s DNA;
  • Accelerates cell turnover;
  • Boosts skin’s support structure;
  • Inhibits UV-induced discolorations.

Wednesday, 11 June 2008

Nicholas Perricone: Importance of Water Intake for Skin (8-10 Glasses)

We must drink 8 to 10 glasses of water a day to maintain health and beautiful skin, as all biochemical reactions in the body take place in the presence of water.

Wednesday, 11 June 2008

Nicholas Perricone: Coffee and Not Caffeine is Deletrious

Coffee (and it's not the caffeine) can result in elevated levels of cortisol and insulin, leading to weight gain. Remember, elevated insulin puts a lock on body fat. If you substitute green tea for coffee, and do nothing else differently, you will lose 10 pounds in six weeks.

Wednesday, 11 June 2008

Nicholas Perricone: Incontrovertible Importance of Essential Fatty Acids

Essential fatty acids are necessary for elevated mood, beautiful skin, healthy immune system, increased mental clarity and normalizing weight (you need to eat fat to burn fat).

Wednesday, 11 June 2008

Nicholas Perricone: Benefits of Cayenne Peppers

Eating hot peppers can relieve various types of headaches, such as cluster headaches, migraines and sinus headaches.

Monday, 22 June 2009

Nicholas Perricone: Skin is a Barometre of the Entire Organism

Our skin is a perfect reflection of our internal health and when our skin visibly improves from this anti-inflammatory lifestyle, we automatically reduce our risk of age-related disease and body weight normalizes.

Monday, 22 June 2009

Nicholas Perricone: Basic Properties of an Anti-Inflammatory Diet

The anti-inflammatory diet consists of high quality protein, like that found in fish, colorful fresh fruits and vegetables, and adequate amounts of good fat, like that found in salmon, flax, nuts, seeds and olive oil.

Monday, 20 July 2009

Nicholas Perricone: Sugar is Primarily Responsible for Inflammation

"Sugar is the number one enemy. It causes inflammation that destroys our bodies and attaches to collagen, which results in stiff, inflexible, sagging skin. Controlling our blood sugar level and insulin levels will improve our health and give us beautiful, youthful skin. "

Monday, 20 July 2009

Nicholas Perricone: Inflammation is the Root of All Diseases (including Aging)

Inflammation is at the basis of age-related diseases such as heart disease, diabetes, cancer, auto immune disease, and wrinkled, sagging skin. The wrong foods—such as sugar, processed foods, pasta, breads, pastry and baked goods—can increase levels of the pro-inflammatory peptides.

Friday, 13 June 2008

Dry Winter Skin Treatment

Dry Winter Skin Treatment

Dry winter skin results from a lack of water in the skin — specifically in the outer layer of skin cells known as the stratum corneum — originating largely from environmental and skin care factors. The most rudimentary dry winter skin treatment focuses on re-establishing water levels in the stratum corneum above all else.


Like any organ, the physical functioning of skin that's dry is well below par in general — no firming, otherwise rejuvenating, "anti-aging" or antioxidant treatment will function as well when skin is dry.

Aesthetically, dry winter skin appears immediately less soft, firm and flexible, and is generally less resistant to any and all forms and degrees of deterioration.

At worst, dry winter skin is a prime symptom of eczema, ichtyosis and hyperkeratosis.

In reality all skin — including oily skin afflicted by acne — is drier in winter than at other times. For all practical purposes, no skin type can approach being "too moist." Skin care usage based on conventional skin type descriptions (oily/dry/acne/sensitive etc.) fails skin's health needs and appearance potential by unnecessarily curtailing hydration year round.

To avoid losses in skin quality, sustain and build on the benefits of skin care and treatment established in warmer times by avoiding any drop in your skin's hydration levels.

Prevention is better than treatment, so avoid encouraging dry skin through:

A few people still use soap, all forms of which, including "cleansing bars" marketed as not being soap (such as that used in the Clinique 3-Step System), are a one way ticket to skin that's measurably drier than it need be.

Reverse-cycle air conditioning, hot water and, ironically, hyaluronic acid/sodium hyaluronate, can also draw moisture from the skin by evaporation and unwanted hygroscopic actions.

Unless you are sub-clinically dehydrated or worse, drinking "a lot of water" has zero effect on dry skin, or your skin's health in general.

While they aren't a complete answer to dry winter skin treatment alone, emollients are:

  • the standard stand-alone treatment for all dry and/or scaly winter skin conditions and

  • easy to use.

Emollients smooth, soothe and hydrate dry winter skin.

Emollients need to be applied frequently (at least twice daily) to be effective.

If you've accrued more than 12 months' consistent personal Tewameter data tied to uninterrupted use of only your prescribed skincare, winter is the ideal time to have your use tailored to extract better therapy from another of the emollients analysed for their active and passive hydrating properties.

Not all emollients are the same — single emollients (for example, Vaseline) and combinations of emollients (moisturizers generally) have different therapeutic, aesthetic and sensory properties:

  • some skins respond better to some emollients than others;

  • in winter weather, some moisturizers, such as Darphin Hydraskin Light, are a poor choice for all skin types;

  • the most effective emollients, if used alone or with few other skin care ingredients, are relatively unpleasant to use, particularly for extended periods of time.

For more information surrounding dry winter skin treatment:

If taking cholesterol-lowering drugs, refer ideal cleansing for patients taking cholesterol-lowering drugs.

For dry hands, refer dry hands.

Friday, 6 June 2008

Marini Lash Press Release from Jan Marini Skin Research

Marini Lash Press Release from Jan Marini Skin Research

Jan Marini Skin Research Introduces Marini Lash™ for Full and Lush Eyelashes.

Jan Marini Revolutionizes Cosmetic Eyelash Enhancement — Again!

San Jose, CA — Jan Marini Skin Research, Inc. (JMSR; www.janmarini.com) today introduced Marini Lash, a revolutionary eyelash formulation designed to give users amazingly gorgeous, dense and lush eyelashes.

In 2005 JMSR revolutionized eyelash enhancement with a technological first that inspired a host of imitators. Now, JMSR sets the pace again by introducing a proprietary and spectacular non-prostaglandin eyelash formulation. JMSR research and development uncovered a recently discovered proprietary peptide which, when combined with other essential factors, produces extraordinary eyelash and brow enhancement.

Jan Marini Portrait

“For three decades, I have been dedicated to developing products that provide men and women with real solutions for their skin and hair, offering them the full benefit of the latest scientific innovations,” said Jan Marini, president and CEO of Jan Marini Skin Research. “I was overwhelmed by the incredibly passionate response of women worldwide to my previous eyelash enhancement formulas. I am confident that Marini Lash will give everyone spectacular-looking, lush lashes.”

Marini Lash, offered in a mascara-style container, is available through physicians and licensed skin care professionals worldwide.

Wednesday, 18 June 2008

Marini Lash News from Jan Marini

A new "non-prostaglandin" Eyelash Enhancement product, "Marini Lash", will soon be marketed, to take the place of the invidious Jan Marini Age Intervention Eyelash/Eyelash Conditioner.

  1. Eyelash Enhancement Gets Another Look — Wall Street Journal.

Refer Jan Marini Age Intervention Eyelash/Eyelash Conditioner.

Thursday, 5 June 2008

A New Proposal for Reducing Hyperpigmentation: Jan Marini Age Intervention Enlighten

A New Proposal for Reducing Hyperpigmentation: Jan Marini Age Intervention Enlighten

Jan Marini Age Intervention Enlighten is a new addition to the range of topical home-use treatments aimed at helping lessen the appearance of hyperpigmentation.

Jan Marini Age Intervention Enlighten references:

  1. Jan Marini Age Intervention Enlighten Skin Care Information — June 2008;
  2. Jan Marini Age Intervention Enlighten Skin Care Information — May 2008;
  3. Jan Marini Age Intervention Enlighten Ingredients;
  4. Jan Marini Age Intervention Enlighten Instructions for Use;
  5. Jan Marini Age Intervention Enlighten Information from Jan Marini.

Thursday, 5 June 2008

Jan Marini Age Intervention Enlighten Skin Care Information — June 2008

"Age Intervention Enlighten treats hyperpigmentation caused by sun damage, melasma and ethnicity.

Hyperpigmentation can often cause the skin to look aged and unhealthy.

Jan Marini Age Intervention Enlighten aims to reverse discoloration in order to restore the appearance of health and vibrancy.

A blend of powerful lightening ingredients work together to both diminish and prevent hyperpigmentation.

In addition, Jan Marini Age Intervention Enlighten smoothes away fine lines and wrinkles for an even more youthful-looking complexion."

Wednesday, 7 May 2008

Jan Marini Age Intervention Enlighten Information from Jan Marini

Jan Marini Portrait

SAN JOSE, Calif., May 6 /PRNewswire/ -- Jan Marini Skin Research, Inc. (JMSR; http://www.janmarini.com) today introduced Age Intervention Enlighten, a remarkable new composition that brightens and encourages the uniform appearance of facial discoloration -- even stubborn hyperpigmentation.

"Women often associate fine lines and wrinkles with aging but discoloration is an even more visual sign of the aging process," explains Jan Marini, president and CEO of Jan Marini Skin Research. "Age Intervention Enlighten is an exceptional brightening technology with de-aging agents that result in refined, rejuvenated and illuminated skin."

Uneven skin tones and discoloration can age the look of facial skin just as dramatically as lines and wrinkles. Overly pigmented facial areas that may occur due to melasma, cumulative sun exposure and ethnicity are some of the most common and difficult to concerns to treat.

Enlighten contains a combination of two exceptional topical agents that add